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FORMULASI SEDIAAN SABUN CAIR ANTIBAKTERI MINYAK ATSIRI DAUN KEMANGI (Ocimumamericanum L.) DAN UJI TERHADAP BAKTERI Staphylococcus epidermidis dan Staphylococcus aureus Febry Astuti Abu; Yusriadi Yusriadi; Muhammad Rinaldhi Tandah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.449 KB) | DOI: 10.22487/j24428744.2015.v1.i1.4835

Abstract

Basil (Ocimum americanum L.) is a plant that has antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis that is a bacteria can cause infection. Basil contains essential oils that act as an antibacterial. This research aims to formulate the essential oil of basil leaves into a liquid soap, determine antibacterial activity against S.aureus and S.epidermidis bacteria with the agar diffusion method using wells and determine the stability of the preparation. Antibacterial activity data that gain was analyzed by one-way ANOVA with a level of trust 95% followed by Duncan test. The results of the research showed basil essential oil liquid soap preparation has antibacterial activity. The analysis results showed that there were significant differences in the concentration of 2%, 3%, 4%, and the Duncan test results showed no significant difference between the concentration of 4% with control (+). The results of the t-student analysis of liquid soap include viscosity, pH and dispersive capacity does not fill the parameters of stability during the storage period of 28 days
FORMULASI GEL EKSTRAK PATIKAN KEBO (Euphorbia hirta L.) DAN UJI AKTIVITAS TERHADAP BAKTERI Staphylococcus epidermidis Tri Novrianti Djanggola; Yusriadi Yusriadi; Muhamad Rinaldhi Tandah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.065 KB) | DOI: 10.22487/j24428744.2016.v2.i2.5954

Abstract

Patikan kebo (Euphorbia hirta L.) is a plant that have activity of inhibiting the Staphylococcus epidermidis bacteria, which was known as the cause of acnes. Flavonoids and tannin as antibacterial compounds which supposedly can act as an active antiacne. Purposes of this research is formulating extract gel of patikan kebo and antibacterial activity against Staphylococcus epidermidis by agar difussion method using paper disc and to know stability of the gel. The result was analyzed by One Way ANOVA with confidence level of 95%, followed by Duncan test. The result of this research showed test antibacterial activity that difference among the concentration extract has a noticeable difference zone of inhibition and extract gel of patikan kebo not have good physical quality during 28 days of storage. Keywords: Patikan kebo (Euphorbia hirta L.), gel, antibacterial, Staphylococcus epidermidis
PENGARUH GEL EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Fina Ulviani; Yusriadi Yusriadi; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.124 KB) | DOI: 10.22487/j24428744.2016.v2.i2.5977

Abstract

Research on Gel Formulation of red betel leaf extract (Piper crocatum Ruiz & Pav) for the treatment of burn wounds in rabbits (Oryctolagus cuniculus) has been conducted. This study aimed to determine variation’s effect of concentration in gel of red betel leaf extract for the treatment of burn wounds in rabbits which had been wounded using hot metal. In this study, the viscous extract was formulated into gel with concentrations of 1%, 2% and 3%. The Gel’s Physical quality evaluation included organoleptic, pH, homogeneity and dispersive ability tests on day 0 until day 28. The gel activity test was performed on 5 rabbits divided into five treatment groups. Each rabbit was burn-wounded using hot metal plate at diameter of 20 mm. Each group was given five wounds consisting of a negative control, 1%, 2%, 3% of extract formula and a positive control. The diameter measurement of the wounds was done on the 1st, 3rd, 5th, 7th, 9th and the 21st day. Data of wound healing percentage was statistically analyzed with Two-Way ANOVA. The results showed that the gel with 3% of red betel leaf extract of which percentage of healing as much as 85.81% compared to gel extract 1% and 2% with percentage 65,32% dan 76,58%.
GEL ANTI JERAWAT EKSTRAK DAUN BUTA-BUTA (Excoecaria agallocha L.) DAN PENGUJIAN ANTIBAKTERI Staphylococcus epidermidis Ika Olivia Borman; Yusriadi Yusriadi; Evi Sulastri
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.783 KB) | DOI: 10.22487/j24428744.2015.v1.i2.6215

Abstract

Buta-Buta (Excoecaria agallocha L.) leaf is a type of mangrove plants that has antibacterial activity againtsbacteriacausing acne, Staphylococcus epidermidis,. This study aims to formulate buta-buta leaf extract with the concentration of 12.5 % into anti-acne gel using two gels, namely HPMC 8% (Formula 1) and Carbopol 940 2%(Formula 2). Antibacterial activity test was carried out by agar diffusion method using well. The stability and antibacterial activity data during 28 days were analyzed statistically using unpaired t-student with a degree of confidence of 95% (α = 0.05). The evaluation results of anti-acne gel form of buta-buta leaf extract in Formula 2 showedbetter characteristics than Formula 1, which include organoleptic examination, homogenity, pH and viscosity during 28 days. The antibacterial test showed the diameter of inhibition zone of Formula 2 is 11.03 mm ±0,01. The statistic analysis showed a significant difference between Formula 2 with a positive control (klindamisin gel).
UJI AKTIVITAS REPELAN LOTION EKSTRAK ETANOL KULIT BUAH LANGSAT (Lansium parasiticum Osbeck.) TERHADAP NYAMUK Aedes aegypti Pebrianti Pebrianti; Yusriadi Yusriadi; Ingrid Faustine
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.81 KB) | DOI: 10.22487/j24428744.2015.v1.i2.6242

Abstract

Repellents are substances that can provide protection from nuisance insects by interfering with its sensory function. Lanzones fruit is known to contain triterpenoids which have activity as repelan. This study was to examine the repellent activity and to determine protection capacity of lotion containing ethanol extract of lanzones (Lansium parasiticum) peel against  Aedes aegypti mosquitoes. The ethanol extract was obtained by macerating the peel with 96% ethanol. The lotion is prepared in three extract concentrations, 15%; 20%; and 25% followed by its physical stability evaluation and activity examination. Data of pH, viscosity and dispersive capacity evaluation obtained were statistically analyzed using paired samples t-test. The results showed that the lotion preparations are stable on organoleptic observation and homogeneity evaluation. The statistical analysis of pH, viscosity, and the dispersive capacity evaluations showed that their results are significantly different after day 0 to day 28 storage (p> 0.05). Repellent activity examination of the lotion was carried out for 4 hours, using the Aedes aegypti mosquitoes. Of the three concentrations examined, each concentration has different repellent activity that concentration of 15% and 20% indicated a 100% protection up to 1 minute, and concentration of 25% indicated up to 135 minutes
Formulasi Mikroemulsi Ekstrak Terpurifikasi Daun Bayam Merah (Amaranthus tricolor L.) Sebagai Suplemen Antioksidan: Microemulsion Formulations of Purified Extract of Red Leaves Spinach (Amaranthus tricolor L.) as Antioxidant Supplements Dwi Lestari Handayani; Yusriadi Yusriadi; Ririen Hardani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 1 (2017): (March 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.11 KB) | DOI: 10.22487/j24428744.2017.v3.i1.8133

Abstract

A research has conducted about the microemulsion formulation of purified extract of red spinach leaves (Amaranthus tricolor L.) as an antioxidant supplement with the aim to be able to know the formula to form a microemulsion which meet the physical quality stability and determine antioxidant activity (IC50) of the preparation. Extracts prepared by maceration method using ethanol 96% and then later do the purification using solvent n-hexane and ethyl acetate, after it tested its antioxidant activity. Formula to form a microemulsion purified extract of red spinach leaves clear is to use virgin coconut oil (VCO) by 15%, tween 80 for 40%, 35% glycerin and 10% distilled water. Physical stability test was conducted on the organoleptic test, measuring the diameter of globules, pH test, test and test viscosity centrifugation. Test of antioxidant activity in vitro using DPPH method and using Vitamin C as a positive control. Measurement data were statistically analyzed using paired samples T test. The test results of antioxidant activity microemulsion purified extracts of spinach leaves, red show IC50 values on day 1 was 1.83 ppm and the 28th day amounted to 3.71 ppm. While vitamin C microemulsion shows IC50 values on day 1 of 0.24 ppm and the 28th day of 2.51 ppm. Despite the decreased antioxidant activity, but each of the stocks included in the category of very powerful antioxidants.
Optimasi Pembentuk Film Polivinil Alkohol dan Humektan Propilen Glikol pada Formula Masker Gel Peel off Sari Buah Labu Kuning (Cucurbita moschata Duchesne) sebagai Antioksidan: Optimization of Film Forming Polyvinyl Alcohol and Propylene Glycol Humectant in Pumpkin Juice (Cucurbita moschata Duchesne) Peel-off Gel Mask Formula as Antioxidants Tricia Andini; Yusriadi Yusriadi; Yuliet Yuliet
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.143 KB) | DOI: 10.22487/j24428744.0.v0.i0.8773

Abstract

Telah dilakukan penelitian tentang formulasi dalam bentuk sediaan masker gel peel-off. Penelitian ini bertujuan untuk mengetahui konsentrasi optimum polivinil alkohol sebagai pembentuk film dan propilen glikol sebagai humektan terhadap sifat fisik dan kimia sediaan masker gel peel-off sari buah labu kuning, stabilitas formula optimummasker gel dan aktivitas antioksidan sediaan. Formula optimum yang didapatkan yaitu formula 1 dengan konsentrasi PVA 10% dan PG 10% kemudian dilakukan evaluasi karakteristik mutu fisik kimia dan stabilitas meliputi pengujian daya sebar, pH, viskositas dan lama pengeringan. Pengamatan dilakukan tiap minggu selama 4 minggu penyimpanan pada suhu ruang. Data yang diperoleh dianalisis secara deskriptif dan secara statistik menggunakan metode paired sample t test. Hasil penelitian masker gel peel-off pada formula optimum menunjukkan sediaan stabil selama penyimpanan dimana tidak terjadi perubahan yang signifikan pada tiap parameter uji. Aktivitas antioksidan gel masker peel-off tergolong kuat yang dinyatakan dengan peresen peredaman formula optimum pada hari ke- 2 adalah 75,18% dan 73,37% pada hari ke- 30 setelah penyimpanan pada suhu ruang
Kadar Albumin Pada Ikan Sidat Anguilla marmorata Q Gaimard dan Anguilla bicolor Asal Sungai Palu dan Danau Poso Jamaluddin Jamaluddin; Gugun Gunawan; Siti Nurhafsah; Padhlun A Jerni; Dytha Okvhyanitha; Ade Fazliana Mantika; Jessica Jessica; Asty Ivon Samaliwu; Yusriadi Yusriadi; Agustinus Widodo
Ghidza: Jurnal Gizi dan Kesehatan Vol 4 No 1 (2020): July
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v4i1.37

Abstract

Ikan sidat termasuk ikan yang memiliki kandungan gizi yang tinggi seperti vitamin A, vitamin B, DHA(Docosahexaenoic acid), EPA(Eicosapentaeonic acid), dan protein albumin. Albumin memiliki peranan penting sebagai sarana pada proses transportasi dalam darah, pembentukan jaringan tubuh yang baru pada masa pertumbuhan, senyawa proteksi hati dan juga bermanfaat dalam proses penyembuhan luka pada pasien pasca operasi. Penelitian ini bertujuan untuk mengetahui perbandingan kadar albumin ikan sidat Anguilla marmorata dan Anguilla bicolor pada fase glass eel, elver, yellow eel dan silver eel asal Sungai Palu dan Danau Poso. Sampel diambil menggunakan metode purposive sampling berdasarkan pada jenis, berat, ukuran, dan lokasi pengambilan. Pengujian kadar albumin ditentukan dengan menggunakan metode Bromocresol green dengan alat fotometer dan hasil penelitian menunjukkan bahwa kadar albumin tertinggi terdapat pada fase silver eel, yakni sebanyak 1,62 gram / 100 gram pada Anguilla marmorata asal Danau Poso dan kadar paling rendah terdapat pada fase elver sebanyak 0,24 gram / 100 gram pada Anguilla bicolor asal Danau Poso. Hal ini menunjukkan bahwa spesies Anguilla marmorata memiliki kadar albumin yang lebih tingi dari Anguilla bicolor.
AKTIVITAS EKSTRAK DAUN RUMPUT BERMUDA (Cynodon dactylon L. Pers) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oyctolagus cuniculus) Nurlaila Ramadhani; Yusriadi; Khildah Khaerati
Jurnal Ilmiah Medicamento Vol 5 No 2 (2019): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v5i2.846

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun rumput bermuda (Cynodon dactylon L. Pers) terhadap penyembuhan luka bakar serta mengetahui konsentrasi yang efektif terhadap penyembuhan luka bakar. Hewan uji yang digunakan pada penelitian ini adalah kelinci jantan (Oryctolagus cuniculus) yang dibagi dalam 5 kelompok uji. Setiap kelinci dibuat luka bakar di bagian punggung dengan diameter 2 cm, kelompok uji I diberi gel Bioplasenton (kontrol positif), kelompok II diberi basis Na CMC (kontrol negatif), kelompok uji III, IV, dan V diberi sediaan ekstrak daun rumput bermuda dengan konsentrasi masing-masing 1%, 3%, dan 5%. Pengukuran luka bakar menggunakan alat jangka sorong dilakukan setiap hari selama 21 hari. Data yang diperoleh dianalisis menggunakan uji One way Anova dan dilanjutkan uji Post hoc Duncan. Hasil statistik menunjukkan bahwa ekstrak daun rumput bermuda memiliki aktivitas dalam penyembuhan luka bakar pada kelinci. Konsentrasi yang efektif adalah konsentrasi 5%.
AKTIVITAS EKSTRAK ETANOL DAUN PEPOLO (Bischofia javanica BLUME) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Suhaeni Zainuddin; Yusriadi; Akhmad Khumaidi
Jurnal Ilmiah Medicamento Vol 5 No 2 (2019): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v5i2.848

Abstract

Tumbuhan daun pepolo (Bischofia javanica Blume) merupakan salah satu tumbuhan yang digunakan untuk pengobatan luka bakar. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun pepolo terhadap penyembuhan luka bakar pada kelinci (Oryctolagus cuniculus). Pengujian aktivitas ekstrak etanol daun pepolo menggunakan 5 ekor kelinci yang dibagi dalam 5 kelompok perlakuan yaitu kontrol negatif (basis gel tanpa ekstrak), ekstrak etanol daun pepolo dalam basis gel dengan konsentrasi 5%, 10%, 15% dan kontrol positif (gel Bioplacenton). Pengukuran diameter luka dilakukan pada hari ke- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, dan 21. Data yang diperoleh dianalisis secara statistik dengan Metode One Way Anova. Hasil analisis statistik menunjukkan bahwa ekstrak daun pepolo pada konsentrasi 5%, 10% dan 15% memiliki aktivitas penyembuhan luka bakar. Penyembuhan luka bakar yang efektif yaitu konsentrasi 15%, yang memberikan penyembuhan sebesar 92,34%.
Co-Authors A. Khairinisa, Miski A.A. Ketut Agung Cahyawan W Abdul Rahman Adam, Aisyah Azhar Ade Fazliana Mantika Agus Syahrani Agustinus Widodo Akhmad Khumaidi Aldilla, Dilla Alowisya Futwembun Alwiyah Mukaddas Alwiyah Mukaddas Amal, Citra Amalia amelia rumi, amelia Amri, Faizal Ana Silviana Anak Agung Istri Sri Wiadnyani Anderbeck, Karl Andi Alfianto Andi Mustika Andi Nuddin Andi Ratihsekarningrum Siradje Ansar Apriyana Soputra Aqdar Fitrah, Muhammad Ardiansah, Ardiansah Ari Prabowo Arminas, Arminas Armini Syamsidi Asfar, Dedy Ari asnahwati asnahwati, asnahwati Asriana Sultan Asty Ivon Samaliwu Asyura, Putri Azzahra, Najwa Salsabilla Bakhrul Amal Birdayanthi, Birdayanthi BOB ANDRIAN Buti, Sri Cristadeolia Oktaviani Cristadeolia Oktaviani, Cristadeolia David Pakaya Desa, Susilo Sudarman Deviana, Alda Didi Darmadi, Didi Dinda Rahmiyati Dwi Lestari Handayani Dwiyanti, Andi Amitya Resty Dytha Okvhyanitha Evi Sulastri Fadilah, Sandi Fatruhrrosi, Fathurrosi Febry Astuti Abu Fina Ulviani Finta Amalinda Friskilla Friskilla Ginting, Suranta Bill Fatric Gugun Gunawan GUSTI IRYA ICHRIANI, GUSTI IRYA Haryanto Atmowardoyo, Haryanto Hasniar Hasniar Hasriyanti, Nunik Heni Pujiastuti Hermansyah Hermansyah Hidayat, Novit Idrus, Irnawaty Ika Olivia Borman Ikmal, Ikmal Imam Mishbach Imron Muttaqin, Imron Ince Agus Nurcholis Ingrid Faustine Irawan, Dika Iskandar Sulaiman, Iskandar Ismail Ismail Ismail, Nur Afia Jamaluddin Jamaluddin Jamaluddin Jamaluddin Janes Krisly Jessica Jessica Joko Tri Haryanto Joni Iskandar, Joni Joni Tandi, Joni Juniawati Kartini Kartini Khaerunnisa, Munira Khairizzaman Khairizzaman Khildah Khaerati Klerensia Defneir Titing Lestari, Sri Ayu Liyatin Gea lubis, kartika sari M Sulaiman Zubair M Yusuf Mansur Mansur Mega Fia Lestari Miftahul Jannah Misnawati Misnawati Misnawati Misnawati Moh. Rifki Muhamad Rinaldhi Tandah Muhammad Faisal Muhammad Lutfi Hakim Muhammad Muhammad Muhammad Rinaldhi Tandah Muhammad Sulaiman Zubair Muhammad, Rizki Munawar Munawar Muslimin ., Muslimin Mustolehudin Mustolehudin Muthi’ah H Z Mutiani, Santi Nandiska Maladjili Natasya, Putri Nela Sharon Nelly Mujahidah Norawati, Suarni Nordin, Zaimuariffudin Shukri Novianti Batti Novita Christiana Ponganan Nufiar Nufiar Nuha, Jumrotin Nur Amri, Azhari Nur Fuady, Muhammad Ikram Nur Hamzah Nurhajawarsi Nurhalifah Ibrahim Nurlaila Ramadhani Nuur Aanisah Paddiyatu, Nurhikmah Padhlun A Jerni Papriani, Nada Pertiwi Pebrianti Pebrianti Pramita Putri Pramita Putri Purnomo, Nurul Purwanti, Rani Rafinda, M. Syarif Ramadan, Rafsanjany Ramadhani, Nurlaila Ririen Hardani Ritha Pratiwi Rochaeti , Nur Ruslan, Ismail Sahabuddin Latif Saidy, Akhmad Rizalli Saipul Maulana Salawali, Rismul Trianto Seprililianti Seprililianti Serli, Serli Setyaningrum, Saumi Shin, Chong Shobikah, Nanik Shukri bin Nordin, Zaimuarifuddin Siti Nurhafsah Sri Sulistiana Suhaeni Zainuddin Suherman Suherman, Suherman Syahsudarmi, Siti Syarifuddin, Nuryani Syariful Anam Tamba, Nesli Towolioe, Sherly Tri Novrianti Djanggola Tricia Andini Triyanti, Tiya Tuah, Dilah Tuah, Dilah bin Umi Farida Utami, Hermin Hardyanti Wardatul Nurjannah Yantama, Akmal Andri Yonelian Yuyun Yuli Arnida Pohan Yuliet Yuliet Yusri, Andi Yusriadi, Yusriadi Zainuddin, Suhaeni Zuhri Arif