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All Journal HAYATI Journal of Biosciences Majalah Kedokteran Bandung Medical Journal of Indonesia Nexus Kedokteran Translasional Jurnal Farmasi Klinik Indonesia Biomedika Majalah Obat Tradisional Jurnal Gizi dan Kesehatan Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Policy and Management Journal of Health Promotion and Behavior Journal of Maternal and Child Health Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Pena Medika : Jurnal Kesehatan Narra J Journal of Health and Nutrition Research Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Media Penelitian dan Pengembangan Kesehatan Jurnal Kesehatan Masyarakat
Dono Indarto
Fakultas Kedokteran, Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Effect of Toxoplasma Infection Dosage on IgG, IgM, Fetus Weight and Body Length, and Necrosis of Placenta and Fetal Heart Nurinasari, Hafi; Sajidan; Purwanto, Bambang; Indarto, Dono; Subekti, Didik T
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.596-602

Abstract

One of the most prevalent zoonotic illnesses in the world, toxoplasmosis, affects both humans and animals and is caused by the parasite Toxoplasma gondii. The infection will trigger the immune system to increase antibody production. This study aims to determine the dose of toxoplasma that causes necrosis in rats placental and fetal hearts. This study was laboratory experimental research with a Randomized Control Trial (RCT). The study design used a post-test only with a control group design. The Ig G variable obtained from the control group (CG) and treatment group 3 (TG3) is the most significant because the mean value difference was the largest (176.56). The Ig M variable obtained from the control group with treatment group 3 (TG3) is the most significant because the mean value difference is the largest (33.47). The fetus weight variable obtained from the control group with treatment group 3 (TG3) is the most significant because the mean value difference is the largest (2.6). The body length variable obtained from the control group between treatment group 3 (TG3) is the most significant because the mean value difference is the largest (1.26). There was a significant difference in placental tissue necrosis (p = 0.034) and heart (p = 0.025) between the control group (CG) and treatment group 3 (TG3). Therefore, there was a significant difference in Ig G, Ig M, fetus weight, body length, placental tissue necrosis, and fetal heart at the 10³ dose compared to the 102, 101, and normal doses.
The effects of raja banana (Musa acuminata) peel extract on body weight, body mass index, body fat percentage, and visceral fat mass in male rats with obesity Devina, Kezia Elian; Indarto, Dono; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 2, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(2).115-125

Abstract

Background: Obesity is a risk factor for metabolic syndrome which can increase mortality. Obese sufferers often fail to lose body weight (BW) through non-pharmacological therapy. Obesity synthetic drugs can cause side effects, so natural ingredients are needed as alternative therapies.Objectives: This study aims to determine the effect of raja banana peel extract (RBPE) on BW, body mass index (BMI), body fat percentage (BFP), and visceral fat mass in obese male rats.Methods: The research subjects were 30 male Wistar rats weighing 125-200 g, aged eight weeks. Obesity was induced by being given high-fat high fructose (HFHFr) feed for 28 days. Rats were randomized and divided into five groups: the negative control group (C-) was given standard feed and distilled water, the positive control (C+) was given standard feed and orlistat, treatment 1 (T1), treatment 2 (T2), and treatment 3 (T3). Which were given standard feed and RBPE doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day. Data before and after the induction of obesity were analyzed using paired t-tests. BW, BMI, and visceral fat mass were analyzed using the One-Way Analysis of Variance (ANOVA) and Repeated Measure ANOVA tests. BFP was analyzed using the Kruskal-Wallis test and the Friedman test.Results: RBPE can significantly reduce BW (p=0.026), BMI (p<0.001), and BFP (p<0.001). However, all groups had no significant difference in visceral fat mass (p=0.187). T3 was the group with the lowest average BW, BMI, BFP, and visceral fat mass although the highest weight loss during the intervention period occurred in C+.Conclusions: RBPE has the potential as an alternative therapy for obesity because it can reduce BW, BMI, and BFP. Future studies can investigate the effect of RBPE on other obesity parameters such as lipid profiles.
Association between vaspin rs2236242 gene polymorphism and atherosclerosis in ischemic stroke patients with diabetes mellitus in the Indonesian population Danuaji, Rivan; Suroto; Purwanto, Bambang; Indarto, Dono; Muhammad, Faizal; Mirawati, Diah Kurnia; Widyaningsih, Vitri; Soetrisno; Subandi; Budianto, Pepi; Hambarsari, Yetty; Hamidi, Baarid Luqman; Prabaningtyas, Hanindia Riani; Hutabarat, Ervina Arta Jayanti; Ristinawati, Ira; Tejomukti, Teddy; Tedjo, Raden Andi Ario
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247566

Abstract

BACKGROUND Stroke is the third leading cause of morbidity and second in mortality worldwide. Diabetes mellitus (DM) is a risk factor for stroke. Vaspin and single nucleotide polymorphism (SNP) rs2236242 involved DM pathogenesis. This study aimed to explore the correlation between SNP rs2236242, serum vaspin levels, and atherosclerosis in patients with ischemic stroke and DM. METHODS This study was conducted in Dr. Moewardi Hospital from 2022 to 2023. The case group included patients with ischemic stroke and DM, while the controls were those with ischemic stroke only. Tetra-primer amplification refractory mutation system-polymerase chain reaction was used to determine the genotypes. RESULTS There were 31 cases and 33 control. SNP rs2236242 showed that odds ratio (OR) (95% confidence interval [CI]) for AA-TT was 0.273 (0.241–0.305) and for TA-TT was 0.315 (0.298–0.341). The OR (95% CI) for allele A to T was 0.789 (0.373−1.669). The mean (standard deviation) serum vaspin level in the case group compared to the control was 1,570 (2,108) ng/ml versus 1,630 (1,428) ng/ml (p = 0.064). Higher vaspin levels were found in T allele of the TT (1,523 [2,269] ng/ml, p = 0.021) and TA (1,760 [1,349] ng/ml, p = 0.004) genotype groups than the A allele of the AA genotype group (0.914 [0.329] ng/ml). CONCLUSIONS Vaspin gene polymorphism AA genotype or A allele significantly reduces vaspin levels in patients with ischemic stroke with DM.
Effect of clove flower extract (Syzygium aromaticum) administration timing on skeletal muscle damage induced by eccentric exercise: An in vivo study Ningrum, Tyas Sari Ratna; Doewes, Muchsin; Indarto, Dono; Cilmiaty, Risya; Kristiyanto, Agus; Widyaningsih, Vitri
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1680

Abstract

Eccentric exercise often leads to oxidative stress, inflammation, and muscle damage that impair athletic performance. To counter these adverse effects, clove flower extract (Syzygium aromaticum) offers promising potential as a natural remedy to promote muscle repair with its potent antioxidant and anti-inflammatory properties. The aim of this study was to assess the effects of clove flower extract administration timing on oxidative stress and inflammatory responses in skeletal muscle damage induced by acute eccentric exercise in mice. This study used a post-test-only control group design, involving 35 male mice (Mus musculus, Balb/c) randomly divided into five groups: a healthy control group (HC) with no exercise and no treatment, a negative control group (NC) with exercise but no treatment, and three treatment groups: T1, T2, and T3 (clove flower extract 24 hours before exercise, immediately after exercise, and 24 hours after exercise, respectively). The treatment groups received a single dose of clove flower extract (500 mg/kg body weight). The skeletal muscle damage of mice was collected for the NADPH oxidase (NOX) and superoxide dismutase (SOD) activities using spectrophotometry, and toll-like receptor 4 (TLR4) and interleukin-8 (IL-8) measurements using enzyme-linked immunosorbent assay (ELISA). Moreover, the skeletal muscle damage was analyzed through the histopathological method. Data were analyzed using one-way analysis of variance (ANOVA) followed by Fisher's least significant difference (LSD) tests as a post hoc test. The result showed that clove flower extract significantly reduced NOX activity (p=0.049) and IL-8 levels (p=0.032), and increased SOD activity (p=0.001) while not significantly affecting the TLR4 levels (p=0.532). Moreover, the results showed a significant reduction in muscle damage (p=0.001). The study highlights that the administration of clove flower extract (500mg/kg bw) can be given 24 hours before, immediately after exercise, or 24 hours after exercise to prevent muscle damage.
Evaluating autologous peritoneum grafting for enhanced healing of bile duct injuries: A preliminary data from an animal study Nugroho, Anung N.; Mudigdo, Ambar; Soetrisno, Soetrisno; Yarso, Kristanto Y.; Nurwati, Ida; Indarto, Dono; Pamungkasari, Eti P.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1873

Abstract

Increased incidence of laparoscopic cholecystectomy-related bile duct injuries (BDIs), combined with its risk of serious complications and mortality, highlights the need for a more effective repair technique. Although the use of autologous graft in BDI repair has been promoted, the role of autologous parietal peritoneum remains underexplored. The aim of this study was to evaluate the effect of autologous parietal peritoneum grafts in rabbit models of partial BDI, emphasizing its effect on the expression of cluster of differentiation 68 (CD68) and transforming growth factor-β (TGF-β). An experimental post-test-only design was employed, using 27 male New Zealand rabbits (Oryctolagus cuniculus) aged 8–10 months. The rabbits were allocated into three groups: control (primary closure), autologous parietal peritoneum graft, and autologous gallbladder graft. Partial BDI measuring 15×5 mm were surgically created and repaired according to group assignments. The expression of CD68 and TGF-β were measured via enzyme-linked immunosorbent assay (ELISA), while the anastomosis was pathologically examined through hematoxylin and eosin (H&E) staining on days 3, 7, and 14 post-surgery. Statistical analysis was performed using analysis of variance (ANOVA) followed by Bonferroni post hoc tests. No statistically significant difference was observed in the expression of CD68 or TGF-β among the three treatment groups on days 3, 7, and 14 post-surgery, indicating that the effects of autologous parietal peritoneum graft were comparable to the control and the autologous gallbladder graft in promoting wound healing. Fibroblast density on day 3 was significantly lower in the parietal peritoneum group (p=0.040), reflecting delayed recruitment, but normalized by day 14, indicating successful integration and remodeling. The study highlights the potential role of autologous parietal peritoneum grafts for BDI.
A Meta-Analysis on the Risk Factors of Low Back Pain in Health Workers Akbar, Muh. Syaiful; Rahardjo, Setyo Sri; Indarto, Dono
Journal of Epidemiology and Public Health Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Low back pain is a common prob
Multilevel Analysis: The Contextual Effect Village on The Risk Hypertension in Magelang, Central Java Diyantana, Wawan; Indarto, Dono; Murti, Bhisma
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Hypertension affects one billion people worldwide. Death due to hypertension in the world is estimated at 9.4 million people every year. Factors related to lifestyle can increase the risk of hypertension. In addition, demographic and topographic factors of resi
Meta Analysis the Effect of Body Mass Index on the Flat Foot Incidence Kurniagung, Philipus Prihantiko; Indarto, Dono; Rahardjo, Setyo Sri
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Musculoskeletal disorders in the form of flat foot, back pain and knee pain are often found in people who are obese. Flat foot is a musculoletal disorder characterized by a decrease or decrease in the height of the medial arch as a parameter, especially those that can be observed and measured in height. This study aims to estimate the average size of the effect of BMI on the risk of flat foot.Subjects and Method: Meta-analysis study and systematic reviews were applied to this study using the electronic database Pubmed, Science Direct, Google Scholar and Springer Link. Keywords to search for articles are as follows: "flat foot", "adult flat foot", "Flexible Flat Foot", "Body Mass Index", "Pediatric flat foot", "pes planus", "obesity", "overweight", "Ado
Consumption of Jelly Combination of Salacca Seed (Salacca zalacca) and Moringa Leaves Flour (Moringa oleifera) on Hemoglobin level in Female Adolescents with Moderate Anemia Wijayanti, Poppy; Dewi, Yulia Lanti Retno; Indarto, Dono
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Adolescent girls are at risk for iron-deficiency anemia. Various food fortifications have been developed to reduce the incidence of anemia. This study aimed to investigate the effect of consumption of jelly combined with salacca pondoh seed flour and Moringa leaf flour on hemoglobin levels in adolescent girls with moderate anemia.Subjects and Method: The Randomized Control Trial study was conducted in high schools, Banyuwangi, East Java, from August to September 2020. A total of 75 high school girls with moderate anemia were randomly divided into three groups with 25 people in each group, namely: (1) Control group (C) get a combination of 100g plain jelly, and iron tablets; (2) Treatment group 1 (T1) received 100g of jelly combined with 14.9g of salacca pondoh seed flour and 5.7g of Moringa leaf flour; and (3) Treatment group 2 (T2) received 100g of jelly which had been combined with 7.5g of salacca pondoh seed flour and 3g of Moringa leaf flour. The treatment was given twice per week for 8 weeks. The dependent variable is hemoglobin level. The independent variable was administering a combination of jelly with salacca seed flour and Moringa leaf flour. Hemoglobin data was taken by laboratory examination on days 30 and 60. Data were analyzed using One Way Anova.Results: After the intervention, the average hemoglobin levels in the three groups increased during the 30th day of observation: C (Mean= 14.68; SD= 0.75), T1 (Mean= 15.50; SD= 0.90), and T2 (Mean= 14.47; SD= 0.79). There was an average increase in hemoglobin levels in the three groups during the 60th day of observation, namely: C (Mean= 14.96; SD= 0.81), T1 (Mean= 15.20; SD= 0.78), and T2 (Mean= 14.96; SD= 0.69). On the 30th and 60th day observations, the difference in mean between the three groups was not statistically significant (p= 0.412) and (p= 0.703).Conclusion: The administration of jelly combined with salacca pondoh seed flour and Moringa leaves is effective compared to plain jelly with iron tablets in increasing Hb levels.Keywords: combination jelly, salacca seeds, moringa leaves, hemoglobin, anemia, young womenCorrespondence: Poppy Wijayanti. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: popzala04@gmail.com. Mobile: +6285235925411.Indonesian Journal of Medicine (2021), 06(03): 307-314https://doi.org/10.26911/theijmed.2021.06.03.08  
Antibacterial and Antibiofilm of Cinnamomum burmanii Bark Oil (CbBO) against Klebsiella pneumoniae ATCC 700603: In Vitro Study Inayati, Inayati; Hartono, Hartono; Indarto, Dono; Suryawati, Betty
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97396

Abstract

Many cases of multidrug-resistant (MDR) bacterial infections are caused by Klebsiella pneumoniae (K.pn), an infectious disease bacterium. Hospital inpatients can be exposed to this occurrence; MDR has transformed 26.96% of infections at Klaten Hospital into highly infectious biofilms, while 54.49% of infections have produced biofilms. Approximately 80% of bacterial illnesses resistant to antibiotics are caused by biofilm-forming bacteria. To reduce biofilm formation, antibacterial compounds, one of which comes from natural products, are necessary. Renowned for its essential oil, Cinnamomum burmanii Bark Oil (CbBO) has been utilized extensively in herbal medicine to combat pathogenic bacteria such as Pseudomonas aeruginosa, Candida albicans, Enterobacter spp., and Staphylococcus aureus. This study aims to evaluate CbBO’s antibacterial capabilities using the microdilution method and its antibiofilm properties against K. pneumoniae ATCC 700603 using the MTT test. A CbBO minimum bactericidal concentration (MBC) of 0.25 mg/mL and a minimum inhibitory concentration (MIC) of 0.125 mg/mL were employed for antibacterial activity. The antibiofilm potential was determined by measuring the minimum biofilm eradication concentration (MBEC) at 0.5 mg/mL and the minimum biofilm inhibition concentration (MBIC) at 0.25 mg/mL. In conclusion, CbBO demonstrated antimicrobial and antibiofilm qualities. However,                   a greater concentration of CbBO was required for antibiofilm formation than for antibacterial purposes.
Co-Authors A.A. Ketut Agung Cahyawan W Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Ahmad Hamim Sadewa Akbar, Muh. Syaiful Ali Djamhuri Ambar Mudigdo Amilia Yuni Damayanti Andina, Puri Dwi Argyo Demartoto, Argyo Arta Farmawati Avelia, Annisa Ayusari, Amelya Augusthina Azizah, Shofura Badri, Baarizah Febriana Balgis Balgis Bambang Purwanto Bhisma Murti Brian Wasita Budianto, Pepi Budiyanti Wiboworini Budiyanti, Novita Damayanti, Ana Dea Linia Romadhoni Diah Kurnia Mirawati Didik Gunawan Tamtomo Didik T Subekti Didik Tamtomo, Didik Diyantana, Wawan Dwi Rahayu Endang Sutisna Sulaeman Ernawati Ernawati Fajar Alam Putra, Fajar Alam Fara Ayu Febyawati, Hani Firdaus, Jihan Fitriana Fitriana Gilang Akbar Shobirin Hambarsari, Yetty Hamidi, Baarid Luqman Hartono Hartono Hastami, Yunia Hastuti, Nunik Maya Hermanu Joebagio Herviana, Herviana Hutabarat, Ervina Arta Jayanti Ida Ayu Putu Sri Widnyani Ida Nurwati Inayati Inayati Irma Isnafia Arief Isfaizah Jatmiko Susilo Kezia Elian Devina Kurniagung, Philipus Prihantiko Kusnandar, K Kusumadewi Eka Damayanti Laksana, Budi Liana, Gladya Lady Lilik Wijayanti Mahendra Wijaya Maryati, Warsi Mashuri, Yusuf Ari Muchsin Doewes Muhammad, Faizal Nasrullah, Adam Haviyan Ningrum, Sri Setiyo NINGRUM, TYAS SARI RATNA Nor Istiqomah Nugroho, Anung N. Nunuk Suryani Nurfitria, Fadhila Balqis Nurinasari, Hafi Nurochim, Erna Pamungkasari, Eti P. Paramasari Dirgahayu Perdana, Muhammad Vidi Pesik, Riza N. Prabaningtyas, Hanindia Riani Prahesti, Ratna Prasetyaningsih, Roh Hastuti Pratiwi, Ayudhia Purnama, Siswanta Jaka Purwaningsih, Yustina Puspita, Rumeyda Chitra Putri, Anak Agung Alit Kirti Estuti Narendra Putri, Risma Aliviani Putri, Widya Kaharani Rahardjo, Setyo Sri Rahardjo, Setyo Sri Retiyansa, Yesi Retiyansa, Yesi Ristinawati, Ira Risya Cilmiaty, Risya Rivan Danuaji Riza Novierta Pesik RUBEN DHARMAWAN Sajidan Sari, Septi Ayu Arum Yuspita Satriani, Hayu Andita Selfi Handayani Sena, Anantha Setyaningrum, Th. Catur Wulan Shanti Listyawati Soetrisno Soetrisno Soetrisno Sri Sulistyowati Sugiarto S Sundari, Isti SUROTO SURYAWATI, BETTY Susanti, Rahmah Purwaningsih Febri Suselo, Yuliana Heri Suselo, Yuliana Heri Susilawati, Eva Tedjo, Raden Andi Ario Tejomukti, Teddy Thesman, Inggrit Bela Tiyas, Dwi Wahyuning Tonang Dwi Ardyanto Tri Agustina, Tri Tri Harsono Tri Nugraha Susilawati Ulfia, Mila Umarghanies, Sarah Safira Utami, Agustina Dwi Vitri Widyaningsih Vitria Sari Dewi Wahyuni, Ardianti Wardhani, Lusi Oka Widiasih, Ghina Widyanti, Fera Wijayanti, Poppy Wulandari, R. AJ. Sri Wulandari, RAJ Sri Yarso, Kristanto Y. Yatty Destani Sandy Yudhani, Ratih D. yulia lanti retno dewi Yuliana Heri Soesilo Yusrizal, Mirza