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Journal : Proceeding International Conference on Global Resource Conservation

Virtual Screening of Natural Compounds for HIV 1 Reverse Transcriptase Inhibitor as Potential Drug’s Candidate Fadilah, Rizka Elan; Fauzi, Ahmad; Widiansyah, Arindra Trisna; Wijayanti, Erna
Proceeding International Conference on Global Resource Conservation Vol 6, No 1: Proceeding of 6th ICGRC 2015
Publisher : Proceeding International Conference on Global Resource Conservation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.209 KB)

Abstract

AIDS is one of mayor health problem in the world, commonly caused by Human Immunodeficiancy virus 1 (HIV-1).  Reverse transcriptase is the target of the most widely used treatments for AIDS. One of the problem from treatments is drug resistant. This research aim to discover a new potential drug’s candidate from natural compound to inhibit activity of HIV 1 Reverse Transcriptase. Top ten compounds from Specs Natural Products database as the result of virtual screening by MTIOpenScreen are docked and analyzed using Pyrx 0.8 software. Based on analysis and visualization of 2D and 3D sructure using LigPlus and PyMol softwares, known that ZINC57657 (-8 Kcal/mol)and common drug against HIV 1 Reverse Transcriptase, Lamivudine (-5,6 Kcal/mol) equally capable to bind in several amino acids (Thr 131 and Gln 23) located in the active site of HIV 1 Reverse Transcriptase.Keywords: Drug’s candidate; HIV 1 reverse transcriptase; natural compounds; virtual screening
The Inventory of Aquatic Macroinvertebrates in Various Waterfall in East Region of Malang, East Java Wijayanti, Erna; Fauzi, Ahmad; Widiansyah, Arindra Trisna; Mustofa, Zainul; Setyanto, Haqqi Anajili; Sukoco, Restu Megadiana; Nuha, Ulin; Fadilah, Rizka Elan
Proceeding International Conference on Global Resource Conservation Vol 6, No 1: Proceeding of 6th ICGRC 2015
Publisher : Proceeding International Conference on Global Resource Conservation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.209 KB)

Abstract

Indonesia as Maritime Island has many water regions. Waterfall is one of the water region that has a large number of aquatic macroinvertebrates. The aim of this research is to collect and identify the various aquatic macroinvertebrates that can be found in several waterfalls in east Region of Malang, East Java. The research was carried out on September until November 2015 in six waterfalls: Coban Jahe, Coban Pelangi, Coban Trisula, Coban Kembar, Coban Ringin Gantung and Coban Pitu. Dragnet was used to collect the samplesof aquatic macroinvertebrates in some sampling point. The result of this research was found 38 families that belonged to 18 ordo in 6 different classes: Insecta, Oligochaeta, Gastropoda, Hirudinae, Turbellaria, and Crustacea. The information about the inventory of aquatic macroinvertebrates will give another suggestion for the local government to conserve this animals especially waterfall environment, not only as tourist area but also as a source of knowledge to do another research. Keywords: Aquatic macroinvertebrates; inventory; Malang; waterfalls
Co-Authors ., Supeno Adi Irawan Adianto Syahbana Adinda Dwi Putri Lestari Afif Rafi Alaudidin Ainaya Nafiza Nazali Ainun Tiana Akbar Fattah Al Abshor Charisma Akhmad Alifurizal Romli Alivia Khoirunnisa Alvina Hermawaty Alvira Fedora Alya Salma Qothrun Nada Amalia Melinda Amanda Putri Elysia Amelia Fiska Fajar Cahyani Anjar Dwi Setyorini Arindra Trisna Widiansyah, Arindra Trisna Arintia Prasasti Setyo Ningrum Arista Eka Kumalasari Asifa Khoirun Nisa Astriya Indah Sari Aulia Salsabila Ayu Putri Wulandari Bagas Permana Putra Bela Zain Taqiyya Cici Lia Ayu Fatmawati Dharmawan, Wahyu Diah Wahyuni Diah Wahyuni Dian Ayu Puspitasari Dina Emiliana Dinnar Lambang Kinasih Dwi Wahyuni Elok U.P. Wulandari Elvina Camelia Erna Wijayanti Fadri, Firda Faidatul Masyruroh Fatah An Naufal Fayza Dwi Ega Leonida Febi Lusiana Marta Ferry Budi Prasetya Fira Aulia Annur Rizky Firda Fadri Firdha Yumar Firdha Yusmar Fuddah, Lutfiaul Gesta Pramatasari Hakim, Wihdatu Insanil Hanif Krisna Adhiansyah Haqqi Anajili Setyanto, Haqqi Anajili Hasanah, Rafiatul Hilma Farilla I Gusti Bagus Wiksuana I Ketut Mahardika Iftidah Dian Furaida Imilda Ailiyah Fatikhah Indri Wulandari Indriani, Rini Intan Dwi Yuswanti Ismawati, Aisyah Emelia Ivan Rizki Fauzi Jihan Nabilatus Sholihah Juwanda, Kuntoro Kharisma Husnul Khotimah Khirzin , Muhammad Habbib Khofifatu Nurisya Kholifatun Khasanah Khuril ‘Aini Lutfiaul Fuddah Maretha Dewi Anggraeni Mayla Syifani Zulfa Mohamad Amin Nadilatus Salsabila Nadya Arini Atmaja Najma Fatimatuz Zakiyah Nanda Tiara Putri Nanda Zakiatus Solihah Napasti, Friny Nia Nur Afni Fitria Niken Putri Arina Nilna Ulfia Nuril Ayyamil Izza Nurisya, Khofifatu Nurlaily Azizah Purti Wahyu Nurjanah Putra, Zhidan Z. Putri Dwi Hariyanto Putri, Alifiah Rahmah Wulandari Rayendra Wahyu Bachtiar Restu Megadiana Sukoco, Restu Megadiana Reza Yunita Pratiwi Rina Tut Jayati Rini Indriani Rizka Hayu Faradillah Rizky, Adinda Dhea Roufatul Mucharromah Rusdianto RUSDIANTO ., RUSDIANTO Rusdianto Rusdianto Rusdianto Rusdianto S Suratno Silvia Agustiyani Siti Khasfiyatin Siti Nur Bahiroh Soraya Firdausi Sri Rejeki Dwi Astuti Sri Wahyuni Sri Wahyuni Sri Wahyuni Supeno Supeno Supeno Supeno Susanti, Laily Yunita Sya'adah, Himatus Syifa Nafiatus Sa’diyah Tantri, Ananda Kaliana Thoriq Wildan Ulin Nuha Ulin Nuha Ulin Nuha Ulin Nuha, Ulin Umi Lestari Umie Lestari Villa Febianti Vinna Ariyani Wahyuni*, Sri Wulandari, Rahmah Yenni Eka Septiani Yuliana Babul Jannah Zainul Mustofa, Zainul Zakiyah Izza Avkarinah Zhidan Z. Putra