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All Journal Medula Jurnal Kreativitas PKM Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Mandala Pharmacon Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Buguh: Jurnal Pengabdian Kepada Masyarakat Jurnal Kedokteran Ibnu Nafis JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Risti Graharti
Bagian Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PEMANFAATAN POTENSI ALAMI SEBAGAI ANTIOKSIDAN Happy, Terza Aflika; Septiani, Linda; Graharti, Risti; Andrifianie, Femmy
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1825

Abstract

Indonesia is one of the world’s most biodiverse countries and possesses a vast potential of medicinal plants as natural therapeutic resources. Many medicinal plants traditionally used by local communities are known to contain secondary metabolites with antioxidant properties. Antioxidants play an essential role in preventing oxidative stress associated with degenerative and infectious diseases. This article aims to review the potential of secondary metabolite compounds from Indonesian medicinal plants as antioxidant agents based on previous studies. This study was conducted using a literature review method by analyzing relevant national and international scientific publications. The results indicate that various medicinal plants, including sweet potato leaves, green tea, roselle, celery, and Peperomia pellucida, contain polyphenolic compounds such as flavonoids, tannins, and phenols, as well as other secondary metabolites including alkaloids, saponins, terpenoids, quinones, coumarins, and anthocyanins. These compounds exhibit antioxidant activity through free radical scavenging, hydrogen atom donation, and inhibition of lipid peroxidation processes. In conclusion, Indonesian medicinal plants demonstrate significant potential as natural sources of antioxidants and offer promising prospects for further development in pharmaceutical and health applications, particularly as raw materials for phytopharmaceutical products and supportive therapies.
Efektivitas Beberapa Ekstrak Tanaman sebagai Ovisida terhadap Aedes aegypti dalam Pencegahan Demam Berdarah Dengue Septiani, Linda; aflika happy, terza; Graharti, Risti; Andrifianie, Femmy; Setyaningrum, Endah
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1827

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern, with Aedes aegypti serving as the primary vector. The continuous use of synthetic insecticides has led to resistance development and environmental concerns, highlighting the need for safer and sustainable alternatives. This review aims to evaluate the ovicidal potential of selected plant extracts against Aedes aegypti as an early-stage vector control strategy. A literature review was conducted using relevant national and international publications focusing on plant-based ovicides. The findings indicate that extracts from Piper nigrum L., Ocimum basilicum, Syzygium myrtifolium Walp., Tithonia diversifolia, Acorus calamus L., Solanum lycopersicum, and Euphorbia hirta L. effectively reduce egg hatchability of Aedes aegypti. The ovicidal activity is associated with secondary metabolites such as flavonoids, alkaloids, saponins, tannins, terpenoids, polyphenols, and essential oils, which disrupt egg membranes and inhibit embryonic development in a concentration-dependent manner. These findings suggest that plant extracts possess promising potential as natural ovicides and may serve as a basis for further pharmaceutical development and formulation in sustainable dengue vector control.
Perbandingan Ekstrak Biji Pinang Terdelipidasi dan Non-Terdelipidasi: Karakterisasi, Fitokimia, dan Aktivitas Antibakteri terhadap Cutibacterium acnes Andrifianie, Femmy; Daffa, Meysha Nur; Anggraeni, Ranesya Eka; Wardhani, Oktiva Risma; Graharti, Risti; Ali, Nur Fitriana Muhammad; Adjeng, Andi Nafisah Tendri
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.899

Abstract

Jerawat merupakan masalah kulit umum, terutama pada remaja, dan salah satu bakteri penyebabnya adalah Cutibacterium acnes. Biji pinang (Areca catechu L.) memiliki aktivitas antibakteri karena memiliki kandungan metabolit sekunder meliputi  alkaloid, tanin, flavonoid, dan fenolik. Namun, penelitian aktivitas antibakteri ekstrak etanol biji pinang setelah didelipidasi masih belum dilakukan. Penelitian ini bertujuan membandingkan karakterisasi, kandungan fitokimia, dan aktivitas antibakteri ekstrak etanol biji pinang sebelum dan sesudah delipidasi terhadap bakteri Cutibacterium acnes. Serbuk simplisia biji pinang diperoleh melalui proses pengeringan dan penghalusan biji pinang. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96%, sedangkan proses delipidasi dilakukan melalui ekstraksi cair-cair menggunakan n-heksan. Standarisasi ekstrak mengikuti prosedur Farmakope Herbal Indonesia. Skrining fitokimia meliputi pengujian alkaloid, flavonoid, saponin, tanin, steroid, dan terpenoid. Uji aktivitas antibakteri terhadap Cutibacterium acnes dilakukan dengan metode difusi sumuran pada berbagai konsentrasi ekstrak (5–40%). Rendemen ekstrak etanol kental sebesar 26,8%, sedangkan ekstrak terdelipidasi memiliki rendemen 78,73% dari ekstrak awal. Kedua ekstrak memenuhi parameter spesifik dan nonspesifik farmakope. Skrining fitokimia menunjukkan peningkatan intensitas alkaloid, flavonoid, tannin, dan saponin setelah delipidasi. Aktivitas antibakteri meningkat seiring konsentrasi, dengan zona hambat rata-rata ekstrak terdelipidasi lebih besar daripada ekstrak etanol, khususnya pada 20% (12,19?mm) dan 40% (12,84?mm) dibandingkan EE 20% (9,18?mm) dan EE 40% (8,52?mm). Delipidasi meningkatkan kandungan senyawa aktif polar/semi-polar sehingga aktivitas antibakteri ekstrak biji pinang terhadap Cutibacterium acnes lebih tinggi. Ekstrak terdelipidasi berpotensi dikembangkan sebagai bahan alami perawatan kulit berjerawat.
HUBUNGAN ANTARA HORMONE REPLACEMENT THERAPY DENGAN RISIKO KANKER PAYUDARA PADA WANITA PASCAMENOPAUSE: THE ASSOCIATION BETWEEN HORMONE REPLACEMENT THERAPY AND BREAST CANCER RISK IN POSTMENOPAUSAL WOMEN Devya Aulia; Windarti, Indri; Graharti, Risti; Sangging, Putu Ristyaning Ayu
Jurnal Kedokteran Ibnu Nafis Vol. 14 No. 2 (2025): Desember 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v14i2.1064

Abstract

Kanker payudara adalah penyebab utama kematian akibat kanker pada wanita, dengan insidensi global meningkat akibat faktor genetik, lingkungan, hormonal, dan gaya hidup, di mana estrogen dan progesteron mendorong proliferasi sel payudara melalui reseptor estrogen yang dapat memicu transformasi malignan. Pada wanita pascamenopause, penurunan estrogen diatasi dengan Hormone Replacement Therapy (HRT), yang meredakan gejala menopause dan mencegah osteoporosis, namun meningkatkan risiko kanker payudara. Kajian literatur ini meninjau hubungan HRT dengan risiko kanker payudara berdasarkan bukti epidemiologis, mekanisme biologis, dan temuan klinis. Metode yang digunakan adalah narrative review melalui pencarian artikel di PubMed, ScienceDirect, dan Google Scholar (2019–2025) dengan kata kunci “hormone replacement therapy”, “breast cancer risk”, dan “HRT breast cancer”, mencakup RCT, kohort, atau studi prospektif. Hasil telaah menunjukkan bahwa terapi estrogen tunggal menurunkan risiko kanker payudara 22% (HR 0.78; 95% CI 0.65–0.93) pada wanita pascahisterektomi, sedangkan kombinasi estrogen–progestin meningkatkan risiko 28% (HR 1.28; 95% CI 1.13–1.45). Studi kohort mengonfirmasi peningkatan risiko pada penggunaan kombinasi lebih dari lima tahun, terutama pada wanita dengan indeks massa tubuh rendah dan densitas payudara tinggi. Temuan ini menunjukkan bahwa peningkatan risiko terutama disebabkan oleh komponen progestin, sementara estrogen sendiri memiliki efek minimal. Stratifikasi risiko individu penting dalam mempertimbangkan manfaat dan risiko jangka panjang terapi HRT.
Prevalensi Komplikasi Kematian Ibu Dengan Persalinan Sectio Caesarea Di RSUD Dr. H. Abdul Moeloek Pada Tahun 2019 Agung Assirri; Risti Graharti; Intan Kusumaningtyas
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1761

Abstract

Maternal mortality is defined as the number of deaths in women that occur during pregnancy up to 42 days after delivery, caused by conditions directly related to pregnancy or its management, not by accidents or injuries. In Indonesia, the pattern of causes of maternal mortality over time has remained relatively constant, with hemorrhage, preeclampsia-eclampsia, and infection as the dominant factors contributing to high maternal mortality rates. One medical intervention that can help reduce the risk of maternal mortality is delivery by cesarean section (CS), especially in cases where the condition of the mother or fetus does not allow for vaginal delivery. This study aims to identify the prevalence of complications that cause maternal mortality in cesarean section deliveries at Dr. H. Abdul Moeloek Regional General Hospital. The research design used is a descriptive study with a qualitative approach. Secondary data were collected from patient medical records, and the sampling method used was total sampling, so that all 351 cases of C-section deliveries during the study period were analyzed. The results showed that there were 2 cases of maternal mortality out of a total of 351 C-section deliveries, or 0.57%. Both deaths were caused by postpartum hemorrhage (50%) and pre-existing heart disease (50%). These findings indicate that although the maternal mortality rate in CS deliveries at Dr. H. Abdul Moeloek Regional General Hospital is relatively low, risk factors such as hemorrhage and comorbidity still require special attention in delivery management.
Co-Authors A.P, Gadila Ade Yonata, Ade Adrifianie, Femmy aflika happy, terza Agatha Catherine Agung Assirri Agustyas Tjiptaningrum Airlangga Damara Akbar, Fareel Wahyu Al Ghifari, Ghaza Ahmad Ali, Nur Fitriana Muhammad Andika, Gede Agus Andrifianie, Femmy Angga Wijaya, Angga Anggraeni, Ranesya Eka Annisa Fath Ari Wahyuni Arif Yudho Prabowo Arnida Rahman Asep Sukohar Aulia Berliana Avisa Jinan Azura Ayu, Putu Ristyaning Bayu Anggileo Pramesona Benny Syahputra Gumay betta kurniawan Betta Kurniawan, Betta Boy K.H, High Cintawan, Ni Made Karenina Rini Dwi Daffa, Meysha Nur Devya Aulia Dewi Nur Fiana Diaru Fauzan Farizy Disaputera, Alfafa Tsalaatsa Djausal, Anisa Nuraisa Dorisman, Hari Dwiki WIjaya Rahman Endah Setyaningrum, Endah Evi Kurniawati Fardiansyah, Ahmad Irzal Farhah, Putri Dzahabiyyah Farid Rakhman Fatmasari, Dina Fitria Saftarina George Pestalozi Gigaramadan Sema Hadibrata, Exsa Hafizh, Ahmad Fauzan Happy, Terza Aflika Helmi Ismunandar Hendra Tarigan Sibero Idris, Mohamad Indri Windarti Indriyani, Reni Intan Kusumaningtyas Intanri Kurniati Iswandi Darwis Izdihar, Adinda Fairuz Jati, Pandu Kumaya Khairun Nisa Khairunnisa, Aulia Kurniawaty, Evi Kusumaningrum, Desy Liana Sidharti, Liana Maharani, Atifah Fadilah Mallarangeng, Andi Nafisah Tendri Adjeng Maulida, Syakira Zahra Mayasari, Diana Muhammad Ihsan Fariqy Muhammad Maulana Muhammad Ricky Ramadhian Ningrum, Kurnia Nisa, Lutfi Khoirun Novita Carolia Nuraini, Bianti Nurul Utami Oktoba, Zulpakor Prameswari, Putu Arya Indira Pratiwi, Aulia Sari Prayogi, Norbertus Marcell Purnama Sari, Faraztya Putri, Syalika Dianisa Putu Ristyaning Ayu Rachman Aziz Rahmadani, Tiara Sekar Rahmat, Aprin Nabila Rahmayani, Fidha Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reni Indriyani Retno Mareintika Ricky Rivalino Sitepu, Ricky Rivalino Rika Lisiswanti Rina Hayati Risal Wintoko rizki_novtarina21 Rodiani Roro Rukmi Windi Roro Rukmi Windi Perdani, Roro Rukmi Rudianto, Waluyo Ruslani, Nada Oktista Sangging, Putu Ristyaning Ayu Sany Setiawan Sema Gigaramadan Septa, Tendry Septiani, Linda Setiawan, Putri Ayundari Setiorini, Anggi Sheira Indah Anjani Soemarwoto, Retno Ariza Soeprihatini Sofyan Musyabiq Wijaya Suharmanto Sulthan Alam Yasyfa Susianti Susianti Sutarto Sutarto Sutarto Sutarto Syahrul Hamidi Nasution Syazili Mustofa TA Larasati Tri Umiana Soleha Wardhani, Dyah Wulan Sumekar Rengganis Wardhani, Oktiva Risma Widjaja, Jovan Winda Trijayanthi Utama, Winda Trijayanthi