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All Journal ADMINISTRASI PUBLIK Jurnal Pustaka Ilmiah Al-Mishbah: Jurnal Ilmu Dakwah dan Komunikasi Jurnal Insan Farmasi Indonesia Jurnal Cakrawala Ilmiah Jurnal Riset Farmasi Journal of Innovation Research and Knowledge CEMERLANG :Jurnal Manajemen dan Ekonomi Bisnis Jurnal Pendidikan, Sains dan Teknologi Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Vitamedica: Jurnal Rumpun Kesehatan Umum Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan MUALLIMUN : JURNAL KAJIAN PENDIDIKAN DAN KEGURUAN Kreasi: Jurnal Pengabdian Masyarakat Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Inovasi Kesehatan Global Vitamin: Jurnal Ilmu Kesehatan Umum Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan Jurnal Riset Multidisiplin Edukasi AT-TAKLIM: Jurnal Pendidikan Multidisiplin
Nor Latifah
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REVIEW PENGARUH BINDER TERHADAP SIFAT FISIK PADA FORMULASI SEDIAAN TABLET KUNYAH M Jian Prayoga; Gina Norhalija; Nabilah; Rina Sa'diah; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 3: Nopember 2024
Publisher : Bajang Institute

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Abstract

Binder atau bahan pengikat memiliki peran penting dalam formulasi tablet kunyah karena mempengaruhi karakteristik fisik seperti kekerasan, kerapuhan, dan waktu hancur tablet. Penelitian ini bertujuan untuk menganalisis pengaruh berbagai jenis dan konsentrasi binder terhadap sifat fisik tablet kunyah melalui studi literatur. Binder yang tepat diperlukan untuk mencapai stabilitas fisik dan keseragaman dalam tablet kunyah, yang sering digunakan untuk memperbaiki pengalaman pengguna terutama pada pasien pediatrik dan lansia. Metode penelitian dilakukan dengan mengkaji literatur terkait formulasi tablet kunyah menggunakan binder, serta mengevaluasi bagaimana variasi binder dapat meningkatkan atau mengurangi kualitas fisik tablet. Hasil studi menunjukkan bahwa binder dengan konsentrasi yang tepat dapat meningkatkan kekerasan dan memperpanjang waktu hancur tablet, namun penggunaan binder yang berlebihan justru meningkatkan kerapuhan. Pemilihan binder yang optimal tidak hanya meningkatkan stabilitas tablet tetapi juga meningkatkan kesesuaian tablet kunyah dengan preferensi pengguna. Kesimpulannya, pemilihan binder yang tepat sangat penting dalam pengembangan tablet kunyah yang berkualitas, dan penentuan konsentrasi binder yang sesuai dapat mendukung kualitas fisik tablet secara keseluruhan
REVIEW: PENGARUH PERBEDAAN EKSIPIEN BINDER PADA TABLET PARACETAMOL TERHADAP WAKTU HANCUR DAN PELEPASAN OBAT Iqbal Nurwahid; Alfia Mujahra; Muhammad Zairullah; Riska Hidayah; Helsy Indarwati; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 3: Nopember 2024
Publisher : Bajang Institute

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Abstract

This study aims to evaluate and compare the effectiveness of natural and synthetic binders in paracetamol tablet formulation, focusing on sweet potato starch, pregelatinized cassava, and pectin as natural binders, as well as synthetic binders commonly used in the pharmaceutical industry. The method used in this study is a literature review, by collecting, analyzing, and synthesizing various relevant previous research results regarding the effect of binders on the physical properties of tablets and drug dissolution rates. Based on the literature analysis, it was found that natural binders, such as pregelatinized starch and pectin, showed comparable or even better results in several parameters, such as disintegration and drug release, compared to synthetic binders. Pregelatinized starch, in particular, showed a faster dissolution rate, while pectin gave good results in terms of tablet hardness and friability. In addition, natural binders are more economical and environmentally friendly than synthetic materials.
REVIEW: INOVASI ZAT AKTIF DALAM FORMULASI GRANUL EFFERVESCENT DARI EKSTRAK HERBAL Fatimah Salsabila Algina; Oktriyisa Tantia Mini; Surya Alvina Nazaha; Zulfa Muthi’ah; Mirnawati, Mirnawati; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 3: Nopember 2024
Publisher : Bajang Institute

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Abstract

This study aims to explore the innovative incorporation of active compounds from herbal extracts into effervescent granule formulations. Effervescent granules, known for their rapid dissolution and pleasant taste, have gained significant interest in the pharmaceutical industry. The utilization of herbal extracts as active ingredients in these formulations offers a promising approach to develop novel and natural-based pharmaceutical products. This review will delve into various aspects, including the selection of appropriate herbal extracts, the formulation process, and the evaluation of the physicochemical properties of the resulting granules. Additionally, the challenges and opportunities associated with the development of herbal-based effervescent granules will be discussed. By providing a comprehensive overview of the current state-of-the-art, this review seeks to stimulate further research and development in this exiciting area of pharmaceutical sciences.
REVIEW: PENGARUH PERBEDAAN EKSIPIEN BINDER PADA TABLET PARACETAMOL TERHADAP WAKTU HANCUR DAN LAJU DISOLUSI OBAT Dhea Nadilla; Ghina Rahima; Ridha Febriyanti; Ahmad Muhaimin; Muhammad Lukmannul Hakim; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 3: Nopember 2024
Publisher : Bajang Institute

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Abstract

Penggunaan tablet paracetamol sebagai obat analgetik dan antipiretik banyak diminati, namun kualitas fisik tablet sangat dipengaruhi oleh jenis eksipien binder yang digunakan. Binder memiliki peran penting dalam menentukan kekuatan tablet, waktu hancur, dan laju disolusi obat. Penelitian ini bertujuan untuk menganalisis pengaruh perbedaan eksipien binder pada tablet paracetamol terhadap waktu hancur dan disolusi obat melalui studi literatur yang melibatkan lima artikel terkait. Berbagai bahan pengikat yang diuji dalam penelitian ini mencakup amilum singkong, pati umbi porang, tepung bonggol pisang, pati ubi jalar putih, dan pati umbi gembili. Hasil penelitian menunjukkan bahwa penggunaan binder seperti amilum singkong pregelatinized dan kombinasi PVP dengan amilum umbi porang memberikan hasil terbaik dalam meningkatkan laju disolusi dan mempercepat waktu hancur tablet. Sementara itu, bahan pengikat alami lainnya, meskipun memberikan hasil yang baik, cenderung menghasilkan laju disolusi yang sedikit lebih lambat. Pemilihan binder yang tepat dapat meningkatkan kualitas sediaan tablet paracetamol, yang pada akhirnya berkontribusi pada efektivitas pengobatan yang lebih optimal.
"REVIEW: FORMULASI DAN EVALUASI FISIK TABLET EKSTRAK HERBAL MENGGUNAKAN METODE GRANULASI BASAH" Dhiya Shoufi Sahaja; ⁠Marisa Susanti; Nur Prettiya Salha; ⁠Peni Oktariyani Putri; Wima Triana; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 4: Desember 2024
Publisher : Bajang Institute

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Abstract

Penelitian ini mencakup formulasi dan evaluasi fisik tablet ekstrak berbagai bahan alam dengan metode granulasi basah. Ekstrak alga coklat (Sargassum sp.), herbal meniran (Phyllanthus niruri L.), buah pare (Momordica charantia L.), daun gedi hijau (Abelmoschus manihot), dan daun salam (Eugenia polyantha W.) diformulasikan menjadi tablet dengan menggunakan berbagai bahan pengikat, seperti polivinil pirolidon (PVP) dan gelatin, pada konsentrasi yang berbeda. Hasil evaluasi menunjukkan bahwa variasi konsentrasi bahan pengikat mempengaruhi sifat fisik tablet, seperti kekerasan, kerapuhan, waktu hancur, dan keseragaman ukuran. Formulasi tablet effervescent herbal meniran menunjukkan kualitas fisik yang baik dengan konsentrasi asam dan basa tertentu, sedangkan ekstrak daun gedi hijau dan buah pare menghasilkan tablet yang memenuhi beberapa kriteria, meskipun ada kekurangan pada uji kekerasan dan kerapuhan. Formula terbaik ditemukan pada konsentrasi gelatin 10% pada ekstrak daun salam, yang menghasilkan tablet dengan kualitas fisik optimal. Penelitian ini memberikan wawasan penting tentang pengaruh bahan pengikat terhadap kualitas sediaan tablet dari ekstrak tanaman, yang dapat digunakan untuk pengembangan obat herbal dalam bentuk tablet.
Review Artikel : Sifat Fisik Bahan Pengikat Tablet Hisap Anisa Anisa; Jenni Getbriela T; Mifta Dewi; Nor Tiara Sari; Siti Fatimatuzzahra; Nor Latifah
Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Vol. 2 No. 4 (2024): Desember : Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebida
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/corona.v2i4.867

Abstract

The purpose of lozenges is to allow the tablet to dissolve in stages in the mouth. Lozenges are solid preparations consisting of more than one pharmaceutical chemical, the base material is flavored, and the taste is sweet. Binders are important excipients, especially when making lozenges, because they increase intragranular and intergranular strength, forming tablets that meet the required physical qualities. The purpose of this review paper is to gather data about the physical characteristics of lozenge binders. Based on the literature study conducted, binders of lozenges namely Gelatin, CMC-Na, Hydroxypropyl Methyl Cellulose (HMPC), Jackfruit Seed Starch and Durian Seed Starch affect the physical properties of lozenges.
Review Artikel: Pengaruh Penggunaan Bahan Pengikat Alami dan Sintetis pada Kualitas Fisik Tablet Siti Nurhaliza; Nur Luthfia Salim; Annisa Normiani Putri; Lidya Syahjiah; Muhammad Dhaiffullah; Nor Latifah
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1946

Abstract

Tablets are one of the most preferred forms of medication due to their compact shape, portability, and good stability. A key factor that greatly influences the physical quality of tablets is the binder used. This article reviews various studies on the effects of using natural and synthetic binders on the physical quality of tablets in drug formulations, including PVC, HPMC, CMC-Na, jackfruit seed starch, banana heart starch, and white sweet potato starch, which contribute to forming tablets with optimal physical properties. Data on the use of tablet binders were collected through a literature study method. The results concluded that the use of PVC, HPMC, CMC-Na, jackfruit seed starch, banana heart starch, and white sweet potato starch binders have an impact on the physical properties of tablets.
Pengaruh Variasi Bahan Pengikat Alami dan Sintetis terhadap Kekerasan dan Kerapuhan Tablet Muhammad Rezky Wahyudi; Yumna Zaida; Fiona Maulidia; Regina Nabila; Della Puspita; Nor Latifah
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1955

Abstract

Tablets are one of the most widely used pharmaceutical forms due to their practicality and cost-effectiveness. In the tablet formulation process, binders play an important role in ensuring appropriate hardness and friability, which are crucial in maintaining the physical quality of the tablet. This study aims to compare the effectiveness of natural and synthetic binders in enhancing tablet hardness and reducing friability. The method used is a literature review from various scientific sources. The results show that natural binders, such as starch and gelatin, can increase tablet hardness and reduce friability, making them an eco-friendly alternative. Synthetic binders, such as HPMC and PVP, are also effective but come with higher production costs. This study provides guidance for the pharmaceutical industry in selecting optimal binders for high-quality tablet formulations..
Review Jurnal: Evaluasi Kekerasan Sediaan Tablet Kunyah dengan Metode Kempa Langsung Ghina Faiha; Rina Suspa Nita; Nadia Nadia; Devira Niken Putri Ferdinand; Akhmad Rizky Akbar; Nor Latifah
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1956

Abstract

Tablets are one of the most widely used forms of preparation on the market, one type of tablet preparation is chewable tablets. Chewable tablets are drugs that are consumed by chewing first before being swallowed. The manufacture of chewable tablets usually uses the direct felt method which is done by directly shaking a mixture of powder (active substances and excipients). The purpose of this article is to analyze various aspects related to the quality, efficiency, and stability of chewable tablets made using the direct felt method, to identify the hardness test parameters. The method used in this article includes a literature analysis from five journals that discuss the hardness test on chewable tablets on several formulations used. The level of hardness on the tablet was carried out using a hardness tester. Tablets are declared good or meet the requirements when at a weight of 4-8kg the tablets are crushed.
Review: Peran Zat Pelicin dalam Meningkatkan Efisiensi Proses Pembutan Sediaan Tablet Oral Mikdat Adam; Veressa Alfianti; Nisa Aulia Sera; Della Prastyka; Putri Novianur Ramadhani; Nor Latifah
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1969

Abstract

The use of lubricants in oral tablet formulations has an important role in improving the efficiency of the production process. The lubricating agent helps to reduce friction between the particles and the mold wall, minimizing the risk of tablet damage during the printing and separation process. The study reviewed different types of lubricants, such as magnesium stearate and stearic acid, as well as their effects on the compactness, crushing time, and release of the active ingredient of the tablets. Optimal formulation is needed to avoid quality degradation due to excessive lubrication. Thus, the selection of the right lubricant is key to ensuring consistent tablet quality and a more efficient production process.
Co-Authors Abu Dzar Alghifary Adelia Ikrima Ahmad Muhaimin Aida Savitri Akhmad Rizky Akbar Alfia Mujahra Ali Iskandar Zulkarnain Amanda Cahyani Anisa Anisa Annisa Annisa Annisa Normiani Putri Annur tasya alfiati Aulia Azkia Aura Nasyafa Cheina Nazerina Yoshi Della Prastyka Della Puspita Desy Maimunah Devira Niken Putri Ferdinand Dhea Nadilla Dhiya Shoufi Sahaja Elita rahmah Erlina Fatmasari Fatimah Salsabila Algina Fayza Nindya Nur’Assyfa Fiona Maulidia Ghina Faiha Ghina Rahima Gina Norhalija Hairun Nisa Hairunnisa Hairunnisa Hana Salma Cantika Harris Noorrahman Helsy Indarwati Hidayatur Rizky Husain, Aghnaita Iqbal Nurwahid Irma Muthiah Irma Nadia Yanti Jaida Rahma Jannatun Nisa Jayawarsa, A.A. Ketut Jenni Getbriela T Khusnul Khotimah Laila manada Lidya Syahjiah Luthfia Raisah Ahyati M Jian Prayoga M. Chaidir Hafidz M. Jian Prayoga Mahabatul Hasanah Marisa Susanti Maulida Maulida Maura Putri Ariqah Mifta Dewi Mikdat Adam Muhammad Arif Akbar Muhammad Dhaiffullah Muhammad Fadhli Muhammad Faqih Madhani Muhammad Fathur Rahman Muhammad hafiz adha Muhammad Lukmannul Hakim Muhammad Reihan Ridha Muhammad Rezky Wahyudi Muhammad Rizky Muhammad Romansyah Khatami Muhammad Zairullah Nabila Sativa Nabila Syifa Firdaus Nabilah Nabilah Nabilah Nadia Nadia Nadila Nadila, Nadila Nailia Nur Isma Sumarno Neela Afifah Nia Kusumadewi Nicky Saputra Niken Widya Ningrum Nisa Aulia Sera Nita Rahmadani Noor Kamalliyah Nor Tiara Sari Norhikmah Norhikmah Norhikmah Nur Latipah Sulistiawanti Nur Lutfia Salim Nur Luthfia Salim Nur Prettiya Salha Nur Rifa Ashya Nurlaila Nurlaila Nurul Hasni Julianti Nurul Mas'adah Nurul Mas’adah Oktriyisa Tantia Mini Padma Azzahra Ramadhani Putri Novianur Ramadhani Rakha Widyastama Randani Randani Ratna Habibah Raudatul Hasanah Raudatul Jannah Regina Nabila riauwati, Rosa Ridha Febriyanti Rifka Annisa Rina Rina Rina Sa'diah Rina Suspa Nita Riska Hidayah Salma Fitriyanti Sindy Maulida Siti Fatimatuzzahra Siti Nor Adidah Siti Nurhaliza Sri Hidayati Sri Muliany Sri Tami Dewi SUNARNO Surya Alvina Nazaha Taufik Akbar Trisnia Widuri Ufaul Apriani Veressa Alfianti Wima Triana Yenni Hafizah Yumna Zaida Zalmi, Zalmiati Zulfa Muthi’ah ⁠Marisa Susanti ⁠Peni Oktariyani Putri