Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Narra J

Effects of SGLT2 inhibitor administration on blood glucose level and body weight in type 1 diabetes rat model Syukri, Maimun; Zaini, Lia M.; Kartasasmita, Arief S.; Gondhowiardjo, Tjahjono D.; Lesmana, Ronny
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.194

Abstract

The prevalence of diabetes worldwide is increasing and 629 million people are projected to have diabetes by 2045, and the most significant burden of the disease being concentrated in low- and middle-income countries (LMICs). Type 2 diabetes is mainly treated with insulin adjunctive therapies such as metformin to improve insulin sensitivity and sodium-glucose co-transporter 2 (SGLT2) inhibitors to lower blood glucose levels. However, there was limited study on the application of SGLT2 inhibitors on type 1 diabetes, particularly empagliflozin. Therefore, this study aimed to determine the effect of SGLT2 inhibitors on blood glucose levels and body weights in a rat model of type 1 diabetes. To mimic type 1 diabetes, the rats were injected with streptozotocin 60 mg intra-peritoneally. Twenty-four rat models were randomly divided into four groups: normal rat group (negative control), untreated diabetic rat group (positive control), type 1 diabetic rats treated with metformin, and type 1 diabetic rats treated with empagliflozin. Blood glucose levels and body weight were recorded before and after induced with streptozotocin and on weeks 4, 6, 8 and 10 of the treatment with anti-diabetic drugs. This study found that the blood glucose levels before and after treatment significantly decreased in all groups (p<0.05), except in the negative control group. Similar results were observed in body weight of the rats, which all groups experienced weight loss, except the negative control. These results suggested that apart from being used in type 2 diabetes, SGLT2 inhibitors may also be used as a treatment for type 1 diabetes.
Co-Authors . SETIAWAN . Susianti Abd. Rasyid Syamsuri Abdul Hadi Hassan Ace Tatang Hidayat Achadiyani Agus Muji Santoso Agus Syahrani Agus Syahrani Ahmad Kurniawan Ahmad Kurniawan Ahmad Ramdan Ajeng Diantini Aldo Hartono Aldo, Mochammad Alia Bihrajihant Raya Alia Bihrajihant Raya Ambrosius Purba Ambrosius Purba Anang Wahid M.Diah Anas Subarnas Anas Subarnas Andrew Citrawan Anggraeni Dyah S Anggraeni Dyah Sulistiowati Anindya Putri Parmadhi Parmadhi Anissa Anissa Anissa, Anissa Annisa F. Dewi Arief Budiono Arief Cahyanto Arief S. Kartasasmita Arifin Dwi Saputro Arto Yuwono Soeroto Astrid Feinisa Khairani Astrid, Stephanie Aulina, Datin Zahira Aziis Mardanarian Rosdianto Aziiz Mardanarian Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Rosdianto Azis Mardanarian Azmi, Mohamad Nurul Bachtiar, Willy Bahjah, Firda Hanan Baniasih, Akbar I. Baniasih, Akbar I. Bashari, Muhammad H. Bela Ita Karina Daba, Mariel Dani Sujana Darmayanti, Meita Decky Gunawan, Decky Dewi, Annisa F. Diana K Jasaputra Diana Krisanti Jasaputra Diana Krisanti Jasaputra Diandra Syifa Dimpuulina Erna Mariati Dwi Putri Larasati Edi Sukmana Edi Sukmana Edward J Hadi Endang Sutedja Endang Sutedja Enny Rohmawaty Euis Julaeha Evi Rinata Fajar Ari Widyatmoko Fani Rahma Yenita Fathurachman Fathurachman Fatona Suraya, Fatona Febriana Kurniasari Ferdyan Efza Fernandez, Veronica Fifi Veronica Filza Yulina Ade Finda Meyditia Finda Meyditia Fitri Fadhilah Galuga Sinalusur Sari Genta Syaifrin Laudza Gilang Muhamad Nur Iqbal Goenadi, Julia Windi Gondhowiardjo, Tjahjono Darminto Gunadi, Julia Windi Gunawan, Hanna Hadi Hadi Hana Goenawan Hanna Goeanawan Hanna Goenawan Hanna Goenawan Hanna Goenawan Hanna Gunawan Hanom Husni Syam Hasbilla, Raihan Fathurrahman Hendra Gunawan Hendy Setiawan Hendy Setiawan Herlina, Lien Herry Herman Hilmi Al Wahid Huda, Fathul Huda, Fathul I Made Joni Ida Ayu Putu Sri Widnyani Ieva B. Akbar Ieva Baniasih Akbar Ika M. Silviana Imam Megantara Indahwati, Dwiwahju Dian Irma Erika Herawati Irma Erika Herawati Irma Melyani Puspitasari Irma Ruslina Defi Isa Mahendra Ivan Christian Channel Ivanna Valentina Iwan Setiawan Iwan Setiawan Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Jihan Mudrika Rahmi Julia W Gunadi Julia Windi Gunadi Julia Windi Gunadi Jutti Levita Kanakarajah, Sarmmila Kartasasmita, Arief Sjamsulaksan Kartika Hajar Kirana, Kartika Hajar Kastella, Faysal Keiichi Motoyama Khairinisa, Miski A. Krisnadi, Sofie Riyani Kusmawan, Steven Zerin Putra Lazuardhi Dwipa Leonardo Lubis Lia Meuthia Zaini, Lia Meuthia M.T., Vita Madhani Pradiptha Nugroho Maharani, Julia Maimun Syukri, Maimun Mariel Daba Mas Rizky A.A. Syamsunarno MEGANTARA, SANDRA Meita Dhamayanti Muchtaridi Muchtaridi Mulya, Putri Nabillah Mulyanaga, William Giovanni Mutakin Mutakin Mutiarahmi, Citra Nur Nabilah Muhamad Naini, Al Arofatus Nanang Wahyudin Nanang Wahyudin Nanny N. N. M. Soetedjo Nasrul Wathoni Norisca Aliza Putri Nova Sylviana Nova Sylviana Nuraini Yasmin Nuroh Najmi Nurul Fadhilah Oki Suwarsa Okta Wismandanu Oktorina, Lenny Pangestuti, Balqist Sriprobo Pardede, Akim Manaor Hara Penny Setyawati Martioso Permadi, Andieni Faqhira Permana, Noah Jefferson Permana, Shenny S.S Pinkan Al Shabrina Pitu Wulandari Prasetyo, Wibowo Budi Prayudi Santoso Putri Tessa Putri, Aufa A.D Qiantori, Adziqa Ammara Radhiyanti, Putri Teesa Rahdiyanti, Putri Teesa Ramadhanti, Julia Ramdani Hamzah Ray, Hamidie Ronald Daniel Rejeki, Purwo Sri Renaldi Prasetia Reni Farenia Reni Farenia rima siburian Riska A Safira Risna Agustina Risna Agustina Roro Wahyudianingsih Rosdianto, Aziis Mardanarian Rosdianto, Aziiz M. Rosdianto, Aziiz Mardanarian Rurini Retnowati Rusdin, Agus Ruswana Anwar Safriansyah, Wahyu Salam, Supriyanto Sandra Amalia Riyadi Sarmmila Kanakarajah Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Shelly Iskandar Silviana, Ika M. Simanungkalit, Jayne Mary Siti Baitul Mukarromah Siti Mukarromah Siti Nuriyatus Zahrah Slamet Imron Sofie R. Krisnadi Sofiyanti, Santi Sri Adi Sumiwi Steffi Liem Sudigdo Adi Sudrajat, Ratu Z.A.P sugianli, Adhi Sukmayani, Jasmine Y. Sunarjati Soedigdoadi Sunarjati Sudigdo Adi Sunarjati Sudigdo Adi Sunarjati Sudigdoadi Sunaryati S. Adi Supriatno Salam Susanti Husen Susianti Susianti Susianti Susianti Susianti, Susianti Susiarno, Hadi Tarawan, Vita M. Tarawan, Vita M. Teresa Lucretia, Teresa Teti Madiadipoera TIANA MILANDA Tina Rostinawati Titing Nurhayati Tjahjono D. Gondhowiardjo Tri Mayanti Trianing Tyas Kusuma Tyagita Hartady Unang Supratman Vita M. Tarawan Vita Muniarti Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Lubis Vita Mutia Tarawan Wahyudianigsih, Roro Wahyuni, Indah S. Willy Bachtiar Yanuar Dwi Prastyo Yasmin, Nuraini Yenny Noor Yudi Feriandi Yulia Sofiatin Yumilia, Hoo Yunas, Aisya Astri Yuni Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yusuf, Muchamad R.A Zaini, Lia M. Zakiyah, Neily Zulhendri, Felix