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All Journal International Journal of Public Health Science (IJPHS) Jurnal Keperawatan Jurnal Kedokteran Brawijaya JURNAL ILMIAH KESEHATAN KEPERAWATAN Research Journal of Life Science Journal of Mathematical and Fundamental Sciences MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kesehatan FKUB Jurnal Kesehatan Mesencephalon Jurnal Kesehatan Mesencephalon Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Chemistry Journal Of Holistic Nursing Science Indonesian Journal of Cardiology International Journal of Community Service Learning Journals of Ners Community Care : Jurnal Ilmiah Ilmu Kesehatan The Indonesian Journal of Health Science Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Ilmiah Kesehatan Rustida Heart Science Journal JSMARTech : Journal of Smart Bioprospecting and Technology Babali Nursing Research Jurnal Health Sains Indian Journal of Forensic Medicine & Toxicology Caring : Jurnal Pengabdian Masyarakat Journal of Applied Nursing and Health International Journal of Science and Society (IJSOC) Nursing Information Journal Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Journal of Nursing Science Update DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Jurnal Ilmiah Kesehatan Keperawatan Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) NurseLine Journal
Titin Andri Wihastuti
Brawijaya University
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pengaruh Relaksasi Otot Progresif terhadap Penurunan Ansietas dan Peningkatan Kualitas Tidur Pasien Neurosa di Wilayah Kerja Puskesmas Kepanjen Kidul Kota Blitar Nawang Wulandari; Titin Andri Wihastuti; Lilik Supriati
Journal of Ners and Midwifery Vol 2 No 2 (2015)
Publisher : STIKes Patria Husada Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26699/jnk.v2i2.ART.p154-163

Abstract

Neurosa a psychic reaction with typical anxiety where clients are in fear that unconsciously displayed in various forms of behavior. Anxiety can leads physical imbalance such as increased blood pressure, insomnia, muscle tension and palpitations. Muscle tension and sleep difficulties are often experienced anxiety response. Some psychotherapy can be given to clients of anxiety one of which is progressive muscle relaxation therapy. The  aims of this study was to determine the effect of progressive muscle relaxation therapy to decrease anxiety and improve the quality of sleep in patients neurosa in Health Center Area Kepanjen Kidul Blitar. Research design was quasy experimental Pre-Post Test With Control Group with purposive sampling. Number of samples 26 respondents were divided into control and treatment groups. Collecting data using questionnaires that have tested the validity and reliability. Results of analysis of anxiety and sleep quality was obtained p <0.05 in the treatment group and control before and after treatment, the difference in scores of anxiety and sleep quality of patients neurosa between the treatment group and the control group after a given intervention p <0.05. There is no correlation between the anxiety with the quality of sleep with p> 0.05. Therapy progressive muscle relaxation and deep breathing therapy can be used to reduce anxiety and improve sleep quality in patients neurosa.
Comparison of γ-Oryzanol Content Using HPLC Profiling and Bioactivity in Three Indonesian Brown Rice (Oryza sativa L.) Varieties Umar, Ja’far; Palis, Christine Natalia; Suyanto, Eko; Turhadi, Turhadi; Wihastuti, Titin Andri; Fatchiyah, Fatchiyah
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100139

Abstract

Brown rice (BrR) is a nutrient-rich staple food and a potential source of γ-oryzanol, which has the potential to promote health effects in hypercholesterolemia. However, the availability and biological mechanism of γ-oryzanol in Indonesian BrR remain unexplored. This study aimed to characterize γ-oryzanol content in three Indonesian BrR varieties, Black Madras, Lawang, and UB BrR, and evaluate its biological functions for hypercholesterolemia. γ-Oryzanol was identified using HPLC, antioxidant activity by the ferric reducing antioxidant power (FRAP) method, and anticholesterol activity by the Lieberman-Burchard method. In silico analysis was performed to assess γ-oryzanol derivatives' interaction with microsomal triglyceride transfer protein (MTP). Black Madras BrR showed the highest γ-oryzanol content (0.3007 ± 0.0011 g). γ-Oryzanol was comprised of four main derivatives: cycloartenyl ferulate, 24-methylenecycloartanyl ferulate, campesteryl ferulate, and β-sitosteryl ferulate. Black Madras BrR exhibited strong antioxidant (IC50 18.89 ± 0.37 μg/mL) and anticholesterol (IC50 14.02 ± 0.23 µg/mL) activities. Docking simulations revealed that γ-oryzanol derivatives interact with MTP lipid-binding residues (Leu643, Ile666, Phe813, Val817) with the same binding energy as lomitapide. Molecular dynamics indicated γ-oryzanol stable interaction, closer to lomitapide. These findings proposed the potential bioactivity of γ-oryzanol from Black Madras BrR as antioxidant, anticholesterol, and a natural MTP inhibitor for hypercholesterolemia treatment.
Effect of lemongrass aromatherapy on insomnia severity among adult smokers: A quasi-experimental study Kumboyono Kumboyono; Yati Sri Hayati; Mayu Rahmayanti; Titin Andri Wihastuti
Jurnal Keperawatan Vol. 17 No. 1 (2026): January
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/jk.v17i1.42819

Abstract

Introduction: Smoking is associated with a higher prevalence of insomnia and anxiety, which contributes to reduced sleep quality among adult smokers. Lemongrass aromatherapy has shown potential benefits in modulating sleep patterns and reducing anxiety symptoms.Objectives: This study aimed to investigate the effect of lemongrass aromatherapy on the severity of insomnia among smokers.Methods: A quasi-experimental pretest-posttest control group design was used with 50 adult smokers in each group selected through purposive sampling. Participants were divided into an intervention group that received lemongrass essential oil aromatherapy and a control group that received standard care. Insomnia Severity Index (ISI), GAD-7 for anxiety, and Fagerström Test for Nicotine Dependence (FTND) were used for data collection. Data were analysed using an independent t-test and a paired t-test.Results: The intervention group showed a significant reduction in insomnia scores (p-value < 0.01), whereas the control group showed no significant change. The improvement was more prominent among participants with moderate nicotine dependence and baseline anxiety symptoms. Given the applied community setting, the findings are subject to limitations related to the quasi-experimental design and unmeasured lifestyle factors, which should be considered when interpreting the results. Conclusions: Lemongrass aromatherapy is effective in reducing insomnia symptoms among smokers and may serve as a complementary therapy in community nursing care. The integration of aromatherapy into non-pharmacological nursing interventions is recommended to improve sleep quality.
Training on Creating Locally Context-Based Print and Digital Media for Tuberculosis Education for the Community Shila Wisnasari; Elvira Sari Dewi; Fransiska Endang Widyastuti Dapi; Akhiyan Hadi Susanto; Yulian Wiji Utami; Titin Andri Wihastuti; Nurul Uswatin
International Journal of Community Service Learning Vol. 10 No. 1 (2026): February
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/ijcsl.v10i1.95038

Abstract

The high number of Tuberculosis (TB) cases in Manggarai Regency, East Nusa Tenggara, indicates the low effectiveness of community health education. Furthermore, low public health literacy and communication practices lacking socio-cultural relevance, particularly in remote areas with complex cultural diversity, are contributing to the high number of TB cases. One cause is the lack of local context-based media in the delivery of information. This Community Service aims to analyze the effectiveness of training in creating locally context-based printed and digital educational media to improve the knowledge and skills of TB program managers. The type of activity used was participatory training with an andragogical approach, involving 25 TB program managers in Manggarai Regency. Data were collected through a pretest and posttest using a knowledge questionnaire and a skills observation sheet and analyzed descriptively. The results showed an 85% increase in participants' knowledge and a 72% increase in their ability to use simple applications to create educational media. This activity proved effective in increasing the capacity of TB program managers in developing locally context-based educational media. The implication is that similar training can be replicated in other regions to strengthen local culture-based health communication strategies.
Comparative Performance of TIMI and GRACE Scores for Predicting Mortality and MACE in Acute Coronary Syndrome Winoto, Fajar Prasetyo; Wihastuti, Titin Andri; Yuliatun, Laily
Journal of Applied Nursing and Health Vol. 8 No. 2 (2026): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v8i2.695

Abstract

Background: TIMI and GRACE scores are widely used for prognostic risk stratification in acute coronary syndrome (ACS), yet comparative evidence across ACS subtypes, settings, follow-up periods, and outcomes remains heterogeneous. This scoping review mapped evidence comparing TIMI and GRACE scores for predicting mortality and MACE in patients with ACS or suspected ACS. Methods: This scooping review followed the PRISMA-ScR guidelines, the PCC framework, and the Arksey and O’Malley approach. Searches were conducted in ProQuest, Scopus, and CINAHL using Boolean search terms related to TIMI, GRACE, ACS, mortality, and MACE. Eligible studies were empirical quantitative studies comparing TIMI and GRACE for predicting mortality and MACE in adults with ACS. Records were screened, full texts were assessed, data were recorded using a standardized form, and findings were synthesized narratively based on outcomes and clinical settings. Results: A total of 187 records were identified, 45 duplicates were removed, 142 records were screened, 44 full-text reports were assessed, and 12 studies were included. Studies were published between 2022 and 2025 and included at least 12,039 participants from China, Lithuania, India, Turkey, Spain, Pakistan, and Iran. For mortality, GRACE more consistently demonstrated stronger discrimination than TIMI, particularly in NSTEMI, broader AMI cohorts, and STEMI patients undergoing reperfusion or PCI. For MACE, findings were more heterogeneous; GRACE generally performed better in confirmed NSTE-ACS and STEMI PCI cohorts, whereas TIMI showed comparable or sometimes higher discrimination than GRACE in undifferentiated emergency chest pain populations. Conclusion: The comparative performance of TIMI and GRACE depends on ACS phenotype, clinical context, and outcome definition. GRACE appears more robust for mortality prediction, while TIMI retains practical value as a simple bedside tool, especially in rapid triage contexts. Future studies should standardize MACE definitions, reporting metrics, and subgroup analyses across ACS populations.
The Effect of Polysaccharide Peptide (PsP) Administration on Lowering Triglyceride Level in Smokers with Dyslipidemia Titin Andri Wihastuti; Wiesye Roryn Sanyoto; Zahra Nazkiano; Faza Zahruna Fakhra; Kumboyono Kumboyono; Indah Nur Chomsy
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 14, No 1 (2026): EDITION MARCH 2026
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v14i1.7914

Abstract

Cigarette smoking is a major contributor to health problems worldwide and is highly prevalent in Indonesia, especially among young adult males. Nicotine in cigarettes disrupts lipid metabolism, leading to increased triglyceride levels and dyslipidemia, which are closely related to the double nutrition problem, characterized by abnormalities in the lipid profile. Smoking induces these abnormalities, indicating the need for antioxidant administration. This study aims to investigate the effect of Polysaccharide Peptides from Ganoderma lucidum on lowering triglycerides lipid profile level in active smokers with dyslipidemia. This experimental study used a pretest-posttest control group design involving 28 active smokers aged 18-21 years with dyslipidemia. Subjects were assigned to either a polysaccharide peptide (PsP) therapy group, receiving PsP extracted from Ganoderma lucidum, or a control group. Fasting serum triglyceride concentrations were measured before and after treatment. Statistical analyses used paired and unpaired t-tests to assess triglyceride level changes. The results showed a significant lowering of triglyceride levels in the PsP-treated group (p= 0.006). While the difference before and after PsP administration reached marginal statistical significance (p= 0.059), clinical improvement in triglyceride profiles was observed compared to controls. In conclusion, Ganoderma lucidum-derived PsP lowers triglyceride lipid profiles in smokers with dyslipidemia. These findings support the use of PsP as a therapeutic herbal intervention to improve lipid metabolism disturbed by smoking-induced inflammation.
INNOVATION IN HOLISTIC HEALTH PROMOTION FOR SMOKERS: DEVELOPMENT OF A LEMONGRASS (Cymbopogon citratus) ESSENTIAL OIL HERBALINHALER Titin Andri Wihastuti; Mayu Rahmayanti; Kumboyono Kumboyono
NurseLine Journal Vol. 10 No. 2 (2025): November 2025
Publisher : Program Studi Ilmu Keperawatan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/nlj.v10i2.60262

Abstract

Background: Community nurses play a collaborative role in developing holistic complementary therapies for smoking cessation. Lemongrass (Cymbopogon citratus) essential oil, known for its anxiolytic properties, was formulated into a herbal inhaler as a candidate Nicotine Replacement Therapy (NRT) to complement psychological and behavioral interventions for smokers.Objective: This study aimed to evaluate smokers' acceptance of the lemongrass-based herbal inhaler as a potential NRT. Methods: Threeinhaler formulations were developed, with lemongrass essential oil as the active ingredient. Stability testing was tested among 90 participants over a 4-week storage period, assessing homogeneity and power of Hydrogen (pH) levels. Results: Results indicated no significant differences in homogeneity or pH across the storage period, with p-values at week 0, 1, 2, 3, and 4 being 0.716, 0.754, 0.771, 0.710, and 0.674, respectively (p> 0.05). Conclusion: The findings demonstrate that the lemongrass essential oil herbal inhaler exhibits favorable physical stability and is well-accepted by smokers as a smoking cessation therapy.
Co-Authors A.A Istri Dalem Hana Yundari A.A. Ketut Agung Cahyawan W Abdul Patawari Abdul Patawari Adi Suyitno Adi Suyitno, Adi Agus Putra Murdani Agustina, Mulya Akbar Farid Hasibuan Akhiyan Hadi Susanto Aldita Husna Violita Amanda, Efina Amanda, Febrina Andrik Hermanto Antonius Christianto Anwar Santoso Ardhia, Jessica Fio Ardiansyah, Wahyu Arif Wicaksono Arifah, Medisa Roro Putri Nur Ariska, Hanisa Iis Ariyani, Anita Dwi Asti Melani Astari Asy’ary, Qomaruddin Awaliyah Muslimah Suwetty Ayut Merdikawati Ayut Merdikawati, Ayut Balqis, Rani Diana Basyar Adnani Berty Febrianti Rahayu Caressa, Dea Amanda Cathrine Theodora Sukotjo Cece Indriani Cholid Tri Tjahjono Christianingsih, Siska Christianto, Antonius Cipto Susilo Damayanti, Fransiska Erna Debby Hatmalyakin Dewi Kartikawati Ningsih Dewi Kartikawatiningsih Dewi, Heriberta Tabita Marta Dhelya Widasmara Dhiar Widianingtyas, Dhiar Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dudella Desnani Firman Yasin, Dudella Desnani Firman Dwi Agustian Faruk Ibrahim Efris Kartika Sari, Efris Kartika Eko Suyanto Elvira Sari Dewi Emi Wuri Wuryaningsih Endrian Kurniawan, Dicky Erik Irham Lutfi Evie, Sova Fahmi, Muhamad Fajar Ari Nugroho fatchiyah . Fatchiyah Fatchiyah Faza Zahruna Fakhra Firman Prastiwi FitriaNugraha Aini Fransiska Endang Widyastuti Dapi Hasibuan, Akbar Farid Hayati, Yati Sri Heri Kristanto Heri Kristianto Hidayat Sujuti Husnul Khotimah I Wayan Edi Sanjana Ida Ayu Putu Sri Widnyani Indah Nur Chomsy Indah Nur Chomsy Indhiarti, Tantri Refa Indriyani, Damayanti Inggita Kusumastuty Intan Yusuf Habibie Ismail, Dina Dewi Sartika Lestari Jannah, Riska Raudhatul Jatim Sugiyanto Juwitasari Juwitasari Kartika, Annisa Wuri Karyono Mintaroem Katsuhiro Miyajima Kawitantri, Orchidara Herning Kumboyono Kumboyono Kumboyono Kumboyono Kumboyono Kumboyono Kumboyono Kumboyono Kurnianingsih, Nia Kurnianingsih, Novi Kusuma, Ayu Widia Kusumawati, Diana Laily Yuliatun Lidwina Faraline Triprisila Lidwina Faraline Triprisila Liemena Harold Adrian Lilik Supriati Lilik Supriati Lilik Supriati Lilik Supriati, Lilik Lola Ayu Istifiani M Saifur Rohman Machfud, Savinka Salsabiela Iriana Maria Fatimah Fouk Maulidah Maulidah Mayu Rahmayanti Merry P Mochamad Ali Sodikin Muhammad Ridwan Mukhamad Fathoni Mukhamad Fathoni Muladefi Choiriyah Munif, Badrul Nana Septiana Widayati Nanang Bagus Sasmito Nanik Setijowati Narwasthu, Sekararum Nawang Wulandari Nawang Wulandari, Nawang Nofita Dewi Kok Mesa Nur &#039;Aini Nurdiana Nurdiana Nurdiana Nurdiana Nurul Evi Nurul Muslihah Nurul Uswatin Olivia Handayani Palis, Christine Natalia Pamungkas, Akhmad Yanuar Fahmi Patawari, Abdul Prasanti Mahesa Anjani Prasetyawan, Riyan Dwi Putra Agina Widyaswara Suwaryo Rahmawan, Fajri Andi Renny Nova Renny Nova, Renny Retno Lestari Retno Lestari Ridhoyanti Hidayah, Ridhoyanti Rina Anggraini Rislan Faiz Muhammad Rismawan Adi Yunanto Rista Nikmatu Rohmah Rista Nikmatu Rohmah, Rista Nikmatu Rizal, Ardian Roesardhyati, Ratna Roshanti, Dian Rosikhah Al-Maris Rosuli, Ahmad Rudiyanto Rudiyanto, Rudiyanto Safira Dita Arviana Sanjana, I Wayan Edi Saputri, Diana Nanda Sartika Lestari Ismail, Dina Dewi Sasnita Salam Sassanti, Suci Wulandari Satrianto, Anang Satwikajati, Sawitri Septi Dewi Rachmawati Servasius To’o Jala Mulu Setyoadi Setyoadi Setyoadi Setyoadi Shahdevi Nandar Kurniawan, Shahdevi Nandar Shila Wisnasari Siska Christianingsih Siska Puji Lestari Siska Puji Lestari Siska Puji Lestari Suis Galischa Wati Supriyadi, Muchamad Suryanto Suryanto Susilowati Susilowati Susilowati Susilowati Suwaryo, Putra Agina Widyaswara Swastikaputri, Valerina Yogibuana Teuku Heriansyah Tina Handayani Nasution Tita Hariyanti Toga, Erik Tony Suharsono Tony Suharsono Tony Suharsono, Tony Turhadi Turhadi Umar, Ja’far Widiani, Luh Widito, Sasmojo Wiesye Roryn Sanyoto Winoto, Fajar Prasetyo Wisnasari, Shila Yati Sri Hayati Yati Sri Hayati Yoga Tribakti Rachmad Yulian Wiji Utami Yulian Wiji Utami Yulian Wiji Utami Yulian Wiji Utami Yuliatun . Yuliatun ., Yuliatun Yuyun Yueniwati Zahra Nazkiano