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Ratih Puspita Febrinasari
Faculty of Medicine, University of Sebelas Maret
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Caesalpinia bonduc (L) Roxb Seed Extract Dosage and Sex Effects on Pathobiological Changes in A Rat Model of Diabetes Mellitus Sopianti, Densi Selpia; Doewes, Muchsin; Sumandjar, Tatar; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita; Nurwati, Ida
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.349

Abstract

Caesalpinia bonduc (L) Roxb is a medicinal plant commonly utilized in traditional Indonesian medicine, particularly for the treatment of diabetes mellitus (DM). This study examined the effects of varying doses C. bonduc extract on fasting blood sugar (FBS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and pancreatic histology in male and female wistar rats with diabetes. The study design included six groups of 18 male and female rats (Wistar strain) each. To develop diabetes, nicotinamide (NA) (110 mg/kg) and streptozotocin (STZ) (45 mg/kg) were supplied, followed by oral administration of C. bonduc extract at dosages of 200, 400, and 600 mg/kg for 21 days. We utilized ELISA to analyze biochemical parameters and employed H&E staining to evaluate histological changes. A factorial design was employed for the statistical analysis to examine the effects of both dosage and sex. This study offers a unique comparative examination of the antidiabetic efficacy of C. bonduc across genders, a dimension seldom explored in experimental diabetes research. The findings indicated that C. bonduc markedly reduced levels of FBS, MDA, TNF-α, and TGF-β (p < 0.05) enhanced the structural integrity of the pancreas. There were no significant differences between males and female (p > 0.05). The dosage and sex influenced MDA and TGF-β. The extract of C. bonduc shown the ability to lower blood sugar, fight free radicals, and reduce inflammation; however, the intensity of these benefits depended on the dosage given. This means that it might assist persons with diabetes minimize oxidative stress and damage to the pancreas.
Co-Authors . Suyatmi . Widardo A.A. Ketut Agung Cahyawan W Adi Magna Patriadi Nuhriawangsa Ahmad Ahid Mudayana Akhmad Azmiardi Alfi Yasmina Ali, Agni Shalha Anshari, Shafira Yasmine Asaduddin, Aiman Hilmi Asih Anggraini Bachnas, Muhammad Adrianes Binti Maulina Brian Wasita Bustami, Mursyid Colti Sistiarani Dara, Rizki Wulan Dedi Febriandaru DIAN LESTARI Didik Gunawan Tamtomo Dilma’aarij, Dilma’aarij Dyonisa Nasirochmi Pakha Erna Kristin Ernawati, Dwi Arini Eti Poncorini Pamungkasari Hamka, Dwi Wulandari Aaas Hanif Mustikasari Harioputro, Dhani Redhono Hariyanti, Lusiana Pradana Haruni, Diah Sekar Ida Nurwati Imanisa, Octavia Intan Indarta, Ardhia Fefrine Kristiani, Shinta Laksmi Wardhani, Tri Martya Ningrum Lilik Wijayanti Lisyawati, Shanti MIFTAKHUL JANNAH Muchsin Doewes Mustara, Mustara Mustiqa Febriniata Nafi'ah, Radifatun Nita Dwi Astikasari Nur Hafidha Hikmayani Nur Hasanah, Laras Eka Oktaviani oktaviani Paramasari Dirgahayu Rahardjo, Setyo Sri Rio Nanda Pratama Riris Arizka Wahyu Kumala, Riris Arizka Wahyu Rizaldy Pinzon RR. Ella Evrita Hestiandari Satwika, Ariq Ratya Setyani, Rizka Ayu Shinta Shinta Solikah, Tri Agusti Sopianti, Densi Selpia Sri Darnoto Sri Mulyani Sumandjar, Tatar Sumardiyono Susanto, Agnes Syamsiar, Syamsiar Vitri Widyaningsih Widardo . Windayani, Komang Yanuarini, Triatmi Andri Yulia Lanti Retno Dewi