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Journal : Medula

Hubungan Kejadian Hiperbilirubinemia dengan Inkompatibilitas ABO pada Bayi Baru Lahir di RSUD Abdul Moeloek Provinsi Lampung Mentariasih Maulida; Ratna Dewi PS; Syazili Mustofa
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.205

Abstract

Bilirubin is a sequence product of red blood cells in the reticule-endothelial system. At excessive concentrations, about 5 mg/dL bilirubin will appear clinically as a yellow color on the skin and mucous membranes which is called jaundice. Jaundice can be physiological and pathological or commonly known as hyperbilirubinemia. Hyperbilirubinemia is a pathological condition that arises at the first day of birth and increasing of bilirubin levels 5 mg/dL per day rapidly, ABO incompatibility is the most common risk factor causes hyperbilirubinemia in newborns. ABO incompatibilities included in the main blood group antigen are blood group A and B which are the most common cases in newborns. This study aims to determine whether there is a relationship between incidences of hyperbilirubinemia with ABO incompatibility in newborns at Abdul Moeloek Hospital, Lampung. This is observational analytic study using cross sectional method. Total sampling method was done. Medical record was data source of this study. Data analysis was performed by chi-square test with p <0.05. The study used 325 medical records with 20% hyperbilirubinemia of newborn, 80% without hyperbilirubinemia, ABO incompatibility incidence is 20.9% and 79.1% without ABO incompatibility. Data analysis showed significant relationship of hipebilirubinemia with ABO incompatibility in newborns at Abdul Moeloek Hospital Lampung (p<0, 05). There study showed relationship between hypebilirubinemia with ABO incompatibility in newborn at Abdul Moeloek Hospital Lampung.
Cara-cara mempercepat penyembuhan luka takhfa nur asyifa; Syazili Mustofa; Helmi Ismunandar; Winda Trijayanthi
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.531

Abstract

A wound is a disconnection of tissue continuity due to damage, or loss of tissue substance due to injury or surgery. wounds are the most common injuries found in our daily lives. there are 3 phases of wound healing process are inflammatory phase, proliferation phase and maturation phase. this process is influenced by many factors like patient factors, wound factors and local factors. in the wound healing process, there are several things that can accelerate wound healing are away from cigarettes, reducing stress, improving nutrition by adding supplements (protein, vitamins and minerals), control chronic disease, stop consume alcohol, prevent infections (wound dressings and antibiotik), and avoid medical drugs that can affect wound healing. by understanding the physiology of good wound healing, we can accelerate wound healing and minimize unwanted effects
Perbandingan Efek Jus Buah Pare (Momordica charanti L), Jus Biji Petai (Parkia speciosa Hassk) Dan Kombinasi Keduanya Terhadap Kadar HDL (High Density Lipoprotein) Dan Kadar LDL (Low Density Lipoprotein) Darah Tikus Putih Jantan (Rattus Norvegicus) Galur andestya nanda pratama; Syazili Mustofa; Tri Umiana Soleha
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.546

Abstract

Background: Dyslipidemia is an abnormality of lipid fraction in blood plasma, Dyslipidemia can cause coronary heart disease (CHD) which is the main cause of death in the world. Bitter melon juice (Momordica charanti L), bitter beans juice (Parkia speciosa Hassk) has an antioxidant (antidislipidemia) that able to influence the LDL and HDL level. Purpose: Compare Bitter melon Fruit Juice, bitter beans Juice and the combination of HDL and LDL levels in male white rats with a high-fat diet. Method: An experimental study using a posttest control only design group. Using 30 white Wistar rats. There were 5 groups, there are the negative control group (K-) were only given a standard diet, 4 other controls were given a high-fat diet, the positive control group (K+) were only given 2ml/200gBB quail egg yolk, bitter melon (P1) 100ml/KgBB , bitter beans juice (P2) 100ml/KgBB/day, and combination juice (P3) 200ml/KgBB, for 14 days. Results: Average HDL levels in bitter melon juice group (78.73 ± 1.42 mg/dl), bitter beans juice group (65.74 ± 2.02 mg/dl), and combination juice group (70.37 ± 1.35mg/dl). The mean LDL level in the bitter melon fruit juice group (75.92 ± 1.28 mg/dl), bitter beans juice group (76.52 ± 1.20 mg/dl), and combination juice group (52.12 ± 1.20 mg/dl). The mean HDL and LDL levels in treatment groups were significantly different from negative (K-) and positive (K+) control groups with p <0.05 Conclusion: Giving fruit juice is better than HDL levels, and combination juice is better for LDL levels in male white rats on a high-fat diet.
Gambaran Profil Lipid Pasien Infark Miokardium Akut di RSUD DR. H. Abdul Moeloek Lampung tahun 2021 Kevin Jeremia Purba; agustyas tjiptaningrum; syazili mustofa
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.573

Abstract

Acute myocardial infarction (AMI) is a condition in which the myocardium or heart muscle necrotizes as a result of a sudden lack of oxygen in the heart caused by atherosclerosis as the result of embolism or total thrombus. The risk factor of the disease is Dyslipidemia, characterized by disturbed lipid profiles such as decreasing of high density lipoprotein (HDL), increasing of low density lipoprotein (LDL), total cholesterol, and triglycerides. This study is usefull for understanding and describing the lipid profile in AMI patients at RSUD DR. H. Abdul Moeloek Lampung Province in 2021. This descriptive study used a cross-sectional research design and was conducted in the Medical Records section of RSUD DR. H. Abdul Moeloek Lampung Province. The results of this study showed that the dominant sex group was male with a total of 50 (79.4%) people. The dominant age group is the 56-65 year age group with a total of 27 (42.9%) people. The largest group of occupation were farmers with 11 (17.5%) people. The group with the most HDL cholesterol level was in the low limit (<40 mg/dl) as many as 31 (49.2%) people. The group with the highest LDL cholesterol level was in the optimal category (<100 mg/dl) of 24 (38.1%) people. The group with the highest triglyceride level was in the optimal category (<150 mg/dl) with a total of 38 (60.3%) people. The group with the highest total cholesterol level was in the optimal category (<200 mg/dl) with 41 people (65.1%). The group with the highest LDL/HDL cholesterol ratio was in the low category (<44) with 56 people.
. Metode Gyssens Sebagai Pilihan Utama Dalam Evaluasi Kualitatif Penggunaan Antibiotik di Indonesia Dheti Efrilia -; Novita carolia; syazili mustofa; rasmi zakiah oktarlina
Medula Vol 13 No 2 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i2.526

Abstract

Antibiotic resistance is a global health problem in the world. Antibiotic resistance is defined as the absence of inhibition of bacterial growth by systemic administration of antibiotics with normal doses or minimal inhibitory levels. The World Health Organization (WHO) seeks to control antibiotic resistance globally by making global action plans to combat bacterial resistance to antibiotics, namely increasing the wise use of antibiotics and evaluating the use of antibiotics. The qualitative evaluation that can be used is the Gyssens method. The Gyssens method was chosen because this method has more specific aspects to evaluate each of the important parameters included in the use of antibiotics such as indication, effectiveness, safety, price and spectrum, and can also evaluate treatment duration, dose, interval, and route of administration as well as time of giving. Therefore, this method is the main choice for evaluation of antibiotics in Indonesia.
Pengembangan Riset Terkini Pemanfaatan Tanaman Obat dalam Penemuan Obat Baru dan Mekanismenya dalam Pengobatan Penyakit: Pengembangan Riset Terkini Pemanfaatan Tanaman Obat dalam Penemuan Obat Baru dan Mekanismenya dalam Pengobatan Penyakit Mustofa, Syazili; Namdes, Fitri Cyntya
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.805

Abstract

Medicinal plants are plants that have medicinal properties or uses and are used to cure and prevent various diseases. Medicinal plants, both leaves, stems and roots, are partly used by the community for traditional or alternative medicine. The use of medicinal plants has evolved from generation to generation, with knowledge being passed down from generation to generation. In its utilization, medicinal plants have good opportunities, such as they are often sold as food supplements, use by the public is increasingly popular and promises minimal side effects and has challenges that must be faced, namely the need for scientific evaluation, a long time with large capital, there is a distance between preclinical models and its applications used in clinical trials as well as the lack of clinical trial data. Many drugs developed from natural sources have had revolutionary impact in medicine, including antibiotics, antiparasitic, antimalarial, lipid control agents, immunosuppressants for organ transplantation, and anticancer drugs. Medicinal plants that have properties or uses as medicinal ingredients which are currently being researched include miswak plants, centella asiatica plants, and mangrove plants.
PERSIAPAN MASA PURNABAKTI, PENTINGNYA PENINGKATAN PENGETAHUAN POLA HIDUP SEHAT DAN MENGATASI MASALAH KESEHATAN PADA USIA PENSIUN Mustofa, Syazili; Sani, Nanda Apri
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.826

Abstract

Retirement is a crucial phase and must be well-prepared. Retirement is the end of regular work and entering a period of rest. Someone approaching retirement age should be prepared with knowledge about healthy lifestyle and various health issues and their management. This will increase individual preventive efforts to maintain their health. Healthy lifestyle can be achieved by consuming a balanced nutritious diet, engaging in proper and regular physical activities or exercises, managing stress well, avoiding smoking, and maintaining personal hygiene. In addition, health problems can occur in the elderly because as they age, the physiological abilities of the body decline, increasing the risk of degenerative diseases such as hypertension, musculoskeletal problems, diabetes, heart attacks, strokes, chronic kidney disease, and cancer. These diseases can be managed by recognizing symptoms, seeking early treatment, and preventing them before they occur. Knowledge about retirement preparation about healthy lifestyle and various health issues and their management is essential to improve the quality of life during retirement.
METODE MOLEKULER UNTUK MENDETEKSI MIKROBA PENYEBAB PENYAKIT PATOGEN Mustofa, Syazili; Putri Adilla
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.917

Abstract

Pathogenic diseases are diseases that are an important problem for public health, especially in developing countries like Indonesia. This disease occurs when disease-causing microorganisms infect the host's body tissue and then multiply and react to the organism being attacked because of the toxins they produce. Several types of disease pathogens can be caused by viruses, bacteria, fungi and parasites. Detection of pathogenic bacteria as a source of infection still relies on isolation methods in pure media culture and microscopic analysis followed by biochemical reactions. However, when using existing techniques, it is difficult to isolate some bacteria in pure culture media, making it a challenge to develop other methods to identify the source of the infection. So far, identification and detection of pathogenic bacteria has only been carried out by observation based on clinical symptoms and history of disease, as well as morphological and physiological characteristics. However, this method is less efficient so a technique is needed that can detect pathogenic bacteria quickly and accurately. There are several types of methods that can be used to identify pathogenic bacteria, namely, methods that target nucleic acids, immunology-based methods, and biosensor-based methods.
LITERATUR REVIEW: TRIKIASIS Gerliandi, Egi Oktarian; Mustofa, Syazili; Lisiswanti, Rika; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1008

Abstract

Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. This research utilizes a method of sear Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering. ching for articles on Google Scholar, PubMed, and NCBI. The search is limited to a specific year range determined by the researcher. The search is conducted using keywords such as trichiasis, etiology of trichiasis, pathophysiology of trichiasis, classification of trichiasis, clinical manifestations of trichiasis, diagnosis of trichiasis, and management of trichiasis. The study's findings revealed that the cause of trichiasis remained unknown, however it was hypothesized to be a result of infection. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering.
Mekanisme Kerja & Penggunaan Klinis N-Acetylcystein (NAC) Pada Penyakit Paru & Saluran Napas Poty, Pitha Maykania; Mustofa, Syazili; Kurniawaty, Evi; Soleha, Tri Umiana
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1083

Abstract

Lung disease is one of the leading causes of illness and death worldwide. Lung disease can be caused by inflammation of the tissues due to oxidative stress. Oxidative stress plays a role in the pathogenesis of lung disease, both acute and chronic. Oxidative stress in the lungs occurs when antioxidant capacity is depleted due to external exposures, such as changes in oxygen pressure due to pollutants, and internal exposures, such as systemic disease and activation of inflammatory cells in response to exposure. Oxidative stress is an imbalance in the production of oxidants and antioxidants in the body's metabolism. In lung disease, oxidative stress increases in endogenous metabolism so exogenous antioxidants in the form of N-acetylcysteine ​​(NAC) are needed. NAC is a glutathione precursor that can replenish total thiols (cysteine, cysteinylglycine, glutathione, and homocysteine). The mechanism of action of NAC is by interacting with ROS so that it can increase antioxidant capacity again. Oxidative stress can deplete antioxidants, NAC will release Thiol groups directly thereby neutralizing oxidants such as N and NO2. Clinically, NAC has been proven to be useful as a treatment for lung diseases such as COVID-19, asthma, bronchiectasis, COPD, and TB at high doses, namely 1200 mg/day.
Co-Authors Achmad Gozali Ade Yonata Adityo Wibowo, Adityo Adli, Farhan Kamali Afriyana, Regi Agung Kurnia, Ahmad Fadila Agus Dwi Susanto Agus Wantoro Agustia Pratiwi Agustyas Tjiptaningrum agustyas tjiptaningrum Ahmad A Anindito Aisyah A Putri Ananta, Yoga andestya nanda pratama Andika Ridwan Nugraha Harahap Anggi Adelia Anggraeni Janar Wulan Anggraeni Janar Wulan, Anggraeni Janar Anggraeni, Liza Annisa Adietya Pratama Antoni Antoni Apga Repindo Ari Wahyuni Asep Sukohar Aviv Fitria Yulia Ayu, Putu Ristyaning Benny Syahputra Gumay Betta Kurniawan Betta Kurniawan, Betta Budhi Antariksa Caesaria Sinta Zuya Caesarridha, Dhaifany Karissa Chicy WIdya Morfi Christi Natalia Sirait Dansen Frans Louise Draven Rudyanto David Tongon Silaen Debby Handayati Harahap Dewi Nur Fiana Dheti Efrilia Dheti Efrilia - Dimas Trend PB Dorisman, Hari Dwi Indria Anggraini Dwi Sarwindah Dyah Wulan Sumekar Rengganis Wardani Ekawati, Diyan Eksa, Dwi Robbiardy Elman Dani Firdaus Endah Setyaningrum Ersa, Rakhmigasti Citra Erumbia, Ilham Akbar Ety Apriliana Evi Kurniawaty Evy Kurniawaty Faisal Rohmadhiyaul Haq Faisal Yunus Faisol Rohmadhiyaul Haq Fauziah Hanif Fayza Syachrani Febrianti, Arlin Febrihartati, Isura Feby Aulia Hasanah Femmy Andrifianie Fikri Muhammad Rifai Patongai Firantika Dias Puteri Fitria Saftarina Fitriyah . Fitriyah Fitriyah Fitriyah Fitriyah Fransisca Sinaga Fredison, Fredison Gerliandi, Egi Oktarian Gigih Setiawan Gilang Kukuh Megantoro Ginting, Bisart Giska Tri Putri Gusti Agung Putu Yogy Veda Ananta Gusti Wahyu, Pratiwi Hakim Alhaady Juhana Hakim Alhaady Juhana, Hakim Alhaady Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Busman Herdato, M. Junus Didiek Hetti Rusmini I Made Afryan SL I Made Galih Fradiva Giantara Idzni Mardhiyah Ifan Aulia Candra Ilma Puteri Hutami Indri Windarti Infianto, Andreas Intan Kusumaningtyas Intanri Kurniati Isnamurti Ciptaningrum Isura Febrihartati Izzati, Marwah Aulia Jamsari Jamsari Jati, Pandu Kumaya Jhons Fatriyadi Suwandi Karima, Nisa Karina, Salwa Al Kevin Jeremia Purba Khairun Nisa Khoiri, Ratu Kirana Siva Kholis Abdurachim Audah Kurniawaty, Evi Kusumajati, Pusparini Linda Septiani Listiandoko, Raden Dicky Wirawan Lucky Togihon M. Rakha Gerizha M., Tria Mallarangeng, Andi Nafisah Tendri Adjeng Mayasari, Diana Meiwa Rizky Ardhi Blla Putri Mentariasih Maulida Mia Esta Poetri Afdal Faisal Mirza Purwitasari Morfi, Chicy Widya Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Maulana Muhammad Ricky Ramadhian Muhartono Muhartono Muhartono NA, Ahmad Mufid Nadhifa, Farin Nadya Febriani Namdes, Fitri Cyntya Naufal Rivo Aditya Ni Sayu Putu Desya Laksmi Putri Nicholas Alfa Nickyta Yolandita Rosti Novita Carolia Novita Carolia Novita Carolia Nuriah Nuriah Nuriah, Nuriah Nursidiq, Iqbal Muhammad Rafi Oktadoni Saputra, Oktadoni Pinaka Baladika, Dimas Trend Poty, Pitha Maykania Pralia Winda Sari Pratama, Arianda Puan Raissa Lenka Puteri, Vadiyani Fricillya Putra, Andika Chandra Putranata, Naufal R. Putri Adilla Putri, Reny Arienta Rahmasari, Fania Asfi rahmawati, selvi Ramadhan, Muhammad Alif Ramadhana Komala Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi PS Ratna Dewi Puspita Sari Retno A S Soemarwoto Retno Ariza S Soemarwoto Retno Ariza S. Soemarwoto Retno Ariza Soeprihatini Soemarwoto Rheza Paleva Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Putra Sanjaya Rizki Putra Sanjaya Rizki Putra Sanjaya Rosari HS, Felicya Rr Astri Nur Azizah Utama S Rahmanisa Sani, Nanda Apri Saputra, Tetra Arya Saputra, Tito Tri Sarasmita Nirmala Dewi Septiani, Linda Setiorini, Anggi Shina Megaputri Shinta Nareswari, Shinta Silaen, David Silvia Andriani Sinaga, Fransisca T.Y. Sinaga, Fransisca TY Siti Hazrina Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza S Soemarwoto, Retno Ariza Soeprihatini Soeprihatini Soemarwoto, Retno Ariza Soeprihatini, Retno Ariza Soraya Rahmanisa Soraya Rahmanisa Soraya Rahmanisa Sri Janahtul Hayati Sri Janahtul Hayati Sri Puji Hartini Suharyani Suharyani Suharyani Suharyani Sukarti Sukarti Suryani Agustina Daulay Susianti Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutyarso Sutyarso Sutyarso Suwarno, Sukarti San Syaka, Muthiiah Khodista Syakir, Muhammad Addin Syiefa Renanda Surya takhfa nur asyifa Tarigan, Clara Yulianti Terza Aflika Happy Tito Tri Saputra Tito Tri Saputra Tito Tri Saputra Tiwuk Susantiningsih Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Veny Anisya Victoria Hawarima Virginia, Nur Ayu W Bahagia Wawan Abdullah Setiawan Wayan Ferly Aryana Winda Trijayanthi Utama, Winda Trijayanthi Wisnugroho, Cahyo Wulan, Anggraini Janar Yana Ayu, Dwi Yandri Yanwirasti Yuningrum, Hesti Zen Hafy Zulia Yasminanindita Fahmi Zulkifli