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The Biochemical and Kidney Histopathological Parameters in Hyperoxaluria Rats Treated with Breadfruit Leaf Extract Susilo, Jatmiko; Purnama, Siswanta Jaka; Wahyuni, Ardianti; Purwanto, Bambang; Doewes, Muchsin; Indarto, Dono
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1437

Abstract

Purpose: This study was to analyze the administration of breadfruti leaf extract to changes in biochemical parameters and renal histology in hyperoxaluria rats.Methodology: The experimental study used 6 groups, each of 5 mice that are EG, Normal, Vitamin E, an ethanol extract of breadfruit 100, 200 and 400 mg/kg BW. Blood data for the analysis of biochemical parameters and kidney were taken at the end of the experiment for histological analysis of kidney changes. Results: Research shows that the purified ethanol extract of breadfruit leaf can prevent increases in MDA levels, reduce creatinine and BUN levels, increase body weight, prevent hypertrophy and kidney damage Conclusion: Purified ethanol extract of AA leaves has an antioxidant, nephroprotective activity, protect kidney inflammation, and kidney damage in nephrolithiasis rats and the effective dose is 400 mg/kg BW. The higher the extract dose, the more effective to reduce the biochemical and histopathological parameters in hyperoxaluria rats.Applications/Originality/Value: as a basis for futher studies of molecular biology in the prevention of kidney disorder.
Finding Airon Deficiency Anemia (IDA)at Young Women with Overweigth or Obesity Ayusari, Amelya Augusthina; Azizah, Shofura; Wijayanti, Lilik; Indarto, Dono; Suselo, Yuliana Heri; Mashuri, Yusuf Ari; Hastami, Yunia; Rahayu, Dwi
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2015: Proceeding ISETH (International Conference on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.2395

Abstract

Background: Young women can suffer from anemia due to monthly menstruation and by having many activities without adequate iron-filled nutrition. Otherproblems found on them are overweight and obesity. The data show that one with overweight or obesity can lead to iron deficiency anemia (IDA) along with increasingproinflammatory cytokines, which will cause the transcription of hepcidin. The increaseof hepcidin transcription will inhibit the absorption of iron from the intestine into the circulation, inhibiting spending iron reserves into circulation, and inhibitingthe release of iron recycled from splenic macrophages. This can cause IDA. The purpose of this study was to obtain the proportion of iron deficiency anemia in overweight or obese young women.Methods: The design of this study was cross sectional using purposive sampling. The subjects of this study were the student from fiveselected Senior high schools inBoyolali, Central Java, Indonesia. The determination of IDAis done by using hemoglobin and indexes of erythrocytes. Results: This study was the follow-upof the previous study, which was conducted to 14 obese and/or overweightyoung women withanemia From 14 subjects, there wasone subject suffered from other anemia and 13 subjects with IDA (using index erythrocytes examination). Their mean of MCV was 72.68±4.29fl, MCH was 23.08±2.63pg, and MCHC was 35.21±0.65 %.Conclusions: From this study, almost all overweight or obeseyoung women with anemia were indicated as IDA (92.8%).
Effect of Freeze-Drying, Spray-Drying, and Foam-Mat-Drying Encapsulation Techniques on Vitamin C Level in Fruit Powder: A Scoping Review Baruroh, Durotul; Suselo, Yuliana Heri; Kusumawati, Ratna; Dono Indarto
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.586

Abstract

Vitamin C is an essential micronutrient with important antioxidant and physiological roles. However, it is highly unstable during processing due to its sensitivity to heat, oxygen, and light. This scoping review mapped evidence on drying-based encapsulation techniques: freeze drying, spray drying, and foam-mat drying. It examines their effect on the vitamin C level in fruit powder. A systematic search was conducted in PubMed, ScienceDirect, Springer, MDPI, and Google Scholar for studies published between 2015 and 2025. The search followed the PRISMA-ScR framework. Seven studies met the criteria and covered acerola, camu-camu, banana, açaí, papaya, satsuma mandarin, orange peel, and mulberry. The findings show that freeze-drying was consistently the most effective technique for retaining vitamin C levels. Some studies even reported an increase in vitamin C levels, possibly due to the breakdown of the fruit matrix, which made the nutrient more available. During Spray drying, low retention values (11%) were obtained in banana paste, and almost total retention (99%) was achieved in camu-camu pulp. The retention of mulberry juice during optimized foam-mat drying amounted to a maximum level of 90%. Coating materials, such as gum Arabic (GA) and carboxymethyl cellulose (CMC), provided better stability in vitamin C levels. However, there are some gaps regarding encapsulation efficiency, degradation kinetics, and particular mechanisms of the matrix that could clarify retention rates beyond 100%. Thus, future studies should focus on these parameters for the refinement of scalable yet low-cost drying strategies of functional fruit powders.
The Development of Snack Bars from Salak Seed Flour and Red Beans as Potential Supplementary Food for Anemic Adolescent Girls Liana, Gladya Lady; Indarto, Dono; Suselo, Yuliana Heri
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.591

Abstract

Anemia is a condition in which the body experiences a lack of Hb in the blood. One of the causes of anemia is the need for iron and protein that is not fulfilled by the daily intake. Snake fruit seed flour and red beans have high potential to be developed into health-beneficial products such as snacks. The purpose of this study was to develop snack bars as a treatment for anemia in adolescent girls and to analyze hedonic tests, microbiological contamination, and nutritional content. The data analysis used was the Kruskal-Wallis test with Dunn's Post-Hoc test. This study shows that the snack bar formulation of snake fruit seed flour and red bean has a statistically significant effect with a p-value <0.05. Based on the level of liking of high school adolescent girls, the most preferred formulations are formulations P0 and P3. The P0 treatment has nutritional content (carbohydrate 43.33%, protein 14.30%, fat 19.70%, total calories 400 Kcal, iron 3.6 mg, vitamin C 24.5 mg, and zinc 4.8 mg) and the P3 formulation has nutritional content (carbohydrate 49.49%, protein 10.71%, fat 13.53%, total calories 360 Kcal, iron 11.4 mg, vitamin C 28.0 mg, and zinc 5.2 mg), so it has the potential to innovate supplementary feeding for anemic adolescent girls.
Enhancing Anthocyanin Butterfly Pea Stability using Encapsulation: A Scoping Review of Coating Materials and Techniques Firdaus, Jihan; Indarto, Dono; Listyawati, Shanti
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.682

Abstract

Butterfly pea flowers are rich in anthocyanin and have therapeutic benefits, particularly due to their antioxidant properties. However, their use in the food and pharmaceutical industries is still limited due to their low stability in environmental conditions, which causes degradation, decreased stability and bioavailability. Nanoencapsulation is a potential method for improving the stability and effectiveness of anthocyanin. This review aims to identify various coating materials and encapsulation techniques used to protect  anthocyanin in butterfly pea flowers, as well as to evaluate their effects on the final product's stability, characteristics, and physicochemical properties. Literature search were conducted through PubMed, ScienceDirect, Scopus, and SpringerLink using structured keywords, following the inclusion criteria based on the Population, Concept, Context (PCC) framework and the PRISMA-ScR protocol. A total 7 published articles met the inclusion criteria. The results show that combination gelatin with coating materials such as pectin or maltodextrin was effective and commonly used. The use combination of gelatin+pectin or gelatin+maltodextrin with freeze drying is capable of forming a strong film, binding anthocyanin, stabilising colour, and proceting anthocyanin from degradation due to its low-temperature process, resulting in high encapsulation efficiency, high retention, and good morphology and particele size. In conclusion, no ideal coating material and encapsulation techniques. Further in vivo bioavailability studies are warranted to evaluate the most promising combinations, gelatin + pectin or gelatin + maltodextrin with freeze drying.
The effects of raja banana (Musa acuminata) peel extract on body weight, body mass index, body fat percentage, and visceral fat mass in male rats with obesity Devina, Kezia Elian; Indarto, Dono; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 2, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(2).115-125

Abstract

Background: Obesity is a risk factor for metabolic syndrome which can increase mortality. Obese sufferers often fail to lose body weight (BW) through non-pharmacological therapy. Obesity synthetic drugs can cause side effects, so natural ingredients are needed as alternative therapies.Objectives: This study aims to determine the effect of raja banana peel extract (RBPE) on BW, body mass index (BMI), body fat percentage (BFP), and visceral fat mass in obese male rats.Methods: The research subjects were 30 male Wistar rats weighing 125-200 g, aged eight weeks. Obesity was induced by being given high-fat high fructose (HFHFr) feed for 28 days. Rats were randomized and divided into five groups: the negative control group (C-) was given standard feed and distilled water, the positive control (C+) was given standard feed and orlistat, treatment 1 (T1), treatment 2 (T2), and treatment 3 (T3). Which were given standard feed and RBPE doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day. Data before and after the induction of obesity were analyzed using paired t-tests. BW, BMI, and visceral fat mass were analyzed using the One-Way Analysis of Variance (ANOVA) and Repeated Measure ANOVA tests. BFP was analyzed using the Kruskal-Wallis test and the Friedman test.Results: RBPE can significantly reduce BW (p=0.026), BMI (p<0.001), and BFP (p<0.001). However, all groups had no significant difference in visceral fat mass (p=0.187). T3 was the group with the lowest average BW, BMI, BFP, and visceral fat mass although the highest weight loss during the intervention period occurred in C+.Conclusions: RBPE has the potential as an alternative therapy for obesity because it can reduce BW, BMI, and BFP. Future studies can investigate the effect of RBPE on other obesity parameters such as lipid profiles.
Edukasi Pencegahan dan Deteksi Dini Penyakit Kardiovaskular di Masa Pandemi COVID-19 Kusumawati, Ratna; Sulastomo, Heru; Indarto, Dono; Jusup, Sinu Andhi; Rahardjo, Setyo Sri; Purwaningtyas, Niniek; Susilawati, Tri Nugraha; Suselo, Yuliana Heri; Wulandari, Sri
Smart Society Empowerment Journal Vol 3, No 1 (2023): Maret
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i1.70327

Abstract

Pendahuluan: Jumlah kasus penyakit kardiovaskular (PKV) di dunia menunjukkan kecenderungan meningkat termasuk di Indonesia. Kabupaten Sukoharjo di Jawa Tengah melaporkan adanya peningkatan penyakit hipertensi dan diabetes mellitus (DM) yang menjadi faktor risiko penting PKV. Penyakit hipertensi dan DM merupakan penyakit penyerta utama pada kasus coronavirus disease 2019 (COVID-19) sehingga dapat memperburuk gejala dan menyebabkan kematian. Tujuan dari kegiatan pengabdian ini adalah memberikan edukasi tentang pencegahan dan deteksi dini PKV di wilayah Kecamatan Kartasura, Sukoharjo, Jawa Tengah di masa pandemi COVID-19.Metode: Kegiatan pengabdian dilaksanakan di RT 03 RW 02 desa Gowongan, Pucangan, Kartasura, Sukoharjo, Jawa Tengah. Metode pengabdian yang dilakukan berupa pelatihan pengukuran denyut nadi latihan, talk show  mengenai pencegahan dan deteksi dini PKV serta pemeriksaan kesehatan berupa pemeriksaan tekanan darah dan kadar gula darah.Hasil dan pembahasan: Hasil kegiatan pengabdian ini peserta mendapatkan informasi yang valid mengenai pencegahan dan deteksi dini PKV. Selain itu, kegiatan ini menstimulasi keperdulian peserta untuk melakukan upaya pencegahan dan deteksi dini melalui pemeriksaan tekanan darah dan kadar gula darah. Hasil lain yang didapatkan adalah peserta dapat melakukan pengukuran denyut nadi latihan secara mandiri untuk mengoptimalkan olahraga yang dilakukan.Kesimpulan: Edukasi pencegahan dan deteksi dini PKV kepada masyarakat talkshow, pelatihan dan layanan kesehatan telah terlaksana dengan baik. Kegiatan ini dapat memberikan informasi valid kepada masyarakat dan memacu keperdulian masyarakat untuk melakukan upaya pencegahan dan deteksi dini PKV.
Edukasi dan Pemeriksaan Kesehatan Anggota Klub Jantung Sehat Rahardjo, Setyo Sri; Jusup, Sinu Andhi; Indarto, Dono; Wulandari, Sri; Suselo, Yuliana Heri; Kusumawati, Ratna; Sulastomo, Heru; Purwaningtyas, Niniek; Susilawati, Tri Nugraha
Journal of Midwifery in Community Vol 1, No 2 (2023): Oktober
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jmc.v1i2.79502

Abstract

Data Riset Kesehatan Dasar (Riskesdas) di Indonesia secara nasional memperlihatkan bahwa penyakit tidak menular (PTM) terutama penyakit kardiovaskular (PKV) cenderung mengalami peningkatan. Hal tersebut terjadi juga di wilayah kota Surakarta. Tim Pengabdi berinisiatif melaksanakan kegiatan edukasi dan pemeriksaan kesehatan yang bertujuan untuk meningkatkan pengetahuan anggota Klub Jantung Sehat (KJS) terkait PKV sekaligus untuk skrining faktor risiko PKV yang meliputi hipertensi, hiperkolesterol, diabetes mellitus (DM), dan obesitas. Metode yang digunakan berupa penyuluhan dan pemeriksaan tekanan darah, gula darah sewaktu, kolesterol dan antropometri. Kegiatan pengabdian masyarakat ini diikuti oleh 85 anggota KJS dan diselenggarakan pada hari Minggu, 18 Juni 2023 jam 07.00 - 09.00 di Fakultas Keolahragaan Universitas Sebelas Maret (FKOR UNS) Jl. Menteri Supeno, Manahan, Banjarsari Kota Surakarta Jawa Tengah. Dari kegiatan pengabdian masyarakat ini pemahaman para anggota KJS terkait PKV melalui diskusi dan tanya jawab selama penyuluhan dan konseling selama pemeriksaan kesehatan mengalami peningkatan. Kegiatan sejenis perlu dilakukan secara rutin dan berkesinambungan sebagai upaya preventif dan promotif terhadap penyakit tidak menular di masyarakat.
Edukasi dan Deteksi Dini Penyakit Diabetes Melitus Susilawati, Tri Nugraha; Jusup, Sinu Andhi; Rahardjo, Setyo Sri; Indarto, Dono; Wulandari, Sri; Suselo, Yuliana Heri; Kusumawati, Ratna; Sulastomo, Heru; Purwaningtyas, Niniek
Journal of Midwifery in Community Vol 2, No 2 (2024): Oktober
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jmc.v2i1.93242

Abstract

Indonesia currently is experiencing a shift in disease patterns marked by a significant increase in the number of non-communicable diseases (NCDs), especially cardiovascular diseases, specifically diabetes mellitus (DM). A similar phenomenon also occurs in Surakarta city. Community service team conducts educational activities and health checks that aim to increase the knowledge of members of the Klub Jantung Sehat (KJS) related to cardiovascular disease as well as for screening risk factors for cardiovascular diseases including hypertension, hyperuricemia, diabetes mellitus (DM), and obesity. The methods used are counseling and checking blood pressure, uric acid, blood sugar at any time, and anthropometry. This community service activity was attended by 33 KJS members and was held on Sunday, 23 June 2024 at 07.00 - 09.00 at the Faculty of Sports, Sebelas Maret University (FKOR UNS) Jl. Menteri Supeno, Manahan, Banjarsari, Surakarta City, Central Java, however only 19 participants took part in the complete screening. The results achieved from this community service are an increase in the knowledge of KJS members related to cardiovascular diseases through discussions during counseling as well as during health checkups. The results of the health examination, it was found that 6 people (31.58%) had hypertension, 2 people (10.52%) had DM, and 11 people (57.89%) were found to meet the criteria of overweight and obesity. The members of KJS who had uric acid levels above normal were 10 people (52.63%). Similar activities should be carried out regularly and continuously as a preventive and promotive effort against non-communicable diseases in the community.
Co-Authors ., Hudiyono A.A. Ketut Agung Cahyawan W Adam Haviyan Nasrullah Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Ahmad Hamim Sadewa Akbar, Muh. Syaiful Alfian Abdul Rajab Ali Djamhuri Ambar Mudigdo Amilia Yuni Damayanti Andina, Puri Dwi Argyo Demartoto, Argyo Ari Natalia Probandari Arief Suryono Arta Farmawati Asti Swari Paramanindita Astri Purwanti Avelia, Annisa Ayusari, Amelya Augusthina Azizah, Shofura Azzumar, Farchan Badri, Baarizah Febriana Balgis . Balgis . Balgis Balgis Balgis Balgis Bambang Purwanto Baruroh, Durotul Bhisma Murti Brian Wasita Brian Wasita Brian Wasita Brian Wasita Brian Wasita Budianto, Pepi Budiyanti Wiboworini Budiyanti, Novita Damayanti, Ana Dandi Sanjaya Dea Linia Romadhoni Dewi, Dwi Hananta Diah Kurnia Mirawati Dian Eka Widyasari Didik Gunawan Tamtomo Didik Gunawan Tamtomo Didik T Subekti Didik Tamtomo, Didik Diffah Hanim Diffah Hanim Diffah Hanim Diffah Hanim Diffah Hanim Dina Okfina Ria Dinar Putri Rahmawati Diyantana, Wawan Endang Sutisna Sulaeman Ernawati Ernawati Eti Poncorini Pamungkasari Eti Poncorini Pamungkasari Fadhila Balqis Nurfitria Fajar Alam Putra, Fajar Alam Fara Ayu Febyawati, Hani Farchan Azzumar Firdaus, Jihan Fista Utami Fitriana Fitriana Gilang Akbar Shobirin Gracia, Vera Viviana Deo Hambarsari, Yetty Hamidi, Baarid Luqman Hani Fara Ayu Febyawati Hartono Hartono Hastami, Yunia Hastuti, Nunik Maya Hermanu Joebagio Heru Sulastomo Herviana, Herviana Hudiyono . Hutabarat, Ervina Arta Jayanti Ida Ayu Putu Sri Widnyani Ida Nurwati Ida Nurwati Inayati Inayati Indah Kusumawati Irma Isnafia Arief Isfaizah Isti Sundari Iwansyah, Ade Chandra Jatmiko Susilo Jatu Aphridasari Jusup, Sinu Andhi Jusup, Sinu Andhi K Kusnandar Kezia Elian Devina Kurniagung, Philipus Prihantiko Kusnandar Kusnandar Kusnandar, K Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Laksana, Budi Liana, Gladya Lady Lilik Wijayanti Luberta Ebta Wiyani M Rizal Permadi M. Yogi Riyantama Isjoni Mahendra Wijaya Martha Arum Nugraheni Maryati, Warsi Mashuri, Yusuf Ari Mila Ulfia Muchsin Doewes Muhammad, Faizal Muthmainah Muthmainah Nanda Eka Sri Sejati Nasrullah, Adam Haviyan Ningrum, Sri Setiyo NINGRUM, TYAS SARI RATNA Niniek Purwaningtyas NITYASEWAKA, PRATHITA Noor Khalwati Afdhaliya Nor Istiqomah Nor Istiqomah Nor Istiqomah Nugraheni, Martha Arum Nugroho, Anung N. Nunuk Suryani Nurfitria, Fadhila Balqis Nurinasari, Hafi Nurochim, Erna Nurwati, Ida Nurwijayanti Oktaviani, Ratna Pamungkasari, Eti P. Paramasari Dirgahayu Paramasari Dirgahayu Perdana, Muhammad Vidi Pesik, Riza N. Prabaningtyas, Hanindia Riani Prahesti, Ratna Prasetyaningsih, Roh Hastuti Pratama, Yoga Mulia PRATHITA NITYASEWAKA Pratiwi, Ayudhia Purnama, Siswanta Jaka Purwaningsih, Yustina Purwaningtyas, Niniek Puspita, Rumeyda Chitra Putri, Anak Agung Alit Kirti Estuti Narendra Putri, Risma Aliviani R. Aj. Sri Wulandari Rahardjo, Setyo Sri Rahardjo, Setyo Sri RAJ Sri Wulandari Ratih D. Yudhani Ratna Kusumawati Ratna Kusumawati Ratna Oktaviani Retiyansa, Yesi Retiyansa, Yesi Reviono Reviono Ristinawati, Ira Risya Cilmiaty AR Risya Cilmiaty, Risya Rivan Danuaji Riza N. Pesik Riza Novierta Pesik Riza Novierta Pesik RUBEN DHARMAWAN Sajidan Sarah Safira Umarghanies Sari, Septi Ayu Arum Yuspita Satriani, Hayu Andita Sejati, Nanda Eka Sri Selfi Handayani Selfi Handayani Sena, Anantha Setyaningrum, Th. Catur Wulan Setyo Sri Rahardjo Shanti Listyawati Shanti Listyawati Sinu Andhi Jusup Sinu Andhi Jusup, Sinu Andhi Soetrisno Soetrisno Soetrisno Sri Sulistyowati Sri Wulandari Sri Wulandari Sugiarto - Sugiarto S Sugiarto Sugiarto Sugiarto Sugiarto Sulastomo, Heru Suminah Suminah Sunarto Tetes Lugito Sundari, Isti Suradi Suradi SUROTO SURYAWATI, BETTY Susanti, Rahmah Purwaningsih Febri Suselo, Yuliana Heri Suselo, Yuliana Heri Suselo, Yuliana Heri SUSELO, YULIANA HERI Susilawati, Eva Tamtomo, Didik Gunawan Tantri Febriana Putri Tedjo, Raden Andi Ario Tejomukti, Teddy Thesman, Inggrit Bela Tiyas, Dwi Wahyuning Tonang Dwi Ardyanto Tri Agustina Tri Agustina, Tri Tri Harsono Tri Harsono Tri Nugraha Susilawati Ulfia, Mila Umarghanies, Sarah Safira Utami, Agustina Dwi Vitri Widyaningsih Vitria Sari Dewi Vitria Sari Dewi Wahyuni, Ardianti Wardhani, Lusi Oka Wariyanti, Astri Sri Widiasih, Ghina Widya Kaharani Putri Widyanti, Fera Wijayanti, Poppy Winda Rizki Pebrina Batubara Wulandari, R. AJ. Sri Wulandari, RAJ Sri Yarso, Kristanto Y. Yatty Destani Sandy Yoga Mulia Pratama Yudhani, Ratih D. yulia lanti retno dewi Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Suselo Yuliana Heri Suselo Yunilla Prabandari Yusrizal, Mirza