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Journal : Indonesian Journal of Pharmaceutical and Clinical Research

 1 
Effect of Plectranthus amboinicus, Lour. Spreng. n-Hexane Extract on T47D Cells Line: Proliferation, Apoptosis and It’s Combination with Doxorubicine Zaitun Hasibuan, Poppy Anjelisa; Rosidah; Nasution , Pandapotan; Ilyas , Syafruddin
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 1 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i1.3323

Abstract

The objectives of the study are to investigated the growth-inhibiting and apoptosis mediating effect of Plectranthus amboinicus (Lour.) Spreng n-hexane extract (PANE) on T47D cell lines. The assays were performed in the study were cytotoxicity assay and apoptosis induction of T47D cells. The cytotoxicity effects were determined by using MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide] assay. The effect of apoptosis were observed by ethidium bromide-acrydine orange method. The growth of T47D was inhibited by treatment with PANE on concentrations 20; 40; dan 80 µg/mL. The cell death (apoptosis) induced by PANE was characterized by orange fluorescent on the IC50 concentration. These results concluded that the n-hexane extract of Plectranthus amboinicus, (Lour.) Spreng. inhibited the growth of T47D breast cancer cells in dose and time dependent manners. PANE also could induced apoptosis on T47D breast cancer cells, but the combination of PANE-doxorubicine did not show the synergistic effect. The results suggesting that PANE may be a potent agent for the chemoprevention of breast cancer.
Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats Simanjuntak, Nerly Juli Pranita; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4303

Abstract

Traditionally pirdot leaves are used to treat various diseases. The purpose of this study was to determine determine the potential for acute toxicity of ethanolic extract of pirdot leaf (Saurauia vulcani Korth.) with value LD50 and hematological Parameters in rats. The acute toxicity of ethanolic extract of pirdot leaf was evaluated by OECD guidelines. The number of animals used in this research were 15 female rats. The control group was given Na CMC 0.5%, the treatment groups were given ethanolic extract of pirdot leaves with doses 2000 and 5000 mg/kg bw. The results showed that ethanolic extract of pirdot leaves with doses of 2000 and 5000 mg/kg bw did not show any toxicity signs. There was no mortality was observe. The ethanolic extract of pirdot leaves did not cause any changes in hematological parameters, these include red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet, white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils levels as compared to normal control (P>0.05). It was estimated that LD50 of ethanolic extract of pirdot leaves was higher than 5000 mg/kg bw and the extract were practically non-toxic. The ethanolic extract of pirdot leaves did not cause any toxic effect on hematological parameters.
Immunomodulator Activity of Puguntano (Picria fel-terrae Lour.) Extract in White Male Mice By Carbon Clearance Method Rezza Fikrih Utama; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4306

Abstract

Poguntano Herb Plants (Picria fel-terrae Lour.) contains flavonoids compounds that have been potentially to developed into immunomodulators. The purpose of this study was to determine the immunomodulatory activity of Poguntano herb extract (Picria fel-terrae Lour.), with the method of carbon clearance. n-hexane extract puguntano herb(ENHHP), extract of ethyl acetate of Poguntano herb (EEAHP), and ethanol extract of puguntano herb(EEHP) Poguntano multistage results in the test of immunomodulatory activity with a method of carbon clearance. Results showed that the EEHP 200 mg/kg BB showed a strong immunostimulation effect, EEAHP 200 mg/kg BB showed strong immunostimulation effect, ENHP 200 mg/kg BB demonstrated strong immunostimulation effect. It is thought that extract N-hexane herb Poguntano (ENHHP), extracts of ethyl herb acetate Poguntano (EEAHP), and herb ethanol extract Poguntano (EEHP) Poguntano herb may increase phagocytosis activity. Extract of ethyl acetate Poguntano herb 200 mg/kg bw (EEAHP) has the best phagocytosis activity with a value of 2.376 which indicates there is a significant difference (P < 0.05) with another treatment group.
Poguntano Herba Extract Immunostimulant Activities (Picriafel-terraeLour). in Immunosupression Rats Infected by Staphylococcus aureus Against Total Leukocytes and Differential Leukocytes Ningtias, Anggitha; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5378

Abstract

Poguntano (Picriafel-terraeLour.) is a medicinal plant in North Sumatra that has been used in traditional medicine to treat degenerative diseases.Poguntano extract contains flavonoid compounds that have the potential to be developed into immunomodulators. This study showed the immunostimulant activity of poguntano herb n-hexane extract (PHNHE), poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) in immunosuppressed rats infected with Staphylococcus aureus. The evidence of poguntano herb as an immunomodulator was carried out by testing total leukocytes and differential leukocytes. Poguntano herb n-hexane extract (PHNHE) can not increase the total and differential leukocytes; Poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) can increase the total and differential leukocytes in immunosuppressed rats induced by Staphylococcus aureus.
The Lipid Profile and Aorta Histopathology On Hyperlipidemic Rat by Saurauia vulcani Korth. Leaves Extract Octora, Debi Dinha; Rosidah; Silalahi, Jansen; Satria, Denny
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.6521

Abstract

Abstract. Dyslipidemia is a pathological condition characterized by increased levels of total cholesterol, triglycerides and LDL and decreased levels of HDL. Dyslipidemia causes cardiovascular disease risk factors by increasing cholesterol levels, increasing triglyceride levels, lowering HDL levels, and increasing LDL levels, as well as decreasing the proliferation of cardiac aortic cells in dyslipidemic rats. The pirdot plant (Saurauia vulcani Korth.) has long been known by the Simalungun, Toba and Karo communities to have the potential to treat various diseases caused by disruption of lipid processes in the body. Pirdot leaves contain bioactive compounds of flavonoids, tannins and saponins that have the potential to improve lipid profiles and prevent cardiovascular disease. This study aims to determine the activity of EEDP on the lipid profile of dyslipidemic rats. Pirdot leaf simplicia powder was extracted by maceration with 96% ethanol solvent and the extract was used on 30 dyslipidemic rats which were divided into 6 groups. Group 1 (Na-CMC), group 2 (Atorvastatin), group 3, 4, 5, 6 EEDP doses of 50, 100, 200, 400 mg/kg BW were administered orally for 21 days. At the end of the treatment, the levels of total cholesterol (TC) and aortic cell proliferation were measured. The results showed that Saurauia vulcani Korth had water content (6.23%), water soluble extract (10.50%), simplicia content soluble in ethanol (14.77%), total ash content (7.05%) and acid insoluble ash content (0.48%). From the antidyslipidemic study it was shown that EEDP 400 mg/kg BW improved blood lipand to increase aortic cell proliferation dyslipidemic rats was 69.84±0.27. Based on the explanation above, it is concluded that EEDP has an antidyslipidemic effect.
Co-Authors Abdul Halik Abdul Rahman Adi Suhendra, Adi Aditama Agustian Affan Solihin Afriyanni Agus Rahmanto Agus Waluyo Ahmad Dwi Priyatno Ahmad Fatoni Ahmad Talib Ainun, Rezki Awalia Akhmad Affandi Akis, Dwi Ihza Sari Akmal Hidayat Aldi Musthofainal Ahyar Aldiano Rahmadya Ali Harokan Alifa Alimuddin Amiruddin Anaguna, Nursyam Andi Baso Kaswar Andi Baso Kaswar Andi Dio Nurul Awalia Andi Rhyta Samantha Valda Andika Isma Andina Ainayah Naim Annajmi Rauf Annesya Atma Battya Annisa Indah Pratiwi Aprisal Arie Wahyudi Arieb Shintami, Rica Arsyad, Meisaraswaty Asham Bin Jamaluddin Asis Nojeng asmaun, asmaun Asri Ismail Asriadi Asriwan Ayu Afika Catur Wibowo Budi Santoso, Catur Wibowo Budi Corry Vidiati Darwis, Aida Fadhilla Dary Mochamad Rifqie Della Fadhilatunisa Denalis Rohaningsih Denny Satria, Denny Desi Arianti Devi Miftahul Jannah Devina Dewi Fatmarani Surianto Elma Nurjannah Eny Setyaningsih, Eny Erlisya Puspandhani, Mitha Esa Negarawati Fadhil Zil Ikram Fadiyah Putri Nur Habibah Fajar Arwadi Farihah, Nailil Fika Alimna FItria Arifiyanti Guillermo Bautista Hadi Purnomo Hamda Hanifah Nurus Sopiany Hardiansyah Harefa, Herman Yaarozatulo Hasibuan, Poppy Anjelisa Zaitun Herie Saksono, Herie Hisyam Ihsan Hodijatussolihah Ilham Minggi Ilyas , Syafruddin Imam Radianto Anwar Setia Putra, Imam Radianto Anwar Setia Indah Sari Irwan Irwansyah Suwahyu Israwati Hamsar Jansen Silalahi Kunnati M. Miftach Fakhri Mahatma Kresnha Radityo Manoby, Worry Mambusy Margareta Rahayuningsih Mazidan, A.M Yusran Melati, Irma Miratul Maghfiroh Muh Galang Nusantara Muhalim Muhammad Arafah Alif Muhammad Dwi Andika Muhammad Fajar B Muhammad Fajar B Muhammad Fardan Muhammad Fikri Aqil Muhammad Takwin Machmud Munib Musaytir Husain Nabila Janan Nasrullah Nasution , Pandapotan Nia Asdina Ningtias, Anggitha Norma Rizki Silviana Novitasari, Anik Eko Nur Fadhylah As Nur Ilmi Nur Rahayu Utami Nur Rahmah Sari Nur Syafitra Ramadhani Nurhalimah Ramadhani Nurjannah Nurmasitoh Nurrahmah Agusnaya Nursyam Anaguna Nursyam Anaguna Nurul Setiadewi Nurwati Djam’an Nuryani, Yuni Ocsirendi Octora, Debi Dinha Olivia, Alya Parida Marjuliana Perez, Liann Camille Davalos Pipit Yuliarpan Pradika, Rizka Ardhi Pranasari, Melati Ayuning Pratama, Muh Idul Akbar Purwadi Putri Fariza Putri Nirmala Rafiqah Ameliah Kasim Rasyid, Aliy Relita Novianti Rezza Fikrih Utama Riky Kurniawan Rina Ari Pratiwi Rismayanti rita apriliani Rita Hernawati Rizky Aulia Roffi Grandiosa Roffi Grandiosa Herman Sabri Setialaksana, Wirawan - Shera Afidatunisa Silvia Syavira Simanjuntak, Nerly Juli Pranita Siti Aisyah Siti Fatimah Azzahra Namar SITI KHODIJAH Siti Nurmar Laela Sofyan, Vina Annisa Sri Mulyani Sri Yuyun Suci Emilia Fitri Suci Hayati Sudarmanto Jayanegara Sugiarti Surojo Sutanto, Hari Prasetyo SUWARTI Syafirah Audiwinanda Syukur, Pramudya Asoka Talib, Dr. Ahmad Tasya Alifia Tini Apriani, Tini Usman Mulbar WAHYUDI Wahyuniar Pamungkas Walim Lili Widyawati Wiradirja, Hj. Imas Rosidawati Yaarozatulo Harefa, Herman Yanto Lesmana Yantoro Yohana Rara Yuandani Yuanita B Yudhi Alfian Zul Jalali Wal Ikram