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Journal : Pharmacoscript

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DEVELOPMENT AND EVALUATION OF PEPEROMIA PELLUCIDA L. PEEL-OFF GEL MASK AS ANTI-ACNE AGENT Indra, Indra; Yadi Aditya, Prawira; Fajar, Setiawan
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.1981

Abstract

This study investigates the development of a peel-off gel mask formulated with Peperomia pellucida L. extract as a natural treatment for acne. Peperomia pellucida L., traditionally valued for its medicinal properties, was characterized microscopically and macroscopically to confirm the plant’s identity and quality. Ethanol extraction yielded 16.54% bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, known for their antibacterial and anti-inflammatory activities. The research utilized a concentration-dependent approach, formulating three gel variants with 5% (F1), 10% (F2), and 15% (F3) extract concentrations. Antibacterial testing against Propionibacterium acnes showed that F3 exhibited the largest inhibition zone (10.72 mm), significantly outperforming the positive control (4.6 mm). Stability testing revealed that the formulations maintained consistent color, odor, and pH but faced challenges in viscosity and homogeneity at extreme temperatures. Hedonic testing indicated that participants favored F2 (10% extract) for its balanced aroma, color, and ease of application, although F1 and F3 were preferred for texture. Despite stability challenges, the formulations, mainly F3, demonstrated promising antibacterial efficacy. In conclusion, the peel-off gel mask containing Peperomia pellucida L. extract (F3) shows significant potential as a natural alternative to synthetic acne treatments. Further refinement is needed to enhance stability and user experience while maintaining its high antibacterial activity. study explores the development of a peel-off gel mask formulated with Peperomia pellucida L. extract for acne treatment. Peperomia pellucida L., traditionally known for its medicinal properties, was characterized microscopically and macroscopically, confirming the plant’s identity and quality. The ethanol extraction process yielded 16.54% of bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, known for their antibacterial and anti-inflammatory properties. Phytochemical screening confirmed these compounds’ presence, and antibacterial testing against Propionibacterium acnes revealed concentration-dependent inhibition, with the highest inhibition zone observed in the 15% extract formulation (F3). The gel formulations were evaluated for physical properties, stability, and user acceptance. Stability testing demonstrated consistency in colour, odour, and pH but revealed challenges in inhomogeneity and viscosity at extreme temperatures. Despite these issues, the formulations maintained antibacterial efficacy, mainly F3. Hedonic testing showed that participants favored F2 (10% extract) for its balanced aroma, color, and ease of application, although F1 and F3 were preferred for texture. In conclusion, the peel-off gel mask containing Peperomia pellucida L. shows significant potential as a natural, effective treatment for acne. However, further refinement is needed to optimize stability and user-friendliness while maintaining high antibacterial efficacy. These findings suggest that the extract could be a valuable addition to topical acne treatments, offering a natural alternative to synthetic products
Co-Authors Aam Slamet Rusydiana, Aam Slamet Abdul Mughni Afifah, Kuni Agus Priyono Agus Umar Hamdani Agustina, Adinda Agustinawati, Dwi Al Rasyidin Alexius Ulan Bani Alfiyanti, Dwi Ali, Ramsah Ali, Zulkarnain Muhammad Amna Emda Anak Agung Istri Sri Wiadnyani Andi Bungawati, Andi Andi Rosman N Andrilolo, Andrilolo Andy Arya Maulana Wijaya Anita Priantina Annisa Agelina, Annisa Ardhina, Aried Ariani Trisna Murti, Ariani Trisna Arifin, Dadang Arip Rahman Arnianti Arnianti Asia Arifin asih, yekti purwo Aufa, Aufa Aulia Puspa Ayu Aulia Rahman Auliansyah, Auliansyah Avedta, Sherrindra Azzahro, Siti Fatimah Bernadus Gunawan Sudarsono Bravo, Bram Budiono, Rachmat Chaliluddin, Makwiyah A. Darmawan Darmawan Depari, Genesis Sembiring Dewi, Trihoni Nalesti Dewi, Yasdiafiani Dhanny Cahyadi, Dhanny Diah Supatmiwati Dito Anurogo, Dito Dumar, Bergita Efin Shu Elvi Juliansyah Jamari Endang Silaningsih Eni Kurniati, Eni Ernawati Ernawati Erni Yuningsih Ervien Ervien, Ervien Erwin Purwanto Fajar, Setiawan Falihin, Dalilul Fatany, Alief Ihram Fatimah, Tri Firnanda, Teguh Fissilmi, Annisa Fitri Wijayanti Fitriya, Fitriya Gaffar, Emmilya Umma Aziza Gagal Rencana, Feri Susilo Habiba, Syahrir Hadidtyo Wisnu Wardani Hamdan Hamdan Harda Armayanto Hasmina Tari Mokui Hasni, Mutiara Hilda Hastuti Hudiarto Hudiarto, Hudiarto Hunowu, Sri Yulian Hussin, Mohd Fauzi bin Abu Ichsan Setiawan Ihsan, Fahrun Ilahi, Vitratul Imaduddin, Imaduddin Indra Indra Indrawan, Mohamad Gita Insani, Risna Nurul Iqram, Muh. Isnaini, Nadia Jumardi Budiman Kamal, Kamal Kamarubayana, Legowo Karimah, Diva Azka Khoe Yao Tung Kurniaty, Dwi La Taena, La Lis Suryadi, Lis Luqyan Tamanni, Luqyan Maria Ulfa Martono Martono Maryadi Masyitha Wahid Maula, Rizka Meti Kusmiati, Meti Mia Sari, Mia MUFTI MUFTI, MUFTI Muh. Darwis Muhammad Hanif Muhammad Ilham Muhammad Rusdi Muhammad Yusuf Ibrahim Muis, Nurmuliayanti Mukhram, Muhammad Muliati Muliati, Muliati Murdani, Agus Murdia, Agus Miranda Mustarum Musaruddin Mutia Alif Cahyani Nadrun, Nadrun Naniwarsih, Andi Nashr Akbar, Nashr Nasrun, Muhammad Syaifuddin Nasution, Nurwinda Aulia Nazarudin Novita Anggraeni Noyumala, Noyumala Nur, Nahya Nuralamsah Zulkarnaim Nurmalasari, Novianti NURUL HIDAYAH Nurul Inayah Nurunnasikin, Nurunnasikin Nurwati Nurwati Oslan Jumadi Pamuncak, Mohammad Bintang Prajaputra, Vicky Pramono, Sigid Eko Pratiwi, Asty Eka Putri, Isra Mulia Putri, Tiara Resta Rabiatul Adawiyah Rachmad, Dedy Rafiqa, Syarifa Rahagia, Rasi Rahmah, Aziza Ramadan Ramadan Ramadhan Sitepu, Yuda Mulia Rian Adrian Riski, Cantika D. Risno, Risno Rizaldi, Agung Rizki, Akang Abdika Robin Robin, Robin Rosul, Mekar Bunga Allamanda Sahputra, Roza Samsinar Samsinar Sartika , Sartika Sartika Sartika Sartika, Sartika Satifa, Siti Annisa Satria, Akbar Dimas Sinaga, Sopian Siti Rahma Sawalia Nabila Sufriadi, Elly Sukendi, Agis Maulana Sukiman Sukiman Sulasti, Sulasti - Sulindrina, Andra Sumarno . Suntoro, Adib Fattah SUSENO, JOKO Sutarman Sutarman Suyatna, Riki Gana Syahputra Nasution, Kurnia Syaiful Bachri Syaiful Bachri Syaifullah Muhammad Syamsidah, Syamsidah Syarifah Balkis, Syarifah Taufieq, Nur Anny S. Tirkaamiana, Muhammad Taufan Triyani, Anggi Udin Rinaldi Vivi Adriana Wibisono, Chabulullah Wibowo, Daniel Budi Wibowo, Herry Widyaningsih, Atria Tiffany Wirman, Wirman Wisandra, Ade Yadi Aditya, Prawira Yanti Mustarin Yesi Aprianti Yuana yuana, Yuana Yudi Santoso, Yudi Yulia, Yulfa Zaerofi, Afif zainuddin Abdussamad Zainuddin, Zainuddin ZUHRONI, ZUHRONI Zulfadli, Muhammad