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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Indonesian Journal of Cardiology Narra J Indonesian Journal of Health Science Indonesia Journal of Physical Medicine and Rehabilitation eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia International Journal of Cell and Biomedical Science Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Folia Medica Indonesiana
E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/ Rumah Sakit Dr. Cipto Mangunkusumo
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Narra J

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Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial Putranto, Rudi; Setiati, Siti; Nasrun, Martina W.; Witjaksono, Fiastuti; Immanuel, Suzanna; Subekti, Imam; Harimurti, Kuntjoro; Siswanto, Agus; Shatri, Hamzah; Suwarto, Suhendro; Megantara, Marcelino A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1342

Abstract

The coexistence of depression and type 2 diabetes mellitus (T2DM) can significantly worsen disease prognosis and lower quality of life. Emerging evidence suggests that vitamin D deficiency contributes to the progression of T2DM and is closely associated with the development of depression. The aim of this study was to investigate the effects of cholecalciferol on depression in patients with T2DM, exploring its mechanisms by analyzing its impact on C-peptide, serotonin, and neurotrophin-3 levels. A double-blind, randomized, placebo-controlled clinical trial was conducted at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from April 2021 to September 2022. Patients with T2DM and depressive symptoms were randomly assigned to two groups: received 4000 IU of cholecalciferol daily and received a placebo for 12 weeks. Depression was assessed using the Beck Depression Inventory-II (BDI-II) before and 12 weeks after the intervention. The levels of C-peptide, serotonin, and neurotrophin-3 were measured at the end of the fourth week of intervention using the enzyme-linked immunosorbent assay (ELISA) method. Between-group comparisons were made using independent Student t-tests and Mann-Whitney U tests. Paired Student t-tests or Wilcoxon tests were applied for within-group comparisons between pre- and post-intervention. A total of 70 T2DM patients with depression were included in this study, comprising 38 patients in the cholecalciferol group and 32 in the placebo group. C-peptide levels increased significantly in the cholecalciferol group compared to the placebo group (p=0.006). No significant differences were observed in serotonin and NT-3 levels between the cholecalciferol group compared to the placebo group. The cholecalciferol group had a significantly greater reduction in BDI-II scores compared to the placebo group (p<0.001). This trial highlights that taking cholecalciferol might help ease mild to moderate depression symptoms in patients with T2DM by enhancing c-peptide levels, though its effects on serotonin and neurotrophin-3 are still unclear.
Validity and reliability testing of the Shatri Sinulingga psychosomatic test (SSPT) questionnaire as a screening instrument for psychosomatic disorders in Indonesia Shatri, Hamzah; Sinulingga, Dika I.; Faisal, Edward; Irvianita, Vinandia; Putranto, Rudi; Ardani, Yanuar; Erlita, Diana; Jeger, Dian P.; Browijoyo, Isa A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1373

Abstract

The incidence of psychosomatic disorders is increasing in Indonesia, and therefore screening instruments that are culturally appropriate for the Indonesian population are needed. The aim of this study was to assess the validity and reliability of the Shatri Sinulingga psychosomatic test (SSPT) questionnaire as a screening instrument for psychosomatic disorders in Indonesia. An analytic descriptive cross-sectional study divided into two stages (questionnaire formulation and distribution through the Psikosom.id application) was conducted in 2023. The validity test was carried out using the product moment technique, and Cronbach's alpha assessment was carried out to evaluate the reliability of the questionnaire. A total of 372 participants were included, with a mean age of 39.24 years old. The SSPT questionnaire scores had strong correlations with the scores of hospital anxiety and depression scale (HADS) (r=0.668; p<0.001) and the Symptom Checklist-90 (SCL-90) (r=0.674; p<0.001); and moderately correlated with the score of fatigue severity scale (FSS) (r=0.505; p<0.001) and Pittsburgh Sleep Quality Index (PSQI) (r=0.492; p<0.001). The correlation coefficient (r) value of each SSPT question ranged from 0.389–0.726, and all r higher than r table with an overall Cronbach’s alpha of 0.744. The SSPT questionnaire's strong predictive performance: had a sensitivity of 75.6% and specificity of 71.4% with an area under the curve (AUC) of 81% (95%CI: 76.6–85.4%; p<0.001) to HADS; sensitivity of 80% and specificity of 58.6% with an AUC of 75.1% (95%CI: 70–80.2%; p<0.001) to FSS; sensitivity of 64% and specificity of 67.5% with an AUC of 71.2% (95%CI:  65.4–77%; p<0.001) to PSQI; and had sensitivity of 78% and specificity of 67.4% with an AUC of 80.9% (95%CI:  76.6–85.3%; p<0.001) to SCL-90. The study highlights that the SSPT questionnaire is valid and reliable to be used as a screening instrument for psychosomatic disorders in Indonesia.
Effects of traditional music therapy on the psycho-neuro-immuno-endocrine aspect of burnout syndrome in healthcare workers: A randomized controlled trial Ardani, Yanuar; Shatri, Hamzah; Koesnoe, Sukamto; Yunir, Em; Wiguna, Tjhin; Wibowo, Heri; Sawitri, Dian R.; Sarwono, Sugeng J.; Masyur, Muhtaruddin; Ricardo, William; Katarina, Matilda; Anggono, Rendi F.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1686

Abstract

Burnout syndrome (BOS) is an occupational phenomenon highly prevalent among healthcare workers, particularly physicians and nurses. Despite its prevalence, no single therapy universally addresses all cases of BOS. The aim of this study was to develop a novel approach to managing BOS through traditional music therapy, evaluated from psychosomatic, neurological, immunological, and endocrine perspectives. The study involved 80 participants who were randomly assigned to either the intervention or control group. The intervention group received traditional music therapy for 10–15 minutes, three times a week, over four weeks. Key outcomes were assessed at weeks 2 and 4. Measurements included the Maslach Burnout Inventory (MBI), heart rate variability (HRV), saliva cortisol, saliva β-endorphin, saliva immunoglobulin A (IgA), and serum FOXP3. Instruments included the MBI-HSS questionnaire and HRV measuring devices. Over four weeks, significant improvements were observed in the MBI scores (p=0.001), HRV (p=0.001), and FOXP3 delta (p=0.035) in the intervention group compared to the control group. However, no significant differences were found for cortisol, β-endorphin, or IgA. These findings suggest that traditional music therapy positively impacts the psychological, neurological, and immunological aspects of BOS and potentially influences immunological and endocrine responses. Future research should explore the effects of longer intervention durations, test varying doses, and examine the combination of music therapy with other non-pharmacological treatments to enhance its therapeutic potential.
Co-Authors -, Arles - -, Darmadi Achmad Fauzi Adhiatma, Kresna Aditama, Humala Prika Aditya Wardhana Adityo Susilo, Adityo Adli, Mizanul Agung, Ratih Arianita Agus Siswanto Agus Sudiro Waspodo Agustinus, Taolin Ahadini, Putri Aliya Aida Lydia Alexander, Reinaldo Ali Sakti Ali Sakti, Ali Alvina Widhani, Alvina Andhika Rachman Andri Sanityoso Andru, Gestana Anggono, Rendi F. Angraeni, Sri Anwar, Bariani Ardani, Yanuar Ari Fahrial Syam Arif Mansjoer Arif Sejati Aryadi Kurniawan Aryadi Kurniawan Asir, Taufik Rizkian Atmakusumah, Tubagus Djumhana Aulia Rizka, Aulia Azri Nurizal, Azri Azzaki Abubakar Azzaki Abubakar, Azzaki Bernard Agus Sakti Dhaki Bernard Agus Sakti Dhaki, Bernard Agus Sakti Birry Karim Bonar, Maruhum Bonar H Browijoyo, Isa A. Budi Sampurna Budi Sampurna C Rinaldi A Lesmana C. Martin Rumende, C. Martin Ceva W. Pitoyo Chairani, Aisha Putri Charlex, Harold Jefferson Matthew Cleopas Martin Rumende Cleopas Martin Rumende Cleopas Martin Rumende Cophiadi Irawan Cosphiadi Irawan Dadang Makmun Damayanti Sekarsari Dedi Wihanda, Dedi Dewi Gathmyr Diah Martina, Diah Dian R. Sawitri, Dian R. Diana Sunardi Dono Antono Dyah Purnamasari Dyah Purnamasari E Mudjaddid E Mudjaddid, E E. Mudjaddid E. Mudjaddid, E. Mudjaddid Eddy Mart Salim Eddy Mart Salim, Eddy Mart Edi Mulyana, Edi Edward Faisal Edward Faisal Edward Faisal Edy Rizal Wahyudi Eka Ginanjar Elizabeth Yasmine Elizabeth Yasmine, Elizabeth Em Yunir Em Yunir Em Yunir, Em Endang Susalit Endy Novianto Endy Novianto, Endy Erlita, Diana Erni Juwita Nelwan, Erni Juwita Esa, Dekta Filantropi Evy Yunihastuti Fahmi Razi Darkuthni Faisal, Edward Felicia Kurniawan, Felicia Ferliani Ferliani Ferliani Ferliani, Ferliani Ferry Tigor P Purba Ferry Tigor P Purba, Ferry Tigor P Fiastuti Witjaksono Findy Prasetyawati Findy Prasetyawati, Findy Firsyada, Fajar Fita Fitrianti Fitrianti, Fita Funay, Prijander L B Ginova Nainggolan Ginova Nainggolan Grecia Rachmaningrum Gurmeet Singh Habibah Hanum Nasution Habibah Hanum Nasution, Habibah Hanum Harahap, Agnes S. Harry Isbagio Harry Isbagio Harry Yusuf Hasan Maulahela Hatma, Ratna Djuwita Hendra Koncoro Henry Ratno Diono Silalahi Henry Ratno Diono Silalahi, Henry Ratno Diono Heri Wibowo Heru Sundaru Heru Sundaru Ibrahim, Febiansyah Idrus Alwi Idrus Alwi Idrus Alwi Ika P Wijaya, Ika P Ika Prasetya Wijaya Ikhwan Rinaldi Ilyas, Mohammad Imam Subekti Imelda Maria Loho, Imelda Maria Indra, Suwito Irawan, Cophiadi Iris Rengganis Irman Firmansyah Irsan Hasan Irvianita, Vinandia Ivona Oliviera, Ivona Jeger, Dian P. Juferdy Kurniawan Kaka Renaldi Katarina, Matilda Kemal Fariz Kalista, Kemal Fariz Ken Ayu Mastini Ken Ayu Mastini, Ken Ayu Kosasih, Kartika Anastasia Kumalawati, July Kuntjoro Harimurti Kurniawidjaja, Meily Kusumaningrum, Profitasari Laurentius Aswin Pramono Leonard Nainggolan Lianda Siregar Linda Armelia Lindrawati Tjuatja Lugyanti Sukrisman Luhuna, Muslimah Lusiani Lusiani Lusiani Rusdi, Lusiani Lutfiah, Evah M Bonar Marbun Mansur, M. Tasrif Marbun, M Bonar Marbun, Maruhum Bonar Hasiholan Marcellus Simadibrata Marcellus Simadibrata K Margaluta, Ariansah Marthino Robinson Marthino Robinson Martin, Cleopas Maruhum B.H. Marbun Maruhum Bonar HM, Maruhum Bonar Masyur, Muhtaruddin Megantara, Marcelino A. Melinda Harini Melinda Harini Mizanul Adli Muhadi Muhadi Muhadi Muhadi Muhadi Muhadi, Muhadi Muhammad Ali Apriansyah Muhammad Ali Apriansyah, Muhammad Ali Muhammad Yamin Muhammad Yamin Murdani Abdullah Murdani Abdullah Murdani Abdullah Murdani Abdullah Nadia Ayu Mulansari, Nadia Ayu Nanda N. Muhammad Nanda N. Muhammad, Nanda N. Nasrun, Martina W. Nikko Darnindro Noorwati Sutandyo Noorwati Sutandyo Noorwati Sutandyo Nunuk Mardiana, Nunuk Nurfitria, Nandika Oryza Gryagus Prabu Parhusip, Santi Sumihar Rumondang Parlindungan Siregar Parlindungan Siregar Petrin Redayani Lukman S Poespitasari, Vinandya Irvianita Pratiwi, Amalia Nur Prihartono, Nurhayati Adnan Prijander Lombardia Funay Pringgodigdo Nugroho, Pringgodigdo Puranto, Rudi Purba, Ferry Tigor P. Purwita Wijaya Laksmi Puspadina, Shafira Putranto, Rud Rachmaningrum, Grecia Raniah, Nida Rasco Sandy Sihombing Rasco Sandy Sihombing, Rasco Sandy Ratih Arianita Agung Reinaldo Alexander Ricardo, William Rino Alvani Gani Rino Alvani Gani Rooshoeroe, A. G. Rudi Putranto Rudi Putranto Rudi Putranto Rudi Putranto Rudy Hidayat Rumagesan, Djahalia Rustam, Musfardi S.Pd. M Kes I Ketut Sudiana . Sabarinah Prasetyo Sally Aman Nasution Salman Paris Harahap Salman Paris Harahap, Salman Paris Sarwono, Sugeng J. Saskia Aziza Nursyirwan, Saskia Aziza Sepmeitutu, Iwandheny Siahaan, Billy Stinggo Sihwastuti, Sihwastuti Simanjuntak, Tiroy Sari Bumi Sinulingga, Dika Sinulingga, Dika I. Siti Setiati Siti Taqwa Fitria Lubis, Siti Taqwa Fitria Soejono, C. H. Suhendro Suwarto Suhendro Suwarto, Suhendro Sukamto Koesnoe Sukamto Koesnoe Sumariyono Sumariyono Suzanna Immanuel Tagor, Alvin Tahir, Andi Cahaya Tanadi, Caroline Tandan, Manu Taufik Rizkian Asir Tedjasukmana, Deddy Teguh Harjono Karjadi, Teguh Harjono Teng, Wei THARIQAH SALAMAH, THARIQAH Tjhin Wiguna Tresia Fransiska U Tambunan Tri Juli Edi Tarigan Triyanta Yuli Pramana Tubagus Djumhana Atmakusumah Valy Wulani, Valy Veronica, Raja Merlinda Victor, Hildebrand Hanoch Virnanda Amu, Ivan Wardoyo, Elizabeth Y Wika Hanida Wika Hanida, Wika Wulyo Rajabto Wuryantoro Wuryantoro, Wuryantoro Yustar Mulyadi Yusuf, Harry Zubairi Djoerban Zubairi Djoerban Zubairi Djoerban Zulkifli Amin Zulkifly, Steven