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Hubungan Kualitas Tidur dengan Indeks Massa Tubuh (IMT) di Fakultas Kedokteran Universitas Prima Indonesia Angkatan Tahun 2022 Mahani, Yensielia; Wienaldi, Wienaldi; Fachrial, Edy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i11.62564

Abstract

Kualitas tidur yang buruk dapat memengaruhi keseimbangan metabolik tubuh dan berdampak pada perubahan Indeks Massa Tubuh (IMT). Mahasiswa kedokteran merupakan kelompok yang rentan mengalami gangguan tidur akibat beban akademik yang tinggi dan pola hidup tidak teratur. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas tidur dengan Indeks Massa Tubuh (IMT) pada mahasiswa Fakultas Kedokteran Universitas Prima Indonesia angkatan tahun 2022. Jenis penelitian ini adalah kuantitatif dengan metode analitik cross-sectional. Data dikumpulkan melalui kuesioner Pittsburgh Sleep Quality Index (PSQI) untuk menilai kualitas tidur serta pengukuran berat dan tinggi badan untuk menentukan IMT. Jumlah sampel sebanyak 178 mahasiswa yang dipilih dengan metode total sampling. Analisis data dilakukan menggunakan uji Chi-Square dan uji Cramer’s V dengan bantuan program SPSS. Hasil penelitian menunjukkan bahwa 94 responden (52,8%) memiliki kualitas tidur baik dan 84 responden (47,2%) memiliki kualitas tidur buruk. Mayoritas responden memiliki IMT normal sebanyak 113 orang (63,5%), sedangkan 29 orang (16,3%) tergolong obesitas. Uji Chi-Square menghasilkan nilai p < 0,001 yang menunjukkan adanya hubungan signifikan antara kualitas tidur dengan IMT, dengan kekuatan hubungan sedang (Cramer’s V = 0,492). Kesimpulan penelitian ini adalah semakin buruk kualitas tidur seseorang, semakin tinggi kecenderungan mengalami peningkatan IMT.
The Effect of Ethanol Extract of Cat's Whiskers Leaves (Orthosiphon stamineus) on Reducing Cholesterol Levels in Female Sprague Dawley Rats Ira Manda Sari Berampu; Edy Fachrial; I Nyoman Ehrich Lister
Jurnal Penelitian Pendidikan IPA Vol 10 No SpecialIssue (2024): Science Education, Ecotourism, Health Science
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10iSpecialIssue.8400

Abstract

This study aims to test the administration of ethanol extract of cat's whisker leaves (Orthosiphon stamineus) to reduce cholesterol levels in female Sprague Dawley rats. This type of research is a quasi-experiment design using a one group pre-test and post-test design. The population in this study was 30 female Sprague Dawley rats aged ± 3 months with a body weight of around 150-250 grams. Data were analyzed using the t test statistic at = 5%. The results of the research showed that the highest decrease in cholesterol levels was in female Sprague Dawley rats at a test dose of 1000 mg/kgBW and there was an effect of ethanol extract of cat's whisker leaves (Orthosiphon stamineus) on reducing cholesterol levels in female Sprague Dawley rats
The Potential Of Fungi And Bacteria As α-Glucosidase Inhibitors For The Future Treatment Of Type 2 Diabetes Edy Fachrial; Ismawati; Afif P Jati; Titania T Nugroho; Saryono
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.9457

Abstract

Diabetes, a disorder of hemostasis of carbohydrate and lipid metabolism, is one of today's leading killers. The most prevalent form of diabetes is type 2 diabetes mellitus (T2DM). Rapid hydrolysis of starch by pancreatic α-amylase and α-glucosidase, followed by intestinal absorption of glucose, causes a sudden increase in blood glucose. Available therapies for T2DM are oral insulin secretagogues, sulfonylureas, repaglinide, nateglinide, biguanides, thiazolidinediones, α-glucosidase, inhibitors and insulin. However, several hypoglycemic agents have limitations, such as side effects and increased diabetes complications. α-glucosidase inhibitors are structurally similar to natural oligosaccharides with a higher affinity for α-glucosidases, and they produce a reversible inhibition of membrane-bound intestinal α-glucoside hydrolase enzymes. This causes delayed carbohydrate absorption and digestion and results in a reduction in postprandial hyperglycemia. Natural α-glucosidase inhibitor drugs from natural sources can be used as a therapeutic approach to treat postprandial hyperglycemia for their assumed lower side effect and more affordable price than synthetic drugs. In this article, the author summarizes the potential of α-glucosidase inhibitors from microorganisms, namely fungi and bacteria, along with several active compounds with better activity than commercial α-glucosidase inhibitors.
Aktivitas Antioksidan dan Inhibitor Enzim Tirosinase Ekstrak Daun Jeruk Manis (Citrus sinensis L.) Saragih, Runitasari; Fachrial, Edy; Pranita Simanjuntak, Nerly Juli
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.211

Abstract

Sweet orange leaves (Citrus sinensis L.) are a potential source of bioactive compounds that can be developed as natural antioxidants and tyrosinase inhibitors for the prevention of premature skin aging and hyperpigmentation. This study aimed to evaluate the phytochemical constituents, antioxidant activity, and tyrosinase inhibitory potential of the ethanol extract of sweet orange leaves. Extraction was carried out using ultrasonic-assisted extraction with 70% ethanol as the solvent. Phytochemical screening revealed the presence of flavonoids, tannins, alkaloids, and steroids, while saponins were not detected. Antioxidant activity was evaluated using the DPPH radical scavenging method at concentrations of 200–500 ppm and showed a concentration-dependent increase in inhibition, with values of 76.46% (200 ppm), 78.61% (300 ppm), 82.32% (400 ppm), and 84.43% (500 ppm), indicating strong antioxidant activity. Tyrosinase inhibition was assessed using L-DOPA as the substrate and demonstrated inhibition percentages of 51.13% and 51.01%, indicating good inhibitory activity. Based on these findings, thethanol extract of sweet orange leaves exhibits promising antioxidant and tyrosinase inhibitory properties and may be further developed for pharmaceutical and cosmetic applications, particularly as natural anti-aging and antihyperpigmentation agents.
Aktivitas Antioksidan dan Inhibitor Enzim Tirosinase Ekstrak Daun Pepaya (Carica papaya L.) Simamora, Yohana; Fachrial, Edy; Syahputra, Hariyadi Dharmawan
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.212

Abstract

Skin aging and hyperpigmentation are closely related to increased oxidative stress and tyrosinase enzyme activity in the melanogenesis process. Utilization of natural ingredients that have antioxidant activity and the ability to inhibit tyrosinase is one potential approach in skin care. This study aims to evaluate the antioxidant activity and the potential for inhibiting the tyrosinase enzyme from ethanol extract of papaya leaves (Carica papaya L.). The study was conducted experimentally through the stages of simplicia preparation, extraction using the ultrasonication method, phytochemical screening, antioxidant activity testing using the DPPH method, and tyrosinase inhibition test using L-DOPA and kojic acid as a positive control substrate. The results of the phytochemical screening showed that the ethanol extract of papaya leaves contained flavonoids, alkaloids, tannins, and triterpenoids, while saponins were not detected. Antioxidant activity testing showed an increase in free radical inhibition ability along with increasing extract concentration. In addition, the results of the tyrosinase enzyme inhibition test showed that papaya leaf extract was able to significantly suppress enzyme activity. Based on these results, papaya leaf ethanol extract has the potential to be developed as a source of natural antioxidants and a tyrosinase enzyme inhibitor agent.
A microbiological analysis of coliform bacteria in street food around Universitas Prima Indonesia, Medan Davin, Radhitya Qowiyyul; Fachrial, Edy; Wienaldi, Wienaldi
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.8083

Abstract

Background: Street foods, particularly fried snacks, are highly popular among university students due to their convenience and affordability. However, the safety of such foods is a public health concern, as they are susceptible to contamination by coliform bacteria, which can cause gastrointestinal illnesses such as diarrhea. This study aimed to analyze the total coliform bacteria in fried snacks sold around the Universitas Prima Indonesia campus area in Medan as an indicator of food safety. Methods: This descriptive laboratory study analyzed fried snack samples of two types (rissole and filled tofu) collected from six street vendors on Jalan Ayahanda, Medan. Samples were obtained using a simple random sampling technique, resulting in a total of 12 samples. The presence of coliform bacteria was determined using the Most Probable Number (MPN) method with a 3-3-3 tube series, which included a presumptive test using Lactose Broth (LB) medium. Data were analyzed descriptively by comparing results with the standard set by the Indonesian Ministry of Health Regulation No. 2 of 2023 (maximum permissible limit <3.6 MPN/gram). Results: All 12 samples tested negative in the presumptive test, indicated by the absence of gas bubbles in the Durham tubes after 48 hours of incubation. The MPN value for all samples was <3 MPN/gram, confirming they met the required safety standard (<3.6 MPN/gram). Conclusion: Fried snacks sold around the Universitas Prima Indonesia campus were free from coliform bacterial contamination and are considered safe for consumption based on current regulations. Factors such as the high-temperature deep-frying process (>150°C) and adequately maintained vendor sanitation practices likely contributed to the absence of contamination.
Co-Authors Abednego S. Karosekali Adek Amansyah Afif P Jati Ainy, Al-Annisa Fadhila Aisar Novita Alhoi Hendry Henderson Aloysius Aloysius Aloysius, Aloysius Angelin Christin Anggita Kasih Fianti Situmorang Anggraini, Sari Anjurniza Ulfa Annisa Amalia Ariatama, Bayu Armansyah, Adek Balkis, Tiara Bayu Pratomo Bayu Pratomo Bella Sari Sijabat Buter Samin Buter Samin Calvin Christian Karo Karo Chiuman, Linda Chrismis Novalinda Ginting Christine Halawa Citra, Arma Clarissa Lister DAMERIA DAMERIA Davin, Radhitya Qowiyyul Dea Christa Amanda Deborah Angelin Purba Delyuzar, Delyuzar Dini Ariyska Edward Kosasih Edwin Waroka Ehrich Lister, I Nyoman Eka Susilawati Erika Yolanda Ginting Ermi Girsang Ester Putri Mentary Mendrofa Felix Felix Ferdinand, Sahna Fibrina, Dewi Finna Piska Fioni, Fioni Ginting, Chrismis Novalinda Ginting, Sahna Ferdinand Girsang, Ermi Girsang, Ermi Gusbakti Rusip Hakim Nasution, Ikhwanul Hanna Christsela Purba Hanna Sari Widya Kusuma, Hanna Sari Widya Harmileni Harta Winata, Jaya Henderson, Alhoi Hendry Henny Safrita Ginting I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister I Nyoman Ehrich Lister Indra Setiawan Rambe Intan Hasibuan, Febria Nurul Intisari, Yayo Ira Manda Sari Berampu Ismawati Ismawati Ismawati Juli elisabeth mayen Juli Elisabeth Mayen Meliala Jusri, Ridza Karo Sekali, Abednego Suranta Khainir Akbar, Khainir Komala, William Laura J. Pinem Liana Liana Liena Liena Lina, Juliana Linda Chiuman Lisma Viany Lister Ehrich I Nyoman Lister, Clarissa Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, I Nyoman Enrich Lister, I. Nyoman Ehrich Lister, Nyoman Ehrich Lokot Donna Lubis M. Andriady Saidi Nst Mahani, Yensielia Marbun, Togi Rut Marlita Marpaung, Hans Hotma Masdalena Nasution Muhammad Aditya Kurnia Nabila, Pivi Naidu, Ramawathy Nasution, Muhammad Hasan Basri Natalia Desvalentina Lase Neswita, Elfia Niranti, Tasya Putri Novriani, Erida Nyoman Ehrich Lister, I Obet Edom Ginting Ongko, Nicolas Xavier Pinem, Laura Juita Pranita Simanjuntak, Nerly Juli Purba, Greace Hasianna Purba, Rosi Krisdayanti Qodariah, Rismawati Laila Rama Riana Sitinjak Ramadhani, Shafira Ricky Kinarta Sembiring Rika Silvany Rita Kusuma Ritonga, Lestina Rizal Rizal Rizal Rizal Rr. Anisa Siwianti Handayani Rudi Chandra Saipul Sihotang Saragih, Ria Natalia Saragih, Runitasari Sari Anggraini Saryono Saryono Saryono Siahaan, Cory Oriensia Sianturi, Naomi Silaban, Agnes Novica Putri Silalahi, Elsa Debora Simamora, Yohana Sinaga, Ade Putra Fratama Sinaga, Theresia Margaretha Siregar, Hafiz Hawari Siregar, Irma Dolsyeria Situmorang, Anggita Kasih Fianti Sofiyana, Maria Sonya Bonifacia Mahadi Sormin, Delores Elisabeth Sumartin, Sonia Apriani Sunarti Sunarti Surya Dharma Syahputra, Hariyadi Dharmawan Tandiah Asan Tarigan, Lela Diyana Br Tarigan, Nuzulul Akbar Tengku Muhammad Sahiril Anhar Tengku Rachmi Hidayani Titania T Nugroho Titania Tjandrawati Nugroho Tri Widyawati Ulfa, Anjurniza Urip Harahap Vebbly, Vebbly Vicky Vrianty, Dela WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Waroka, Edward Widodo, Wahyu Setia Widya Yanti Sihotang Wienaldi, Wienaldi Wijaya, Raysha Awlia Wilsen Wilsen Yasmin, Nabila Yonias Saleh Tria Zebua Yuliani Mardiati Lubis Yunita Dewani