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In Silico Study of Cladosporol and Its Acyl Derivatives as Anti-Breast Cancer Against Alpha-Estrogen Receptor Herdiansyah, Mochammad Aqilah; Ansori, Arif Nur Muhammad; Kharisma, Viol Dhea; Alifiansyah, Mochamad Radika Tory; Anggraini, Dhea; Priyono, Qiara Amelia Putri; Yusniasari, Putri Antika; Fetty, Amelia Julia Tria; Zainul, Rahadian; Rebezov, Maksim; Kolesnik, Evgeniy; Maksimiuk, Nikolai
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 1 (2024): April 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v15i1.949

Abstract

Breast cancer is a chronic health problem that causes 690,000 deaths worldwide. The development of secondary metabolite compounds from natural preparations through an in silico approach is needed as a predictive tool to prevent breast cancer, one of them is cladosporol from Cladosporium spp. This study aims to utilize an in silico approach to predict the potential of cladosporol against alpha-estrogen receptors. The alpha-estrogen receptor with code 6CBZ was selected based on group function as pharmacophore in ligand-receptor interaction. The methods used in this study are by using an in silico approach with Molegro Virtual Docker (MVD) Ver 5.5 for the docking process and CABS-flex 2.0 for identifying the stability of the complexes. ADMET properties analysis was also performed to know the pharmacokinetics attributes of cladosporol. Based on research conducted, stated that cladosporol octanoate has the lowest rerank score with a -84.3593 value and the RMSD value is 1.195 Å so it’s valid for molecular docking. Exploration of cladosporol for anti-breast cancer from Cladosporium spp fungi can be a novelty for the development of future pharmaceutical research. Thus, the development of anti-cancer drugs for early prevention can be carried out to reduce the number of breast cancer cases worldwide.
Pengaruh Variasi Ukuran Ketebalan Material Terhadap Karakteristik Termoelektrik Sistem C/CuO Sari, Putri Manda; Putra, Ananda; Zainul, Rahadian; Sanjaya, Hary
Periodic Vol 13, No 3 (2024): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v13i3.125603

Abstract

One of the factors that can affect the quality and characteristics of thermoelectric materials is the size of the material.. This study aims to determine how the effect of material size is varied in width and thickness. The material used is activated carbon obtained from previous research that has met the SNI No. 06-3720-1995 content test. The activated carbon is then composited with Copper (II) Oxide. Based on the tests that have been carried out, the best material obtained is the material with a thickness size variation of 0.5 cm. With a high electrical conductivity value of 0.9507 MΩ-.cm-, low thermal conductivity of 0.1805 J/s and has a high Seebeck coefficient of 0.020 mV/K. Thermoelectricity offers sustainable energy to maintain energy needs, namely by converting wasted heat energy into electrical energy that can overcome the current global warming problem.
Fotokatalis Titanium Oksida (TiO2) Doping Tembaga (Cu) Menggunakan Metode Sol Gel untuk Fototransformasi Zat Warna Methylene Blue Anjali, Ghoury Kharisma; Zainul, Rahadian
MASALIQ Vol 4 No 1 (2024): JANUARI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v4i1.2475

Abstract

Methylene blue is a heterocyclic synthetic dye used in the textile industry, but it has a negative impact on water quality and the surrounding environment. This research aims to degrade Methylene blue using a photocatalytic method. The catalyst used for degradation is TiO2 doped with 10% Cu. In this research, the degradation process uses 25 watt Uv light using a reactor. The degradation process was carried out by varying stirring at a speed of 1500 rpm and without stirring at 30, 60, 90 and 120 minutes. The degradation results were measured using a UV-Vis spectrophotometer to see the absorbance before and after degradation, and FTIR to see the shift in compound bonds. The results of this research showed that degradation using stirring had a higher percentage of degradation than without stirring. The maximum degradation percentage obtained in the research was 92.31% with a stirring speed of 1500 rpm for 120 minutes of exposure.
Optimation of Fe3+ Ion Desorption Using Sulfonate Modified Silica Gel-GPTMS Elvina, Elvina; Oktavia, Budhi; Nasra, Edi; Zainul, Rahadian
Jurnal Pijar Mipa Vol. 19 No. 5 (2024): September 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i5.7453

Abstract

Silica gel is one of the adsorbents widely used in adsorption, but silica gel has a low ability to absorb metals. Hence, modifications need to be made to improve it. Silica gel modified using sulfonate groups from monosodium salt compound of 4-amino-5-hydroxy-2,7-naphthalene disulfonic acid using GPTMS coupling compound for adsorption and desorption of Fe3+ ions by column method was carried out. The adsorption process of Fe3+ ions using silica gel-GPTMS-sulfonate has been carried out in previous studies and obtained an optimum state at pH 6 and a concentration of 20 ppm. After the adsorption process is carried out, the desorption process is continued with variations in the type of desorption eluent and concentration variations. The types of desorption agents are NaCl, CaCl2, HCl, and HNO3, with the optimum desorption agent being HNO3 with a release of 0.077517 mg of Fe3+ ions from 0.1587403 mg of Fe3+ ions absorbed and a desorption percentage of 48.83%. The concentration variations are 0.5 M, 1 M, 2.5 M, and 5 M, with an optimum concentration of 2.5 M HNO3 with a release of 0.098505 mg Fe3+ ions and a desorption percentage of 64.43%.
Designing an Interactive Virtual Laboratory Learning Experience for Acid-Base Indicators Putra, Abrar Suryadi; Zainul, Rahadian
Orbital: Jurnal Pendidikan Kimia Vol. 8 No. 2 (2024): Orbital: Jurnal Pendidikan Kimia
Publisher : Chemistry Education Department of Education and Teaching Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/ojpk.v8i2.24630

Abstract

Science education, especially chemistry, plays a vital role in the development of conceptual understanding and practical skills among students. In the modern digital era, the integration of technology into education is indispensable to meet the demands of modern curricula. Virtual laboratories provide a safe and efficient way of teaching chemical concepts without the hazards that come with physical laboratories. This research was conducted to design, validate, and determine the feasibility of interactive virtual laboratory learning media for acid-base indicators. This research used the ADDIE model: Analysis, Design, Development, Implementation, and Evaluation. There were 79 Phase F high school students, and seven expert validators involved in the research, comprising chemistry lecturers and teachers. The data collection used questionnaires and interviews, while the validation used Aiken's index. The results showed that the virtual laboratory achieved high validity scores across content, construct, and technical quality, ranging from 0.76 to 0.90. The results indicated that the interactive virtual lab significantly enhanced the students' visualization of abstract chemical concepts, thus improving their engagement and understanding. This illustrates the potential of integrating technology into chemistry education to create more effective and engaging learning experiences.
Development of growth mindset in higher education in support of the World-Class University Setiawan, Risky; Dewi, Radeni Sukma Indra; Zainul, Rahadian
International Journal of Evaluation and Research in Education (IJERE) Vol 13, No 6: December 2024
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijere.v13i6.30145

Abstract

This study aims to develop a tool to measure the growth mindset of university lecturers, which is associated with performance and professionalism in institutions, especially at Universitas Negeri Yogyakarta (UNY) to go to a World-Class University (WCU). This research is a research and development (R&D) research with a quantitative approach measuring the quality of university growth mindset instruments. The measuring tool developed is a questionnaire using the confirmatory factor analysis (CFA) method. The results of each indicator are analyzed and integrated with structural equation modeling (SEM). The results of the growth mindset study of the academic community at UNY. The growth mindset instrument construct for the academic community is qualified to measure the ability of growth mindset from lecturers. The results show that the developed instruments show a valid and reliable construct. Advanced analysis by multiple regression method with path analysis shows that the academic level is the moderate variable with the most influence on the growth mindset path analysis model. Increasing the academic level will optimize the growth mindset of lecturers; performance will evolve.
DEVELOPMENT OF STUDENT WORKSHEETS ON THE PERIODIC SYSTEM OF ELEMENTS BASED ON CONTEXTUAL TEACHING AND LEARNING FOR PHASE-E SENIOR HIGH SCHOOL Risty, Chika Mei; Kurniawati, Desy; Hardeli, Hardeli; Zainul, Rahadian; Syolendra, Dwi Finna
Chimica Didactica Acta Vol 12, No 2: December 2024
Publisher : FKIP USK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jcd.v12i2.42002

Abstract

This study aimed to produce teaching materials in student worksheets based on contextual teaching and learning and to determine the validity and practicality of the student worksheets developed. The research method used is educational design research (EDR), with the Plomp development model carried out until the validity and practicality test stages are achieved. This development research shows that the contextual teaching and learning-based student worksheets developed are valid and practical. This is supported by the validation results, which have an average value of 0.91 and are included in the very valid category. The practicality results obtained from the small group test of students get a percentage of 95%, and the percentage result from the teacher is 92%, which is included in the Highly practical category. These results indicate that the student worksheets developed are feasible to be applied to learning to help students' understanding of concepts on the material of the periodic system of elements and encourage students to become active, creative, and critical learners. The results of this study indicate that the student worksheets developed are suitable for use in the learning process on the material of the periodic system of elements in phase E Senior High School.
INOVASI PRODUK PISANG MENJADI BERBAGAI JENIS PRODUK DI NAGARI PANTI SELATAN KECAMATAN PANTI KABUPATEN PASAMAN Anni Faridah; Sari Mustika; Rahadian Zainul; Ezi Anggraini; Durain Parmanoan
Journal of Community Service Vol 6 No 2 (2024): JCS, December 2024
Publisher : Ikatan Dosen Menulis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56670/jcs.v6i2.261

Abstract

Kecamatan Panti, Nagari Panti Selatan, memiliki produksi pisang terbesar di Kabupaten Pasaman. Jumlah produksi pisang di daerah ini pada saat panen raya cukup besar, sehingga terjadi kelebihan produksi. Produksi pisang lebih besar daripada permintaan. Kondisi ini menyebabkan produksi pisang berlebihan karena masyarakat hanya menganggap pisang sebagai pisang untuk dijual dan tidak dikonsumsi secara signifikan. Selain itu, harga pisang sangat berubah-ubah dan cenderung rendah. Kegiatan pengabdian ini mempunyai tujuan untuk meningkatkan pengetahuan dan keterampilan pedagang kecil di nagari Panti Selatan, Kecamatan Panti, Kabupaten Pasaman sebagai mitra dengan memanfaatkan potensi daerah yang ada tetapi belum termanfaatkan secara optimal yaitu pisang menjadi produk yang bervariasi, seperti dodol pisang, nugget pisang, keripik pisang, dan stik pisang.
Computational Calculation and Molecular Docking of Thymol and O-Benzoyl Thymol as Inhibitor TYK2 Enzyme Maahury, Mirella Fonda; Baharudin, Muhammad Daswar A.; Zainul, Rahadian; Khalid, Ahmad Khudzairi; Jakmola, Vikash; Rebezov, Maksim
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 03 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss03/405

Abstract

Thymol is the active ingredient in plants from Thymus vulgaris (thymus). The calculations and molecular docking have been done computationally for the thymol and o-benzoyl thymol. This computational calculation aims to obtain a stable structure and electronic properties of thymol and o-benzoyl thymol. The computational analysis used DFT for geometry optimization in the gas phase using B3LYP functional and 3-211G(d) as the basis set. The optimized structure of thymol and o-benzoyl thymol is not planar. The functional benzoyl decreases the bond length, increases the bond angle, and turns the dihedral. The electronic properties, such as atomic charge and density of HOMO-LUMO, show the difference between the two molecules. The optimized structure of thymol and o-benzoyl thymol is used for molecular docking with the TYK2 enzyme (tyrosine kinase). In this research, thymol and o-benzoyl thymol can inhibit TYK2 enzyme with the bond affinity is about -5.909 kcal/mol and -7.456 kcal/mol, respectively, for thymol o-benzoyl thymol. The primary molecular interaction is hydrophobic.
Synthesis of Kaolinite Nanotubes as Heterogeneous Catalysts for Transesterification Reaction of Waste Cooking Oil into Biodiesel Muhammad Rizki; Fitri, Ernarisa; Syukri Arief; Rahadian Zainul; Syukri
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 04 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss04/545

Abstract

Kaolinite, a naturally abundant clay mineral, possesses a significant surface area and catalytic properties. To enhance its catalytic efficiency, modification into kaolinite nanotubes is necessary, as this transformation increases surface area and porosity. The synthesis of kaolinite nanotubes was achieved through a solvothermal method, incorporating multiple intercalation and rolling processes influenced by ultrasonic waves, subsequently utilizing these nanotubes as heterogeneous catalysts. The resulting kaolinite nanotube catalysts exhibited well-defined nanotube morphology and were applied in the transesterification of waste cooking oil, with variations in methanol-to-oil ratios. The optimal biodiesel yield achieved was 49.84%, obtained after a 3-hour reaction period using a 3% w catalyst at 60 °C, with a methanol-oil ratio of 3:1. This research highlights the potential of kaolinite nanotubes as effective catalysts in biodiesel production.
Co-Authors -, Bahrizal Adi Sofyan Ansori, Muhammad Admin Alif Afria Yolanda Agil Aditya Dinata Agustina, Niken Ahmad Fauzi Ahmed, Shafique Aini, Syamsi Alfian, Fariz R. Ali Amran Alif, Admin Alifiansyah, Mochamad Radika Tory Alifiansyah, Mochamad RT. Alizar Alyaa Farrah Dibha Amalia Putri Lubis Amaq Fadholly Ananda Putra Andini, Namira Tri Andre Juliano, Muhammad Andrean, Maifil Dwi Andromeda Andromeda Andromeda Anggraini, Dhea Anggriani Sirait, Nova Anjali, Ghoury Kharisma Anni Faridah Ansori, Arif NM. Antonius, Yulanda Ardi, Ahmad Maulana Arif Nur Muhammad Ansori Ariusni Ariusni Ariusni Elida Arli Aditya Parikesit Artha, Dwirani Puspa Asnil Asnil Asral, Suci Sukma Taruna Atmaja, Peter Y. Aulia, Halimatus S. B, Syamsul Amar Baharudin, Muhammad Daswar A. Bahrizal - Bambang Sudarmanta Bonkalo, Tatyana Budhi Oktavia Burkov, Pavel Butarbutar, Suryani Cika Dania Marca Deandra Savira Derkho, Marina Deski Beri Desy Kurniawati Devi Purnamasari Dhea Kharisma, Viol Dian, Farida Aryani Dinda Sahara Dings, Tim Godefridus Antonius Dori Yuvenda Durain Parmanoan Durry, Fara D. Dwi Finna Syolendra Edi Nasra Efran Ustia Rahmad Elfianah, Verah elida elida Elkhool, Tarek A. Ellizar ellizar Elvina Elvina Erdiwansyah Erdiwansyah Erwandri, Rianovriani Ethica, Stalis N. Ezi Anggraini Fadila Gusman Fajriah Azra Fauzan Yan Hawari Feriani, Feby Festiyed Fetty, Amelia JT. Fetty, Amelia Julia Tria Firmansyah Khairul Kamal Firmansyah, Muhammad Reffi Fitrah Mey Harmi Siregar Fitri, Ernarisa Fredy Kurniawan Goh, Khang Wen Guntur Bagus Pamungkas Hardeli Hardeli Hardeli Hary Sanjaya Hayaza, Suhaila Herdiansyah, Mochammad A. Herdiansyah, Mochammad Aqilah Hermansyah Aziz Hery Purnobasuki Hidayati, Shil ike sabaria Illyas Md. Isa Indah Permata Sari Indah Permata Sari Indang Dewata Irda Yunita Isa, Illyas Md Istiqamah, Siti Sarah Jakhmola, Vikash Jakmola, Vikash Jamaluddin, Indra P. Jamaludin Jamaludin Kadek Rachmawati Karlinda Karlinda Karlinda Karlinda Khairun Nisa Khairunnisa Khairunnisa Khalid, Ahmad Khudzairi Kharisma, Viol D. Kharisma, Viol Dhea Kolesnik, Evgeniy Kovalchuk, Dmitriy F. Krismadinata Krismadinata Lubis, Amalia Putri Lufri Lufri Ma'firah, Marla Maahury, Mirella Fonda Maksim Rebezov Maksimiuk, Nikolai Maria Kiseleva Marla Ma'firah Muhammad Andre Juliano Muhammad Haris Effendi Hasibuan Muhammad Hermawan Widyananda Muhammad Nizar Muhammad Rizki Muhammad Rusdi Muhardi, - Muji Setiyo Mulia, Melindra Murtadlo, Ahmad AA. Murtadlo, Ahmad Affan Ali Musa, Susan H. Nadezhda Kenijz Nafika Nurullita Naw, Sin W. Nizar, Umar Kalmar Novela, Riana Novera Elsi Mudia Oki Muraza Oktarina, Cindy Parikesit, Arli A. Pera Meilita Pernadi, Niza Lian Pratiwi, Intan A. Priyono, Qiara Amelia Putri Putra, Abrar Suryadi Putra, Ananda Putra, Justitia ERP. Putra, Randi Purnama Putri Fatimah Putri, Intan Anika Qonitah Fardiyah Radeni Sukma Indra Dewi Rahma yulis lubis Rahma Zila Rahmatika Putri, Sinta Rahmi, Maulidia Arsyta Ramli Ramli Rasyadan Taufiq Probojati Ratna Sari Raudhatul Hanifa Rayandra Asyhar Rebezov, Maksim Regina Tutik Padmaningrum Remon Lapisa Revi Gina Gunawan Riga Rijas, Livia Putrima Riko Romas Prayuda Rilla Gina Gunawan Risky Setiawan Risty, Chika Mei Rizaldy, Rafli Rohadatul Nadya Maurani Roza Herlina Saklani, Taru Salsabila Tri Rahmi Sari Mustika Sari, Putri Manda Sari, Yollit Permata Scherbakov, Pavel Sepiashvili, Ekaterina Seprianto Setianingsih, Primanita NM. Shmeleva, Svetlana Siltiwi Mandar Sinta Rahmatika Sinta Rahmatika Putri Skunda Diliarosta Sofia Sri Rizki Putri Primandari Sri Ulfa Sentosa Sri Wahyu Wardani Sri Wahyuningsih Sri Whayu Wardani Suci Sukma Taruna Asral Sukma Sahadewa, Sukma Sunarto Sunarto Sunarto Sunarto Susilo, Raden JK. Suyanta Suyanta Svetlana Artyukhova Syaifuddin Yana Syamsi Aini Syifa Rahma Ayunda Syukri Syukri Arief Syukri Syukri Tacharina, Martia Rani Tafonao, Leni Anggraeni Tamara, Anindya Putri Teguh Hari Sucipto, Teguh Hari Tri Haryati Trihanto Setiadi Trisna Kumala Sari Turista, Dora Dayu Rahma Ullah, Md. Emdad Umar Kalmar Nizar Urmatul Uska Akbar Veneliza, Adila Vika Erlina Vikash Jakhmola Viol Dhea Kharisma Visca Alisia Arianti Visca Alisia Arianti Yanni, Fitri Yeni, Isra Yohandri Yosephi, Valensa Yulia Matrosova Yulia Mona Liza Yuni Aulia Putri Djasli Yusniasari, Putri Antika Yusrianti, Ike