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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kesehatan Masyarakat Medical Journal of Indonesia Nexus Biomedika Proceeding Seminar LPPM UMP Tahun 2014 Public Health of Indonesia Paediatrica Indonesiana AcTion: Aceh Nutrition Journal Al-sihah: The Public Health Science Journal Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Policy and Management Journal of Health Promotion and Behavior Journal of Maternal and Child Health Jurnal Surya Masyarakat Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Jurnal Respirasi (JR) Jurnal Surya Masyarakat Nusantara Science and Technology Proceedings Narra J Proceedings of the International Conference on Nursing and Health Sciences Journal of Health and Nutrition Research Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Plexus Medical Journal Journal of Safety, Health, and Environmental Engineering International Journal of Health Literacy and Science Media Penelitian dan Pengembangan Kesehatan
Vitri Widyaningsih
Department of Public Health and Preventive Medicine, Faculty of Medicine, Sebelas Maret University Surakarta. Jl. Ir. Sutami No. 36 A Kentingan Jebres, Surakarta 57126 Telepon (0271) 664178 2 Occupational Health and Safety Program, Faculty of Me
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Journal : Narra J

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Correlation between circulating fibrosis biomarkers with left atrial function and left atrial volume index in rheumatic mitral stenosis Asrial, An A.; Reviono, Reviono; Soetrisno, Soetrisno; Setianto, Budi Y.; Widyaningsih, Vitri; Nurwati, Ida; Wasita, Brian; Pudjiastuti, Anggit
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.293

Abstract

Mitral stenosis is the most common rheumatic heart disease (RHD) disorder worldwide, including in Indonesia. This pathological condition causes left atrial pressure, leading to left atrial fibrosis that affects the structure and function of the left atrial as well as the clinical condition. The aim of this study was to assess the correlation between circulating fibrosis biomarkers with net atrioventricular compliance (Cn) as a parameter of left atrial function, and left atrial volume index (LAVI) as a parameter left atrium structure of changes. A cross-sectional study was conducted at Panti Rahayu Hospital and Permata Bunda Hospital, Purwodadi, Central Java, with a total of 40 RHD patients with severe mitral stenosis. The ELISA was used to measure the levels of carboxy-terminal propeptide of type I procollagen (PICP), matrix metalloproteinase I (MMP-1), tissue inhibitor matrix metalloproteinase 1 (TIMP-1), and transforming growth factor-β1 (TGF-β1). The left atrial function was assessed by measuring Cn, and the LAVI parameters were measured to assess left atrium structure/size. The mean levels of circulating fibrosis biomarkers were as follows: PICP 153.96±89.12 ng/mL; MMP-1 1.44±2.12 ng/mL; MMP-1/TIMP-1 ratio 0.38±0.54 and TGF-β1 2.66±1.96 pg/mL. From the echocardiographic evaluation, the mean Cn was 5.24±1.93 mL/mmHg and the mean LAVI was 152.55±79.36 mL/m2. There were significant correlation between MMP-1 and MMP-1/TIMP-1 ratio with Cn (r=0.345 and r=0.333, respectively; both had p<0.05). PICP and TGF-β1 biomarkers did not significantly correlate with Cn (p>0.05). Meanwhile, none of the biomarkers had a significant correlation with LAVI (p>0.05). This study highlights that MMP-1 and MMP-1/TIMP-1 ratio are potentially to be used as markers to determine the Cn in RHD patients with severe mitral stenosis. However, further studies with a higher sample size are needed to confirm this finding.
Aerobic exercise improves spatial memory in a rat model of meningitis Zaidah, Lailatuz; Soetrisno, Soetrisno; Purwanto, Bambang; Kristiyanto, Agus; Wasita, Brian; Widyaningsih, Vitri
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.977

Abstract

Infections of the nervous system, such as acute bacterial meningitis, pose serious health problems that require immediate intervention. In experimental animals, exposure to lipopolysaccharide (LPS) is used to induce meningitis. Aside from drug intervention to reduce inflammation in meningitis, aerobic exercise helps to maintain the regulatory mechanisms of brain homeostasis through anti-inflammatory mechanisms. The aim of this study was to evaluate the effect of aerobic exercise on malondialdehyde (MDA), nuclear factor-kappa B (NF-κB), insulin-like growth factor 1 (IGF-1), endothelial nitric oxide synthase (eNOS), brain-derived neurotrophic factor (BDNF), apoptosis, and spatial memory. A four-week experimental study was conducted using 18 rats, which were randomly divided into three different groups (six rats per group): healthy rats as negative controls (non-meningitis), a treatment group treated with antibiotic treatment (meningitis group), and a third group (aerobic exercise group) treated with antibiotics and aerobic exercise following LPS-induced meningitis. Data were analyzed using a one-way analysis of variance (ANOVA) test, and the comparison between groups used the Bonferroni post-hoc test. The results showed that aerobic exercise significantly reduced MDA (p<0.001), NF-κB (p=0.035), and apoptosis (p=0.020) while increasing the serum levels of IGF-1 (p<0.001), eNOS (p=0.011), and BDNF (p=0.001) levels. Improvement in spatial memory was significant in the aerobic exercise group (p<0.001). This study suggested that aerobic exercise could be a promising adjunct therapy in meningitis management strategies, particularly due to its effect on improving spatial memory. Further clinical trials are needed to confirm these findings for clinical use.
Effect of clove flower extract (Syzygium aromaticum) administration timing on skeletal muscle damage induced by eccentric exercise: An in vivo study Ningrum, Tyas Sari Ratna; Doewes, Muchsin; Indarto, Dono; Cilmiaty, Risya; Kristiyanto, Agus; Widyaningsih, Vitri
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1680

Abstract

Eccentric exercise often leads to oxidative stress, inflammation, and muscle damage that impair athletic performance. To counter these adverse effects, clove flower extract (Syzygium aromaticum) offers promising potential as a natural remedy to promote muscle repair with its potent antioxidant and anti-inflammatory properties. The aim of this study was to assess the effects of clove flower extract administration timing on oxidative stress and inflammatory responses in skeletal muscle damage induced by acute eccentric exercise in mice. This study used a post-test-only control group design, involving 35 male mice (Mus musculus, Balb/c) randomly divided into five groups: a healthy control group (HC) with no exercise and no treatment, a negative control group (NC) with exercise but no treatment, and three treatment groups: T1, T2, and T3 (clove flower extract 24 hours before exercise, immediately after exercise, and 24 hours after exercise, respectively). The treatment groups received a single dose of clove flower extract (500 mg/kg body weight). The skeletal muscle damage of mice was collected for the NADPH oxidase (NOX) and superoxide dismutase (SOD) activities using spectrophotometry, and toll-like receptor 4 (TLR4) and interleukin-8 (IL-8) measurements using enzyme-linked immunosorbent assay (ELISA). Moreover, the skeletal muscle damage was analyzed through the histopathological method. Data were analyzed using one-way analysis of variance (ANOVA) followed by Fisher's least significant difference (LSD) tests as a post hoc test. The result showed that clove flower extract significantly reduced NOX activity (p=0.049) and IL-8 levels (p=0.032), and increased SOD activity (p=0.001) while not significantly affecting the TLR4 levels (p=0.532). Moreover, the results showed a significant reduction in muscle damage (p=0.001). The study highlights that the administration of clove flower extract (500mg/kg bw) can be given 24 hours before, immediately after exercise, or 24 hours after exercise to prevent muscle damage.
Co-Authors . Muthmainah Abd. Rasyid Syamsuri Achmad Arman Subijanto, Achmad Arman Agus Kristiyanto Ahadiyati, Dyah Mubarokah Al Biruni, Nada Ali, Agni Shalha Amalia, Najlah Anik Lestari Anshari, Shafira Yasmine Ardina, Safira Cindra Ari Natalia Probandari Ari Probandari Asaduddin, Aiman Hilmi Asrial, An A. Ayu Setyani, Rizka Bachnas, Muhammad Adrianes Bambang Purwanto Berek, Maria Imakulata Bhisma Murti Brian Wasita Budianto, Pepi Burhannudin Ichsan Cahyani, Mey Ditaputri Chatarina Umbul Wahyuni Dewantara, Bayu Putra Diah Kurnia Mirawati Didik Gunawan Tamtomo Dono Indarto Endang Surani, Endang Endang Sutisna Sulaeman Erin Rizkiana Eti Poncorini Pamungkasari Fadhila, Shofia Nur Fardhiasih Dwi Astuti Farida Farida Fitri Febrianti Ramadhan, Fitri Febrianti Habibatullah, Afifa Intifadha Hambarsari, Yetty Hamidi, Baarid Luqman Haris Setyawan Harjanti, Anis Harsono Salimo Hartanti, Ainurrizma Tri Hema Dewi Anggraheny Hutabarat, Ervina Arta Jayanti Ida Nurwati Idulhaq, Mujaddid Imam Setya Arifian, Imam Setya Indarta, Ardhia Fefrine Ipop Sjarifah Jayanti, Saktryana Endang Ragil Juanda Dewi Bambang Bangun Wibowo, Shaviera Ketaren, Enge Surabina Khotijah Khotijah Kumalasari, Dwi Tour Kurniatri, Maniek indah kusnandar kusnandar Leli Saptawati Lusi Ismayenti, Lusi Mahardika Yudianti, Manda Talitha Mahendra, Putu Gede Oka Maingu, Bertha Sylvester Maki Zamzam Merry Tiyas Anggraini Monica, Windhy Ms Khotijah, Ms Muchsin Doewes Muhammad Riza Muhammad, Faizal Muvida Muvida Nawanindha, Natasha Ningrum, Fiki Cahya NINGRUM, TYAS SARI RATNA nugroho wisnu murti Nur Hafidha Hikmayani Palupi, Raras Indung Paulus Kusnanto Prabaningtyas, Hanindia Riani Prasetya, Hanung Pravitasari, Ines Ratni Pudjiastuti, Anggit Puspita, Ita Fijanah Puspitasari, Yunita Dwi Quraisy, Cut Cahaya Rani Saifa Alhajd Rachmawati, Nur Cahya Rahardjo, Setyo Sri Rahardjo, Setyo Sri Rahmawati Ratih Puspita Febrinasari Reni Wijayanti Reviana, Prita Alvina Reviono Reviono Reviono, R Rico Januar Sitorus Ristaning Belawati, Yeny Ristinawati, Ira Risya Cilmiaty, Risya Rivan Danuaji Rosyida, Rufaida Rusfianti, Alfia Rusnoto, R Saputra, Rhyan Darma Saputri, Nurul Aini Suria Sari, Niken Kartika Setianto, Budi Y. Setyo Sri Raharjo Shalih, Ahmad Sabiq Sholihah, Imrok Atus Simatupang, Nanda Agustian Siti Nur Hidayati Soestrisno, Soestrisno Soetrisno Soetrisno Soetrisno Sri Mulyani Sri Widarti, Sri Sukamto, Ika Sumiyarsi Sumardiyono Sumardiyono SUROTO Tedjo, Raden Andi Ario Tejomukti, Teddy Titisari, Bening Rahimi Tri Nugraha Susilawati Uki Retno Budihastuti Ulul Azmi Zuhaira Wahyu Gito Putro Wayanshakty, Janur Wibawa, Lathifa Diyang Widayati, Purwika Widiatmaja, I Gusti Bagus Panji Wulansari, Galuh Yanri Wijayanti Subronto Yanuari, Ridha Rossela yulia lanti retno dewi Zahidah, Fairuz Zaidah, Lailatuz