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INOVASI MP-ASI: PENDAMPINGAN PEMBUATAN SUSU BIJI DURIAN DI DESA KARANG ANYAR Femmy Andrifianie; Suryani Agustina Daulay; Terza Aflika Happy; Syazili Mustofa; Linda Septiani; Sutarto, Sutarto; Andi Nafisah Tendri Adjeng
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 1: Juni 2025
Publisher : Bajang Institute

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Abstract

Stunting merupakan permasalahan gizi kronis yang masih menjadi tantangan utama di berbagai daerah, termasuk di Desa Karang Anyar, Kabupaten Lampung Selatan. Upaya pencegahan stunting memerlukan intervensi edukatif yang efektif serta inovasi pemanfaatan pangan lokal sebagai alternatif sumber nutrisi. Biji durian (Durio zibethinus Murr), yang selama ini kurang dimanfaatkan, memiliki potensi sebagai bahan dasar susu MP-ASI (Makanan Pendamping-Air Susu Ibu) karena kandungan gizinya yang tinggi. Kegiatan ini bertujuan untuk meningkatkan pemahaman masyarakat terkait stunting dan pemanfaatan biji durian sebagai MP-ASI melalui pendekatan edukatif. Metode yang digunakan adalah pretest dan posttest pada 30 peserta dengan sepuluh pertanyaan yang sama sebelum dan sesudah edukasi. Hasil menunjukkan adanya peningkatan signifikan pada seluruh indikator pemahaman setelah edukasi, dengan rata-rata jumlah peserta yang menjawab benar meningkat dari 10–16 orang menjadi 25–30 orang (p < 0,0001). Edukasi juga efektif dalam memperkenalkan konsep baru terkait nilai gizi dan cara pengolahan biji durian. Kesimpulannya, edukasi berbasis pangan lokal dapat meningkatkan pengetahuan masyarakat secara signifikan dan berpotensi mendukung upaya pencegahan stunting di tingkat desa. Temuan ini menunjukkan pentingnya integrasi edukasi gizi dan inovasi pangan lokal dalam strategi intervensi kesehatan masyarakat
TERAPI OKSIGEN HIPERBARIK: INDIKASINYA, EFEK FISOLOGIS, BIOKIMIA DAN FARMAKOLOGISNYA : Syazili Mustofa, Ratu Kirana Siva Khoiri Mustofa, Syazili; Khoiri, Ratu Kirana Siva
Jurnal Kedokteran Universitas Lampung Vol. 9 No. 1 (2025): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila.v9i1.pp102-111

Abstract

Terapi oksigen hiperbarik merupakan metode terapeutik di mana pasien menghirup oksigen murni (100%) dalam ruang bertekanan tinggi (≥1 ATA) guna meningkatkan kadar oksigen terlarut dalam plasma. Terapi ini secara signifikan mempercepat pelepasan karbon monoksida dari hemoglobin dan digunakan secara klinis untuk menangani keracunan CO, penyakit dekompresi, luka iskemik, infeksi berat, serta luka kronis seperti ulkus diabetik. Efek fisiologis utama terapi oksigen hiperbarik meliputi peningkatan oksigenasi jaringan, pengurangan edema, dan stimulasi proses penyembuhan. Di tingkat biokimiawi, terapi oksigen hiperbarik memodulasi stres oksidatif dan respons inflamasi melalui peningkatan enzim antioksidan (SOD1, GPX2) dan sitokin pro-regeneratif (IL-1β, VEGF), sekaligus menekan TNF-α. Efektivitasnya juga terbukti dalam perbaikan klinis pasien COVID-19 dengan pneumonia hipoksemik melalui peningkatan saturasi oksigen dan penurunan penanda inflamasi serta koagulasi. Dengan spektrum indikasi luas dan dampak molekuler yang mendalam, Terapi oksigen hiperbarik merupakan terapi tambahan yang menjanjikan dalam berbagai kondisi klinis, meskipun beberapa kontraindikasi absolut dan relatif tetap perlu diperhatikan.
SILICOSIS, A WORK-RELATED DISEASE IN CONSTRUCTION WORKERS AND MINERS EXPOSED TO SILICA DUST Mustofa, Syazili
Jurnal Kedokteran Universitas Lampung Vol. 9 No. 1 (2025): JK UNILA
Publisher : Fakultas Kedokteran

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Abstract

Silicosis is a fibrotic lung disease caused by the inhalation, retention, and reaction to crystalline silica. The primary factors contributing to the pathogenesis of silicosis are dust particles and the body's response, particularly the respiratory tract's reaction to these dust particles. Silica is a naturally occurring substance found in some types of rocks, sand, and clay. Silicosis primarily affects workers exposed to silica dust in occupations such as construction and mining. The mediators that play the most significant role in the pathogenesis of silicosis are Tumor Necrosis Factor (TNF)-α, Interleukin (IL)-6, IL-8, the activity of platelet-derived growth factor (PDGF), and transforming growth factor (TGF)-β. The major criteria for diagnosing silicosis include a significant history of silica dust exposure, characteristic radiological abnormalities (such as pulmonary nodules on chest X-rays or CT scans), and sometimes clinical symptoms, including a progressive cough and shortness of breath. The management of silicosis is symptomatic, meaning it is only aimed at reducing symptoms. It is very important to eliminate the source of exposure to prevent the disease from worsening. Keywords: silicosis, pathogenesis, diagnosis, treatment
Hubungan Kadar Bromotyrosine Urin Dengan Terapi Montelukast, Beclometasone/Formoterol, Dan Kombinasi Selama 3 Bulan Pada Pasien Asma Di Klinik Harum Melati Pringsewu Pinaka Baladika, Dimas Trend; Soeprihatini Soemarwoto, Retno Ariza; Mustofa, Syazili; Yunus, Faisal; Ekawati, Diyan; Wibowo, Adityo
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 7 (2025): Volume 12 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i7.20239

Abstract

Bromotyrosine urin memiliki banyak keuntungan sebagai biomarker potensial penyakit asma mengingat stabilitasnya dan pengumpulan sampel urin yang bersifat non-invasif. Dalam manajemen tatalaksana asma leukotriene receptor antagonist (LTRA) merupakan obat alternatif lini pertama setelah kortikosteroid inhalasi. Penelitian ini bertujuan untuk mengetahui hubungan kadar bromotyrosine urin dengan terapi montelukast selama 3 bulan. Penelitian ini melibatkan 82 pasien berusia antara 6-65 tahun dari Klinik Harum Melati, Pringsewu dari bulan Mei – Desember 2023. Dilakukan uji spirometri, urin, differential count sebelum dan setelah terapi 3 bulan, diklasifikasikan derajat obstruksi ringan (n= 66) dan sedang-berat (n=6) serta pasien non-asma untuk kontrol (n= 10). Hanya 28 pasien yang datang untuk evaluasi setelah 3 bulan terapi. Pasien dibagi menjadi 3 kelompok, yaitu kelompok terapi montelukast (n=14), beclometason/formoterol (n=5), dan kombinasi montelukast dan beclometason/formoterol (n=9). Kadar bromotyrosine urin penderita asma secara bermakna lebih tinggi dibandingkan dengan kontrol (154.11 ng/ml vs 11,87 ng/ml, p= 0,000). Tidak terdapat perbedaan bermakna kadar bromotyrosine urin setelah terapi montelukast (104.24 ng/ml vs 40.79 ng/ml, p=0,433) dan setelah terapi beclometason/formoterol (136,25 ng/ml vs 33,20 ng/ml, p= 0,345. Terjadi penurunan kadar bromotyrosine urin yang bermakna pada kelompok setelah terapi kombinasi montelukast dan beclometasone/formoterol (39.63 ng/ml vs 11.13 ng/ml) (95% CI 3.90-42.43, p= 0.028). Hasil penelitian menunjukkan pasien asma memiliki kadar bromotyrosine urin jauh lebih tinggi dibandingkan dengan non-asma. Kadar bromotyrosine urin menurun secara bermakna setelah terapi kombinasi (montelukast dan beclometason/formoterol) selama 3 bulan.
SERUM METALLOPRETEINASE 3 (MMP-3) LEVELS IN LUNG CANCER AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PATIENTS Soemarwoto, Retno Ariza; Mustofa, Syazili; Suwarno, Sukarti San; Yunus, Faisal; Listiandoko, Raden Dicky Wirawan; Sinaga, Fransisca TY; Febrihartati, Isura
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3077

Abstract

Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer are among the diseases with high mortality rates and a similar genetic disposition. COPD is known to be a significant risk factor for lung cancer. Matrix metalloproteinase-3 (MMP-3) is a protein that plays a role in the growth stage of cancer that has the potential to develop COPD into lung cancer. This descriptive observational study aimed to compare plasma MMP-3 levels among four groups: healthy individuals, lung cancer patients, COPD patients, and patients with both lung cancer and COPD. The findings revealed that plasma MMP-3 levels were lowest in the healthy group and higher in the other groups. The increase in plasma MMP-3 levels among pathological subjects suggests a potential association between serum MMP-3 levels and the development of lung cancer in COPD patients. However, further research is needed to clarify this relationship.
Edukasi Pencegahan Infeksi Saluran Kemih pada Ibu Hamil Di Kecamatan Jati Agung, Kabupaten Lampung Selatan Sutarto, Sutarto; Puspita Sari, Ratna Dewi; Utama, Winda Trijayanthi; Mustofa, Syazili
JCOMENT (Journal of Community Empowerment) Vol. 6 No. 3 (2025): Community Empowerment
Publisher : The Journal Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55314/jcoment.v6i3.1052

Abstract

This community service program aimed to improve knowledge and preventive behaviors related to urinary tract infection (UTI) among pregnant women in Karang Anyar Village, Jati Agung Subdistrict, South Lampung Regency. The main problems identified in the community included low awareness of safe drinking water, unhealthy urination habits, and limited access to clean water. The activities consisted of health education sessions, interactive discussions, question-and-answer forums, practical simulations, and distribution of educational materials such as booklets and digital media for posyandu (community health post) cadres. Results from the pre–post evaluation showed a significant improvement in participants’ understanding of UTI risks, the importance of boiling water before consumption, and maintaining personal and environmental hygiene. Participants demonstrated a commitment to behavioral change, including avoiding urinary retention and attending regular antenatal check-ups. Posyandu cadres actively participated as facilitators for ongoing community education. This program not only enhanced individual knowledge and awareness but also strengthened the capacity of health cadres and fostered collaboration among academics, health workers, and village authorities. The outputs, including educational booklets, learning modules, and activity documentation, can serve as sustainable resources to support maternal health programs at the community level.
A Case Report: Side Effect Of Linezolid In Pulmonary Rifampicin Resistance Tuberculosis Mustofa, Syazili; Karina, Salwa Al; Putri, Giska Tri; Busman, Hendri; Syakir, Muhammad Addin
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 1 (2025): Volume 12 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i1.18144

Abstract

Linezolid is a very potent treatment for pulmonary tuberculosis, but it has some side effects. Patients with drug-resistant pulmonary tuberculosis may experience anemia as a side effect of taking the multidrug-resistant tuberculosis medication Linezolid. A 58-year-old man's primary complaint in one case reported to RSUD dr. H. Abdul Moeloek Lampung was a weakness. The diagnosis was made based on anamnesis, a physical examination, and supporting examinations. Treatment was given both pharmacologically and non-pharmacologically, including the intervention to discontinue Linezolid. Although linezolid-based combination therapy in program conditions is associated with favorable outcomes, side effects should be monitored closely, which may require discontinuation of the drug and taking appropriate steps to treat side effects. 
Byssinosis, An Occupational Lung Disease: Diagnosis And Management Mustofa, Syazili; Izzati, Marwah Aulia; Soeprihatini, Retno Ariza; Komala, Ramadhana; Silaen, David; Sinaga, Fransisca T.Y.
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 5 (2025): Volume 12 Nomor 5
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i5.18864

Abstract

Byssinosis is an occupational lung disorder mainly caused by exposure of cotton dust during manufacturing. Over the years, it is well known as “Brown lung disease” and “cotton worker’s lung”. Byssinosis is characterized by respiratory symptoms such as cough, shortness of breath, chest tightness, and airway obstruction. The pathogenesis is still unclear. Despite the exposure to cotton dust, endotoxin release that resides in gram-negative in cotton dust also plays an important role in mediating byssinosis. Specify that supporting examination is not yet available. Thus, it is encouraging to relate the history of cotton dust exposure and the symptoms. In byssinosis, medication is given based on the symptoms that occur.
A Case Report: Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Due To Community-Acquired Pneumonia (CAP) Infection In Smokers Mustofa, Syazili; Anggraeni, Liza; Putri, Giska Tri; Kurniawan, Betta; Agung Kurnia, Ahmad Fadila
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 1 (2025): Volume 12 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i1.16265

Abstract

COPD, also know as Chronic Obstructive Pulmonary Disease, refers to a lung condition marked by persistent and progressive airflow blockage. This is usually the result of a chronic inflammatory reaction in the respiratory tract brought on by exposure to harmful gases or particles. Respiratory tract infections like Community-Acquired Pneumonia (CAP) frequently cause COPD exacerbations, while smoking is the main risk factor that contributes to the onset and worsening of COPD. The goal of this case report is to provide an understanding of the underlying mechanism of severe COPD cause by CAP infection in smokers and to diagnose and manage the condition effectively. A 72-year-old man complained of shortness of breath that he had been having for the last year, and that had worsened over the previous three days when he arrived at the emergency unit of Abdoel Moeloek Hospital in Lampung. In addition, he also had a fever and severe cough with yellow sputum. Following a comprehensive review of medical history, physical examination, and supporting examination, it was concluded that a CAP infection was linked to severe COPD exacerbation. The patient received antibiotic medication and hospitalization treatment for symptomatic therapy.
Central Obesity as a Risk Factor for Low Back Pain Putri, Reny Arienta; Setiorini, Anggi; Mayasari, Diana; Mustofa, Syazili
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1380

Abstract

Central obesity, or abdominal obesity, is a condition marked by excessive fat accumulation around internal organs, leading to a variety of health complications such as cardiovascular disease, type 2 diabetes, and musculoskeletal disorders, including low back pain (LBP). Central obesity is defined by increased waist circumference, with values greater than 80 cm in women and 90 cm in men. The condition is primarily influenced by factors such as physical inactivity, poor eating habits, and aging. The relationship between central obesity and LBP is supported by studies indicating that abdominal fat increases mechanical load on the lumbar spine, contributing to disc degeneration and pain. Additionally, adipose tissue secretes pro-inflammatory cytokines that exacerbate inflammation and pain sensitization in the spine, leading to LBP. Obesity-related complications, such as muscle weakness and sleep disturbances, can further reduce quality of life. Preventive measures for LBP include physical exercise, weight reduction, and posture correction. Effective treatment options range from pharmacological therapies to physical rehabilitation and alternative medicine approaches. Understanding the link between central obesity and LBP is critical in developing preventive strategies and improving the management of this common condition.
Co-Authors Achmad Gozali Ade Yonata Adityo Wibowo, Adityo Adli, Farhan Kamali Afriyana, Regi Agung Kurnia, Ahmad Fadila Agus Dwi Susanto Agus Wantoro Agustia Pratiwi Agustyas Tjiptaningrum agustyas tjiptaningrum Ahmad A Anindito Aisyah A Putri Ananta, Yoga andestya nanda pratama Andika Ridwan Nugraha Harahap Anggi Adelia Anggraeni Janar Wulan Anggraeni Janar Wulan, Anggraeni Janar Anggraeni, Liza Annisa Adietya Pratama Antoni Antoni Apga Repindo Ari Wahyuni Asep Sukohar Aviv Fitria Yulia Ayu, Putu Ristyaning Benny Syahputra Gumay Betta Kurniawan Betta Kurniawan, Betta Budhi Antariksa Caesaria Sinta Zuya Caesarridha, Dhaifany Karissa Chicy WIdya Morfi Christi Natalia Sirait Dansen Frans Louise Draven Rudyanto David Tongon Silaen Debby Handayati Harahap Dewi Nur Fiana Dheti Efrilia Dheti Efrilia - Dimas Trend PB Dorisman, Hari Dwi Indria Anggraini Dwi Sarwindah Dyah Wulan Sumekar Rengganis Wardani Ekawati, Diyan Eksa, Dwi Robbiardy Elman Dani Firdaus Endah Setyaningrum Ersa, Rakhmigasti Citra Erumbia, Ilham Akbar Ety Apriliana Evi Kurniawaty Evy Kurniawaty Faisal Rohmadhiyaul Haq Faisal Yunus Faisol Rohmadhiyaul Haq Fauziah Hanif Fayza Syachrani Febrianti, Arlin Febrihartati, Isura Feby Aulia Hasanah Femmy Andrifianie Fikri Muhammad Rifai Patongai Firantika Dias Puteri Fitria Saftarina Fitriyah . Fitriyah Fitriyah Fitriyah Fitriyah Fransisca Sinaga Fredison, Fredison Gerliandi, Egi Oktarian Gigih Setiawan Gilang Kukuh Megantoro Ginting, Bisart Giska Tri Putri Gusti Agung Putu Yogy Veda Ananta Gusti Wahyu, Pratiwi Hakim Alhaady Juhana Hakim Alhaady Juhana, Hakim Alhaady Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Busman Herdato, M. Junus Didiek Hetti Rusmini I Made Afryan SL I Made Galih Fradiva Giantara Idzni Mardhiyah Ifan Aulia Candra Ilma Puteri Hutami Indri Windarti Infianto, Andreas Intan Kusumaningtyas Intanri Kurniati Isnamurti Ciptaningrum Isura Febrihartati Izzati, Marwah Aulia Jamsari Jamsari Jati, Pandu Kumaya Jhons Fatriyadi Suwandi Karima, Nisa Karina, Salwa Al Kevin Jeremia Purba Khairun Nisa Khoiri, Ratu Kirana Siva Kholis Abdurachim Audah Kurniawaty, Evi Kusumajati, Pusparini Linda Septiani Listiandoko, Raden Dicky Wirawan Lucky Togihon M. Rakha Gerizha M., Tria Mallarangeng, Andi Nafisah Tendri Adjeng Mayasari, Diana Meiwa Rizky Ardhi Blla Putri Mentariasih Maulida Mia Esta Poetri Afdal Faisal Mirza Purwitasari Morfi, Chicy Widya Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Maulana Muhammad Ricky Ramadhian Muhartono Muhartono Muhartono NA, Ahmad Mufid Nadhifa, Farin Nadya Febriani Namdes, Fitri Cyntya Naufal Rivo Aditya Ni Sayu Putu Desya Laksmi Putri Nicholas Alfa Nickyta Yolandita Rosti Novita Carolia Novita Carolia Novita Carolia Nuriah Nuriah Nuriah, Nuriah Nursidiq, Iqbal Muhammad Rafi Oktadoni Saputra, Oktadoni Pinaka Baladika, Dimas Trend Poty, Pitha Maykania Pralia Winda Sari Pratama, Arianda Puan Raissa Lenka Puteri, Vadiyani Fricillya Putra, Andika Chandra Putranata, Naufal R. Putri Adilla Putri, Reny Arienta Rahmasari, Fania Asfi rahmawati, selvi Ramadhan, Muhammad Alif Ramadhana Komala Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi PS Ratna Dewi Puspita Sari Retno A S Soemarwoto Retno Ariza S Soemarwoto Retno Ariza S. Soemarwoto Retno Ariza Soeprihatini Soemarwoto Rheza Paleva Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Putra Sanjaya Rizki Putra Sanjaya Rizki Putra Sanjaya Rosari HS, Felicya Rr Astri Nur Azizah Utama S Rahmanisa Sani, Nanda Apri Saputra, Tetra Arya Saputra, Tito Tri Sarasmita Nirmala Dewi Septiani, Linda Setiorini, Anggi Shina Megaputri Shinta Nareswari, Shinta Silaen, David Silvia Andriani Sinaga, Fransisca T.Y. Sinaga, Fransisca TY Siti Hazrina Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza S Soemarwoto, Retno Ariza Soeprihatini Soeprihatini Soemarwoto, Retno Ariza Soeprihatini, Retno Ariza Soraya Rahmanisa Soraya Rahmanisa Soraya Rahmanisa Sri Janahtul Hayati Sri Janahtul Hayati Sri Puji Hartini Suharyani Suharyani Suharyani Suharyani Sukarti Sukarti Suryani Agustina Daulay Susianti Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutyarso Sutyarso Sutyarso Suwarno, Sukarti San Syaka, Muthiiah Khodista Syakir, Muhammad Addin Syiefa Renanda Surya takhfa nur asyifa Tarigan, Clara Yulianti Terza Aflika Happy Tito Tri Saputra Tito Tri Saputra Tito Tri Saputra Tiwuk Susantiningsih Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Veny Anisya Victoria Hawarima Virginia, Nur Ayu W Bahagia Wawan Abdullah Setiawan Wayan Ferly Aryana Winda Trijayanthi Utama, Winda Trijayanthi Wisnugroho, Cahyo Wulan, Anggraini Janar Yana Ayu, Dwi Yandri Yanwirasti Yuningrum, Hesti Zen Hafy Zulia Yasminanindita Fahmi Zulkifli