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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Jurnal Ilmiah Universitas Batanghari Jambi Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Jurnal Farmasi Higea Poltekita : Jurnal Ilmu Kesehatan Contagion: Scientific Periodical Journal of Public Health and Coastal Health Tatar Pasundan : Jurnal Diklat Keagamaan Journal of Telenursing (JOTING) Science Midwifery JPK: Jurnal Proteksi Kesehatan Indonesian Journal of Global Health research Jurnal Dunia Gizi Jurnal Menara Medika Poltekita: Jurnal Pengabdian Masyarakat Narra J FORTE JOURNAL Basic and Applied Nursing Research Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Andalas Dental Journal SENTRI: Jurnal Riset Ilmiah Tatar Pasundan: Jurnal Diklat Keagamaan Jurnal Riset Ilmiah Frontiers on Healthcare Research
Afriwardi Afriwardi
Bagian Fisiologi, Fakultas Kedokteran, Universitas Andalas
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Journal : Frontiers on Healthcare Research

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Effect of Papaya Seed on Mortality and Midgut Histopathology in Aedes aegypti Larvaes Agustini, Cynthia; Hasmiwati, Hasmiwati; Afriwardi
Frontiers on Healthcare Research Vol. 2 No. 2 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n2.p66-75.2025

Abstract

Background: Indonesia is an endemic region for Dengue infection. The World Health Organization (WHO) reported Dengue as one of the top ten global health threats in 2020. Dengue is a viral infection transmitted primarily by the Aedes aegypti mosquito, causing Dengue Fever and Dengue Hemorrhagic Fever. Temephos 1.25% has been the WHO recommended standard larvicide. However, prolonged use and continuously increasing doses may result in resistance and toxicity, posing risks to the environment and human health. This necessitates the discovery of alternative larvicides that are effective in killing larvae with minimal side effects, particularly those derived from natural materials. Methods: This research intends to illustrate the impact of papaya seed extract on the death rate of larvae and the histopathological changes in the midgut of Ae. aegypti larvae. A genuine experimental framework featuring a control group with only post-testing was utilized for this investigation. The sample comprised 750 Ae. aegypti larvae, which were categorized into six groups: one negative control group (aquades), one positive control group (temephos 1. 25%), and four treatment groups using papaya seed extract at varying concentrations of 2 mg/ml (P1), 2. 5 mg/ml (P2), 3 mg/ml (P3), and 3. 5 mg/ml (P4). Results: The results showed that all larvaes died within 24 hours in the positive control, P1, P2, P3, and P4 groups. Probit analysis of papaya seed extract revealed LC50 at 2.599 mg/ml and LC90 at 4.776 mg/ml after 8 hours of exposure. Conclusion: This study concludes that papaya seed extract affects larval mortality and midgut histopathology alterations in Ae.aegypti larvae. These findings indicate that papaya seed extract holds great potential as a natural and environmentally safe as alternative larvicide to disrupt the development of dengue fever vectors.
Co-Authors Adang Bachtiar Adrul Fauzan Afrinita Eka Fitri Agustini, Cynthia Ahmad Wira Aisyah Elliyanti Akdri Andi Alya Misdhal Rini Amanda Besta Rizaldy Antoni, Adi Arina Widya Murni Arni Amir Asril Zahari Asterina Asterina Aulia Fash Farabi Ayu Anissa Bahri Azis, Putri Nurul Syafirah Bestari J. Budiman Biomechy Oktomalioputri, Biomechy Bobby Indra Utama Brian Sri Prahastuti Citra Manela Daan Khambri Dara, Widia Dedi Sutia Dedy Kurnia Delmi Sulastri Delmi Sulastri Desmawati Desmawati Desrida Desrida Detty Iryani Dezi Ilham Dhiaulhaq, Zalva Indira Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Didin Kustantiningtyastuti Dina Arfiani Rusjdi Dwitya Elvira, Dwitya Edison Edison Efendi, Nursyirwan Efrida Efrida Eka Nofita Eldi Sauma Elizabeth Bahar Elmatris Elmatris Elmatris Sy Elsa Noftalina Endang Mutiwara Endrinaldi Eny Yantri Erasta, Junira Erin Desweni Ermayanti, Sabrina Eryati Darwin Eti Yerizel Eva Decroli Eva Decroli Fadhilati Sabrina Fadilla, Utami Budhi Febby Herayono Ferdinand Ferdinand, Ferdinand Fika Anggraini Fika Anggraini Fika Tri Anggraini Ghozi Natul Isral Gumilar, Erry Gusriyani, Sri Gusti Revilla Hardisman Harie Satria ES Haslan Muhaimin Lubis Hasmiwati Hendriati, Hendriati Hidayati Hidayati Hirowati Ali Hirowati Ali, Hirowati Hudila Rifa Karmia Husna Yetti Husnil Kadri Ilhami, Yose Ramda Ilmiawati, Ilmiawati Ilvira Ulpa Ismail Intan Nurwida Hayati Yasrial Iria Ningsih Busri Jamsari Jamsari Johanes C. Mose Joserizal Serudji Julizar Julizar Julizar Julizar Julizar Julizar Lastri Daniati Lili Irawati Lili Irawati Masrul Syafri Mayetti Mayetti Meidiza Ariandiny Mety Dwi Putri Eszy Miftah Irrahmah Miftah Irrahmah Miftah Irramah Miftahul Jannah Milfa Sari Muzamil Mohamad Reza Mudjiran Muhammad Amirul Ihsan Saputra Musrizal Adli Mutia Lailani Najirman Najirman Nega Olavia Nelson, Nelvianti Nova Relida Samosir Noverika Windasari Nur Afrainin Syah Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurfazlina Nurfazlina Nurhajjah, Sitti Nuzulia Irawati Perdanakusuma, David Sontani Prayitno, Irwan Prima Astuti Handayani Pudia M. Indika Putra, Andani E. Putri Anindita Putri Nurul Syafirah Azis Putri, Biomechy Oktomalio Rahmad Syawqi Rahmad Syawqi Raisa Hussein Rama Feriska Putra Rani Ashari Reny Jayusfani Restu Susanti Reza Ekatama Rajasa Rika Susanti Rina Gustia Rini Gusya Liza Rini Gusya Liza, Rini Gusya Rita, Rauza S. Ritonga, Sukhri Herianto Rizki Hidayah Rizqa Fiorendita Hadi Rose Dinda Martini Rozi Sastra Purna Rurin Ardiyanti Russilawati, Russilawati Sabrina Hayati Safitri, Yunni Salman Umar Salman Umar Salwi, Hanifah Emilia Selfi Renita Rusjdi Setia Budi Zein Shafira Widia Putri Siska Andriani Rukmana Siti Coryniken Siti Nurhajjah Sukri Rahman susi susi Syawqi, Rahmat Taufik Hidayat Taufik Hidayat Tiffany Atia Aristi Triananda, Claudia Vaulinne Basyir Vaulinne Basyir Vitresia, Havriza Wahyu Margi Sidoretno Wenny Rahmalia Rezki Wira Ditya Wirsma Arif Harahap Yessy Susanty Sabri Yolanda Syahdia Yose Ramda Ilhami Yose Ramda Ilhsmi Yufri Aldi Yuharika Pratiwi Yulistini, Yulistini Yuniar Lestari Yusnawati Yusnawati Yusrawati Yusrawati Yusri Dianne Jurnalis Zelly Dia Rofinda