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All Journal HAYATI Journal of Biosciences Jurnal Natur Indonesia JBIO: jurnal biosains (the journal of biosciences) Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian JURNAL ILMU PERTANIAN Buletin Penelitian Tanaman Rempah dan Obat Global Medical and Health Communication Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) The Indonesian Biomedical Journal Universa Medicina BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Preventif Journal Jambura Journal of Health Sciences and Research Journal Health & Science : Gorontalo Journal Health and Science Community Seminar Nasional Lahan Suboptimal Jurnal Kesehatan Journal of Health Sciences Jurnal Pendidikan dan Konseling PREPOTIF : Jurnal Kesehatan Masyarakat Buletin Penelitian Tanaman Rempah dan Obat Jurnal Kesehatan Tambusai International Journal of Basic and Applied Science International Archives of Medical Sciences and Public Health International Archives of Medical Sciences and Public Health JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Buletin Kedokteran dan Kesehatan Prima JURNAL KIMIA SAINTEK DAN PENDIDIKAN International Journal of Health and Pharmaceutical (IJHP) Journal of Social Science JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR) Jurnal Kedokteran STM (Sains dan Teknologi Medik) Ranah Research : Journal of Multidisciplinary Research and Development Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Jurnal Mahasiswa Ilmu Kesehatan Nutriture Journal Journal of Pharmascience Proceeding of The International Conference on Health Sciences and Nursing
Edy Fachrial
Faculty Of Medicine, Universitas Prima Indonesia, Medan
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Aktivitas Antioksidan dan Inhibitor Enzim Tirosinase Ekstrak Daun Jeruk Manis (Citrus sinensis L.) Saragih, Runitasari; Fachrial, Edy; Pranita Simanjuntak, Nerly Juli
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.211

Abstract

Sweet orange leaves (Citrus sinensis L.) are a potential source of bioactive compounds that can be developed as natural antioxidants and tyrosinase inhibitors for the prevention of premature skin aging and hyperpigmentation. This study aimed to evaluate the phytochemical constituents, antioxidant activity, and tyrosinase inhibitory potential of the ethanol extract of sweet orange leaves. Extraction was carried out using ultrasonic-assisted extraction with 70% ethanol as the solvent. Phytochemical screening revealed the presence of flavonoids, tannins, alkaloids, and steroids, while saponins were not detected. Antioxidant activity was evaluated using the DPPH radical scavenging method at concentrations of 200–500 ppm and showed a concentration-dependent increase in inhibition, with values of 76.46% (200 ppm), 78.61% (300 ppm), 82.32% (400 ppm), and 84.43% (500 ppm), indicating strong antioxidant activity. Tyrosinase inhibition was assessed using L-DOPA as the substrate and demonstrated inhibition percentages of 51.13% and 51.01%, indicating good inhibitory activity. Based on these findings, thethanol extract of sweet orange leaves exhibits promising antioxidant and tyrosinase inhibitory properties and may be further developed for pharmaceutical and cosmetic applications, particularly as natural anti-aging and antihyperpigmentation agents.
Aktivitas Antioksidan dan Inhibitor Enzim Tirosinase Ekstrak Daun Pepaya (Carica papaya L.) Simamora, Yohana; Fachrial, Edy; Syahputra, Hariyadi Dharmawan
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.212

Abstract

Skin aging and hyperpigmentation are closely related to increased oxidative stress and tyrosinase enzyme activity in the melanogenesis process. Utilization of natural ingredients that have antioxidant activity and the ability to inhibit tyrosinase is one potential approach in skin care. This study aims to evaluate the antioxidant activity and the potential for inhibiting the tyrosinase enzyme from ethanol extract of papaya leaves (Carica papaya L.). The study was conducted experimentally through the stages of simplicia preparation, extraction using the ultrasonication method, phytochemical screening, antioxidant activity testing using the DPPH method, and tyrosinase inhibition test using L-DOPA and kojic acid as a positive control substrate. The results of the phytochemical screening showed that the ethanol extract of papaya leaves contained flavonoids, alkaloids, tannins, and triterpenoids, while saponins were not detected. Antioxidant activity testing showed an increase in free radical inhibition ability along with increasing extract concentration. In addition, the results of the tyrosinase enzyme inhibition test showed that papaya leaf extract was able to significantly suppress enzyme activity. Based on these results, papaya leaf ethanol extract has the potential to be developed as a source of natural antioxidants and a tyrosinase enzyme inhibitor agent.
A microbiological analysis of coliform bacteria in street food around Universitas Prima Indonesia, Medan Davin, Radhitya Qowiyyul; Fachrial, Edy; Wienaldi, Wienaldi
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.8083

Abstract

Background: Street foods, particularly fried snacks, are highly popular among university students due to their convenience and affordability. However, the safety of such foods is a public health concern, as they are susceptible to contamination by coliform bacteria, which can cause gastrointestinal illnesses such as diarrhea. This study aimed to analyze the total coliform bacteria in fried snacks sold around the Universitas Prima Indonesia campus area in Medan as an indicator of food safety. Methods: This descriptive laboratory study analyzed fried snack samples of two types (rissole and filled tofu) collected from six street vendors on Jalan Ayahanda, Medan. Samples were obtained using a simple random sampling technique, resulting in a total of 12 samples. The presence of coliform bacteria was determined using the Most Probable Number (MPN) method with a 3-3-3 tube series, which included a presumptive test using Lactose Broth (LB) medium. Data were analyzed descriptively by comparing results with the standard set by the Indonesian Ministry of Health Regulation No. 2 of 2023 (maximum permissible limit <3.6 MPN/gram). Results: All 12 samples tested negative in the presumptive test, indicated by the absence of gas bubbles in the Durham tubes after 48 hours of incubation. The MPN value for all samples was <3 MPN/gram, confirming they met the required safety standard (<3.6 MPN/gram). Conclusion: Fried snacks sold around the Universitas Prima Indonesia campus were free from coliform bacterial contamination and are considered safe for consumption based on current regulations. Factors such as the high-temperature deep-frying process (>150°C) and adequately maintained vendor sanitation practices likely contributed to the absence of contamination.
AMELIORATIVE EFFECTS OF HYDROALCOHOLIC OCIMUM BASILICUM LEAF EXTRACT ON BIOCHEMICAL AND HISTOLOGICAL ALTERATIONS IN CISPLATIN-INDUCED CARDIOTOXICITY IN MALE WISTAR RATS Tarigan, Novitasari; Dianda, Feby; Lister, I. Nyoman Ehrich; Fachrial, Edy
International Archives of Medical Sciences and Public Health Vol. 6 No. 2 (2025): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v6i2.1393

Abstract

Cardiotoxicity is a common side effect of cisplatin (CIS) chemotherapy, often accompanied by gastrointestinal, renal, and hematological toxicities. This study investigated cardioprotective potential of hydroalcoholic basil leaf extract against CIS-induced toxicity in rats, evaluated through Troponin-T, high-sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA) levels, and cardiac histopathology. A quasi-experimental design was employed with eight groups of rats (n = 6 per group): normal, negative control, positive control (vitamin C), and treatment groups receiving basil extract (400 and 800 mg/kg body weight). CIS administration significantly elevated Troponin-T, Hs-CRP, and MDA levels while reducing SOD activity. Treatment with basil extract, particularly at 800 mg/kg, markedly attenuated these changes, restoring biochemical markers toward normal values. Histopathological analysis further confirmed the cardioprotective effect. In conclusion, basil leaf extract demonstrates promising potential as a cardioprotective agent against CIS-induced cardiotoxicity.
AMELIORATIVE EFFECTS OF HYDROALCOHOLIC OCIMUM BASILICUM LEAF EXTRACT ON BIOCHEMICAL AND HISTOLOGICAL ALTERATIONS IN CISPLATIN-INDUCED CARDIOTOXICITY IN MALE WISTAR RATS Tarigan, Novitasari; Dianda, Feby; Lister, I. Nyoman Ehrich; Fachrial, Edy
International Archives of Medical Sciences and Public Health Vol. 6 No. 2 (2025): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v6i2.1393

Abstract

Cardiotoxicity is a common side effect of cisplatin (CIS) chemotherapy, often accompanied by gastrointestinal, renal, and hematological toxicities. This study investigated cardioprotective potential of hydroalcoholic basil leaf extract against CIS-induced toxicity in rats, evaluated through Troponin-T, high-sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA) levels, and cardiac histopathology. A quasi-experimental design was employed with eight groups of rats (n = 6 per group): normal, negative control, positive control (vitamin C), and treatment groups receiving basil extract (400 and 800 mg/kg body weight). CIS administration significantly elevated Troponin-T, Hs-CRP, and MDA levels while reducing SOD activity. Treatment with basil extract, particularly at 800 mg/kg, markedly attenuated these changes, restoring biochemical markers toward normal values. Histopathological analysis further confirmed the cardioprotective effect. In conclusion, basil leaf extract demonstrates promising potential as a cardioprotective agent against CIS-induced cardiotoxicity.
Inhibisi Enzim α-Glukosidase oleh Bacillus Megaterium ITU 9 Isolat Sumber Air Panas Sumatera Utara Finna Piska; Chrismis Novalinda Ginting; Harmileni Harmileni; Edy Fachrial
Journal of Pharmascience Vol. 11 No. 1 (2024): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.17045

Abstract

Diabetes adalah penyakit multifaktor yang insidensinya meningkat dengan pesat di negara berkembang. Diabetes mellitus (DM) tipe 2 adalah jenis diabetes yang paling umum ditemui, dimana penyakit ini erat kaitannya dengan kemajuan industri dan teknologi sehingga mempengaruhi gaya hidup seseorang. Penanggulangan penyakit ini dapat dilakukan dengan menghambat aktivitas α-glukosidase. Beberapa mikroorganisme terutama dari sumber air panas dapat dimanfaatkan sebagai penghasil senyawa inhibitor α-glukosidase. Pada penelitian sebelumnya isolat Bacillus megaterium ITU 9 merupakan isolat yang diisolasi dari sumber air panas. Pada penelitian ini diuji kemampuan isolat Bacillus megaterium ITU 9 sebagai penghasil inhibitor α-glukosidase dengan metode sumur. Daya persen inhibisi supernatan B. megaterium ITU 9 terhadap kerja enzim α-glukosidase adalah sebesar 46,67%, sedangkan daya persen inhibisi acarbose yaitu 70%. Dalam hal ini B. megaterium ITU 9 termofilik memiliki daya inhibisi terhadap enzim α-glukosidase. Kata Kunci: Bakteri Termofilik, Inhibitor, Akarbose, Metode Sumur, Persen Inhibisi Diabetes is a multifactorial disease whose incidence is increasing rapidly in developing countries. Diabetes mellitus (DM) type 2 is the most common type of diabetes, where this disease is closely related to industrial and technological advances, thus affecting a person's lifestyle. This disease can be controlled by inhibiting α-glucosidase activity. Several microorganisms, especially from hot springs, can be used to produce α-glucosidase inhibitor compounds. In previous research, the Bacillus megaterium ITU 9 isolate was an isolate isolated from hot springs. In this study, the ability of the Bacillus megaterium ITU 9 isolate to produce α-glucosidase inhibitors was tested using the well method. The percent inhibition power of B. megaterium ITU 9 supernatant on the action of the α-glucosidase enzyme was 46.67%, while the percent inhibition power of acarbose was 70%. In this case, the thermophilic B. megaterium ITU 9 has inhibitory power against the α-glucosidase enzyme.
Antidiabetic and Liver Tissue Improvement Potency of Surf Redfish (Actinopyga mauritiana) in Alloxan-Induced Diabetic Mice Arma Citra; I Nyoman Ehrich Lister; Edy Fachrial; Sahna Ferdinand Ginting
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5270

Abstract

Long-term hyperglycemia is associated with various organ damage. One of these damages is Non-Alcoholic Fatty Liver Disease (NAFLD). One of the potential natural products that may improve this impact is Surf Redfish. Hence this study aimed to investigate the antidiabetic and liver protection effects of Surf Redfish in some diabetic male Mice. This study was an experimental study that used 25 male mice grouped into control, standard, Surf Redfish Extract-I (100 mg/ kg BW), II (200 mg// kg BW), and III (400 mg/ kg BW). This study evaluated the blood glucose level (before and after induction, third, sixth, ninth, twelfth, and fifteenth days) and histology study of liver tissue. This study showed that the Surf Redfish ethanol extract significantly decreased blood glucose levels every day for fifteen days (P-Value < 0.05). This extract also showed a significant decrease in vacuolated degeneration after fifteen days of extract administration (P-Value). Hence, it can be concluded that the most effective dose of Surf Redfish extracts in this study was 400 mg/ kg BW to decrease blood glucose level and width of vacuolated degeneration after fifteen days of administration.
Leadership Style with Paramedic Work Motivation on General Hospital Performance Natalia Natalia; Edy Fachrial; Suandy Suandy; Yohani Theresia; I Nyoman Ehrich Lister
Proceeding of the International Conference on Health Sciences and Nursing Vol. 2 No. 1 (2025): Proceeding of the International Conference on Health Sciences and Nursing
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ichsn.v2i1.53

Abstract

This study examines the influence of leadership style and paramedic work motivation on the performance of general hospitals. The research aims to investigate how leadership approaches and motivation levels among paramedics affect hospital outcomes. Using a quantitative approach, data was collected from paramedics working in several general hospitals. The analysis included statistical methods such as regression analysis and mediation analysis to test the direct and indirect effects of leadership style and work motivation on hospital performance. The results showed that leadership style and work motivation significantly affect hospital performance. Specifically, effective leadership and high work motivation among paramedics contributed to improved hospital performance indicators. This study provides insights into how hospital management can improve performance by focusing on leadership development and motivation enhancement strategies. The findings highlight the importance of fostering a supportive leadership environment and promoting work motivation among paramedics to achieve better hospital performance.
Co-Authors Abednego S. Karosekali Adek Amansyah Afif P Jati Ainy, Al-Annisa Fadhila Aisar Novita Alhoi Hendry Henderson Aloysius Aloysius Aloysius, Aloysius Angelin Christin Anggita Kasih Fianti Situmorang Anggraini, Sari Anjurniza Ulfa Annisa Amalia Ariatama, Bayu Arma Citra Armansyah, Adek Balkis, Tiara Bayu Pratomo Bayu Pratomo Bella Sari Sijabat Buter Samin Buter Samin Calvin Christian Karo Karo Chiuman, Linda Chrismis Novalinda Ginting Chrismis Novalinda Ginting Christine Halawa Clarissa Lister Cory Oriensia Siahaan DAMERIA DAMERIA Davin, Radhitya Qowiyyul Dea Christa Amanda Deborah Angelin Purba Delyuzar, Delyuzar Dianda, Feby Dini Ariyska Edward Kosasih Edwin Waroka Ehrich Lister, I Nyoman Eka Susilawati Erika Yolanda Ginting Ermi Girsang Ermi Girsang Ester Putri Mentary Mendrofa Felix Felix Ferdinand, Sahna Fibrina, Dewi Finna Piska Fioni, Fioni Ginting, Chrismis Novalinda Girsang, Ermi Girsang, Ermi Gusbakti Rusip Hakim Nasution, Ikhwanul Hanna Christsela Purba Hanna Sari Widya Kusuma, Hanna Sari Widya Harmileni Harmileni Harmileni Henderson, Alhoi Hendry Henny Safrita Ginting I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I. Nyoman Ehrich Lister Indra Setiawan Rambe Intan Hasibuan, Febria Nurul Intisari, Yayo Ira Manda Sari Berampu Ismawati Ismawati Ismawati Juli elisabeth mayen Juli Elisabeth Mayen Meliala Jusri, Ridza Karo Sekali, Abednego Suranta Khainir Akbar, Khainir Komala, William Laura J. Pinem Liana Liana Liena Liena Lina, Juliana Linda Chiuman Lisma Viany Lister Ehrich I Nyoman Lister, Clarissa Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, I Nyoman Enrich Lister, I. Nyoman Ehrich Lister, Nyoman Ehrich Lokot Donna Lubis M. Andriady Saidi Nst Mahani, Yensielia Marbun, Togi Rut Marlita Marpaung, Hans Hotma Masdalena Nasution Muhammad Aditya Kurnia Nabila, Pivi Naidu, Ramawathy Nasution, Muhammad Hasan Basri Natalia Desvalentina Lase Natalia Natalia Neswita, Elfia Niranti, Tasya Putri Novriani, Erida Nyoman Ehrich Lister, I Obet Edom Ginting Ongko, Nicolas Xavier Pinem, Laura Juita Pranita Simanjuntak, Nerly Juli Purba, Greace Hasianna Purba, Rosi Krisdayanti Qodariah, Rismawati Laila Rama Riana Sitinjak Ramadhani, Shafira Ricky Kinarta Sembiring Rika Silvany Rita Kusuma Ritonga, Lestina Rizal Rizal Rizal Rizal Rr. Anisa Siwianti Handayani Rudi Chandra Sahna Ferdinand Ginting Saipul Sihotang Saragih, Ria Natalia Saragih, Runitasari Sari Anggraini Saryono Saryono Saryono Sianturi, Naomi Silaban, Agnes Novica Putri Silalahi, Elsa Debora Simamora, Yohana Sinaga, Ade Putra Fratama Sinaga, Theresia Margaretha Siregar, Hafiz Hawari Siregar, Irma Dolsyeria Situmorang, Anggita Kasih Fianti Sofiyana, Maria Sonya Bonifacia Mahadi Sormin, Delores Elisabeth Suandy Suandy Sumartin, Sonia Apriani Sunarti Sunarti Surya Dharma Syahputra, Hariyadi Dharmawan Tandiah Asan Tarigan, Lela Diyana Br Tarigan, Novitasari Tarigan, Nuzulul Akbar Tengku Muhammad Sahiril Anhar Tengku Rachmi Hidayani Theresia, Yohani Titania T Nugroho Titania Tjandrawati Nugroho Tri Widyawati Ulfa, Anjurniza Urip Harahap Vebbly, Vebbly Vicky Vrianty, Dela WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Waroka, Edward Widodo, Wahyu Setia Widya Yanti Sihotang Wienaldi, Wienaldi Wijaya, Raysha Awlia Wilsen Wilsen Yasmin, Nabila Yonias Saleh Tria Zebua Yuliani Mardiati Lubis Yunita Dewani