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All Journal Jurnal Penelitian dan Evaluasi Pendidikan Sainteknol : Jurnal Sains dan Teknologi Primary: Jurnal Pendidikan Guru Sekolah Dasar ELEMENTARY SCHOOL JOURNAL PGSD FIP UNIMED Profesi Pendidikan Dasar Phenomenon : Jurnal Pendidikan MIPA E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Pendidikan Biologi Journal of Biology Education Universa Medicina Unnes Science Education Journal REiD (Research and Evaluation in Education) INKUIRI : Jurnal Pendidikan IPA Pendas : Jurnah Ilmiah Pendidikan Dasar Biosaintifika: Journal of Biology & Biology Education Perspektif Ilmu Pendidikan JURNAL PENDIDIKAN TAMBUSAI Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Journal of Innovative Science Education Journal of Primary Education JURNAL PENDIDIKAN MIPA Dinasti International Journal of Education Management and Social Science Community Development Journal: Jurnal Pengabdian Masyarakat Journal of Educational Chemistry (JEC) Journal of Research and Educational Research Evaluation jurnal dikdas bantara Cokroaminoto Journal of Primary Education Afeksi: Jurnal Penelitian dan Evaluasi Pendidikan Life Science Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Prosiding Seminar Nasional Pascasarjana Proceeding of International Conference on Science, Education, and Technology Proceeding Seminar Nasional IPA Prosiding Seminar Nasional Biologi Unnes Science Education Journal Journal of Biology Education International Journal of Active Learning Journal of Research and Educational Research Evaluation Prosiding Seminar Nasional Pengabdian Masyarakat
Wiwi Isnaeni
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Pengaruh Ekstrak Kulit Buah Rambutan terhadap Kualitas Sperma Tikus yang Terpapar Asap Rokok Dewanto, Herdiatmaja Nugroho; ., Lisdiana; Isnaeni, Wiwi
Life Science Vol 6 No 2 (2017): October 2017
Publisher : Universitas Negeri Semarang

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Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit buah rambutan (per oral) terhadap kualitas sperma tikus yang dipapar asap rokok (inhalasi). Penelitian ini merupakan penelitian eksperimental dengan rancangan acak lengkap. Subyek penelitian sebanyak 25 ekor tikus putih jantan galur wistar usia 2-3 bulan, dibagi secara acak menjadi 5 kelompok yaitu K-I sampai dengan K-5. K-1 adalah kelompok kontrol, K-II kelompok dengan perlakuan rokok 3 batang/hari, sedangkan K-III, K-IV dan K-V diperlakukan dengan rokok dan ekstrak kulit buah rambutan dosis 15mg/kg BB/hari, 30mg/kg BB/hari dan 45mg/kg BB/hari. Kulit rambutan yang diekstrak adalah rambutan kultivar lokal (Nephelium Lappaceum). Perlakuan diberikan selama 30 hari. Data yang diamati adalah jumlah sperma, jumlah sperma motil, viabilitas sperma (jumlah sperma yang bertahan hidup), dan jumlah sperma abnormal. Analisis data menggunakan ANAVA satu jalan dan uji BNT. Hasil penelitian menunjukkan bahwa ekstrak kulit buah rambutan berpengaruh dalam meningkatkan kualitas sperma yang telah dipapar asap rokok. Dosis ekstrak kulit buah rambutan yang paling berpengaruh adalah 45 mg/kg BB/hari. This research aimed to know more about the influence of rambutan peel extract (per oral) on mice sperm quality exposed by cigarette smoke (inhalation). The research was a completely randomized experimental design. The research subject as many as 25 male mice (wistar strain) who were randomly divided into 5 groups K-1 to K-5. K-I was control group, K-II was given exposure to smoke from 3 bar cigarette/day group, when K-III, K-IV and K-V were given cigarette and rambutan peels extract of 15, 30, 45mg/kg dose of body weight/day group. The rambutan peel which were extracted was local cultivar (Nephelium Lappaceum). The treatment was given for 30 days. The parameter observed were the number of sperms, motility, viability (the number of life sperms), and abnormality. Data analyzed by one way ANAVA and BNT test. The results showed that rambutan peel extract could increase the sperms quality exposed by cigarette smoke. The most optimum rambutan peel extract dose was 45mg/kg of body weight/day.
Bioaplikasi Kitosan dan Vitamin C terhadap Kadar Hemoglobin Rattus norvegicus yang Dipapar Pb Asetat Ningsih, Eni Widya; Marianti, Aditya; Isnaeni, Wiwi
Life Science Vol 7 No 2 (2018): November 2018
Publisher : Universitas Negeri Semarang

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Abstract

Akumulasi Pb2+ dalam darah dapat menghambat kerja enzim-enzim pensintesis hemoglobin (Hb). Penelitian ini dilakukan untuk menganalisis apakah kombinasi kitosan dan vitamin C akan saling bersinergi mengurangi dampak negatif Pb2+ dalam tubuh, terutama terhadap kadar Hb. Penelitian ini mnggunakan Post Test Control Group Design. Populasi penelitian adalah tikus jantan galur Wistar 30 ekor yang terbagi dalam enam kelompok perlakuan, yaitu kelompok kontrol (KK) diberi makan dan minum ad libitum, kontrol negatif (KN) hanya diberi Pb asetat 175 mg/kg BB, kontrol positif (KP) diberi Pb asetat 175 + kitosan 64 mg/kg BB, dan kelompok perlakuan (P1, P2, P3) dipapar Pb asetat, kitosan, dan vitamin C dosis 100, 200, dan 300 mg/kg BB. Perlakuan dilakukan selama 42 hari. Darah tikus diambil pada hari ke-44 untuk diuji kadar Pb darahnya menggunakan metode Atomic Absorbsion Spectrofotometer (AAS) dan kadar Hb dengan metode Cyanmethemoglobin. Hasil uji Anava menunjukkan terdapat penurunan kadar Pb darah dan kenaikan kadar Hb darah secara signifikan pada kelompok yang dipapar Pb asetat dan diberikan kitosan dan vitamin C. Hasil uji lanjut dengan Duncan Multiple Range Test (DMRT) menunjukkan bahwa kelompok KK, KP, P1, P2, P3 tidak berbeda secara signifikan, namun bebeda signifikan terhadap kelompok KN. Simpulan penelitian ini adalah kombinasi kitosan dan vitamin C saling bersinergi menurunkan kadar Pb darah tikus dan meningkatkan kadar Hb darah tikus yang dipapar Pb asetat. Accumulation of Pb2+ in the blood inhibits various enzymes involved in heme synthesis pathway. This study aims to analyze the synergy potential of chitosan and vitamine C combination in depleting the detrimental effects exerted by Pb2+ exposure in the body, especially to blood Hb levels. This study use Post Test Control Group Design. The population of the study is male Wistar rats and a number of collected samples are 30 samples. The sample were divided into six group, the regular control (KK), that was fed and water ad libitum, the negative control (KN) was administrated only with Pb acetate at dose 175 mg/kg BB, positive control (KP) was administrated with Pb acetate + chitosan 64 mg/kg BB, and treatment group (P1, P2, P3) that was exposed by Pb acetate 175 mg/kg BB, chitosan 64 mg/kg BB, and vitamine C at dose of 100, 200, and 300 mg/kg BB. The treatment were administrated for 42 days. Blood was then collected on the 44th day to measure blood Pb level using Atomic Absorbsion Spectrofotometer (AAS) method, and to measure blood Hb using Cyanmethemoglobin method. The results of one way Anava showed a significant decrease in blood Pb level and increase in blood Hb level on groups exposed to Pb acetate and treated with combination of chitosan and vitamine C. The results of Duncan Multiple Range Test (DMRT) showed that group of KK, KP, P1, P2, and P3 were not significantly different to one another, but significantly different to the KN group. The conclusion of this study is combination of chitosan and vitamine C is synergy to decrease further blood Pb level and and increase blood Hb level in rats exposed with Pb acetate.
Bioaplikasi Kitosan dan Vitamin C terhadap Kadar Hemoglobin Rattus norvegicus yang Dipapar Pb Asetat Ningsih, Eni Widya; Marianti, Aditya; Isnaeni, Wiwi
Life Science Vol 10 No 1 (2021): April 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lifesci.v10i1.47173

Abstract

Akumulasi Pb2+ dalam darah dapat menghambat kerja enzim-enzim pensintesis hemoglobin (Hb). Penelitian ini dilakukan untuk menganalisis apakah kombinasi kitosan dan vitamin C akan saling bersinergi mengurangi dampak negatif Pb2+ dalam tubuh, terutama terhadap kadar Hb. Penelitian ini mnggunakan Post Test Control Group Design. Populasi penelitian adalah tikus jantan galur Wistar 30 ekor yang terbagi dalam enam kelompok perlakuan, yaitu kelompok kontrol (KK) diberi makan dan minum ad libitum, kontrol negatif (KN) hanya diberi Pb asetat 175 mg/kg BB, kontrol positif (KP) diberi Pb asetat 175 + kitosan 64 mg/kg BB, dan kelompok perlakuan (P1, P2, P3) dipapar Pb asetat, kitosan, dan vitamin C dosis 100, 200, dan 300 mg/kg BB. Perlakuan dilakukan selama 42 hari. Darah tikus diambil pada hari ke-44 untuk diuji kadar Pb darahnya menggunakan metode Atomic Absorbsion Spectrofotometer (AAS) dan kadar Hb dengan metode Cyanmethemoglobin. Hasil uji Anava menunjukkan terdapat penurunan kadar Pb darah dan kenaikan kadar Hb darah secara signifikan pada kelompok yang dipapar Pb asetat dan diberikan kitosan dan vitamin C. Hasil uji lanjut dengan Duncan Multiple Range Test (DMRT) menunjukkan bahwa kelompok KK, KP, P1, P2, P3 tidak berbeda secara signifikan, namun bebeda signifikan terhadap kelompok KN. Simpulan penelitian ini adalah kombinasi kitosan dan vitamin C saling bersinergi menurunkan kadar Pb darah tikus dan meningkatkan kadar Hb darah tikus yang dipapar Pb asetat. Keywords: Chitosan; Pb acetate; blood Pb levels; blood Hb levels; Vitamine C, Kitosan; Pb asetat; tingkat Pb darah; tingkat Hb darah; Vitamin C. Accumulation of Pb2+ in the blood inhibits various enzymes involved in heme synthesis pathway. This study aims to analyze the synergy potential of chitosan and vitamine C combination in depleting the detrimental effects exerted by Pb2+ exposure in the body, especially to blood Hb levels. This study use Post Test Control Group Design. The population of the study is male Wistar rats and a number of collected samples are 30 samples. The sample were divided into six group, the regular control (KK), that was fed and water ad libitum, the negative control (KN) was administrated only with Pb acetate at dose 175 mg/kg BB, positive control (KP) was administrated with Pb acetate + chitosan 64 mg/kg BB, and treatment group (P1, P2, P3) that was exposed by Pb acetate 175 mg/kg BB, chitosan 64 mg/kg BB, and vitamine C at dose of 100, 200, and 300 mg/kg BB. The treatment were administrated for 42 days. Blood was then collected on the 44th day to measure blood Pb level using Atomic Absorbsion Spectrofotometer (AAS) method, and to measure blood Hb using Cyanmethemoglobin method. The results of one way Anava showed a significant decrease in blood Pb level and increase in blood Hb level on groups exposed to Pb acetate and treated with combination of chitosan and vitamine C. The results of Duncan Multiple Range Test (DMRT) showed that group of KK, KP, P1, P2, and P3 were not significantly different to one another, but significantly different to the KN group. The conclusion of this study is combination of chitosan and vitamine C is synergy to decrease further blood Pb level and and increase blood Hb level in rats exposed with Pb acetate. Keywords: Chitosan; Pb acetate; blood Pb levels; blood Hb levels; Vitamine C, Kitosan; Pb asetat; tingkat Pb darah; tingkat Hb darah; Vitamin C.
Co-Authors ,, Indriyati - Suprihatin, - ., Lisdiana Abdiyadul Fitriyah Abyadul Fitriyah Abyadul Fitriyah Aditya Marianti Agus Yuwono Ai Astuti, Ai Aidah, Nur Ain Amalia Rahmawati Aini, Siti Hairatul Alfian, Denis Amalia, Devi Amin Retnoningsih Andin Irsadi Andreas Priyono Budi Prasetyo Andrjati, Noening Anggoro, Naufal Sebastian Ani Rusilawati, Ani Ani Rusilowati Ari Yuniastuti Arif Widiyatmoko, Arif Asri, Widi Aswanti, Novita Hawsari Atikah Kurniawati, Atikah Atip Nurwahyunani, Atip B., F. Putut Martin H. Badingatus Sholihah Bambang Subali Bambang Subali Barus, Robi Agape Budi Naini Mindyarto, Budi Naini Candra Abdillah Desy Fatmawati Dewanto, Herdiatmaja Nugroho Dewi Mustikaningtyas Dewi, Novi Ratna Dian Ariani Djuniadi Djuniadi Dua Bunga, Maria Herliyani Dwi Widya Arumsari Dyah Rini Indriyanti Edi Daenuri Anwar Eko Handoyo Eli Trisnowati Elis Risyanti Ellianawati, Ellianawati Elok Fariha Sari Ely Rudyatmi, Ely Endah Peniati Endang Susilaningsih Endang Susilaningsih Enni Suwarsi Rahayu Evira Yustika F. Putut Martin Herry Budijantoro F. Putut Martin, F. Putut Fakhruddin Fakhruddin Fakhruddin Fakhruddin Fardiana, Rina Farid Ahmadi Faridah, Indah Fathayati, Siti Firdaus Firdaus Fitriana, Noorma Fitriyanti, Wahyuning Furi Intan Wahyuni, Furi Intan Ghaida Nisa Hari Bakti Mardikantoro Hartono Hartono Hartono Hartono Hartono Hartono Hastuti Hastuti Heriana, Dena Emarani Heru Setiawan Heru Setiawan Imam Supardi, Kasmadi Irma Paramita, Irma Isti Nur Hayanah Kartika Widyaningrum Kasmadi Imam Supardi Katrina Ramadhani Kukuh Santosa Kumaidi Kumaidi Kumala Sari, Via Indriani Kusumawati, Vita Langlang Handayani Lia, Roudloh Muna Lia Linda Retnowati Lisdiana Lisdiana Lisdiana M. Khumaedi Ma'rifah, Amriyah Ummi Martien Herna Susanti Masrukan Masrukan Masturi Masturi Merdhenita Restuti MIFTAKHUL JANNAH Miftakhul Jannah Muhamad Rapi Muhammad Khumaedi Muhammad Reza Muhammad Reza Muhartati, Dwi Muhartati, Dwi Multazam, Multazam Mustika Sari, Mustika Mutiara Nurul Lita Azizah Nana Kariada Trimartuti Ngudy Jaka Surasa Ngudy Jaka Surasa, Ngudy Jaka Ning Setiati Ning Setiati Ning Setyani Ningsih, Eni Widya Noor Aini Habibah Nugrahaningsih Nugrahaningsih Nugrahaningsih WH, Nugrahaningsih Nugroho, Deni Ebit Nuni Widiarti Nur Rahayu Utami Nur Rahayu Utami Nurahman, Nurul Iman Nurhikmah Nurhikmah Nurkaenah, Nurkaenah Nurul Lita Azizah, Mutiara Prabawati, Desi Ayu Prabawati, Desi Ayu Prayitno, Mohammad Agus Priyanto, Yudi Pujiasih, Pujiasih Putra, Ngurah Made Darma Putri Handayani Putri Handayani Rachmawati, Rivanna C Rahmadhani, Rahmadhani Ramadhani, Katrina Ramadhani, Novanda Adelia Rapi, Muhamad Restuti, Merdhenita Retno Wulandari Rina Fardiana Ristianafi, Diana Putri Rizki Winarsih Rizky Himayanti Robi Agape Barus Roudloh Muna Lia Rusdiyana Rusdiyana Rusdiyana Rusdiyana Sa'idah, Nailiya Sabdhosih, Has Saiful Ridlo Sandra Atikasari, Sandra Sari, Elok Fariha Sari, Nanda Devita Sarie, Fitria Novita Sarini Rahayu Sarwi Sarwi Sarwi Setiawan, Joko Tia Setiyadi, Hafid Setiyorini , Sri Rejeki Setiyorini, Sri Rejeki seviani Oktami Shabrina Caesharah Aulia Shoimatun Febriyani, Shoimatun Sholihah, Badingatus Sigit Saptono Simamora, Mona Yelly Siti Alimah Siti Harnina Bintari Slamet Firdaus Sri Jumini Sri Mulyani Endang Susilowati, Sri Mulyani Endang Sri Sukaesih Sri Sulistriorini Sudarmin Sudarmin Sugianto Sugianto Sugianto Sugiarto, Deasy Renaningtyas Suharto Linuwih Sukestiyarno Sukestiyarno SUMADI SUMADI Sun'an, Ulin Nuha Sun’an, Ulin Nuha Supriyadi Supriyadi Supriyadi Supriyadi Supyan Husain Suraji Suraji suraji suraji Sutikno Sutikno Suwito Eko Pramono Syarofatin, Ririn Hamidatus Sylvia Ervina Safitri Tolang, Korsini Heru Setiawan Tsaniyyah, Dinda Ulfa, Berlina Maika Ulin Nuha Sun’an Wahyu Hardyanto Wahyu Sejati, Dwi Jayanti Wakano, Rafsan Widyaningrum, Kartika Wijanayu, Adiratna Wijayanti, Jihan Sela Wiyanto Wiyanto Woro Sumarni Wulan Christijanti YL Sukestiyarno Yudi Priyanto Zaenuri Mastur Zahra, Nur Izhma Adzkia