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Journal : medisains

In vivo study of cardioprotective effect of bay leaf (Syzygium polyanthum) extract Ikhtiari, Refi; Sari, Laura Kartika; Nasution, Ali Napiah; Ginting, Chrismis Novalinda; Handoko, Erwin; Lister, I Nyoman Ehrich
MEDISAINS Vol 20, No 1 (2022)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v20i1.12502

Abstract

Background: The excessive use of chemotherapy drugs such as doxorubicin might induce cardiovascular diseases. Heart-specific biomarker enzymes such as LDH and BNP indicated the early signs of cardiotoxicity. However, there is no report on the effect of bay leaf on LDH and BNP nor its bioactive compounds and histopathology analysis.Objective: This study aims to determine the cardioprotective effect of Ethanol Extract of Bay Leaf (EEBL) based on phytochemical analysis, LDH and BNP levels, and cardiac histology of rats administered with doxorubicin.Methods: About 24 Wistar rats were divided into six groups treated with 100 mg/kg BW, 300 mg/kg BW, and 500 mg/kg BW of EEBL with CMC-Na 0.5 %, vitamin E, and doxorubicin. Preconditioning was 14 days, followed by 21 days of intraperitoneal administration. LDH and BNP parameters were measured on days 1st, 7th, 14th, and 20th. Histology analysis was conducted on day 21st.Results: Dark green EEBL showed sufficient physical quality and properties for practical application in pharmacy. EEBL has significantly affected LDH, BNP, and cardio recovery dose-dependent. The most effective doses were observed at 500 mg/kg BW, and its performance is not statistically different from those of the commercial vitamin E. The histopathological images revealed significant improvements in interstitial edema, wavy fibers, hemorrhage, intracellular vacuole, and inflammatory cell infiltration. Here we report six bioactive compounds obtained from EEBL have cardioprotective effects; Neophytadiene, squalane, phytol, methyl palmitate, stigmasterol, and  9,12-Octadecanoic acid methyl ester.Conclusion: This study has shown the promising potential of bay leaf extract as a cardioprotector with sufficient quality pharmacological standards.
Co-Authors Ade Irma Suryani Adek Amansyah Adrian Adrian Adrian Khu Afni Kartika, Ajeng Agatha, Yuti Paramitha Ahmad Faried Alya Mardhotillah Azizah Andre, Johannes Anggraini, Livia Anggraini, Suhelis Angnes, Odri ANITA SARI, DEVI Annisa Amalia Anton Timur Jailani Harahap Aqilah Yafa, Wafi Aritonang, Murni Armansyah, Adek Arna Fransisca Mp Awaluddin Ziad Azah, Yunita Wannur Bawean, Popi Latifah Butter Samin Chandra Wilim Chintya Darma, Gladys Chiuman, Linda Chiuman, Veranyca Daniel Prem Raj Pandid Dewi Riastawaty Dewi Sartika DEWI SARTIKA Diana Krisanti Jasaputra Duha, Sonya Marsela Pieta Dwi Astuti Manullang Edy Fachrial Eliani, Eliani Elis Anggeria Emilia Laia, Maria Ermi Girsang Ermi Girsang Ernes, Audrina Eva Latifah Nurhayati Fauziah, Dinda Ferdinand, Sahna Feri irawan Finna Piska Fiska Maya Wardhani Frederick Frederick gan, claris cyntha deninta Geeta, Girsang, Ermi Gultom, Yohania Premita Gusbakti Rusip Hafifah Hafifah Halim, Michael Handayani, Rr. Anisa Siwianti Handoko, Erwin Handriani, Wita Hanna Sari Widya Kusuma Harahap, Viora Rezky Harmileni Hasibuan, Nasyidah Hannum Hasya, Muhammad Nawal Hondo, Alfarikus Hsb, Khairiyani Asri Hutapea, Dwight Mahaputera Marulitua I Nyoman Ehrich Lister I Nyoman Ehrich Lister IKHTIARI, REFI Iksen, Iksen irza Haicha Pratama Johannes Bastira Ginting Karmila Br. Kaban Laurenxius, Vanessa Sinana Linda Chiuman Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, Nyoman Ehrich Lubis, Anisa Taqwa Lumbantobing, Salomo Lydia Ernawati Rahayu Makdalena, Makdalena Manalu, Andika Prianto Mangatas Silaen Manik, Rayani Mariana Mariana Masryna Siagian Maswarni Maulidwina Bethasari Mawarni, Evi Mendrofa, Leli Angelita Mendrofa, Trisman Basri Mendrofa, Tuho Konsultasi Muhammad Chairul Muna Soraya Putri Mustika, Rani Mutia, Maya Sari Nabila, Siti Napiah, Ali Nasution, Ali Napiah Nasution, Isna Gita Amalia Nella Vista Purba, Agnes Nerissa Nasriza Noflita, Noflita Noviawati Noviawati Nurhayati, Evalatifah Oni Fatmala, Cut Panggabean, Dini Desita Panjaitan, Dian Permata Khaira, Azzuhra Pesta Ria, Anna Maria Pinem, Sabriela Br Pulungan, Ica Yulianti Putranto Manalu Rahayu Rahayu Rahmadani, Rani Raif, Martinus Ahmad Ramadhan Efendi Rapael Ginting Razoki, Razoki Rica Tri Septinora Rizal Rizal Rizky, Muhammad Irvan Sahna Ferdinand Ginting Sahna Ferdinand Ginting Santy Deasy Siregar saragih, jean Sari, Laura Kartika Satrio Wibowo Saud Parulian Harianja Siahaan, Destri Safhira Siahaan, Nurisa Tri Ayu Sianturi, Reksaudi Sihombing, Bungaran Sihombing, Nadia Deva Silaen, Mangatas Sinaga, Widya Oktaviani Siregar, Reza Arfan Siti Hardianti, Siti Soekardi, Adi Sri Lestari Ramadhani Nasution Sri Mulyati Sri Ulina, Evita Sri Wahyuni, Devi Subangkit, Mawar Suhartomi Sunarti Suriani Suriani Suyono, Tan Syahputra, Hariyadi Dharmawan Syahrian, Muhammad Faridz Telaumbanua, Rizky Anditino Teresa Liliana Wargasetia The Fransiska Eltania Tiarnida Nababan Tjiawi, Midoro Tobing, Madeline Angeline Tresun Br Turnip, Malna Umar, William Vera Estefania Kaban Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wau, Herbert Widodo, Wahyu Setia Widya Yanti Sihotang Widyastari, Elisa Wienaldi, Wienaldi Wijaya, Johanna Fransiska Winda Sari Winvi, Feli Clarisa Yanti, Ratmi Yolanda Eliza Putri Lubis Yuliansyah, Jeri Yulizal, Ok Yusmaini, Yusmaini Zebua, Sawato Zerry All Vindo Tarigan