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Journal : Journal of Multidisciplinary Applied Natural Science

Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Abstract

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.
Co-Authors Ade Irma Suryani Adek Amansyah Adrian Adrian Adrian Adrian Agatha, Yuti Paramitha Ahmad Faried Alya Mardhotillah Azizah Anditha, Arie Tika Andre, Johannes Anggraini, Jenny Anggraini, Livia Anggraini, Suhelis ANGGREINI, DEVINA Anggriani H, Theresia Angnes, Odri ANITA SARI, DEVI Annisa Amalia Anton Timur Jailani Harahap Aprilia, Shefira Aritonang, Murni Armansyah, Adek Arna Fransisca Mp Astari, Nur Aulia, Makrifatul Aulia, Rumi Awaluddin Ziad Azah, Yunita Wannur Bangun, Chrismas Gideon Bangun, Primta Bawean, Popi Latifah Br Kaban, Karmila Butter Samin Buulolo, Sukriston Calvin, David Chandra Wilim Chintya Darma, Gladys Chiuman , Linda Chiuman, Linda Chiuman, Veranyca Daniel Prem Raj Pandid Datitha Alodia Br Kaban, Karina Dewi Riastawati DEWI SARTIKA Dewi Sartika Dewi, Silvi Tiara Diana Krisanti Jasaputra Duha, Sonya Marsela Pieta Dwi Astuti Manullang Dwight Mahaputera Marulitua Hutapea Edy Fachrial Eliani, Eliani Elis Anggeria Emilia Laia, Maria Erika Erika Ermi Girsang Ermi Girsang Ernes, Audrina Eva Latifah Nurhayati Fadhilla, Jeni Putri Fentia, Lia Ferdinand, Sahna Feri irawan Fiska Maya Wardhani Frederick Frederick gan, claris cyntha deninta Geeta, Ginting, Astriani Natalia Br Ginting, Sahna Ferdinand Girsang, Ermi Guk Guk, Marissa Hardayati Br Raja Gultom, Hanawita Gultom, Yohania Premita Gusbakti Rusip Hafifah Hafifah Halim, Michael Handayani, Rr. Anisa Siwianti Handoko, Erwin Handriani, Wita Hanna Sari Widya Kusuma Harahap, Viora Rezky Harmileni Hasibuan, Nasyidah Hannum Hasya, Muhammad Nawal Hermansyah, Mhd. Farhans Hia, Arman Hondo, Alfarikus Hsb, Khairiyani Asri Hutabarat, Yohana Candra Andini I Nyoman Ehrich Lister I Nyoman Ehrich Lister IKHTIARI, REFI Iksen, Iksen Irwan Irwan irza Haicha Pratama Johannes Bastira Ginting Kartika, amalia Laurenxius, Vanessa Sinana Linda Chiuman Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, Nyoman Ehrich Lumbanraja, Dhea Rebeca Lumbantobing, Salomo Lydia Ernawati Rahayu Makdalena, Makdalena Manalu, Andika Prianto Mangatas Silaen Manik, Rayani Manurung, Grace Nathasya Mariana Mariana Masryna Siagian Maswarni Matondang, Windri Mutiara Maulidwina Bethasari Mawarni, Evi Mendrofa, Gusmina Mendrofa, Leli Angelita Mendrofa, Trisman Basri Mendrofa, Tuho Konsultasi Merrina Arts, Tricya Mucmaini, Rica Muhammad Hidayat Muna Soraya Putri Murni, Faradila Mustika, Rani Mutia, Maya Sari Nabila, Siti Napiah, Ali Nasution, Ali Napiah Nasution, Atika Rimalda Nasution, Isna Gita Amalia Nasution, Sri Lestari Ramadhani Nasution, Sriwahyuni Nella Vista Purba, Agnes Nerissa Nasriza Noflita, Noflita Noviawati Noviawati Nurhayati, Evalatifah Oni Fatmala, Cut Panggabean, Dini Desita Panjaitan, Dian Permata Khaira, Azzuhra Pesta Ria, Anna Maria Pinem, Sabriela Br Piska, Finna Pulungan, Ica Yulianti Purba, Deborah Angelin Puspita, Nadia Enjelika Putranto Manalu Rahanum, Dewi Rahayu Rahayu Rahmadani, Rani Raif, Martinus Ahmad Ramadhan Efendi Rapael Ginting Razoki, Razoki Rica Tri Septinora Rizal Rizal Rizky, Muhammad Irvan Rosari, Anita Rotua, Margaretia Yenni Sahna Ferdinand Ginting Sahna Ferdinand Ginting Santy Deasy Siregar saragih, jean Sari, Laura Kartika Satri, Endah Juni Satrio Wibowo Sembiring, Lidia Henni Siagian, Masryna Siahaan, Destri Safhira Siahaan, Nurisa Tri Ayu Sianturi, Reksaudi Sihombing, Bungaran Sihombing, Nadia Deva Sihura, Belinda Putri E. Silaen, Mangatas Simanungkalit, Jeny Angelica Karolina Sinaga, Widya Oktaviani Siregar, Reza Arfan Siti Hardianti, Siti Sri Mulyati Sri Ulina, Evita Sri Wahyuni, Devi Subangkit, Mawar SUHARTOMI . Sunarti Suriani Suriani Suyono, Tan Syahputra, Hariyadi Dharmawan Syahrian, Muhammad Faridz Telaumbanua, Rizky Anditino Teresa Liliana Wargasetia The Fransiska Eltania Tiarnida Nababan Tjiawi, Midoro Tobing, Madeline Angeline Tresun Br Turnip, Malna Umar, William Vera Estefania Kaban vera vera, vera Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wardhani, Fiska Maya Wau, Herbert Widodo, Wahyu Setia Widya Yanti Sihotang Widyastari, Elisa Wienaldi, Wienaldi Wijaya, Johanna Fransiska Wijaya, Winny Winda Sari Winvi, Feli Clarisa Yanti, Ratmi Yolanda Eliza Putri Lubis Yuliansyah, Jeri Yulita, Emi Yulizal, Ok Yusmaini, Yusmaini Zamili, Effendi Zebua, Sawato Zendrato, Desi Haryanti Zerry All Vindo Tarigan