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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine Sport and Fitness Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia Majalah Obat Tradisional MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Epidemiologi Kesehatan Komunitas Indonesian Journal for Health Sciences (IJHS) ISM (Intisari Sains Medis) : Jurnal Kedokteran INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Interdental Jurnal Kedokteran Gigi (IJKG) Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Clinical and Cultural Psychiatry Jurnal Health Sains Jurnal Kepelatihan Olahraga Open Access Indonesian Journal of Medical Reviews Jurnal Pengabdian kepada Masyarakat Wahana Usada Medika Respati : Jurnal Ilmiah Kesehatan Journal of Global Pharma Technology Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Jurnal Penyakit Dalam Indonesia Paradharma: Jurnal Aplikasi IPTEK Gema Kesehatan Physical Therapy Journal of Indonesia Kinesiology and Physiotherapy Comprehensive Bali Dermatology Venereology and Aesthetic Journal Biosaintifika: Journal of Biology & Biology Education Indonesian Journal of Pharmacology and Therapy
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Pendampingan Herbal Dan Pelatihan Senam Jantung Untuk Lansia di Desa Celuk, Sukawati, Gianyar Widhiantara, I Gede; Rosiana, I Wayan; Wiradana, Putu Angga; Sandhika, I Made Gde Sudyadnyana; Permadi, Agung Wahyu; Jawi, I Made
Paradharma: Jurnal Aplikasi IPTEK Vol. 6 No. 2 (2022): Paradharma: Jurnal Aplikasi IPTEK
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Dhyana Pura – Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (566.522 KB) | DOI: 10.36002/jpd.v6i2.2395

Abstract

ABSTRAKPopulasi penduduk lansia di Desa Celuk, Sukawati, Gianyar, cukup tinggi dengan rata-rata 200 orang di tiap banjar. Sebagian besar lansia menderita keluhan hipertensi yang merupakan faktor resiko penyakit jantung dan stroke. Hasil wawancara dengan beberapa penduduk Desa Celuk bahwa masyarakat lokal secara empiris masih mempertahankan tradisi pemanfaatan herbal untuk mencegah ataupun mengobati penyakit namun kurang memahami cara pengolahan, dosis dan manfaat yang tepat. Program pengadian ini dilaksanakan selama 5 bulan di Desa Adat Celuk, Sukawati Gianyar. Tujuan dari program ini yaitu mengedukasi manfaat tanaman herbal untuk pencegahan dan terapi keluhan kesehatan lansia, melatih mengolah minuman herbal yang higienis, tepat dosis, meningkatkan kesehatan fisik lansia melalui kombinasi minuman herbal dan aktifitas fisik melalui latihan senam jantung. Metode yang diterapkan pada kegiatan ini berupa pendampingan dan pelatihan. Target dan luaran dari program pengabdian ini adalah meningkatkan pengetahuan dan keterampilan lansia dalam mengolah minuman herbal dan meningkatkan kesehatan fisik lansia melalui latihan senam jantung. Hasil kegiatan terjadi peningkatan pemahaman dan keterampilan lansia rata-rata sebesar 50,83 % dalam budidaya dan membuat minuman herbal serta melakukan senam kesehatan jantung.Kata kunci: herbal, latihan fisik, lansia, CelukABSTRACTThe elderly population in Celuk Village, Sukawati, Gianyar, is relatively high, with an average of 200 people in each Banjar. Most of the elderly suffer from hypertension, a risk factor for heart disease and stroke. The results of interviews with several residents of Celuk Village show that the local community empirically still maintains the tradition of using herbs to prevent or treat disease but does not understand how to process them, the proper dosage, and their benefits. This court program was held for 5 months in the Celuk Traditional Village, Sukawati Gianyar. The aim of this program is to educate the benefits of herbal plants for the prevention and treatment of elderly health complaints, train them to process herbal drinks that are hygienic, in the right dosage, improve the physical health of the elderly through a combination of herbal beverages and physical activity through heart exercises. The method applied to this activity is in the form of mentoring and training. The target and outcome of this service program are to increase the knowledge and skills of the elderly in processing herbal drinks and improve their physical health of the elderly through heart exercises. The results of the activity showed an increase in the understanding and skills of the elderly on average by 50.83% in cultivating and making herbal drinks and doing heart health exercises.Keywords: herbs, physical exercise, elderly, Celuk
Hyaluronic acid as an active agent to accelerate bone regeneration aftertooth extraction: a literature review I Putu Gede, Andyka Yasa; I Made Jawi; I Made Muliarta
Indonesian Journal of Pharmacology and Therapy Vol 1 No 2 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1016

Abstract

Tooth extraction is a dental treatment that is performed frequently in dentistry. This procedure will stimulate a sophisticated healing process involving a variety of biological factors although it takes a long time to complete. Three phases occur in this process i.e. the inflammatory phase, the proliferation phase, and the remodeling phase which aim to restore the tissue function. Several interventions can be used to accelerate bone formation after tooth extraction. Recently, hyaluronic acid (HA) has been commonly used in dentistry due to their essential physiological effects for the periodontal connective tissue, gingiva, and alveolar bone. Hyaluronic acidis a natural non-sulfate glycosaminoglycans compound that has high molecular weight consisting of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acidis also a component of the extracellular matrix that plays an important role in morphogenesis and tissue healing. The mechanism of action of HA works in two ways, that is passive and active mechanism. The passive mechanism is depend on physical and chemical properties of HA that can change the molecular weight and concentration properties. The active mechanism of HA works by stimulating signal transduction pathway initiated by ligand binding with its receptors through autocrine or paracrine processes. The administration of HA can accelerate bone formation due to it can enhance bone morphogenetic protein (BMP) which belongs to the TGF- β superfamily that has high osteogenic capacity. The HA works through a passive mechanism that depends on its molecular weight and an active mechanism by increasing BMP activity.
The potential of polyphenols from natural ingredients against SARS-CoV-2 infection: A review Hendrayana, Made Agus; I Made Jawi; Dewa Made Sukrama; Dewa Ngurah Suprapta
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2310

Abstract

All countries in the world are facing the coronavirus disease-19 (COVID-19) pandemic which has resulted in various crises. To date, there is no effective treatment in controlling COVID-19. Many clinical trials of approved drugs against COVID-19 were conducted. However, the results were inconclusive, even severe adverse effects were reported. The new effective drugs are therefore urgently needed. Herbal medicines have been widely used by community to enhance the body immune system during COVID-19 pandemic. Polyphenols are large group of active compounds found in the natural ingredients. These compounds have been proven to have biological activity against various pathogen infections including viral infection. During COVID-19 pandemic, various polyphenol compounds from various medicinal plants have been investigated for their activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) both in silico and in vitro. Among the polyphenols investigated, some of them namely papyriflavonol, catechin gallate, gallocatechin gallate, luteolin, quercetin, tangeretin, naringenin, herbacetin, emodin, eriodyctiol, fenoterol, baicalin, myricetin, quercetagetin exhibited strong activity against SARS-CoV-2. The possibilities of mechanism of actions as antiSARS-CoV-2 of these polyphenols were 1) bind to the N protein causing the inhibition of viral transcription and replication; 2) inhibit the binding of S protein to ACE2 receptors preventing the entry of the virus into the host cells; 3) inhibit 3CLpro function inhibiting the viral transcription and maturation; and 4) bind directly to the ACE2 receptor. In conclusion, some polyphenol compounds from nature ingredients are potential to develop to be future antiSARS-CoV-2. However, further the pre-clinical and clinical studies are required to strengthen existing evidence.
Metabolic aging and cutaneous markers of metabolic syndrome: a narrative review Handayani, Theressia; Jawi, I Made
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 8, Issue 2 (2025)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v8i2.124

Abstract

Metabolic syndrome (MetS) is a constellation of metabolic abnormalities—including central obesity, dyslipidemia, hypertension, and impaired glucose regulation—that considerably increases cardiometabolic risk. Recent evidence emphasizes that MetS significantly influences the skin, which serves as a visible indicator of underlying metabolic dysfunction. The emerging concept of metabolic aging describes the acceleration of biological aging driven by chronic metabolic stress through mechanisms such as inflammaging, oxidative stress, mitochondrial dysfunction, microvascular injury, and the accumulation of advanced glycation end products (AGEs). Cutaneous signs associated with insulin resistance—including acanthosis nigricans, skin tags, acne in PCOS, hidradenitis suppurativa, and early-onset androgenetic alopecia (AGA)—are increasingly recognized as reliable clinical markers of metabolic dysregulation. Early-onset AGA has a strong epidemiological association with insulin resistance, dyslipidemia, and increased cardiometabolic risk. Understanding these links is essential for dermatologists and aesthetic practitioners, as metabolic dysfunction affects wound healing, treatment response, and procedural safety. This narrative review aims to summarize current evidence on the relationship between metabolic syndrome, metabolic aging, and cutaneous manifestations, with particular emphasis on clinically observable dermatologic markers of insulin resistance and their implications for dermatology and aesthetic practice.
Moringa (Moringa oleifera L.) Leaf Extract Gel Is Able to Reduce TNF-α and IL-6 Post Tooth Extraction in Male Wistar Rats (Rattus norvegicus) Dewi, Ni Putu Dian Cipta; Jawi, I Made; Purnawati, Susy
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 1 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i1.13611

Abstract

Background: Tooth extraction is a procedure that can cause injury to the soft tissue. The inflammatory phase that occurs during wound healing triggers a series of tissue changes mediated by the immune system and cytokines. TNF-α and IL-6 cytokine levels should decrease as the wound heals, but otherwise it will slow wound healing and lead to chronic inflammation. The purpose of this study was to determine the effect of the extract gel of Moringa leaves on the wound healing process Materials and Methods: This research was conducted on 24 Wistar rats, which were randomly divided into four groups, 70%, 90% Moringa leaf extract gel group 70% and 90%, the control (+) oxyfresh gel, and the control (-) CMC-Na 2%. The left central incisor tooth was extracted, resulting in an injury to the gingival socket, and was given topical treatment every day for 7 days. Blood sampling from the orbital sinus was carried out on the 4th and 7th day after injury, and the levels of TNF-α and IL-6 were measured by ELISA. The data obtained was tested with two-way ANOVA and Post Hoc LSD. Results: The lowest IL-6 was found in the 90% Moringa leaf extract gel group, with an average of 80.86 ± 1.91, while the lowest TNF-α was found in the 90% day 7 group with 80.56 ± 0.41. There were significant differences between the test groups and the observation time, with p <0.05. Conclusion: Topical application of moringa oleifera gel was effective in reducing TNF-α.and.IL-6 levels after tooth extraction in Wistar rats
Antidyslipidaemic effect of Ipomoea batatas L. extract with increased PCSK-9 levels in atherosclerotic rats Yasa, I Wayan Putu Sutirta; Jawi, I Made; Mahendra, Agung Nova; Wiradana, Putu Angga; I Gede Widhiantara
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7260

Abstract

Atherosclerosis is the largest cause of mortality worldwide, and Low-Density Lipoprotein (LDL) is a primary risk factor for this illness. The purpose of this research was to determine the effect of purple sweet potato (Ipomoea batatas L.) extract on cholesterol, LDL, PCSK9, and MDA levels in rats fed a high-cholesterol diet. This true experimental study used a randomised pre-test-post-test control group design. Wistar rats were randomly assigned to three groups. Purple sweet potato extract (PSPE) was prepared by 24-hour maceration with 70% ethanol. All rats were fed a high-cholesterol diet for 14 days, followed by pre-test measurements of cholesterol, LDL, PCSK9, and MDA on day 15. Rats were then randomly divided into control (no treatment), PSPE (200 mg/day), and Simvastatin (0.9 mg/kg BW) groups. After one month of treatment, post-test analyses were performed for all parameters. The results showed an increase in serum cholesterol, LDL and MDA levels in rats fed a high-cholesterol diet (p<0.05) compared to the PSPE and Simvastatin groups. The high-cholesterol diet also resulted in a significant (p<0.05) decrease in PCSK9 when compared to the PSPE and Simvastatin groups. In the PSPE group there was a decrease in cholesterol, LDL, and MDA, and PSPE (p<0.05) compared to the control group. In the Simvastatin group, the increase in PCSK9 was very low compared to the PSPE group. PSPE has antidyslipidaemic activity by reducing total cholesterol status, LDL, and oxidative stress while promoting PCSK-9 function. Further research is still needed to provide a comprehensive understanding of the mechanism of action of PSPE as an antioxidant source in patients with atherosclerosis.
Co-Authors A.N. Mahendra A.W. Indrayani Achmad Chusnu Romdhoni Adi Saputra Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wahyu Permadi Agung Wiwiek Indrayan Agung Wiwiek Indrayani Aman, I Gusti Made Aman, IGM Amaral, Meriana Barreto Anak Agung Gede Angga Puspa Negara Anak Agung Ngurah Subawa Anom Suardika Ardo Sabir, Ardo Arisandy Achmad Aryana, I Gust Putu Suka Astawastini, I Dewa Ayu Mas Manik Astika, I Nyoman Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Cokorda Agung Wahyu Purnamasidhi Cokorda Bagus Jaya Lesmana Dany Hilmanto Desak Ketut Ernawati Desak Made Puja Astuti Desak Made Widyanthari Desak Made Wihandani Desak Putu Citra Udiyani Dewa Ayu Putu Sri Ista Dewanti Dewa Ngurah Suprapta Dewa Ngurah Suprapta Dewi, L. P. M. K. Dewi, Ni Putu Dian Cipta Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Sucindra Diaz, Leonardo Alpha Dimas Agusta Divasta, I G Mahapraja Dixon E.M. Taek Bete Dyah Kanya Wati Eka Putra Setiawan Elvina Veronica Eva Dharma Yanti Febrianda, Larasati Hanifa Gaga Irawan Nugraha Gede Agung Dhimasena Widyananda Gita Almira Putri Gitari, Ni Made Grudug, Kadek Agastya Widya Sedana Guna, I. M. A. W. Gusti Made Agung Mega Utama Hairudin - Hamsu Kadriyan Handayani, Theressia Hervina Hervina I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Sutjana I Gede Widhiantara I Gusti Ayu Artini I Gusti Bagus Wirawan I Gusti Kamasan Arijana I Gusti Made Gde Surya Chandra Trapika I Kadek Arya Gangga Permana I Ketut Suastika I Made Ady Wirawan I Made Agus Gelgel Wirasuta I Made Bakta I Made Dhita Prianthara I Made Dwi Ariyuda I Made Gde Sudyadnyana Sandhika I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Adiputra I Nyoman Budi Hartawan I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Nyoman Wande I P G. Adiatmika I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Astrawan . I Putu Eka Jaya I Putu Eka Widyadharma I Putu Gede Andyka Yasa I Putu Gede Putra Darmawan I Wayan Gede Artawan Eka Putra I Wayan Lolik Lesmana I Wayan Niryana I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sugiritama I Wayan Suka Yasa I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Ida Bagus Gede Suparyatha Ida Bagus Ngurah Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Putu Putrawan Ida Bagus Subanada Ida Sri Iswari Imakulata Magi Loda Indra Lesmana J. A. Pangkahila Kamayoga, I Dewa Alit Ketut Agus Adrianta Ketut Budiasa Ketut Tirtayasa La Ode Muhammad Gustrin Syah Lesmana, Cokorda Agung Bagus Jaya Losen Adnyan Luh Putu Ratna S Luh Putu Ratna Sundari Luh Putu Widiastini M. Irfan Made Agus Hendrayana Made Wiryana Maharianingsih, Ni Made Manuaba, I.A Ratih Wulansari Mardaningrat, Kadek Herdana Vildan Moh. Ali Imron, Moh. Muh. Irfan Muhammad Irfan Muhammad Irfan Muthia Munawaroh Muthiah Munawaroh N Adiputra N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Naw, Sin War Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Ketut Susilawati Ni Luh Suriani Ni Made Ari Purwaningrum Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Shinta Prasista Sari Ni Putu Wirantari Ni Wayan Mutiara Warmasari Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ode Mahesa Putra Oktovianus Fufu Pande Putu Karina Candra Pangala, Gustinara Bakti Permatasari, Anak Agung Ayu Putri Pramana, I Putu Yudi Pratiwi, Cokorda Agung Pratiwi, Kadek Prastiti Surya Prima S. Sudarsa Pujawan, I Made Naris Purnamawati, Susy Purnami, Ni Ketut Rai Puspitasari, Ni Putu Ayu Intan Putri, Kadek Wina Santhya Putu Angga Wiradana Putu Astawa Putu Ayu Sita Saraswati Putu Belly Sutrisna R. A.T. Kuswardhani Raka-Sudewi A. A. Regina Sesilia Noy Rita Maria Sang Ayu Arta Suyantari Sanjaya, Feliani Santosa, I Gusti Ngurah Putra Eka Sari, P. M. N. A. Sawitri, Anak Agung Sagung Sri Maliawan Sugijanto - Sugosha, M. J. Sukawati, C. B. A. C Sumawirawan, K. D. Susy Purnawati Sutema, Ida Ayu Manik Partha Syahmirza Indra Lesmana Thomas Eko Purwata Tirtha Yasa, I Nyoman Wawan Wahyuddin, Wahyuddin Wahyuni Novianti, I Gusti Ayu Sri Wayan Suardana Widhiantari, Ni Ketut Evitri Widia Danis Swari Widiarthini, Ida Ayu Alit Widiyanti, I Gusti Ayu Widnyana, M. Widowati, I Gusti Ayu Rai - Wiwekowati Wuga, Kristina Supartin Monika Yenny Kandarini Yogie Wiswadewa Yohanes Seran