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All Journal Farmaka Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN PIKSEL : Penelitian Ilmu Komputer Sistem Embedded and Logic Indonesian Journal of Pharmaceutical Science and Technology Jurnal Akuntansi dan Pajak Jurnal Pendidikan Informatika dan Sains Jurnal Komtika (Komputasi dan Informatika) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan ADMINISTRASI PUBLIK SEIKO : Journal of Management & Business Jurnal Surya Masyarakat JURNAL PENDIDIKAN TAMBUSAI Eksis: Jurnal Ilmiah Ekonomi dan Bisnis Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Ensiklopedia of Journal GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia JAE (Jurnal Akuntansi dan Ekonomi) Jurnal Ilmiah Ekonomi Global Masa Kini JISICOM (Journal of Information System, Infomatics and Computing) Jurnal Abdimas Mahakam Jurnal Review Pendidikan dan Pengajaran (JRPP) RADIAL: JuRnal PerADaban SaIns RekAyasan dan TeknoLogi Jurnal Riset Terapan Akuntansi Syntax Idea ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Surya Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Dinasti International Journal of Economics, Finance & Accounting (DIJEFA) Jurnal Revenue : Jurnal Ilmiah Akuntansi Voice Of Midwifery Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Promotif Preventif Jurnal ABDIMAS (Pengabdian kepada Masyarakat) UBJ Jurnal Jaring SainTek Jurnal Borneo Akcaya : Jurnal Penelitian dan Pengembangan Pelayanan Publik LINEAR: Journal of Mathematics Education Iqtishaduna : Jurnal Ilmiah Mahasiswa Hukum Ekonomi Syariah Journal of Students‘ Research in Computer Science (JSRCS) Jurnal Media Informatika Jurnal Abdimas Ekonomi dan Bisnis JOURNAL OF HUMANITIES, SOCIAL SCIENCES AND BUSINESS (JHSSB) Cermin Dunia Kedokteran Jurnal Bina Bangsa Ekonomika Journal of Trends Economics and Accounting Research Journal of Fundamental Mathematics and Applications (JFMA) Jurnal Kesehatan Kusuma Husada Pharmaceutical Sciences and Research (PSR) Jurnal Abdimas Musi Charitas Jurnal Manajemen Informatika dan Bisnis Digital Jurnal Ekonomi Bisnis, Manajemen dan Akuntansi (JEBMAK) Jurnal Desain dan Analisis Teknologi JEKSya Jurnal Ekonomi dan Keuangan Syariah International Journal of Information Technology and Computer Science Applications (IJITCSA) Gema Kesehatan Journal of Computer Science Contributions (Jucosco) Aktivasi: Jurnal Pemberdayaan Masyarakat Journal of Informatics and Information Security Jurnal Akuntansi RADIAL: Jurnal Peradaban Sains, Rekayasa dan Teknologi Journal Pharmacy of Tanjungpura Jurnal Komtika (Komputasi dan Informatika)
Rafika Sari
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Efektivitas Edible Coating Spray Gel Lidah Buaya (Aloe vera) dan Daun Sirih (Piper betle) Sebagai Sanitizer Pangan Azmi, Afif Fadhil; Kamil, Insan; Maulidia, Yuninta; Fahiratunnisa, Namira Alifah; Pramita, Julianti; Sari, Rafika
Pharmaceutical Journal of Indonesia Vol. 8 No. 2 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.008.02.7

Abstract

Daun sirih dan lidah buaya memiliki sifat antibakteri yang dibuktikan dengan adanya kandungan zat aktif dan senyawa organik lainnya. Aktivitas antibakteri pada kedua tanaman tersebut dipengaruhi oleh adanya metabolit sekunder seperti glukomanan dan fenol yang ada pada lidah buaya serta fenol, saponin dan flavonoid pada daun sirih. Penelitian ini dilakukan untuk mengetahui mekanisme serta aktivitas kombinasi gel lidah buaya dan daun sirih dalam bentuk sediaan edible coating spray sebagai sanitizer pangan. Metode yang digunakan adalah eksperimental murni (true experiment design) in vitro dengan desain rancangan acak lengkap (completely randomized design). Kemudian, untuk menguji kinerja aktivitas antibakteri digunakan metode difusi kertas cakram terhadap bakteri Staphylococcus aureus dan Escherichia coli. Hasil penelitian menunjukkan bahwa terdapat aktivitas penghambatan dari sediaan terhadap kedua bakteri uji. Zona hambat yang paling besar dimiliki oleh sediaan dengan konsentrasi 100% dengan kategori hambat sangat kuat terhadap Escherichia coli dan kategori kuat pada Staphylococcus aureus. Uji one way ANOVA dilanjutkan dengan Post Hoc Test menunjukkan angka signifikan p<0,05 yang merepresentasikan adanya perbedaan bermakna pada kebusukan buah terhadap perlakuan kontrol dengan konsentrasi 100%, sedangkan terhadap perlakuan kontrol dengan konsentrasi 50% dan konsentrasi 30% tidak terdapat perbedaan bermakna. Berdasarkan hasil penelitian ini, maka sediaan dalam bentuk edible coating spray efektif meningkatkan ketahanan pangan di masa pandemi dan mengurangi angka kerugian bagi para petani buah dan sayur.
The Sensitivity of Amphotericin B, Fluconazole, and Flusitosin to Fungal Pathogens Isolated from Wounds of Diabetic Ulcer Patients Sari, Rafika
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.1

Abstract

A diabetic ulcer is a wound caused by infection, ulceration or destruction in people with diabetes mellitus. Mostly, diabetic ulcer found in foot. The purpose of this study was to identify pathogenic fungi in diabetic ulcers and their sensitivity to fungal drugs. The morphological determination of fungal isolates was stained with Lactophenol Cotton Blue. Determination of sensitivity using diffusion discs Kirby Bauer which are classified based on Clinical Laboratory Standard Institute (CLSI) with Amphotericin B, Fluconazole, and Flusitosin. Based on the results of the study found 8 types of pathogenic fungi namely Candida albicans (38.78%), Candida guilliermondii (4.08%), Candida kefyr 10.20%), Candida parapsilosis (10.20%), Fusarium solani (14.29) %), Microsporum audouinii (14.29%), Penicillium sp(2.04%), Trichophyton mentagrophytes (4.08%), and Trichophyton equinum (2.04%). The fungus was identified using Gideon software and the book Description of Medical Fungi. The results of the antifungal sensitivity test showed the results were sensitive to fluconazole. Amphotericin B is intermediate to Candida albicans, Candida guilliermondii, Penicillium sp. and Trichophyton sp. and is resistant to Candida kefyr and Candida parapsilosis. Flusitosin is only an intermediate against Penicillium sp. while other fungal species are immune. The conclusion of this study. The results of diabetic ulcer swabs III and IV indicate the presence of fungal colonies with species of 9 species namely Candida albicans, Candida guilliermondii, Candida kefyr, Candida Parapsilosis, Fusarium solani, Microsporum Audouinii, Penicillium sp., Trichophyton mentagrophytes, and Trichophyton equinum. Antifungal sensitivity tests on all pathogenic fungi showed sensitivity to fluconazole. Amphotericin Bintermediatrics against Candida albicans, Candida guilliermondii, Penicillium sp. and Trichophyton sp. while resistant to Candida kefyrand Candida parapsilosis. Flusitosin is only an intermediate against Penicillium sp. while other fungal species are resistant.
Efektivitas SNEDDS Kombinasi Fraksi Etil Asetat Daun Cengkodok (Melasthoma malabathricum)-Antibiotik terhadap Bakteri Hasil Isolat dari Pasien Ulkus Diabetik Sari, Rafika; Apridamayanti, Pratiwi; Pratiwi, Liza
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.5

Abstract

Diabetic ulcer is a condition where there are neurological abnormalities and peripheral arterial vascular disease that causes infection, ulceration, and/or damage to the deepest skin tissue on the feet of people with diabetes mellitus (DM). The long duration of wound healing is due to the wrong use of antibiotics for a long time, and bacteria tend to become resistant to antibiotics. Antimicrobial compound fraction of cengkodok combined with gentamicin and ciprofloxacin antibiotics for prevention and reduction of antibiotic resistance in the cause of diabetic ulcers. The drug preparation is in the form of self nanoemulsifiying drug delivery system (SNEDDS), which is the optimum combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics. The use of SNEDDS in this study is because the SNEDDS made from nanoemulsion formulations has small particle size, large surface absorption, and good dispersion, so that it can be evenly dispersed on the skin and penetrates the skin layer. This study aims to determine the effectiveness of the formulation cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics against B. cereus and S. aureususing the SNEDDS drug delivery system. The test uses the spotless diffusion method without using paper discs. The results showed that the combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics had better activity against B. cereus and S. aureus than cengkodok leaf fraction, gentamicin and ciprofloxacin only.
Determination of FICI Value of Combination of Ethanol Extract of Aloe Vera (L.) Burm. f. Leaf Peel and Chloramphenicol Against Bacterial Pathogens Sari, Rafika
Pharmaceutical Journal of Indonesia Vol. 9 No. 1 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.009.01.2

Abstract

ABSTRACT The Increasing case of antibiotic resistance encourages a new action that is the combination plant extracts and antibiotics. Aloe vera leaf skin (Aloe vera (L.) Burm f.) contains phenols, flavonoids and anthraquinones that act as antimicrobials. The aim of research is to determine the value of FICI (Fractional Inhibitory Concentration Index) combination of ethanol extract of Aloe vera leaf skin (Aloe vera (L.) Burm f.) and chloramphenicol against pathogenic bacteria. The determination of MIC (Minimum Inhibitory Concentration) value of ethanol extract for Aloe vera leaf skin (Aloe vera (L.) Burm. F.) and chloramphenicol use disc-paper diffusion method. The combination solution is created by a ratio of 1: 1 volumes from the every MIC values. The determination of FICI values ​​was analyzed by descriptive. The combination of Aloe vera leaf skin extract (Aloe vera (L.) Burm. F.) and chloramphenicol are used for Salmonella typhi bacteria which are 12.5mg / ml and 8 μg / ml, and for Bacillus subtilis bacteria is 2.5 mg / ml and 4 μg / ml resulted in inhibit zone 7.77 ± 0.25 and 7.83 ± 0.36. The combination of FICI value is 2 and it has indifference characteristics (not different) when the researcherd compared between single extract and single chloramphenicol. Aloe vera leaf skin ethanol extract (Aloe vera (L.) Burm. f.) and chloramphenicol may inhibit the growth of Salmonella typhi and Bacillus subtilis bacteria and both of the combinations show indifference characteristics of FICI 2 values. Keywords: FICI, Aloe Vera, Antibacterial, Chloramphenicol
Co-Authors Abdillah, Sabiq Abrar Hiswara Achmad H., Andy Adesta, Fillah Akhyar Rezqi Adi Muhajirin Adjar, Dinda Dwi Puspita Agati DJ, Sharlen Taurisya Agnes Sri Harti Ahmad Wildan Ahtian, Muzaid Aida Fitriyani Aida Fitriyani, Aida Aisyah Warsid Ajif Yunizar Pratama Yusuf Alexander, Allan D Almanda, Almanda Ana Hanapi Andani, Herlin Anggraini, Leriza Desitama Aprilianti Maharani Ardan, Raditia Muhammad Ardha Maliki Arifin, Muhammad Khoirul Aris Munandar As-Sanaj, Tyathanesia Dianfitri Ashardi, Muhammad Asni Amin Asyifa, Fatimah Nur Ayu, Visca Anindha Aziatul Febrian, Reny Aziatul Pebriani, Reny Azmi Mutawalli, Khoirul Azmi, Afif Fadhil Azzahra, Mutia A’lana, Lu’lu’ Bambang WIJIANTO Budi Mulyono Cahya, Nilam cahyani, dwi sinta Chyrza Adhea Salsabila Dahniar Dahniar Danu, Julian Firman Desitama Anggraini, Leriza Eka Nursafitri Eki Ayu Safitri Elfri Kartini Hutabarat Elsa Susanti Ema Damayanti Endah Dewi Purnamasari Endang Retnoningsih Fahiratunnisa, Namira Alifah Fajriaty, Inarah Faradilla, Aulia Fata Nidaul Khasanah Fatimah, Alida Zia Fatimah, Hervina Rahmawati Febrianti, Dwi Andini Ferdinan, Ade Fiorentina, Yulia Firdaus, Tiara Fitri, Diah Angraina Freolina, Putri Shanny Gita Widyawati Hafrizal Riza, Hafrizal Hamdan Sayadi, Muhammad Hamidah, Dhiya Azizah Hanapi, Ana Hegryselia, Hegryselia Helmy, Nur Hendarmin , Rum Hendarmin, Rum Hendharsetiawan, Andy Achmad Herlawati Herlawati Hermansyah Hermansyah Hidayatullah, M.Ridho Husnul Hotimah Idaul Hasanah Inne Miftah Dewi Intan Sari A Ira Wikartika, Ira Izza Della Nur Rizki Joniwarta Juhanda Kamil, Insan Kgs. M. Nurkholis Khairunnisa Azani Meilinasary Khairunnisa Azani Meilinasary, Khairunnisa Azani Khalida, Rakhmi Khoirotunnisa, Fani Kusdarnowo, Kusdarnowo Lastria, Lastria Lesi Hertati, Lesi Lestari, Nur’aini Puji Lia Deslianri, Lia Lili Syafitri, Lili Lisa Adhani Liza Pratiwi Lubis, Hendarman Lubis, Nuraina Fika Lukita Tripermata Manullang, Nathasya Grisella Marhamah, Faila Sufa Maulidia, Yuninta Maulidin, Juani Khuswara Mayadi, Mayadi Meilin Veronica Meiriasari, Vhika Meryansumayeka Meryansumayeka Mugiarso Muhammad Andre Reynaldi Muhammad Bahrul Ulum Muhammad Faris, Muhammad Muhammad Hamdan Sayadi Muhammad Saleh Muhammad Wadud Muhani, Mutiara Mukhlis Mukhlis Mutiara, Mega Muzakki, Muhammad Rafi Naim, Awaluddin Najib, Akmal Najini, Robby Nia Purnama Ningsih Ningrum, Citra Urba Nirwan Nirwan Novarizal, Safarin Novianti, Veni Novita Sari Nuansyah, Bayu Dwimas Nur Kholis NURUL AZIZAH Octaviani, Melly Pebriani, Reny Aziatul Periselo, Helen Prabandari, Rosiana Disiati Pramita, Julianti Pramitha, Ayu Pranoto, Imam Aji Prasetiawati, Fisca Ardi Pratama Lumban Tobing, Yoga Pratama, Aldira Ryan Pratama, Maulana Rifqi Pratama, Satrio Aji Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Prima Dina Atika Puspita Sari, Ranti Puspita, Indira Diah Putra, Mgs Prima Darma Putra, Mgs. Prima Darma Putra, Prima Darma Putri Aisyah Putri Shanny Freolina Putri, Andini Utari Rafina Rafina Rahmadya Trias Handayanto Ramdhania, Khairunnisa Fadhilla Rasim Ratna Salkiawati Ratna Sari Ratu, Mutiara Kemala Raynaldi, Marinus Andre Reny Aziatul Febrian Rianita Rifadli, Syahril Risda Waris, Risda Robiyanto Robiyanto, Robiyanto Sabillah, Izzah Safrina, Nina Salsabila, Dio Ivanca Saputro, Sunu Febrian Eko Sari, Chrecencya Nirmalarum Sari, Mei Sastrawati, Nila Semmagga, Nuraeni Seta Samsiana Setiawan, Dwi Adi Sibarani, Steven Arrow Rinel Silfiana, Andi Silvia, Yuni Siti Nani Nurbaeti SITI SETIAWATI SRI RAHAYU Subarkah Subarkah Sugiyatno Sugiyatno Sulhan Faiz Susanti, Ressi Susilawati, Susilawati Suyati - Sylvia Utami Tunjung Pratiwi Tampubolon, Enggal Marito Yuliarti Tien Yustini, Tien Tripermata, Lukita Tyastuti Sri Lestari Umam, Ibni Khoerul uray rima triyanita Uswatun Hasanah Utari K Vegathree, Chandrika Raveena Veronica, Meilin veronica, Vera Wardian, Simon Wijaya, Indra Winda A. K. Winny Andarilla Wirdayanti Yaddarabullah, Yaddarabullah Yani, Resti Yevi Dwitayanti Yosi Bayu Murti Yusnaini, Tien Zikri, Tan Muhamad Zulkardi