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The potential of polyphenols from natural ingredients against SARS-CoV-2 infection: A review Hendrayana, Made Agus; I Made Jawi; Dewa Made Sukrama; Dewa Ngurah Suprapta
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2310

Abstract

All countries in the world are facing the coronavirus disease-19 (COVID-19) pandemic which has resulted in various crises. To date, there is no effective treatment in controlling COVID-19. Many clinical trials of approved drugs against COVID-19 were conducted. However, the results were inconclusive, even severe adverse effects were reported. The new effective drugs are therefore urgently needed. Herbal medicines have been widely used by community to enhance the body immune system during COVID-19 pandemic. Polyphenols are large group of active compounds found in the natural ingredients. These compounds have been proven to have biological activity against various pathogen infections including viral infection. During COVID-19 pandemic, various polyphenol compounds from various medicinal plants have been investigated for their activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) both in silico and in vitro. Among the polyphenols investigated, some of them namely papyriflavonol, catechin gallate, gallocatechin gallate, luteolin, quercetin, tangeretin, naringenin, herbacetin, emodin, eriodyctiol, fenoterol, baicalin, myricetin, quercetagetin exhibited strong activity against SARS-CoV-2. The possibilities of mechanism of actions as antiSARS-CoV-2 of these polyphenols were 1) bind to the N protein causing the inhibition of viral transcription and replication; 2) inhibit the binding of S protein to ACE2 receptors preventing the entry of the virus into the host cells; 3) inhibit 3CLpro function inhibiting the viral transcription and maturation; and 4) bind directly to the ACE2 receptor. In conclusion, some polyphenol compounds from nature ingredients are potential to develop to be future antiSARS-CoV-2. However, further the pre-clinical and clinical studies are required to strengthen existing evidence.
Integrasi Kesehatan Berbasis Partisipasi Masyarakat dalam Pengelolaan Desa Wisata untuk Mendukung Keberlanjutan dan Kesejahteraan Lokal Astawastini, I Dewa Ayu Mas Manik; Wirawan, I Made Ady; Jawi, I Made
Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Vol. 7 (2024): PROSIDING SINTESA
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/snts.v7i.3553

Abstract

Desa wisata berbasis partisipasi masyarakat menawarkan potensi besar dalam mengintegrasikan aspek kesehatan melalui pelibatan aktif komunitas lokal. Integrasi ini penting untuk mengatasi tantangan kesehatan yang sering muncul di destinasi wisata, seperti sanitasi buruk, penyebaran penyakit, dan dampak kesehatan mental akibat interaksi intens antara wisatawan dan penduduk lokal. Namun, penelitian tentang integrasi kesehatan dalam pengelolaan desa wisata masih terbatas, terutama dalam konteks Indonesia. Penelitian ini merupakan tinjauan sistematis yang dilakukan berdasarkan pedoman PRISMA untuk mengevaluasi literatur yang relevan. Artikel yang memenuhi kriteria inklusi adalah studi observasional dan intervensi yang membahas integrasi kesehatan dalam desa wisata berbasis partisipasi masyarakat, diterbitkan dalam 10 tahun terakhir. Pencarian dilakukan di basis data elektronik, seperti PubMed, Scopus, dan Google Scholar, menggunakan kata kunci seperti "community-based tourism," "health integration," dan "CHSE implementation." Sebanyak 19 studi dianalisis, terdiri dari 10 studi observasional dan 9 studi intervensi berbasis community trial. Studi observasional menunjukkan hubungan positif antara wellness tourism dengan peningkatan kesehatan psikologis, fisik, dan sosial wisatawan. Studi intervensi menyoroti keberhasilan penggunaan teknologi, seperti sistem cloud dan platform digital, dalam meningkatkan efisiensi layanan kesehatan di komunitas rural. Partisipasi aktif masyarakat lokal terbukti meningkatkan kesadaran kesehatan dan keberlanjutan desa wisata. Integrasi kesehatan dalam desa wisata berbasis partisipasi masyarakat berkontribusi pada peningkatan kesejahteraan wisatawan dan komunitas lokal. Pendekatan berbasis kolaborasi, pelestarian budaya lokal, dan inovasi teknologi menjadi kunci keberhasilan. Penelitian lebih lanjut diperlukan untuk mengevaluasi dampak jangka panjang dan potensi replikasi di berbagai konteks lokal.
Exploring Meditation Influence on Stem Cell: A Review of Current Evidence Santosa, I Gusti Ngurah Putra Eka; Jawi, I Made; Bakta, I Made; Yasa, I Wayan Putu Sutirta; Wirawan, I Made Ady; Lesmana, Cokorda Agung Bagus Jaya; Kandarini, Yenny; Purnamawati, Susy
Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Vol. 7 (2024): PROSIDING SINTESA
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/snts.v7i.3716

Abstract

Endogenous stem cells play a critical role in maintaining tissue homeostasis, repair, and regeneration. The interconnectedness of mind and body has long been recognized as influencing physical health, with practices such as yoga and meditation demonstrating positive effects on overall well-being. This review aims to synthesize current evidence on the effects of meditation on stem cell function, focusing on both indirect (telomere-related) and direct pathways. Meditation appears to influence stem cell function through various mechanisms. Indirectly, meditation may impact stem cells by modulating telomere length and activity. This modulation is likely mediated through stress reduction, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, melatonin elevation, immune system modulation, and reduction of oxidative stress. Directly, meditation may influence stem cell trafficking and differentiation. While studies suggest potential benefits of meditation on stem cell function, further research is needed to fully elucidate the underlying mechanisms. Emerging evidence suggests that meditation may positively influence stem cell function through both indirect and direct pathways. Future research should focus on clarifying the precise mechanisms, investigating the role of meditation parameters, and conducting clinical trials to assess the therapeutic potential of meditation in promoting stem cell-mediated tissue regeneration and repair. A multidisciplinary approach involving researchers from various fields is crucial for comprehensively understanding the complex interplay between meditation, stem cells, and overall health.
Antidyslipidaemic effect of Ipomoea batatas L. extract with increased PCSK-9 levels in atherosclerotic rats I Wayan Putu Sutirta Yasa; I Made Jawi; Agung Nova Mahendra; Putu Angga Wiradana; I Gede Widhiantara
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7260

Abstract

Atherosclerosis is the largest cause of mortality worldwide, and Low-Density Lipoprotein (LDL) is a primary risk factor for this illness. The purpose of this research was to determine the effect of purple sweet potato (Ipomoea batatas L.) extract on cholesterol, LDL, PCSK9, and MDA levels in rats fed a high-cholesterol diet. This true experimental study used a randomised pre-test-post-test control group design. Wistar rats were randomly assigned to three groups. Purple sweet potato extract (PSPE) was prepared by 24-hour maceration with 70% ethanol. All rats were fed a high-cholesterol diet for 14 days, followed by pre-test measurements of cholesterol, LDL, PCSK9, and MDA on day 15. Rats were then randomly divided into control (no treatment), PSPE (200 mg/day), and Simvastatin (0.9 mg/kg BW) groups. After one month of treatment, post-test analyses were performed for all parameters. The results showed an increase in serum cholesterol, LDL and MDA levels in rats fed a high-cholesterol diet (p<0.05) compared to the PSPE and Simvastatin groups. The high-cholesterol diet also resulted in a significant (p<0.05) decrease in PCSK9 when compared to the PSPE and Simvastatin groups. In the PSPE group there was a decrease in cholesterol, LDL, and MDA, and PSPE (p<0.05) compared to the control group. In the Simvastatin group, the increase in PCSK9 was very low compared to the PSPE group. PSPE has antidyslipidaemic activity by reducing total cholesterol status, LDL, and oxidative stress while promoting PCSK-9 function. Further research is still needed to provide a comprehensive understanding of the mechanism of action of PSPE as an antioxidant source in patients with atherosclerosis.
Comparative Effects of Isometric and Isotonic Progressive Continuous Exercise on miRNA-155 Expression Following Sports-Related Muscle Injury Moh. Ali Imron; Suci Muqodimatul; I Made Jawi; I Putu Gede Adiatmika; Pamudji Utomo
Jurnal Manajemen Informasi Kesehatan (Health Information Management) Vol. 11 No. 1 (2026): Health Information and Management
Publisher : Sekolah Tinggi Ilmu Kesehatan Sapta Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51851/jmik.v11i1.1034

Abstract

Background: Background: Muscle injury often causes pain, inflammation, and reduced function. MicroRNA-155 (miRNA-155) is involved in inflammatory regulation and tissue regeneration after skeletal muscle injury. Exercise rehabilitation may influence these molecular responses, but evidence regarding different exercise modalities remains limited. Objective: To compare the effects of isometric progressive continuous exercise (MPCE) and isotonic progressive continuous exercise (NPCE) on miRNA-155 expression in athletes with grade 1–2 muscle injury. Method: A true experimental randomized pretest–posttest control group design was used. Twenty-one athletes with grade 1–2 muscle injury were randomly assigned to MPCE (n = 7), NPCE (n = 7), or control (CON; n = 7). Intervention groups performed progressive continuous exercise once daily for 7 consecutive days, while the control group received no exercise intervention. Venous blood samples were collected before and after intervention, and miRNA-155 expression was analyzed using real-time quantitative polymerase chain reaction (qPCR). Data were analyzed using within-group tests, Kruskal–Wallis, and post-hoc analysis.. Result: In the MPCE group, miRNA-155 increased from 0.583 ± 0.5 to 3.700 ± 3.6, but the change was not significant (p = 0.066). In the NPCE group, miRNA-155 significantly decreased from 14.273 ± 1.3 to 5.645 ± 3.6 (p = 0.001). The control group showed no significant change from 1.119 ± 1.6 to 1.598 ± 1.4 (p = 0.310). Between-group analysis showed significant differences in baseline values (H = 13.406, p = 0.001) and change scores (H = 12.276, p = 0.002). Post-hoc analysis revealed significant differences between both intervention groups and control, while no difference was found between MPCE and NPCE. Conclusion: Progressive continuous exercise significantly modulated miRNA-155 expression compared with the control group. However, no significant difference was found between MPCE and NPCE, and results should be interpreted with caution due to baseline imbalance. Further studies with larger samples and adjusted analyses are warranted.
Co-Authors A.N. Mahendra A.W. Indrayani Achmad Chusnu Romdhoni Adi Saputra Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wahyu Permadi Agung Wiwiek Indrayan Agung Wiwiek Indrayani Aman, I Gusti Made Aman, IGM Anak Agung Gede Angga Puspa Negara Anak Agung Ngurah Subawa Anom Suardika Ardo Sabir, Ardo Arisandy Achmad Aryana, I Gust Putu Suka Astawastini, I Dewa Ayu Mas Manik Astika, I Nyoman Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Cokorda Agung Wahyu Purnamasidhi Cokorda Bagus Jaya Lesmana Dany Hilmanto Desak Ketut Ernawati Desak Made Puja Astuti Desak Made Widyanthari Desak Made Wihandani Desak Putu Citra Udiyani Dewa Ayu Putu Sri Ista Dewanti Dewa Ngurah Suprapta Dewa Ngurah Suprapta Dewi, L. P. M. K. Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Sucindra Diaz, Leonardo Alpha Dimas Agusta Divasta, I G Mahapraja Dixon E.M. Taek Bete Dyah Kanya Wati Eka Putra Setiawan Elvina Veronica Eva Dharma Yanti Febrianda, Larasati Hanifa Gaga Irawan Nugraha Gede Agung Dhimasena Widyananda Gita Almira Putri Gitari, Ni Made Grudug, Kadek Agastya Widya Sedana Guna, I. M. A. W. Gusti Made Agung Mega Utama Hairudin - Hamsu Kadriyan Hervina Hervina I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Sutjana I Gede Widhiantara I Gusti Ayu Artini I Gusti Bagus Wirawan I Gusti Kamasan Arijana I Gusti Made Gde Surya Chandra Trapika I Kadek Arya Gangga Permana I Ketut Suastika I Made Ady Wirawan I Made Agus Gelgel Wirasuta I Made Bakta I Made Dhita Prianthara I Made Dwi Ariyuda I Made Gde Sudyadnyana Sandhika I Made Krisna Dinata I MADE MULIARTA . I Nengah Sandi I Nyoman Adi Putra I Nyoman Adiputra I Nyoman Budi Hartawan I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Nyoman Wande I P G. Adiatmika I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Astrawan . I Putu Eka Jaya I Putu Eka Widyadharma I Putu Gede Andyka Yasa I Putu Gede Putra Darmawan I Wayan Gede Artawan Eka Putra I Wayan Lolik Lesmana I Wayan Niryana I Wayan Putu Sutirta Yasa I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sugiritama I Wayan Suka Yasa I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Ida Bagus Gede Suparyatha Ida Bagus Ngurah Ida Bagus Ngurah Ida Bagus Putu Putrawan Ida Bagus Subanada Ida Sri Iswari Imakulata Magi Loda Indra Lesmana J. A. Pangkahila Kamayoga, I Dewa Alit Ketut Agus Adrianta Ketut Budiasa Ketut Tirtayasa La Ode Muhammad Gustrin Syah Lesmana, Cokorda Agung Bagus Jaya Losen Adnyan Luh Putu Ratna S Luh Putu Ratna Sundari Luh Putu Widiastini M. Irfan Made Agus Hendrayana Made Wiryana Maharianingsih, Ni Made Manuaba, I.A Ratih Wulansari Mardaningrat, Kadek Herdana Vildan Moh. Ali Imron Moh. Ali Imron, Moh. Muh. Irfan Muhammad Irfan Muhammad Irfan Muthia Munawaroh Muthiah Munawaroh N Adiputra N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Ketut Susilawati Ni Luh Suriani Ni Made Ari Purwaningrum Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Shinta Prasista Sari Ni Putu Wirantari Ni Wayan Mutiara Warmasari Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ode Mahesa Putra Oktovianus Fufu Pamudji Utomo Pande Putu Karina Candra Pangala, Gustinara Bakti Permatasari, Anak Agung Ayu Putri Pramana, I Putu Yudi Pratiwi, Cokorda Agung Pratiwi, Kadek Prastiti Surya Prima S. Sudarsa Pujawan, I Made Naris Purnamawati, Susy Purnami, Ni Ketut Rai Puspitasari, Ni Putu Ayu Intan Putri, Kadek Wina Santhya Putu Angga Wiradana Putu Angga Wiradana Putu Astawa Putu Ayu Sita Saraswati Putu Belly Sutrisna R. A.T. Kuswardhani Raka-Sudewi A. A. Regina Sesilia Noy Rita Maria Sang Ayu Arta Suyantari Sanjaya, Feliani Santosa, I Gusti Ngurah Putra Eka Sari, P. M. N. A. Sawitri, Anak Agung Sagung Sri Maliawan Suci Muqodimatul Sugijanto - Sugosha, M. J. Sukawati, C. B. A. C Sumawirawan, K. D. Susy Purnawati Sutema, Ida Ayu Manik Partha Syahmirza Indra Lesmana Thomas Eko Purwata Tirtha Yasa, I Nyoman Wawan Wahyuddin, Wahyuddin Wahyuni Novianti, I Gusti Ayu Sri Wayan Suardana Widhiantari, Ni Ketut Evitri Widia Danis Swari Widiarthini, Ida Ayu Alit Widnyana, M. Widowati, I Gusti Ayu Rai - Wiwekowati Wuga, Kristina Supartin Monika Yenny Kandarini Yogie Wiswadewa Yohanes Seran