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All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Mathematical and Fundamental Sciences Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JPSCR : Journal of Pharmaceutical Science and Clinical Research FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Mandala Education (JIME) Jurnal Farmasi Indonesia JISIP: Jurnal Ilmu Sosial dan Pendidikan JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia ADI Journal on Recent Innovation (AJRI) Health Information : Jurnal Penelitian Science Midwifery Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Katalisator Majalah Cendekia Mengabdi Journal of Pharmaceutical and Sciences. Journal of Health Management and Pharmacy Exploration (JOHMPE) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pharma Bhakta International Journal of Contemporary Sciences (IJCS)
Gunawan Pamudji Widodo
Universitas Setia Budi
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Journal : Science Midwifery

 1 
Efectiveness of kenitu leaf extract (chyrysophyllum cainito l.) on bone density and histopathology osteoblast-osteoklast in female mice Pare, Nurdiana Tandi; Widodo, Gunawan Pamudji; Iswandi, Iswandi
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1950

Abstract

Osteoporosis is a systemic bone disease characterized by a decrease in bone density and deterioration of bone microarchitecture so that bones become brittle and break easily. Osteoporosis due to long-term use of glucocorticoids causes osteoporosis. There is a lot of clinical evidence about the role of phytoestrogens in the treatment of osteoporosis. Kenitu (Chrysophyllum cainito) contains isoflavone phytoestrogen compounds. The aim of this research was to determine the anti-osteoporosis effect of ethanol extract of kenitu leaves (Chrysophyllum cainito L.), by looking at the increase in bone density as well as the number of osteoblast cells and the number of osteoclast cells in the femur trabecular bone of female mice induced by dexamethasone. In this study, 49 female mice were grouped into 7 groups, namely normal control, negative control, positive control with cabone naturindo, and groups treated using 70% ethanol extract of kenitu leaves with varying doses of 100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW and 800 mg/kg BW. An increase in femur trabecular bone density, the number of osteoblast cells and the number of osteoclast cells were observed using the Histomorphometry method. The results showed that the ethanol extract of kenitu leaves has anti-osteoporosis activity. The ethanol extract of kenitu leaves has a dose of 400 mg/kg BW which is the optimal dose as anti-osteoporosis which is indicated by an increase in bone density, an increase in the number of osteoblast cells and a decrease in the number of osteoclast cells.
Evaluation of the drug management system at the pharmaceutical supplies installation of the Tegal City Health service in 2019 Wibawa, Anggun Setya; Widodo, Gunawan Pamudji; Iswandi, Iswandi
Science Midwifery Vol 13 No 4 (2025): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i4.2096

Abstract

Drug management involves a series of interconnected activities, including planning, procurement, receipt, storage, distribution, control, recording, reporting, disposal, monitoring, and evaluation. This study aimed to evaluate the drug management system, identify challenges and solutions, and assess its compliance with the 2010 Ministry of Health standards at the Pharmaceutical Supply Installation of the Tegal City Health Office. A descriptive design was used, with retrospective data collected from 2019 documents. Primary data were obtained through direct observation and in-depth interviews to identify obstacles, while secondary data were sourced from drug management records based on ten indicators and compared with the 2010 standards. The results revealed several discrepancies: in the planning stage, drug conformity with the Fornas Level I reached 92.54% and planning accuracy was 184.22%; in procurement, drug availability was 92.04%, generic drugs 88.97%, and budget allocation 98.14%. Storage met standards, with 0% expired or damaged drugs. In distribution, the proportion of drugs in the safe category was 46.27% and average stock-out duration was 27.40%, while distribution accuracy reached 100%. Key challenges include the presence of non-Fornas drugs, disruptions in the e-logistics reporting system, and procurement delays due to an underdeveloped e-catalogue system. Recommended solutions include regular training for drug management staff, improved coordination with the TPOT team based on clinical and pharmacoeconomic considerations, and the addition of pharmacist personnel.
Co-Authors Abdul Mahmud Yumassik abdul rofiq Achmad Fudholi Achmad Fudholi Ade Sukma Hamdani Adrianto, Madyo Agnes Christina Budiwati Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Andayani, Tri Murti Aneng Ardiya Sukmawanti Anggun Setya Wibawa, Anggun Setya Arief Nurrochmad arikha ayu susilowati Arisma Nuri Pebryana Aslam, Astri Asri Laksmi Riani Asri Laksmi Riani Astri Aslam Aswandi Aswandi Ayu Wulandari Ayudia Cipta Khairani BETA K. PRAMUDYAWARDHANI Chairun Wiedyaningsih Chandra Arifin Clara Ritawany Sinaga Dan Mona Aprilia Daniel Maharai Daniel Maharai Dedent Eka Bimmaharyanto.s Dewi, Lucia VIta Inandha Dian Marlina Dini Okyaviani Dwi Ningsih Eko Yudha Prasetyo Elin Yulinah Sukandar Elina Endang Sulistyowati Endang Diyah Endang Diyah Endang Dyah Ikasari endey, joverly Ercis Ercis Ercis, Ercis Fauziyyah Al Hasanah Fendy Prasetyawan FEOLISTIN MIENCE POBAS Ferdinan Jalung Ferdinan Jalung Fitrianingsih, Sri Fridly Manawan Gunawan Firmansyah Gusti Ayu Rai Saputri Handayani, Sri Rejeki Handi Mukti Fahrizal Handi Mukti Fahrizal Haris Maspekeh Hartih, Nur Aeni Hartono Hartono Hasbrianti, Armayanti Rindiarko Hastuti, Nita Hasty Martha Wijaya Hierowat, Rina Humaidah, Daffa I Ketut Adnyana Ika Purwidyaningrum INDRAWATI FITRIANA Irmatika Hendriyani Islamiati , Utami Ismi Rahmawati Isna Nur Khasanah Iswandi Iswandi Iswandi Iswandi Ittiqo, Dzun Haryadi Iwan Yuwindry Jason Merari Peranginangin Junagsti Bermalam Kartini Nur Wulandari Latief, Aprilianti A. Lestari, Rizkia Putri Madyo Adrianto Madyo Adrianto Mamik Ponco Rahayu MARIA E.D.O. HUREK MAKING MARIA YANGSYE LENGGU Marlina, Dian Milda Rianty Lakoan Milda Rianty Lakoan Muhamad Aulia Putra Tawakal Muhammad Syukri Mukti, Yusuf Anggoro Naha Ndjurumbaha, Echa Malinda Noval Noval Noval Noval Nugroho , Agung Endro Nugroho Wisnu Putro Nur Aeni Hartih Nuraini Harmastuti Nuraini Harmastuti NURAINI HARMASTUTI Oetari Oetari Oetari Oetari Pare, Nurdiana Tandi Poppy Dwi Citra Jaluri Puspitasari, Ismi R, Herowati R., Wirdah Wati R.A. Oetari R.A. Oetari R.A. Oetari, R.A. Rahmadani . Rahmawati, Ismi Ranowijaya Ranowijaya Recky Patala Rika Arfiana Safitri Rosa Juwita Hesturini Ruly Anggrayni Safwan Safwan, Safwan Santi Dwi Astuti Satibi Satibi . Satibi Satibi Satibi Satibi Satibi Satibi Siswanto, Didik Sri Fitrianingsih Srini, Dwi Sukrasno Sukrasno Suryono Suryono Teodhora, Teodhora Teuku Nanda Saifullah Sulaiman Theedens, Maria Theodora Toding, Ficanata Adhiguna Tri Murti Andayani Tri Murti Andayani Tri Wijayanti Valiandri Puspadina Wahdah, Rismaul Wahid, Abdul Rahman Widayatul Khairi Widia Wati Widyasti, Jena Hayu Windi Astuti Wirdah Wati R. Yeli Trimayanti Yul Mariyah Yuwindry, Iwan Zamzani, Irfan