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- Fakhrurrazi
Universitas Malikussaleh Lhokseumawe Aceh, Indonesia 24314
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Journal : Narra J

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Characterization of red algae (Gracilaria verrucosa) on potential application for topical treatment of oral mucosa wounds in Rattus norvegicus Hakim, Rachmi F.; Idroes, Rinaldi; Hanafiah, Olivia A.; Ginting, Binawati; Kemala, Pati; Fakhrurrazi, Fakhrurrazi; Putra, Noviandi I.; Shafira, Ghina A.; Romadhoni, Yenni; Destiana, Khaerunisa; Muslem, Muslem
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.422

Abstract

Wound healing in the mouth has its challenges due to masticatory movements and the presence of bacteria that can inhibit its process. The aim of this study was to analyze the contents of red algae (Gracilaria verrucosa) from Indonesia, and its potential as a wound-healing agent for oral wounds using animal model. Red algae content was determined by phytochemical tests and gas chromatography-mass spectroscopy (GC-MS). The wound was made by making an incision on the gingival mucosa of Rattus norvegicus and the parameters assessed were bleeding time, number of fibroblast cells, and time of wound closure. Three doses of G. verrucosa gel were used (2.5%, 5%, and 10%) and the gels were applied twice a day, at 6:00 and 18:00. Application was carried out topically by applying 0.1 ml of gel to the incision wound using a 1 mL syringe. Our phytochemical test indicated that the G. verrucosa contained alkaloids, steroids, flavonoids, and phenols. The dominant contains of the G. verrucosa were glycerol (36.81%), hexadecenoic acid (20.74%), and cholesterol (7.4%). The hemostasis test showed that the 2.5% G. verrucosa extract gel had the shortest bleeding time, 33.98±5.33 seconds. On the seventh day of the initial proliferation phase, the number of fibroblasts was not significantly different among groups. On day 14, the number of fibroblasts was only significantly different between 10% G. verrucosa and untreated group (p=0.007). On day 28, however, both 5% and 10% G. verrucosa were significantly higher compared to untreated group, both had p=0.010. Daily clinical examination showed that animals that were given 2.5% and 5% of G. verrucosa extract gel experienced wound closure on day 10. Animals treated with 10% of extract gel, all wounds healed on day 9. This study suggested that G. verrucosa extract could accelerate wound closure and wound healing.
Co-Authors AA Sudharmawan, AA Abd. Rasyid Syamsuri Abdul Khaliq Abidin Nurdin Abu Bakar, Muhammad Bin Ade Luky Setiawan Adriani Muhlis, Adriani Al-Qadar, Al-Qadar - Alfi Reza, Muhammad Almukarramah, Almukarramah Amelia, Irza Amin, Syarkawi M Amiruddin Amiruddin Amiruddin Ketaren Anak Agung Istri Sri Wiadnyani Ananda, Raidha Putri Andi Miswar, Andi Andini, Yulia Rizky Anggeriyani, Desy Anggreini, Sevtia Husna Anita Anita Arif Rahman Asma Mauli Arpika Aulia, Faizul Awaludin Arifin Azizi, Wita Dwi Azli, Muhammad Baidhawi Baidhawi Bakti, Indra Setia Bardan, Fadhilah Binawati Ginting Boihaki Boihaki Budi Bahreisy CUT ITALINA Cut Rizka Al Usrah Destiana, Khaerunisa EDI YUSUF, EDI Effendie, Faryanto Erina Erina Erwin Erwin Ery Jayanti, Ery Fadhil, Rahmat Fajri M. Kasim, Fajri M. Fathiah Fathiah Fitriani Hayati, Fitriani Fuadi Fuadi Ginting, Ledy Mahara Habib, Muhammad Alhada Fuadilah Haikal Ananda, Muhammad Hakim, Rachmi F. Halim, Hendra Halimatus Sakdiah, Halimatus Hamdani Budiman Hanafiah, Olivia A. Hasan Basri Hasanah, Zainatul Helmi, T. Zahrial Hendra Jaya Herliyani Farial Agoes, Herliyani Farial Hesti Rahayu Hidatullah, Taufiqi Hilda, Rauzana HM, M. Amir Humaira, Suci I Gusti Ngurah Antaryama Ilham, Iromi Ilmi, Rauzatul In-In Hanidah Indra P, I Made Indra Setia Bakti Iqbal , Rahmat Iriansyah, Andri Isa Indrawan, Muhammad Ismayli, Ismayli Jannah, Rauzatul Kemala, Pati Kesuma, T. Meldi Khairul Amin Khairulyadi, Khairulyadi Kurniadi Kurniadi, Kurniadi Lismarita, Lismarita Lubis, Arbonas Luh Putu Ratna Sundari M Daud AK M Nur M. Danil M. Jalaluddin, M. M. Nazaruddin, M. Maghfirah, Lailatul Mahdi Abrar Mahrizal Mahrizal Mahyuna, Mahyuna Maisarah Maisarah Maliati, Nulwita Maryulia Dewi Masda Admi Maya Ulfa Meliza, Richa Miranda, Lola Almira Muchlis Muchlis Muchlis Muchlis Muhajir Muhajir, Muhajir Muhammad Arif Muhammad Muhammad MUHAMMAD RIZAL Mukhtar, Makmunzir Munawwaroh Kurniawati, Munawwaroh Muslem Muslem, Muslem Muslim Zainuddin Mutammimul Ula Nabila, Adinda Syah Nafisi, Aura Najla, Najla Naufal Bachri, Naufal Ngarifah, Imroatul Ningsi, Risti Ayu Nirzalin Nisya, Alivia Nur Hafni Nur, M Nuraini Nuraini NURLIANA NURLIANA Nuzul Asmilia Prayogi, Muhammad Yudhi Putra, Noviandi I. R, Abd Rahman R. Rusli Rachman, salwa salsabila Rachmi Fanani Hakim Rachmi Fanani Hakim, Rachmi Fanani Rahimi, Sayyid Afdhal El Ramadhani, Evi Rambe, Saparuddin Rangkuty, Rakhmadsyah Putra Rasyidin Rasyidin Razali, Saidaturrahmah Reghina, Ayu Anisah Rianda, Teguh Rinaldi Idroes Rizki Yunanda Romadhoni, Yenni Rosa, T Shaddiq Rosdiana Rosdiana RR. Ella Evrita Hestiandari Saifuddin Saifuddin Sajidan Sajidan Salahuddin Salahuddin Salman Abdul Muthalib Saptari, Mochamad Ari Saputri, Maya Sari, Meutia Setiawati, Cut lilis Shafira, Ghina A. Siregar, M. Ridha Siti Aisyah Sri Wahyuni Suadi Suadi Suadi Zainal Sugito - Suweleh, Yasser Zein Syamsul Syamsul Syamsuwir Syamsuwir T. Fadrial Karmil Tarmizi M. Jakfar Tutiliana, Tutiliana Veri Ilhadi Wasilah, Nur Welni, Trisia Yunus, Saifuddin Yusnidar, Cut Yusnisar, Cut Yusra, Yusra Yusuf Maulana, Yusuf Yusuf, Bukhari Zahratul Fitri, Zahratul Zahrina, Zahrina Zainal Abidin Zainuddin, Yusran Zamzami, Fatimah Sahara Zikran, Ghrina Zul Akli Zuyudi, Muhammad