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All Journal HAYATI Journal of Biosciences Majalah Kedokteran Bandung Medical Journal of Indonesia Nexus Kedokteran Translasional Jurnal Farmasi Klinik Indonesia Biomedika Majalah Obat Tradisional Jurnal Gizi dan Kesehatan Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Policy and Management Journal of Health Promotion and Behavior Journal of Maternal and Child Health Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Pena Medika : Jurnal Kesehatan Narra J Journal of Health and Nutrition Research Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Media Penelitian dan Pengembangan Kesehatan Jurnal Kesehatan Masyarakat
Dono Indarto
Fakultas Kedokteran, Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Associations of Dietary Intake and Sociodemographic Factors with the Incidence of T2DM among Obese Adults Widiasih, Ghina; Indarto, Dono; Susilawati, Tri Nugraha
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6136

Abstract

Type 2 diabetes mellitus (T2DM) is a major public health concern, particularly among obese individuals. Dietary intake, including energy, protein, and fiber consumption plays a key role in metabolic health, with sociodemographic factors influencing its mechanisms. Objective: This study aimed to analyze the associations of these dietary factors and T2DM incidence in obese adults in Surakarta city. This cross-sectional study included 100 obese adults from Surakarta. T2DM status was determined based on their medical records. Dietary intake data were collected using Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ). Sociodemographic data were collected by interview. Multiple binary logistic regression was performed to analyze the association between dietary intake and T2DM with p<0.05. The most participants were female (75.0%) and Javanese (82.0%). Daily fiber intake was significantly associated with a lower risk of T2DM (OR=0.04, 95%CI=0.01–0.14, p<0.001), while ethnicity, educational history, occupation, and monthly personal expenses were identified as significant risk factors (p<0.05). Further analysis, only daily fiber intake (aOR=0.06, 95%CI=0.01–0.29, p<0.001) and occupation (aOR=16.81, 95%CI=3.98–71.08, p<0.001) remained significantly associated with T2DM. Adequate daily fiber intake was the strongest protective factor, while individuals engaged in work were the strongest predictor of T2DM among obese adults in Surakarta city.
EFEKTIVITAS TABLET FE DAN BISKUIT TEPUNG BIJI SALAK DALAM MENINGKATKAN ASUPAN ZAT BESI, ZINC DAN VITAMIN C PADA REMAJA PUTRI DENGAN ANEMIA Budiyanti, Novita; Indarto, Dono; Handayani, Selfi
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.1935

Abstract

Iron nutritional anemia is a prevalent health issue among adolescent girls. Several factors contribute to anemia in this demographic, including inappropriate growth for age, poor nutritional intake, unhealthy food habits, inadequate or excessive physical activity, irregular menstrual cycles, and lack of nutrition knowledge. To address this, the government has implemented supplementation programs with iron tablets. Additionally, utilizing local foods rich in iron presents a potential complementary strategy.This study aimed to analyze the effect of salak seed flour biscuits (TBS) on the intake of iron (Fe), zinc (Zn), and vitamin C in anemic adolescent girls.This research was designed as a randomized controlled trial (RCT) with a pretest-posttest control group design. The study involved 33 anemic adolescent girls from Indramayu Regency. Data collection methods included interviews using structured questionnaires, 24-hour food recall forms, and anthropometric measurements of body weight and height. Data were analyzed using one-way ANOVA, followed by Bonferroni post hoc tests.The results indicated that the administration of TBS biscuits significantly increased the intake of Fe, Zn, and vitamin C in all groups. Notably, TBS biscuits containing 4.17 mg of Fe per 100 g showed the highest increase in nutrient intake. Over a 60-day period, these biscuits significantly boosted the intake of Fe, Zn, and vitamin C in anemic adolescent girls.The study concluded that TBS biscuits are an effective intervention for increasing the intake of essential nutrients in anemic adolescent girls. The inclusion of such fortified local foods can be a valuable addition to existing anemia prevention programs.
DEVELOPMENT OF ANAEMIA TREATMENT USING ETHANOL EXTRACT OF MIRABILIS JALAPA YELLOW FLOWERS Widyanti, Fera; Indarto, Dono; Suselo, Yuliana Heri
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.2299

Abstract

Mirabilis jalapa merupakan tumbuhan tropis dengan berbagai warna yang banyak ditemukan di Indonesia namun saat ini pemanfaatannya hanya sebatas tanaman hias dan pagar. Kombinasi M. jalapa warna kuning dan pink memiliki fitokimia yang berperan dalam metabolisme zat besi tetapi belum ada penelitian terkait dengan kandungan zat gizi. Penelitian ini bertujuan untuk mengidentifikasi kandungan zat gizi dan fitokimia ekstrak M. jalapa warna kuning dengan jenis penelitian deskriptif eksploratif. M. jalapa warna kuning terlebih dahulu digiling menjadi serbuk kemudian dilakukan maserasi dengan menggunakan larutan heksana dan etanol selama 24 jam di Laboratorium Fitokimia Fakultas Farmasi Universitas Setia Budi Surakarta pada bulan Januari 2024. Besi dan seng dianalisis dengan metode Atomic Absorption Spectrum (AAS) di Fakultas MIPA Universitas Gadjah Mada Yogyakarta.  Kandungan zat gizi dianalisis dengan menggunakan uji proximate dan kandungan fitokimia dengan Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) pada mode ionisasi positif dan negatif di LPPT Universitas Gadjah Mada Yogyakarta. Penelitian dilaksanakan pada bulan Februari-April 2024. Ekstrak etanol M. jalapa kuning mengandung kadar air 18.71%, abu 12.08%, protein 25%, lemak 4.74%, karbohidrat 39.47%, besi 0.11%, seng 8.95% dan vitamin C 5.51%. Fitokimia family Betaxanthin terdeteksi pada mode ionisasi positif sedangkan Betacyanin ditemukan pada mode ionisasi negatif. Ekstrak etanol M. jalapa kuning mengandung besi dan Betaxanthin yang berpotensi untuk terapi alternatif anemia.
PHYTOCHEMICAL AND NUTRIENT ANALYSIS OF ETHANOL EXTRACT SALAK PONDOH (Sallaca edulis Reinw) PEEL FOR DEVELOPMENT OF ANTI-OBESITY Andina, Puri Dwi; Indarto, Dono; Wardhani, Lusi Oka
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 2 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i2.2819

Abstract

Insiden obesitas meningkat di seluruh dunia selama beberapa tahun terakhir. Diet dan aktivitas fisik saja pada penderita obesitas kurang memberikan hasil yang optimal, sedangkan penggunaan obat anti obesitas dalam jangka panjang dapat menyebabkan efek samping. Penelitian ini bertujuan untuk menganalisis nutrisi dan kandungan fitokimia kulit buah salak pondoh untuk mengembangkan pengobatan obesitas. Jenis penelitian ini merupakan eksperimental laboratorium dengan 3 tahap: ekstraksi kulit luar salak pondoh, analisis nutrisi, dan analisis Gas Chromatography and Mass Spectrometry yang selanjutnya disebut GC-MS. Kulit buah salak pondoh diperoleh dari pusat agribisnis di Sleman, Yogyakarta. Kulit buah salak pondoh kering diekstraksi dengan etanol 70% menggunakan metode remaserasi. Kandungan nutrisi yang terdapat pada ekstrak etanol dianalisis di Laboratorium Teknologi Pangan, Fakultas Pertanian, Universitas Sebelas Maret, sedangkan analisis fitokimia dilakukan di Laboratorium Riset Terpadu dan Analisis Pengujian Universitas Gadjah Mada, dengan menggunakan metode Gas Chromatography and Mass Spectrometry (GC-MS). Ekstrak kulit buah salak pondoh (EPP) mengandung persentase karbohidrat (41,33%), mineral (28,37%), dan air (25,31%) yang lebih tinggi dibandingkan persentase serat kasar (3,68%), lemak (2,62%), protein (2,37%), dan vitamin C (0,88%). Hasil GC-MS mengidentifikasi adanya 75 fitokimia di mana dua dari lima senyawa dengan proporsi tertinggi adalah metil ester asam heksadekanoat dan asam n-heksadekanoat. Kandungan fitokimia tersebut memiliki aktivitas biologis yang berpotensi untuk pengembangan terapi obesitas. Perlu dilakukan penelitian lanjutan secara in vitro dan in vivo untuk mengevaluasi sifat anti- obesitas EPP tersebut.
The Biochemical and Kidney Histopathological Parameters in Hyperoxaluria Rats Treated with Breadfruit Leaf Extract Susilo, Jatmiko; Purnama, Siswanta Jaka; Wahyuni, Ardianti; Purwanto, Bambang; Doewes, Muchsin; Indarto, Dono
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1437

Abstract

Purpose: This study was to analyze the administration of breadfruti leaf extract to changes in biochemical parameters and renal histology in hyperoxaluria rats.Methodology: The experimental study used 6 groups, each of 5 mice that are EG, Normal, Vitamin E, an ethanol extract of breadfruit 100, 200 and 400 mg/kg BW. Blood data for the analysis of biochemical parameters and kidney were taken at the end of the experiment for histological analysis of kidney changes. Results: Research shows that the purified ethanol extract of breadfruit leaf can prevent increases in MDA levels, reduce creatinine and BUN levels, increase body weight, prevent hypertrophy and kidney damage Conclusion: Purified ethanol extract of AA leaves has an antioxidant, nephroprotective activity, protect kidney inflammation, and kidney damage in nephrolithiasis rats and the effective dose is 400 mg/kg BW. The higher the extract dose, the more effective to reduce the biochemical and histopathological parameters in hyperoxaluria rats.Applications/Originality/Value: as a basis for futher studies of molecular biology in the prevention of kidney disorder.
Finding Airon Deficiency Anemia (IDA)at Young Women with Overweigth or Obesity Ayusari, Amelya Augusthina; Azizah, Shofura; Wijayanti, Lilik; Indarto, Dono; Suselo, Yuliana Heri; Mashuri, Yusuf Ari; Hastami, Yunia; Rahayu, Dwi
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2015: Proceeding ISETH (International Conference on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.2395

Abstract

Background: Young women can suffer from anemia due to monthly menstruation and by having many activities without adequate iron-filled nutrition. Otherproblems found on them are overweight and obesity. The data show that one with overweight or obesity can lead to iron deficiency anemia (IDA) along with increasingproinflammatory cytokines, which will cause the transcription of hepcidin. The increaseof hepcidin transcription will inhibit the absorption of iron from the intestine into the circulation, inhibiting spending iron reserves into circulation, and inhibitingthe release of iron recycled from splenic macrophages. This can cause IDA. The purpose of this study was to obtain the proportion of iron deficiency anemia in overweight or obese young women.Methods: The design of this study was cross sectional using purposive sampling. The subjects of this study were the student from fiveselected Senior high schools inBoyolali, Central Java, Indonesia. The determination of IDAis done by using hemoglobin and indexes of erythrocytes. Results: This study was the follow-upof the previous study, which was conducted to 14 obese and/or overweightyoung women withanemia From 14 subjects, there wasone subject suffered from other anemia and 13 subjects with IDA (using index erythrocytes examination). Their mean of MCV was 72.68±4.29fl, MCH was 23.08±2.63pg, and MCHC was 35.21±0.65 %.Conclusions: From this study, almost all overweight or obeseyoung women with anemia were indicated as IDA (92.8%).
The Development of Snack Bars from Salak Seed Flour and Red Beans as Potential Supplementary Food for Anemic Adolescent Girls Liana, Gladya Lady; Indarto, Dono; Suselo, Yuliana Heri
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.591

Abstract

Anemia is a condition in which the body experiences a lack of Hb in the blood. One of the causes of anemia is the need for iron and protein that is not fulfilled by the daily intake. Snake fruit seed flour and red beans have high potential to be developed into health-beneficial products such as snacks. The purpose of this study was to develop snack bars as a treatment for anemia in adolescent girls and to analyze hedonic tests, microbiological contamination, and nutritional content. The data analysis used was the Kruskal-Wallis test with Dunn's Post-Hoc test. This study shows that the snack bar formulation of snake fruit seed flour and red bean has a statistically significant effect with a p-value <0.05. Based on the level of liking of high school adolescent girls, the most preferred formulations are formulations P0 and P3. The P0 treatment has nutritional content (carbohydrate 43.33%, protein 14.30%, fat 19.70%, total calories 400 Kcal, iron 3.6 mg, vitamin C 24.5 mg, and zinc 4.8 mg) and the P3 formulation has nutritional content (carbohydrate 49.49%, protein 10.71%, fat 13.53%, total calories 360 Kcal, iron 11.4 mg, vitamin C 28.0 mg, and zinc 5.2 mg), so it has the potential to innovate supplementary feeding for anemic adolescent girls.
Enhancing Anthocyanin Butterfly Pea Stability using Encapsulation: A Scoping Review of Coating Materials and Techniques Firdaus, Jihan; Indarto, Dono; Listyawati, Shanti
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.682

Abstract

Butterfly pea flowers are rich in anthocyanin and have therapeutic benefits, particularly due to their antioxidant properties. However, their use in the food and pharmaceutical industries is still limited due to their low stability in environmental conditions, which causes degradation, decreased stability and bioavailability. Nanoencapsulation is a potential method for improving the stability and effectiveness of anthocyanin. This review aims to identify various coating materials and encapsulation techniques used to protect  anthocyanin in butterfly pea flowers, as well as to evaluate their effects on the final product's stability, characteristics, and physicochemical properties. Literature search were conducted through PubMed, ScienceDirect, Scopus, and SpringerLink using structured keywords, following the inclusion criteria based on the Population, Concept, Context (PCC) framework and the PRISMA-ScR protocol. A total 7 published articles met the inclusion criteria. The results show that combination gelatin with coating materials such as pectin or maltodextrin was effective and commonly used. The use combination of gelatin+pectin or gelatin+maltodextrin with freeze drying is capable of forming a strong film, binding anthocyanin, stabilising colour, and proceting anthocyanin from degradation due to its low-temperature process, resulting in high encapsulation efficiency, high retention, and good morphology and particele size. In conclusion, no ideal coating material and encapsulation techniques. Further in vivo bioavailability studies are warranted to evaluate the most promising combinations, gelatin + pectin or gelatin + maltodextrin with freeze drying.
The effects of raja banana (Musa acuminata) peel extract on body weight, body mass index, body fat percentage, and visceral fat mass in male rats with obesity Devina, Kezia Elian; Indarto, Dono; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 2, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(2).115-125

Abstract

Background: Obesity is a risk factor for metabolic syndrome which can increase mortality. Obese sufferers often fail to lose body weight (BW) through non-pharmacological therapy. Obesity synthetic drugs can cause side effects, so natural ingredients are needed as alternative therapies.Objectives: This study aims to determine the effect of raja banana peel extract (RBPE) on BW, body mass index (BMI), body fat percentage (BFP), and visceral fat mass in obese male rats.Methods: The research subjects were 30 male Wistar rats weighing 125-200 g, aged eight weeks. Obesity was induced by being given high-fat high fructose (HFHFr) feed for 28 days. Rats were randomized and divided into five groups: the negative control group (C-) was given standard feed and distilled water, the positive control (C+) was given standard feed and orlistat, treatment 1 (T1), treatment 2 (T2), and treatment 3 (T3). Which were given standard feed and RBPE doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day. Data before and after the induction of obesity were analyzed using paired t-tests. BW, BMI, and visceral fat mass were analyzed using the One-Way Analysis of Variance (ANOVA) and Repeated Measure ANOVA tests. BFP was analyzed using the Kruskal-Wallis test and the Friedman test.Results: RBPE can significantly reduce BW (p=0.026), BMI (p<0.001), and BFP (p<0.001). However, all groups had no significant difference in visceral fat mass (p=0.187). T3 was the group with the lowest average BW, BMI, BFP, and visceral fat mass although the highest weight loss during the intervention period occurred in C+.Conclusions: RBPE has the potential as an alternative therapy for obesity because it can reduce BW, BMI, and BFP. Future studies can investigate the effect of RBPE on other obesity parameters such as lipid profiles.
Co-Authors A.A. Ketut Agung Cahyawan W Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Ahmad Hamim Sadewa Akbar, Muh. Syaiful Ali Djamhuri Ambar Mudigdo Amilia Yuni Damayanti Andina, Puri Dwi Argyo Demartoto, Argyo Arta Farmawati Avelia, Annisa Ayusari, Amelya Augusthina Azizah, Shofura Badri, Baarizah Febriana Balgis Balgis Bambang Purwanto Bhisma Murti Brian Wasita Budianto, Pepi Budiyanti Wiboworini Budiyanti, Novita Damayanti, Ana Dea Linia Romadhoni Diah Kurnia Mirawati Didik Gunawan Tamtomo Didik T Subekti Didik Tamtomo, Didik Diyantana, Wawan Dwi Rahayu Endang Sutisna Sulaeman Ernawati Ernawati Fajar Alam Putra, Fajar Alam Fara Ayu Febyawati, Hani Firdaus, Jihan Fitriana Fitriana Gilang Akbar Shobirin Hambarsari, Yetty Hamidi, Baarid Luqman Hartono Hartono Hastami, Yunia Hastuti, Nunik Maya Hermanu Joebagio Herviana, Herviana Hutabarat, Ervina Arta Jayanti Ida Ayu Putu Sri Widnyani Ida Nurwati Inayati Inayati Irma Isnafia Arief Isfaizah Jatmiko Susilo Kezia Elian Devina Kurniagung, Philipus Prihantiko Kusnandar, K Kusumadewi Eka Damayanti Laksana, Budi Liana, Gladya Lady Lilik Wijayanti Mahendra Wijaya Maryati, Warsi Mashuri, Yusuf Ari Muchsin Doewes Muhammad, Faizal Nasrullah, Adam Haviyan Ningrum, Sri Setiyo NINGRUM, TYAS SARI RATNA Nor Istiqomah Nugroho, Anung N. Nunuk Suryani Nurfitria, Fadhila Balqis Nurinasari, Hafi Nurochim, Erna Pamungkasari, Eti P. Paramasari Dirgahayu Perdana, Muhammad Vidi Pesik, Riza N. Prabaningtyas, Hanindia Riani Prahesti, Ratna Prasetyaningsih, Roh Hastuti Pratiwi, Ayudhia Purnama, Siswanta Jaka Purwaningsih, Yustina Puspita, Rumeyda Chitra Putri, Anak Agung Alit Kirti Estuti Narendra Putri, Risma Aliviani Putri, Widya Kaharani Rahardjo, Setyo Sri Rahardjo, Setyo Sri Retiyansa, Yesi Retiyansa, Yesi Ristinawati, Ira Risya Cilmiaty, Risya Rivan Danuaji Riza Novierta Pesik RUBEN DHARMAWAN Sajidan Sari, Septi Ayu Arum Yuspita Satriani, Hayu Andita Selfi Handayani Sena, Anantha Setyaningrum, Th. Catur Wulan Shanti Listyawati Soetrisno Soetrisno Soetrisno Sri Sulistyowati Sugiarto S Sundari, Isti SUROTO SURYAWATI, BETTY Susanti, Rahmah Purwaningsih Febri Suselo, Yuliana Heri Suselo, Yuliana Heri Susilawati, Eva Tedjo, Raden Andi Ario Tejomukti, Teddy Thesman, Inggrit Bela Tiyas, Dwi Wahyuning Tonang Dwi Ardyanto Tri Agustina, Tri Tri Harsono Tri Nugraha Susilawati Ulfia, Mila Umarghanies, Sarah Safira Utami, Agustina Dwi Vitri Widyaningsih Vitria Sari Dewi Wahyuni, Ardianti Wardhani, Lusi Oka Widiasih, Ghina Widyanti, Fera Wijayanti, Poppy Wulandari, R. AJ. Sri Wulandari, RAJ Sri Yarso, Kristanto Y. Yatty Destani Sandy Yudhani, Ratih D. yulia lanti retno dewi Yuliana Heri Soesilo Yusrizal, Mirza