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All Journal Medula Jurnal Kreativitas PKM Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Mandala Pharmacon Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Buguh: Jurnal Pengabdian Kepada Masyarakat Journal of Language and Health Jurnal Kedokteran Ibnu Nafis JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Risti Graharti
Bagian Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Prevalensi Komplikasi Kematian Ibu Dengan Persalinan Sectio Caesarea Di RSUD Dr. H. Abdul Moeloek Pada Tahun 2019 Agung Assirri; Risti Graharti; Intan Kusumaningtyas
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1761

Abstract

Maternal mortality is defined as the number of deaths in women that occur during pregnancy up to 42 days after delivery, caused by conditions directly related to pregnancy or its management, not by accidents or injuries. In Indonesia, the pattern of causes of maternal mortality over time has remained relatively constant, with hemorrhage, preeclampsia-eclampsia, and infection as the dominant factors contributing to high maternal mortality rates. One medical intervention that can help reduce the risk of maternal mortality is delivery by cesarean section (CS), especially in cases where the condition of the mother or fetus does not allow for vaginal delivery. This study aims to identify the prevalence of complications that cause maternal mortality in cesarean section deliveries at Dr. H. Abdul Moeloek Regional General Hospital. The research design used is a descriptive study with a qualitative approach. Secondary data were collected from patient medical records, and the sampling method used was total sampling, so that all 351 cases of C-section deliveries during the study period were analyzed. The results showed that there were 2 cases of maternal mortality out of a total of 351 C-section deliveries, or 0.57%. Both deaths were caused by postpartum hemorrhage (50%) and pre-existing heart disease (50%). These findings indicate that although the maternal mortality rate in CS deliveries at Dr. H. Abdul Moeloek Regional General Hospital is relatively low, risk factors such as hemorrhage and comorbidity still require special attention in delivery management.
Laporan Kasus: Pleuritis Tuberkulosis pada Paru Kiri dengan Sekat (SEPTATED) Disertai Tuberkulosis Paru Syazili Mustofa; Rachman Najmu Ramadhan; Soraya Rahmanisa; Risti Graharti; Wely Dwi Nopriansyah
Journal of Language and Health Vol. 6 No. 4 (2025): Journal of Language and Health: December 2025
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v6i4.1057

Abstract

Infeksi tuberkulosis yang disebabkan oleh mycobacterium tuberculosis yang terkait dengan akumulasi cairan di ruang pleura menghasilkan pleuritis Tuberkulosisi kasus TB pleuritis terbanyak yang lebih banyak mempengaruhi pada orang yang lebih muda. Laporan kasus ini bertujuan mendeskripsikan secara sistematis perjalanan klinis, temuan diagnostik, penatalaksanaan, serta hasil terapi pada pasien dengan pleuritis tuberkulosis septated disertai tuberkulosis paru. Data kasus diperoleh dari pemeriksaan dan penatalaksanaan pasien yang dirawat sebanyak satu orang dengan kasus spesifik pleuritis tuberkulosis septated disertai tuberkulosis paru. Hasil analisis disajikan dalam bentuk narasi yang menggambarkan hubungan antara gejala klinis, temuan pemeriksaan, proses penegakan diagnosis, dan efektivitas terapi anti-tuberkulosis maupun terapi penunjang pleuritis. Pasien datang dengan keluhan sesak napas berat di sertai dengan batuk lama lebih dari 2 bulan. Dahak berwarna putih dan berbau. Os juga mengeluh berkeringat malam tanpa didahului aktivitas fisis. Penurunan berat badan 8 kg. Pada pemeriksaan torak di temukan ronki pada kedua lapang paru. Kemudian dilakukan ronsen torak ditemukan efusi pleura masif pada hemithorax kiri dan infitltrat pada lapang paru kanan dan kiri. Kemudian di lakukan USG di temukan tampak cairan pada hemitorak kiri dan bersepta pada pasien. Selanjut kita cek kan TCM Mtb sputum dengan hasil (+). Cek HIV dengan ELISA hasil negatif. Pasien didiagnosis dengan Plueritis TB bersepta.
Hubungan antara Dukungan Keluarga dengan Perilaku Personal Hygiene pada Siswa Amalia Febriyanti; Suharmanto Suharmanto; Risti Graharti; Novita Carolia
Journal of Language and Health Vol. 6 No. 4 (2025): Journal of Language and Health: December 2025
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v6i4.1115

Abstract

Perilaku personal hygiene merupakan salah satu faktor penting dalam menjaga kesehatan anak usia sekolah dasar. Pembentukan perilaku tersebut dipengaruhi oleh berbagai faktor, salah satunya adalah dukungan keluarga. Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan keluarga dengan perilaku personal hygiene pada siswa sekolah dasar. Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional. Subjek penelitian adalah sorang tua dan siswa SDN 1 Kampung Baru Bandar Lampung yang dipilih menggunakan teknik proportionate stratified random sampling. Data dikumpulkan melalui kuesioner dukungan keluarga yang diisi oleh orang tua yang sudah valid (r=0,674-0,750) dan reliabel (alpha Cronbach 0,987) serta perilaku personal hygiene melalui wawancara dengan siswa. Analisis data dilakukan menggunakan uji Chi-Square dengan tingkat kemaknaan p < 0,05. Hasil penelitian menunjukkan bahwa siswa dengan dukungan keluarga yang baik cenderung memiliki perilaku personal hygiene yang lebih baik. Dapat disimpulkan bahwa dukungan keluarga berperan dalam pembentukan perilaku personal hygiene pada anak usia sekolah dasar.
Literature Review: Perbandingan Obesitas Berdasarkan Indeks Massa Tubuh dan Obesitas Sentral terhadap Risiko Penyakit Metabolik dan Kardiovaskular Muhammad Haekal Rabbani; Anggi Setiorini; Risti Graharti; Evi Kurniawaty
Journal of Language and Health Vol. 6 No. 4 (2025): Journal of Language and Health: December 2025
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v6i4.1226

Abstract

Obesitas merupakan salah satu masalah kesehatan global yang prevalensinya terus meningkat dan berperan penting sebagai faktor risiko terjadinya penyakit metabolik dan kardiovaskular. Penilaian obesitas secara klinis umumnya menggunakan indeks massa tubuh (IMT), namun indikator ini memiliki keterbatasan dalam menggambarkan distribusi lemak tubuh. Sebaliknya, obesitas sentral yang diukur melalui lingkar perut atau rasio lingkar pinggang-pinggul mencerminkan akumulasi lemak viseral yang lebih erat kaitannya dengan gangguan metabolik dan kardiovaskular. Oleh karena itu, literature review ini bertujuan untuk membandingkan peran obesitas berdasarkan IMT dan obesitas sentral terhadap risiko penyakit metabolik dan kardiovaskular. Metode yang digunakan adalah kajian literatur dengan penelusuran artikel ilmiah melalui basis data PubMed dan Google Scholar. Artikel yang disertakan dibatasi pada publikasi sepuluh tahun terakhir, berbahasa Indonesia atau Inggris, serta membahas hubungan antara indikator obesitas dan risiko penyakit metabolik maupun kardiovaskular pada populasi dewasa. Jurnal nasional dan internasional didapatkan 380 artikel dan 15 artikel yang memenuhi kriteria inklusi kemudian dianalisis secara komprehensif. Hasil telaah literatur menunjukkan bahwa obesitas sentral memiliki hubungan yang lebih kuat dan konsisten dengan risiko sindrom metabolik, diabetes melitus tipe 2, dislipidemia, hipertensi, serta penyakit kardiovaskular dibandingkan obesitas berdasarkan IMT. Beberapa studi melaporkan bahwa individu dengan IMT normal tetapi memiliki obesitas sentral tetap menunjukkan peningkatan risiko kardiometabolik yang signifikan. Hal ini berkaitan dengan peran lemak viseral dalam memicu resistensi insulin, inflamasi kronik, dan disfungsi endotel. Dapat disimpulkan bahwa obesitas sentral merupakan prediktor risiko penyakit metabolik dan kardiovaskular yang lebih sensitif dibandingkan obesitas berdasarkan IMT. Oleh karena itu, penggunaan indikator obesitas sentral perlu dipertimbangkan secara rutin dalam praktik klinis untuk deteksi dini dan pencegahan penyakit metabolik serta kardiovaskular.
Efektivitas Beberapa Ekstrak Tanaman sebagai Ovisida terhadap Aedes aegypti dalam Pencegahan Demam Berdarah Dengue Linda Septiani; terza aflika happy; Risti Graharti; Femmy Andrifianie; Endah Setyaningrum
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1827

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern, with Aedes aegypti serving as the primary vector. The continuous use of synthetic insecticides has led to resistance development and environmental concerns, highlighting the need for safer and sustainable alternatives. This review aims to evaluate the ovicidal potential of selected plant extracts against Aedes aegypti as an early-stage vector control strategy. A literature review was conducted using relevant national and international publications focusing on plant-based ovicides. The findings indicate that extracts from Piper nigrum L., Ocimum basilicum, Syzygium myrtifolium Walp., Tithonia diversifolia, Acorus calamus L., Solanum lycopersicum, and Euphorbia hirta L. effectively reduce egg hatchability of Aedes aegypti. The ovicidal activity is associated with secondary metabolites such as flavonoids, alkaloids, saponins, tannins, terpenoids, polyphenols, and essential oils, which disrupt egg membranes and inhibit embryonic development in a concentration-dependent manner. These findings suggest that plant extracts possess promising potential as natural ovicides and may serve as a basis for further pharmaceutical development and formulation in sustainable dengue vector control.
Karsinoma Nasofaring: Sebuah Laporan Kasus Gatra Hadimuti Wibowo; Ratu Fajaria; Risti Graharti
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1969

Abstract

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the nasopharyngeal epithelium and is the fourth most common malignancy in Indonesia, with approximately 13,000 new cases annually. Diagnosis is often delayed due to the concealed location of the nasopharynx. Case presentation: A 40-year-old male presented with left-sided tinnitus, earache radiating to the head, hearing loss, nasal congestion, odynophagia, hoarseness, and a 5-7 kg weight loss over 4 months. He had a history of Bell's palsy 8 months prior with House-Brackmann grade III that partially improved. Physical examination revealed no cervical lymphadenopathy. Nasopharyngeal CT scan showed left nasopharyngeal thickening, narrowing of the Rosenmüller fossa, and a hypodense lesion in the left temporal lobe suggestive of intracranial invasion. Discussion: This case is unique due to the combination of early manifestation as Bell's palsy without cervical lymphadenopathy, which differs from the typical NPC pattern where 70-90% of patients present with cervical metastases. Facial nerve involvement in NPC is rare (incidence <1%) and often overlooked as an early sign of malignancy. MSCT and MRI imaging play a crucial role in early detection of intracranial invasion. Conclusion: NPC should be suspected in adults with persistent ear, nose, and throat symptoms accompanied by weight loss, especially if there is an atypical history of Bell's palsy, even in the absence of cervical lymphadenopathy. Histopathological confirmation through nasopharyngeal biopsy remains essential before definitive management.
Mosquito Control Methods and Dengue Fever Disease: a Literature Review Aulia Khairunnisa; Risti Graharti
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1772

Abstract

Dengue Hemorrhagic Fever (DHF) is one of the vector-borne diseases that remains a public health challenge in Indonesia, characterized by high incidence rates, widespread vector distribution, and an increased risk of outbreaks in various endemic areas. The transmission of the dengue virus is greatly influenced by community behavior, residential environmental conditions, and the bioecology of the Aedes aegypti mosquito, which is able to breed in clean water puddles around homes. The dengue virus consists of four serotypes and can survive through vertical and horizontal transmission mechanisms, thereby strengthening the chain of transmission in the environment. On the other hand, vector control efforts using larvicides and chemical insecticides are still widely chosen by the community, even though improper use can cause insecticide resistance. This study aims to examine various methods of dengue vector control, including physical, mechanical, biological, chemical approaches, and the EcoHealth concept. The method used was a literature review of official guidelines, research articles, and the latest scientific publications on DHF and vector control. The results of the study show that physical control methods such as 3M Plus are the most effective and safest, while biological control through larval predators and environmentally friendly bacteria can reduce the larval population without causing negative ecological impacts. Chemical control still provides rapid effects, but must be used wisely to prevent resistance. The EcoHealth approach is considered more comprehensive because it involves environmental, social, cultural, and economic aspects of the community in sustainable control. In conclusion, optimal DHF control requires an evidence-based integrated strategy with cross-sector participation and the application of ecological principles to ensure long-term success in reducing disease incidence.
Faktor Yang Mempengaruhi Kepatuhan Penggunaan Alat Pelindung Diri (APD) Pada Tenaga Kesehatan : Literatur Review Kurnia Ningrum; Risti Graharti; TA Larasati
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1812

Abstract

Abstract The use of Personal Protective Equipment (PPE) is a key component of infection prevention and control in healthcare facilities. Compliance among healthcare workers determines the effectiveness of protection against biological, chemical, and physical hazards in the workplace. However, PPE compliance remains a challenge in many healthcare settings. This literature review aims to identify factors influencing PPE compliance among healthcare workers based on recent studies. The review was conducted using Google Scholar, PubMed, and ScienceDirect databases with the keywords “personal protective equipment,” “compliance,” and “healthcare workers.” Articles published between 2015 and 2025 were included. Of the 62 articles identified, 13 met the inclusion criteria and were analyzed in depth. The analysis focused on synthesizing findings related to individual, organizational, and work environment factors affecting PPE compliance. The results show that individual factors such as knowledge, attitude, risk perception, and work experience significantly influence compliance behavior. Organizational factors, including PPE availability, institutional policies, supervision, safety culture, and continuous training, also play an important role in shaping compliance. In addition, work environment factors such as workload, comfort of PPE, and physical conditions of care areas contribute to compliance levels. Understanding these factors is essential for improving patient and healthcare worker safety through comprehensive intervention strategies. Improving education, strengthening institutional policies, and ensuring adequate PPE supply systems are expected to enhance compliance. In Indonesia, integrated studies examining factors influencing PPE compliance remain limited, highlighting the need for further research to support policy development and occupational safety practices for healthcare workers.
Peran Laju Endap Darah dalam Evaluasi Penyakit Inflamasi Kronik Faraztya Purnama Sari; Putu Ristyaning Ayu Sangging; Risti Graharti
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1821

Abstract

Chronic inflammation is a persistent immune response resulting from continuous inflammatory stimuli, such as chronic infections, autoimmune diseases, and metabolic disorders, and plays a significant role in the pathogenesis of various chronic diseases. Continuous evaluation of inflammatory activity requires laboratory parameters that are easily accessible and capable of reflecting long-term inflammatory processes. The erythrocyte sedimentation rate (ESR) is a non-specific hematological test that remains widely used in clinical practice to assess systemic inflammation. Elevated ESR values occur as a result of changes in acute-phase proteins, particularly fibrinogen and immunoglobulins, which promote erythrocyte aggregation and accelerate the sedimentation process. This review article aims to discuss the role of ESR in the evaluation of chronic inflammatory diseases, including the mechanisms underlying ESR elevation, its advantages, limitations, and comparison with other inflammatory biomarkers. ESR has advantages in representing stable chronic inflammation, its simplicity, and relatively low cost; however, it also has limitations, including low specificity and a slow response to changes in inflammatory activity. Therefore, ESR should be interpreted comprehensively in conjunction with clinical evaluation and other inflammatory biomarkers to support optimal management of chronic inflammatory diseases.
Potensi Tanaman Obat Indonesia sebagai Kandidat Terapi Pendukung pada Demam Berdarah Dengue Terza Aflika Happy; Linda Septiani; Risti Graharti; Femmy Andrifianie
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.2030

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in Indonesia, with high morbidity and mortality rates. Since the current management of DHF is primarily supportive, identifying effective complementary therapies has become an important research priority. Indonesia possesses extraordinary biodiversity, including numerous medicinal plants rich in bioactive secondary metabolites with potential therapeutic properties. This study aimed to review the potential of Indonesian medicinal plants as candidates for supportive therapy in DHF based on available scientific evidence. A literature review was conducted by analyzing national and international publications related to medicinal plants and dengue infection. The findings indicate that several Indonesian medicinal plants, including Phyllanthus niruri L., Psidium guajava, Carica papaya L., and Ipomoea batatas, demonstrate promising potential as supportive therapies for DHF. Their therapeutic effects are mainly attributed to bioactive compounds such as flavonoids, quercetin, saponins, tannins, alkaloids, and polyphenols, which exhibit antiviral, anti-inflammatory, antioxidant, and immunomodulatory activities. These compounds may also promote thrombopoiesis by stimulating granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3, thereby contributing to platelet recovery. In addition, they help reduce oxidative stress, suppress excessive pro-inflammatory cytokine production, and preserve vascular endothelial integrity, potentially preventing disease progression and plasma leakage. Overall, Indonesian medicinal plants represent promising candidates for complementary supportive therapy in DHF. Nevertheless, further preclinical investigations and well-designed clinical trials are required to confirm their efficacy, safety, optimal dosage, and mechanisms of action before they can be recommended for routine clinical practice.
Co-Authors A.P, Gadila Ade Yonata, Ade Adrifianie, Femmy Agatha Catherine Agung Assirri Agustyas Tjiptaningrum Airlangga Damara Akbar, Fareel Wahyu Al Ghifari, Ghaza Ahmad Ali, Nur Fitriana Muhammad Amalia Febriyanti Andika, Gede Agus Andrifianie, Femmy Angga Wijaya, Angga Anggi Setiorini Anggraeni, Ranesya Eka Annisa Fath Ari Wahyuni Arif Yudho Prabowo Arnida Rahman Asep Sukohar Aulia Berliana Aulia Khairunnisa Avisa Jinan Azura Ayu, Putu Ristyaning Azelia Nusadewiarti Bayu Anggileo Pramesona Benny Syahputra Gumay betta kurniawan Betta Kurniawan, Betta Boy K.H, High Cintawan, Ni Made Karenina Rini Dwi Daffa, Meysha Nur Devya Aulia Dewi Nur Fiana Diaru Fauzan Farizy Disaputera, Alfafa Tsalaatsa Djausal, Anisa Nuraisa Dorisman, Hari Dwiki WIjaya Rahman Endah Setyaningrum Endah Setyaningrum, Endah Evi Kurniawati Evi Kurniawaty Faraztya Purnama Sari Fardiansyah, Ahmad Irzal Farhah, Putri Dzahabiyyah Farid Rakhman Fatmasari, Dina Femmy Andrifianie Fitria Saftarina Gatra Hadimuti Wibowo George Pestalozi Gigaramadan Sema Hadibrata, Exsa Hafizh, Ahmad Fauzan Happy, Terza Aflika Helmi Ismunandar Hendra Tarigan Sibero Idris, Mohamad Indri Windarti Indriyani, Reni Intan Kusumaningtyas Intanri Kurniati Iswandi Darwis Izdihar, Adinda Fairuz Jati, Pandu Kumaya Khairun Nisa Kurnia Ningrum Kurniawaty, Evi Kusumaningrum, Desy Liana Sidharti, Liana Linda Septiani Maharani, Atifah Fadilah Mallarangeng, Andi Nafisah Tendri Adjeng Maulida, Syakira Zahra Mayasari, Diana Muhammad Ammar Naufal Muhammad Haekal Rabbani Muhammad Ihsan Fariqy Muhammad Maulana Muhammad Ricky Ramadhian Nisa, Lutfi Khoirun Novita Carolia Novita Carolia Nuraini, Bianti Nurul Utami Oktoba, Zulpakor Prameswari, Putu Arya Indira Pratiwi, Aulia Sari Prayogi, Norbertus Marcell Putri, Syalika Dianisa Putu Ristyaning Ayu Rachman Aziz Rachman Najmu Ramadhan Rahmadani, Tiara Sekar Rahmat, Aprin Nabila Rahmayani, Fidha Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratu Fajaria Reni Indriyani Retno Mareintika Ricky Rivalino Sitepu, Ricky Rivalino Rika Lisiswanti Rina Hayati Risal Wintoko rizki_novtarina21 Rodiani Roro Rukmi Windi Roro Rukmi Windi Perdani, Roro Rukmi Rudianto, Waluyo Ruslani, Nada Oktista Sangging, Putu Ristyaning Ayu Sany Setiawan Sema Gigaramadan Septa, Tendry Septiani, Linda Setiawan, Putri Ayundari Setiorini, Anggi Sheira Indah Anjani Soemarwoto, Retno Ariza Soeprihatini Sofyan Musyabiq Wijaya Soraya Rahmanisa Suharmanto Suharmanto Suharmanto Sulthan Alam Yasyfa Susianti Susianti Sutarto Sutarto Sutarto Sutarto Syahrul Hamidi Nasution Syazili Mustofa TA Larasati Terza Aflika Happy Terza Aflika Happy Tri Umiana Soleha Wardhani, Dyah Wulan Sumekar Rengganis Wardhani, Oktiva Risma Wely Dwi Nopriansyah Widjaja, Jovan Winda Trijayanthi Utama, Winda Trijayanthi