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Journal : juke

THE EFFECT OF ETHANOLIC EXTRACT OF CENTELLA ASIATICA (L) URBAN ADMINISTRATION TOWARDS THE THICKNESS OF PYRAMIDAL LAYER IN THE CA1 REGION OF HIPPOCAMPUS OF SPRAGUE DAWLEY RATS AFTER CHRONIC RESTRAIN STRESS Anggraeni Janar Wulan; Brian Wasita; Nanang Wiyono
JUKE Unila Vol 4, No 8 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

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Abstract

Background: Stress has been shown can change the structure of the brain, especially in the cornu ammonic (CA) I region of hippocampus. Centella asiatica or pegagan as herbal neuroprotector was investigated. The study aimed to determine the effect of ethanolic extract of C. asiatica to the thickness of pyramidal layer in the CA1 region in rats subjected to chronic restrain stress (CRS). Method: This experimental study used post test only group design. Thirty five rats were divided into 6 groups: non stress group (control) and stress only group pulvis gum arabicum (PGA), positive control group (treated with fluoxetin 10mg/kgBW), and 3 treatment groups are treated with C. asiatica 150, 300, and 600mg/kgBW respectively. All groups except non stress group were subjected to CRS, for 6 hours per day for 21 days. Fluoxetin, PGA, and C. Asiatica were applied 30 minutes before CRS done. Rats were sacrificed at the end of 24th day and were perfused transcardially. Processed brain tissue stained with toluidine blue, and measured with Image Raster program. Result: The thickness of pyramidal layer in the CA1 region are increasing significantly in treatment groups which treated with 150 and 300 kg/BW of C. asiatica, but not significant which treated with 600mg/kgBW ethanolic extract of C. asiatica. Conclusion: Ethanolic extract of C. asiatica can improve thickness of pyramidal layer in the CA1 region of hippocampus of Sprague Dawley rats after chronic restrain stress. [JuKe Unila 2014; 4(8):202-207]
Co-Authors -, Muthmainah Abdullah Faqih Abdurrahman Afa Haridhi Achmad Nurul Hidayat Adam Fauzi Adhi, Auliya Yasmin Afia Fitriani Agus Supinganto Agus Supriyanto Amaliah, Lili Amru, Khaeriah Ana Tsalitsal Futiya Roisal Ufqi Anggraeni Janar Wulan Annang Giri Moelyo Anugrah, Tessa Septian Ari Handono Ramelan Ari Probandari Aripa, Lusyana Aris Sudiyanto Aryoseto, Lukman Baharuddin Baharuddin Bakti, Alfonsus Aryo Sunu Baskoro, Reza Setyo Brian - Wasita,dr.,Ph.D Brian Wasita Brian Wasita Brian Wasita Brian Wasita Budi Purnama Budiono, Enrico Ananda Budiyanti Wiboworini Bukhari, Agussalim Bulan Kakanita Hermasari Bulan Kakanita Hermasari Devinta, Salzha Dhoni Akbar Ghozali Dhoni Akbar Ghozali Diah Kurnia Mirawati Dian Fikri Rachmawan Diana Nurrohima Dicky Maulana Lazuardi Djoko Prakosa Dorce Sisfiani Sarimin Duwi Handayani, Juleha Dwi Cahyani Ratna Sari Dwi Teguh Raharjo Dyonisa Nasirochmi Pakha Endang Sri Wahyuni Evy Aryanti Fairuz Zamani Faisal Rahutomo Farhah Millata Hanifa Farida Hidayati Ferianasari, Ineke Winda Firnadi, Jossefa Gabriela Claudia Ginus Partadiredja Hadyan, Rifqi Handayani, Damiana Nirmala Mukti Handayani, Selfi Handayani, Selfi Hanifa, Shafira N. Hanum Ferdian Haridhi, Abdurrahman Afa Hastami, Yunia Hendry Gunawan Herawati, Fitriana Hidayat, Achmad Nurul Hilmy, Farhan Ida Nurwati Ida Nurwati Ilyas, Muhana F. Ilyas, Muhana Fawwazy Ina Kusrini INTAN PRATIWI Irawan, Amelia Tjandra Isna Qadrijati Istiqomah Nur Aziza Joko Hariyono Jossefa Almanita Haepie Firnadi Jusup, Sinu Andhi Kusumadewi, Isnindri Annisa Kusumaningrum, Sulistyani Kuswati Kuswati Lazuardi, Dicky Maulana Lukas, Graciella A. Lutfatul Jannah, Safella M. Nur Dewi Kartikasari Marwatunnisa Al Mubarokah maryatun maryatun Mashudi, Sugeng Mashuri, Yusuf Ari Mohtar Yunianto Muchtar Hanafi Muhammad Fanani Muhammad Farrel Akshya Muhammad Syaifullah Muthaminah, Muthaminah Muthmainah Muthmainah - Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah, Muthmainah Nandyantami, Farah Fauziah Nugroho, Dian Nunqaf, Anjani Maulaya Nurdin, Nugi Nurhadi, Asty A. Nurhani, Ahmad Isnaini Shidqi Nurul Mahmudah, Irvina Nurwijayanti Nuryani Nuryani Nuryani Nuryani Palupi, Pratiwi Indah Paramasari Dirgahayu Penggalih Mahardika Herlambang Pesik, Riza N. Prasetya Utami Pratiaksa, Ardian Pratiwi Indah Palupi Probandari, Ari Rachmi Fauziah Rahayu Raditya Perdana Aryasatya Rahayu, Rachmi F. Rahma, Annisa A. Rahma, Annisa Aghnia Rahmadany, Muhammad Fa'iz Rahmadany, Muhammad Faiz Rahmani, Muhammad Z. Rahmat Hidayat Rahmat Rohmani Rahmatillah, Arif Rani Tiyas Budiyanti Ratih Dewi Yudhani Ratih Puspita Febrinasari Ratih Yudhani Retno Hartati Ridhallah, Muhammad Syauqi Riyanto, Agus Sugeng Riyatun Riyatun Riza Novierta Pesik Rohmaningtyas Hidayah Setyaningrum Sayekti Wahyuningsih Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Sentot Budi Rahardjo Shabrina, Syania Shariza Fakurazi Sholikah, Tri Agusti Sinu Andhi Jusup Siswanto, Febby Gunawan Siti Munawaroh Siti Munawaroh Siti Munawaroh Suharno Suharno Sutrisno Ibrahim Suyatmi Suyatmi Tamaulina Br Sembiring Tandiyo, Desy Kurniawati Tedja Danudjo Oepomo Tri Rejeki Andayani Triniputri, Winastari Y. Ummu Ma’rifatul Afifah Utari Utari Utomo, Hernowo Setyo Veronika Ika Budiastuti Wardhani, Lusi O. Wardhani, Lusi Oka Wasita, Brian Wasita,dr.,Ph.D, Brian - Wijayanto, Matthew A. Windy Ayu Lestari Yarsa, Kristanto Y. Yarso, Kristanto Yuli Yenni Zulhamidah, Yenni Yudhani, Ratih D. Yunia Hastami Yuridian Purwoko, Reza Yusuf Anggara Aji Yuyun Yueniwati Zahrah, Fathimah Afifah Zaki, Shifa Nurzahra