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All Journal Medula Juke Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya JITEK (Jurnal Ilmiah Teknosains) Jurnal Ilmu Kedokteran dan Kesehatan Acta Biochimica Indonesiana Jurnal Medika Malahayati SRIWIJAYA JOURNAL OF MEDICINE Jurnal Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Indian Journal of Forensic Medicine & Toxicology Jurnal Kedokteran Raflesia Jurnal Pengabdian kepada Masyarakat Prosiding Konferensi Nasional PKM-CSR Jurnal Informatika Polinema (JIP) Medic Nutricia : Jurnal Ilmu Kesehatan Majority
Syazili Mustofa
Fakultas Kedokteran Universitas Lampung
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Hubungan Frekuensi Harian Mencuci Wajah dan Pemakaian Sabun Wajah Anti Akne Dengan Derajat Keparahan Akne Vulgaris pada Remaja Putri di SMAN 10 Bandar Lampung Annisa Adietya Pratama; Dwi Indria Anggraini; Syazili Mustofa
MAJORITY Vol 10 No 1 (2021): MAJORITY
Publisher : Majority

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Abstract

Acne vulgaris is a skin problem that often occurs in teenager. Some factors that can cause acne vulgaris include genetic, hormonal, infection, trauma, and diet. The degree of acne is divided into mild, moderate, and severe degrees. Washing face is a prevention or treatment of acne vulgaris, it should be noted the use of the type of face wash and the frequency of facial washing with the incidence of acne vulgaris. Purpose of this research is to find out the relationship of daily frequency facial washing and use of anti acne face wash to the severity of acne vulgaris in teenage girl at SMAN 10 Bandar Lampung. This research used analytic observational method with cross sectional approach. The sample of the research is 89 respondents and using purposive sampling method. The result of univariate analysis was 56,2% of respondents use anti acne face wash and 57,3% of respondents wash their faces ≥ 3 times a day. The result of bivariate analysis showed some variables had a correlation with with the severity of acne vulgaris is the use of anti acne face wash (p value 0,016). Meanwhile, some variables had no correlation with the severity of acne vulgaris witch is the frequency of daily facial washing (p value 0,582). The conclusion is there was relationship between the use of anti acne face wash and the severity of acne vulgaris and there was no relationship between daily frequency facial washing with the severity of acne vulgaris
Diagnosis dan Penatalaksanaan Penyakit Arteri Perifer Christi Natalia Sirait; Syazili Mustofa
MAJORITY Vol 10 No 1 (2021): MAJORITY
Publisher : Majority

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Abstract

Peripheral artery disease (PAD) is one of the most prevalent conditions, and it frequently coexists with vascular disease in other parts of the body. Early diagnosis is important for improving the patient’s quality of life and for reducing the risk of serious secondary vascular events such as acute myocardial infraction (AMI) or stroke. The best noninvasive measure for identifying the presence of occlusive arterial disease is the ankle-brachial index. Lower extremity PAD most frequently presents with pain during ambulation, which is known as “intermittent claudication”. Some relief of symptoms is possible with exercise, pharmacotherapy, and cessation of smoking. The occurrence of PAD is caused by insufficiency in the arteries due to the occurrence of the atherosclerosis process. Aspirin inhibits platelet synthesis through irreversible acetylation of cyclooxygenase (COX) enzymes on platelets. Because platelets do not have a nucleus, platelets are not able to form (COX) enzymes during their lifetime. As a result, the synthesis of thromboxane A2 (TXA2) which plays a major role in platelet aggregation is inhibited. Thus, long-term aspirin in the long term can prevent myocardial infarction and PAD.
Penggunaan Klinis Aktivitas Enzim Gamma-Glutamyl Transferase (GGT) Plasma dan Potensinya sebagai Biomarker untuk Berbagai Penyakit Benny Syahputra Gumay; Syazili Mustofa
MAJORITY Vol 9 No 1 (2020): MAJORITY
Publisher : Majority

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Abstract

Gamma-Glutamil Transferase (GGT) enzyme is a widely distributed transpeptidase in various body tissues. This enzyme is located in cell membranes and cytoplasm of hepatocytes. In addition, the expressions of the GGT enzyme is found in the kidneys, lungs, pancreas, blood vessel endothelium, nerve cells, and blood plasma. It has been used routinely in clinic to diagnose liver damage caused by alcoholism. The normal value of plasma GGT activity is 0–40 U / l. Normally, the GGT activity in blood plasma is low, but liver damage or bile ducts obstruction will increase it. There were significant association between the GGT activities in plasma and various diseases such as cardiovascular disease, metabolic syndrome such as diabetes mellitus and obesity, neurological and neurodegenerative diseases and others various diseases. Related to the measurement of GGT enzyme activity is cheap and easy to do, it's very potential to be developed for marker to diagnosis, prognosis, and further evaluation of various diseases. Further studies are needed to apply it for to be an accurate biomarker for various diseases
Hipertensi: Gambaran Umum Naufal Rivo Aditya; Syazili Mustofa
MAJORITY Vol 11 No 2 (2023): MAJORITY
Publisher : Majority

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Chronic disease is a worldwide health issue. The prevalence of chronic disease is 6,7 billion people worldwide, and has increased over the time. Chronic disease is a noncommunicable disease, but chronic disease is a persistant disease and resulting in substansial years of life lost. One of the chronic diseases is hypertension or high blood pressure. The prevalence of hypertension is 1,2 billion people worldwide and increasing due to an aging population and increasing prevalence of obesity. Hypertension is multifactorial disease involving genetic factors and environmental factors. Aparts from these two factors, behaviors factors can be increasing risk factor for hypertension, such as smooking and excess salt consumption. AHA (American Heart Association) hypertension guidelines, hypertension is diagnosed when blood pressure is consistently >130 for systolic pressure, and or >80 mmHg for diastolic pressure. Hypertension have a significant effects due to CVD (Cardiovascular disease) such as hearth failure, myocardial infarction, stroke and death. Hypertension in older adults have a adverse effects and exacerbated by a decrease in body function and quality, such as mechanical hemodynamic changes, arterial stiffness, neurohormonal and declining renal function, so the management strategies for hypertension in older adults must consider from various aspects, such as comorbidities factors, pyscho-social factors. The management strategies for hypertension can be used non-pharmacological therapy to reduce the risk of hypertension severity and provide appropriate pharmacological therapy according to the patient’s condition, so that it can provide appropriate results.
Pengaruh Pemberian Ekstrak Biji Kopi Robusta (Coffea canephora) Lampung terhadap Aktivitas Enzim Katalase Hippocampus Tikus Putih (Rattus norvegicus) Jantan Galur Sprague dawley yang Diinduksi Monosodium Glutamat Syazili Mustofa; Ni Sayu Putu Desya Laksmi Putri; Lucky Togihon; Wayan Ferly Aryana; Rizki Putra Sanjaya; Tito Tri Saputra
MAJORITY Vol 12 No 1 (2023): MAJORITY
Publisher : Majority

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Abstract

Almost 60 million people worldwide have recovered from pulmonary tuberculosis since 2000, but many of them develop post-tuberculous lung disease. The disease results from a complex interaction between the disease-causing organism, the host, and environmental factors, and this affects the long-term airway. People with this disease have a shorter life expectancy and an increased risk of tuberculosis recurrence. Bronchiectasis is a disease of the dilation of the bronchial tubes which is characterized by decreased mucociliary transport function. It can also be caused by a bacterial infection with Post Tuberculosis Obstructive Syndrome (SOPT). SOPT is a lung disorder characterized by chronic airway obstruction due to complications arising from post-treatment pulmonary tuberculosis. This case describes a patient with bronchiectasis and SOPT who came with symptoms of shortness of breath accompanied by a long cough. From the results of the physical examination and supporting examinations, a working diagnosis was obtained in the form of infected brochiectasis accompanied by post-tuberculosis obstructive syndrome. The patient was then given therapy in the form of oxygenation, nebulized bronchodilators, corticosteroid injections, and antibiotics. In addition, patients are also given chest physiotherapy and a high-calorie, high-protein diet.
Acute toxicity test of Rhizophora apiculata bark extract on rat liver and kidney histology using fixed dose method Syazili Mustofa; Ilma Puteri Hutami; Dwi Sarwindah
Acta Biochimica Indonesiana Vol. 6 No. 2 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.144

Abstract

Background: The therapeutic properties of the ethanol extract derived from the stem bark of Rhizophora apiculata have been investigated. Nevertheless, there is a lack of studies regarding its acute toxicity. Objective: This research aims to evaluate the toxicity of ethanolic extract of R. apiculata bark by examining histological changes in the liver and kidney of rats. Method: The ethanol extract of R. apiculata bark was administered using a fixed-dose approach in preliminary and primary tests, focusing on the kidneys and liver of male Sprague Dawley rats. Four treatment groups received doses of 5, 50, 300, and 2000 mg/kg BW, while one group served as the control. An uninterrupted observation period of 14 days was conducted to determine any indications of acute toxicity in these animals. On the fifteenth day, the rats were terminated. Results: This study indicated the absence of any toxic manifestations, such as tremors, excessive salivation, convulsions, coma, and mortality. Nevertheless, it caused histological damage to the rats’ liver and kidney when administered at doses 300 and 2000 mg/kg BW. Conclusion: While the administration of R. apiculata extracts at doses of 300 and 2000 mg/kgBW resulted in histological damage to the kidneys and livers of the rats, it did not induce any immediate symptoms.
Pengaruh Ekstrak Etanol Daun Rhizophora apiculata terhadap Kolesterol Total dan Trigliserida Rattus norvegicus Galur Sprague dawley yang Diinduksi Diet Tinggi Lemak Mustofa, Syazili; Adli, Farhan Kamali; Wardani, Dyah Wulan Sumekar Rengganis; Busman, Hendri
Jurnal Kesehatan Vol 13 No 3 (2022): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i3.3178

Abstract

Dyslipidemia is a lipid metabolism disorder in the form of an increase and decrease in the lipid fraction which is one of the high-risk factors for coronary heart disease and other non-communicable diseases. Rhizophora apiculata contains secondary metabolites in the form of flavonoid, tannin, alkaloid, saponin, and terpenoid which are thought to have the effect of preventing an increase in total cholesterol and triglyceride. This research is an experimental study with a posttest-only control group design carried out for 30 days using 30 experimental animals of Rattus norvegicus Sprague Dawley. There were 6 treatment groups, KN which was only given standard feed, K+ which was given quail egg yolk induction, simvastatin 10 mg/day, and K- which was given quail egg yolk induction. On the other hand, P1, P2, and P3 were given quail egg yolk induction, respectively. and leaf extract of Rhizophora apiculata with doses of 56mg/KgBW,m28mg/KgBW, and 14mg/KgBW. Then the rats were terminated using ketamine xylazine and blood was taken through the heart to be examined for total cholesterol and triglyceride using spectrophotometry. The results of the normality Shapiro-Wilk and Levene test p-value>0.05. In the One-way Anova test, cholesterol levels were 0.006 and triglyceride 0,002 (p-value
Efek Protektif Ekstrak Kulit Batang Bakau Rhizophora apiculata terhadap Kerusakan Histologi Paru Rattus norvegicus yang Diinduksi Asap Rokok Mustofa, Syazili; Tarigan, Clara Yulianti
Jurnal Kesehatan Vol 14 No 2 (2023): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v14i2.3752

Abstract

Rhizophora apiculata berpotensi dikembangkan sebagai antioksidan. Penelitian ini membandingkan efek protektif beberapa ekstrak kulit batang Rhizophora apiculata pada paru tikus yang terpapar asap rokok. Penelitian ini menggunakan 30 tikus yang dibagi menjadi 6 kelompok. Kelompok KN adalah kontrol normal yang tidak dipaparkan asap rokok. 5 kelompok lainnya mendapat paparan asap rokok 24 batang/hari selama 30 hari. K1 hanya dipaparkan asap rokok, kelompok K2 dipaparkan asap rokok dan diberikan vitamin C dengan dosis 9 mg/kgBB perhari. Kelompok lainnya dipaparkan asap rokok dan diberikan ekstrak etanol (P1) ekstrak methanol (P2) ekstrak n-heksana (P3) kulit batang Rhizophora apiculata. dengan dosis 56,55 mg/kgBB per hari selama 30 hari. Pada hari ke-31, tikus diterminasi dan dilakukan pemeriksaan mikroskopis paru untuk melihat kerusakan jaringan paru pada perbesaran perbesaran mikroskop 400x. Hasil rerata persentase kerusakan paru pada KN, K1, K2, P1, P2, dan P3 secara berurutan adalah 2; 40,667; 23,333; 20; 25,333; 24. Hasil skoring kerusakan paru pada KN, K1, K2, P1, P2, dan P3 secara berurutan adalah 0,06; 1,22; 0,70; 0,60; dan 0,76. Terdapat perbedaan bermakna (p-value
Pengembangan Riset Terkini Pemanfaatan Tanaman Obat dalam Penemuan Obat Baru dan Mekanismenya dalam Pengobatan Penyakit: Pengembangan Riset Terkini Pemanfaatan Tanaman Obat dalam Penemuan Obat Baru dan Mekanismenya dalam Pengobatan Penyakit Mustofa, Syazili; Namdes, Fitri Cyntya
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.805

Abstract

Medicinal plants are plants that have medicinal properties or uses and are used to cure and prevent various diseases. Medicinal plants, both leaves, stems and roots, are partly used by the community for traditional or alternative medicine. The use of medicinal plants has evolved from generation to generation, with knowledge being passed down from generation to generation. In its utilization, medicinal plants have good opportunities, such as they are often sold as food supplements, use by the public is increasingly popular and promises minimal side effects and has challenges that must be faced, namely the need for scientific evaluation, a long time with large capital, there is a distance between preclinical models and its applications used in clinical trials as well as the lack of clinical trial data. Many drugs developed from natural sources have had revolutionary impact in medicine, including antibiotics, antiparasitic, antimalarial, lipid control agents, immunosuppressants for organ transplantation, and anticancer drugs. Medicinal plants that have properties or uses as medicinal ingredients which are currently being researched include miswak plants, centella asiatica plants, and mangrove plants.
PERSIAPAN MASA PURNABAKTI, PENTINGNYA PENINGKATAN PENGETAHUAN POLA HIDUP SEHAT DAN MENGATASI MASALAH KESEHATAN PADA USIA PENSIUN Mustofa, Syazili; Sani, Nanda Apri
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.826

Abstract

Retirement is a crucial phase and must be well-prepared. Retirement is the end of regular work and entering a period of rest. Someone approaching retirement age should be prepared with knowledge about healthy lifestyle and various health issues and their management. This will increase individual preventive efforts to maintain their health. Healthy lifestyle can be achieved by consuming a balanced nutritious diet, engaging in proper and regular physical activities or exercises, managing stress well, avoiding smoking, and maintaining personal hygiene. In addition, health problems can occur in the elderly because as they age, the physiological abilities of the body decline, increasing the risk of degenerative diseases such as hypertension, musculoskeletal problems, diabetes, heart attacks, strokes, chronic kidney disease, and cancer. These diseases can be managed by recognizing symptoms, seeking early treatment, and preventing them before they occur. Knowledge about retirement preparation about healthy lifestyle and various health issues and their management is essential to improve the quality of life during retirement.
Co-Authors Achmad Gozali Ade Yonata Adityo Wibowo, Adityo Adli, Farhan Kamali Agus Dwi Susanto Agus Wantoro Agustia Pratiwi agustyas tjiptaningrum Ahmad A Anindito Aisyah A Putri Ananta, Yoga andestya nanda pratama Andika Ridwan Nugraha Harahap Anggi Adelia Anggraeni Janar Wulan Annisa Adietya Pratama Antoni Antoni Asep Sukohar Aviv Fitria Yulia Ayu, Putu Ristyaning Benny Syahputra Gumay Betta Kurniawan Betta Kurniawan, Betta Budhi Antariksa Caesaria Sinta Zuya Caesarridha, Dhaifany Karissa Chicy WIdya Morfi Christi Natalia Sirait David Tongon Silaen Dheti Efrilia - Dimas Trend PB Dorisman, Hari Dwi Indria Anggraini Dwi Sarwindah Dyah Wulan Sumekar Rengganis Wardani Ekawati, Diyan Eksa, Dwi Robbiardy Elman Dani Firdaus Ersa, Rakhmigasti Citra Evi Kurniawaty Evy Kurniawaty Faisal Yunus Fauziah Hanif Fayza Syachrani Febrihartati, Isura Feby Aulia Hasanah Femmy Andrifianie Firantika Dias Puteri Fitria Saftarina Fitriyah Fitriyah Fransisca Sinaga Gerliandi, Egi Oktarian Gigih Setiawan Gilang Kukuh Megantoro Ginting, Bisart Giska Tri Putri Gusti Agung Putu Yogy Veda Ananta Hakim Alhaady Juhana Helmi Ismunandar Hendri Busman Hendri Busman Hetti Rusmini I Made Afryan SL I Made Galih Fradiva Giantara Ifan Aulia Candra Ilma Puteri Hutami Isnamurti Ciptaningrum Isura Febrihartati Jamsari Jamsari Jati, Pandu Kumaya Jhons Fatriyadi Suwandi Kevin Jeremia Purba Khoiri, Ratu Kirana Siva Kholis Abdurachim Audah Kurniawaty, Evi Linda Septiani Listiandoko, Raden Dicky Wirawan Lucky Togihon M. Rakha Gerizha Mallarangeng, Andi Nafisah Tendri Adjeng Mentariasih Maulida Mia Esta Poetri Afdal Faisal Mirza Purwitasari Muhammad Maulana Muhammad Ricky Ramadhian Muhartono NA, Ahmad Mufid Nadhifa, Farin Nadya Febriani Namdes, Fitri Cyntya Naufal Rivo Aditya Ni Sayu Putu Desya Laksmi Putri Nicholas Alfa Nickyta Yolandita Rosti Novita Carolia Novita Carolia Novita Carolia Nuriah Nuriah Nursidiq, Iqbal Muhammad Rafi Pinaka Baladika, Dimas Trend Poty, Pitha Maykania Puan Raissa Lenka Putra, Andika Chandra Putri Adilla Rahmasari, Fania Asfi Ramadhan, Muhammad Alif Ramadhana Komala Rasmi Zakiah Oktarlina Ratna Dewi PS Retno A S Soemarwoto Retno Ariza S Soemarwoto Retno Ariza S. Soemarwoto Retno Ariza Soeprihatini Soemarwoto Rheza Paleva Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Putra Sanjaya Rizki Putra Sanjaya Rr Astri Nur Azizah Utama S Rahmanisa Sani, Nanda Apri Sarasmita Nirmala Dewi Septiani, Linda Shina Megaputri Shinta Nareswari, Shinta Silvia Andriani Sinaga, Fransisca TY Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza Soeprihatini Soeprihatini Soemarwoto, Retno Ariza Soraya Rahmanisa Soraya Rahmanisa Soraya Rahmanisa Sri Janahtul Hayati Sri Janahtul Hayati Suharyani Suharyani Sukarti Sukarti Suryani Agustina Daulay Susianti Susianti Sutarto Sutarto Sutyarso Suwarno, Sukarti San Syaka, Muthiiah Khodista Syiefa Renanda Surya takhfa nur asyifa Tarigan, Clara Yulianti Terza Aflika Happy Tito Tri Saputra Tito Tri Saputra Tito Tri Saputra Tiwuk Susantiningsih Tri Umiana Soleha Tri Umiana Soleha Veny Anisya W Bahagia Wawan Abdullah Setiawan Wayan Ferly Aryana Winda Trijayanthi Utama, Winda Trijayanthi Wisnugroho, Cahyo Yana Ayu, Dwi Yandri Yanwirasti Yuningrum, Hesti Zulia Yasminanindita Fahmi Zulkifli