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Impact of Donation Frequency on Iron Stores and Hemoglobin Levels in Regular Blood Donors Lili Novri Yanti; Rofinda, Zelly Dia; Syofiati; Rikarni; Husni; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1282

Abstract

Background: Regular blood donation, while crucial for healthcare systems, can lead to iron deficiency and anemia in donors. This study investigated the impact of donation frequency on iron stores and hemoglobin levels in regular blood donors. Methods: A cross-sectional study was conducted on 82 regular blood donors at the blood transfusion unit of Dr. M. Djamil General Hospital from February to April 2024. Participants underwent pre-transfusion screening, including a questionnaire on donation frequency and iron supplement use. Blood samples were collected during donation, and serum ferritin, hemoglobin, and erythrocyte indices (MCV, MCH, MCHC) were measured if the C-reactive protein (CRP) test was negative. Data were analyzed using the Kruskal-Wallis test. Results: The mean age of the donors was 31 years, with the majority being female (56.1%). The most common donation frequency was 6-10 times (34.15%). None of the donors reported using iron supplements. Serum ferritin levels showed significant differences among female donors based on donation frequency (p=0.004) but not among male donors (p=0.114). Hemoglobin levels also differed significantly among female donors (p=0.002), but not among male donors (p=0.213). Significant differences were observed in MCV and MCH values in both male and female donors (p<0.001 and p=0.001, respectively), but not in MCHC values (p=0.135). Conclusion: Donation frequency significantly impacts iron stores and hemoglobin levels in female blood donors but not in male donors. Regular monitoring of iron stores, particularly in female donors, is crucial to prevent iron deficiency and anemia.
The Clinical Significance of DAT Positivity: A Comparative Analysis of IgG, C3d, and IgG/C3d-Positive Patients Khaulah Karimah; Zelly Dia Rofinda; Husni; Rikarni; Deswita Sari; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1288

Abstract

Background: The direct antiglobulin test (DAT) is a crucial diagnostic tool in immunohematology, used to detect the presence of antibodies and/or complement components on the surface of red blood cells. DAT positivity is frequently associated with autoimmune hemolytic anemia (AIHA) and other immune-mediated hemolytic conditions. This study aimed to investigate the clinical significance of DAT positivity by comparing the characteristics of patients with IgG, C3d, and IgG/C3d-positive results. Methods: A retrospective study was conducted on 55 patients with DAT-positive results, identified from the Blood Transfusion Unit of Dr. M. Djamil General Hospital Padang between June 2023 and August 2023. DAT-positive samples were further analyzed using monospecific anti-human globulin (AHG) reagents to determine the presence of IgG, C3d, or both on the red blood cells. Patient demographics, clinical diagnoses, blood groups, transfusion history, and hematological parameters were collected and analyzed. Results: Out of the 55 DAT-positive patients, 51 (92.7%) were positive for IgG alone, 3 (5.5%) were positive for both IgG and C3d, and only 1 (1.8%) was positive for C3d alone. The majority of patients were adults (>18 years old) and female. A history of blood transfusion (>3 times) was common, particularly in the IgG-positive group. Hematological parameters indicative of hemolysis (hemoglobin ≤9 g/dL, reticulocyte count >2%, and total bilirubin >2 mg/dL) were observed in a significant proportion of patients, especially those with IgG and/or C3d positivity. Conclusion: IgG positivity was the most common finding in DAT-positive patients, highlighting the prevalence of warm AIHA. The presence of C3d, alone or with IgG, suggests the involvement of complement activation and may indicate a different underlying pathology. This study emphasizes the importance of using monospecific AHG reagents to characterize DAT-positive results, as this information can aid in the diagnosis, management, and prediction of clinical outcomes.
Immunophenotyping vs. Bone Marrow Aspiration in Pediatric Acute Leukemia: A Comparative Analysis Satria Utomo; Yulia, Dwi; Elfira Yusri; Rismawati Yaswir; Husni; Desywar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1289

Abstract

Background: Acute leukemia is a significant global health concern, with increasing prevalence worldwide and in Indonesia. Accurate diagnosis and classification of acute leukemia subtypes, primarily acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML), are crucial for effective treatment. Immunophenotyping and bone marrow aspiration (BMA) are commonly used diagnostic methods, each with its strengths and limitations. This study aimed to analyze the concordance between immunophenotyping and BMA in diagnosing and classifying acute leukemia in children. Methods: A retrospective cross-sectional study was conducted on 46 children diagnosed with acute leukemia at Dr. M. Djamil General Hospital Padang from January 2022 to July 2023. Data were collected from medical records, including patient demographics, immunophenotyping results, and BMA findings. Concordance between the two diagnostic methods was analyzed using Fisher's exact test. Results: The study population consisted of 30 (65.2%) males and 16 (34.8%) females, with a median age of 4 years. Immunophenotyping identified 24 (52.2%) cases as ALL and 22 (47.8%) as AML. BMA classified 26 (56.5%) cases as ALL and 20 (43.5%) as AML. There was a high concordance between the two methods, with only 2 (4.3%) cases showing discordant results. These two cases were classified as AML by immunophenotyping but as ALL by BMA. Conclusion: Immunophenotyping and BMA demonstrate a high level of concordance in diagnosing and classifying acute leukemia in children. The few discordant cases highlight the importance of considering both methods, especially in challenging cases, to ensure accurate diagnosis and appropriate treatment.
IMPLEMENTASI SISTEM ELECTRONIC MEDICAL RECORD (E-MR) DALAM MENINGKATKAN KUALITAS KLAIM BPJS DI UPTD RSUD LOMBOK TIMUR Novita Laily Shalatiah; Saleh, Muhammad; Husni
Jurnal TAMBORA Vol 9 No 1 (2025): EDISI 24
Publisher : Wakil Rektor 3, Direktorat Riset, Publikasi dan Inovasi, Universitas Teknologi Sumbawa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36761/tambora.v9i1.5550

Abstract

RSUD Lombok Timur menghadapi tantangan dalam implementasi Electronic Medical Record (E-MR) untuk proses pemberkasan klaim BPJS. Sebagai Badan Layanan Umum Daerah (BLUD), rumah sakit ini harus mandiri secara finansial dan bergantung pada klaim BPJS untuk menjaga stabilitas keuangan. Penelitian ini bertujuan untuk menganalisis proses implementasi E-MR dan pengelolaan klaim BPJS di RSUD Lombok Timur serta mengevaluasi efektivitas dan tantangan yang dihadapi. Metode yang digunakan adalah wawancara dengan informan dari berbagai divisi terkait dan analisis data kualitatif. Hasil penelitian menunjukkan bahwa meskipun terdapat kendala teknis seperti keterbatasan infrastruktur, sistem yang belum sempurna, dan gangguan jaringan, penggunaan E-MR terbukti efektif dalam meningkatkan kualitas klaim BPJS. Absensi klaim rumah sakit telah mencapai lebih dari 90%, yang mencerminkan peningkatan efisiensi pengelolaan klaim. Kesimpulannya, RSUD Lombok Timur berhasil mengimplementasikan E-MR dengan baik, namun perlu ada peningkatan pelatihan, infrastruktur, serta sistem monitoring dan koordinasi antar divisi untuk memaksimalkan pengelolaan klaim BPJS. Penelitian lebih lanjut diperlukan untuk menilai faktor-faktor lain yang berperan dalam pengelolaan klaim, khususnya dalam hal pengkodean diagnosis.
KEPEMIMPINAN TRANSFORMASIONAL KEPALA SEKOLAH Yusuf; Yulianti; Husni; Arianto Syahruddin; Munawir; Roswati; Ujuh Ilham Simak
Kelola: Journal of Islamic Education Management Vol. 10 No. 1 (2025): Kelola: Journal of Islamic Education Management
Publisher : Institut Agama Islam Negeri (IAIN) Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24256/kelola.v10i1.6124

Abstract

Kepala sekolah adalah sosok yang memimpin di lembaga pendidikan. Kemajuan kepemimpinan seorang kepala sekolah bergantung pada penerapan teori atau model kepemimpinan yang sesuai. Salah satu model kepemimpinan yang diterapkan adalah kepemimpinan transformasional. Kepemimpinan transformasional adalah gaya kepemimpinan yang mengubah energi dari berbagai sumber daya, termasuk manusia, alat, dan situasi, guna mencapai tujuan yang diinginkan. Kepemimpinan transformasional didasari oleh sifat-sifat yang kharismatik, memiliki kemampuan dalam membangkitkan inspirasi, mampu merangsang intelektual bawahan secara aktif, dan bersikap empatik terhadap individu. Kepemimpinan transformasional ditandai oleh memiliki visi yang jelas, peduli pada kebutuhan individual, memberikan motivasi inspiratif, dan merangsang intelektualitas. Salah satu ciri dari gaya kepemimpinan transformatif Kepala Sekolah adalah keahliannya dalam merumuskan visi, misi, dan program sekolah, menjadi agen perubahan yang memiliki daya tarik, kepemimpinan yang empatik, mendorong pertumbuhan intelektual dan kreativitas, serta memberikan kesempatan yang adil kepada seluruh elemen di lingkungan sekolah. Penerapan kepemimpinan transformasional oleh kepala sekolah berdampak pada penyelenggaraan proses pembelajaran dengan tingkat profesionalisme yang lebih baik. Dengan terciptanya budaya dan iklim sekolah yang kondusif, prestasi belajar siswa dapat mencapai tingkat yang tinggi. Kata Kunci: Kepemimpinan Transformasional, Kepala Sekolah.
An Overview of Drug-Related Criminal Acts as Extraordinary Crimes in Indonesia Husni; Muhammad Nur
International Journal of Law, Social Science, and Humanities Vol. 1 No. 1 (2024): IJLSH - July 2024
Publisher : Lembaga Pusat Studi Sosial dan Humaniora [LPS2H]

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70193/ijlsh.v1i1.142

Abstract

Indonesia is a nation that has unfortunately become a target for drug trafficking, resulting in a growing number of drug-related crimes each year. To address drug crime in Indonesia, the government has issued Law No. 35 of 2009 on Narcotics and Law No. 5 of 1997 on Psychotropic. The Indonesian government's efforts to eradicate drugs crime have not been successful. This study employs a qualitative research design with a normative approach. Our study revealed that law enforcement has been considereed optimal due to the government's establishment of the National Narcotics Agency (BNN) as a specialized, independent institution with broader authority than other law enforcement agencies. The 2009 Narcotics Law, specifically Law No. 35, establishes strict penalties for drug abuse, which can include imprisonment, additional punishment, or even the death penalty
Improving Caregiver Competency in Families of Stroke Patients Husni; Mardiani; Septiyanti; Abdulrauf , Rukayya Adebisi
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 3 No. 2 (2025): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v3i2.384

Abstract

Stroke patients generally need a long recovery because most individuals undergoing hospital treatment experience disabilities in several parts of the body. Therefore, survivors need the help of other people to live daily life; this role is taken on by caregivers. Caregivers play a crucial role for stroke survivors during the process of long-term rehabilitation and must assume many responsibilities. For this reason, knowledge and skills are needed in caring for post-stroke patients at home. One of the efforts that can be done is through education and training for caregivers and health cadres. This community service activity aimed to enhance cadres’ and caregivers’ knowledge and skill in providing care for families after a stroke. The target population comprised 16 caregivers and seven cadres who supported the families. The results of the community service activities demonstrated an increase in caregivers' knowledge by 32.8 points following the training activities, with a p-value of 0.001 (<α= 0.05), indicating that the difference between the pre- and post-values is statistically significant. The results of observations of cadre and caregiver skills regarding post-stroke care at home include Range of Motion (ROM) exercises, assistance with daily activities, and training in communication in the moderate category. Cadres are expected to continue supporting families as caregivers to be able to care for post-stroke patients at home.
Platelet-to-Lymphocyte Ratio in Pediatric Dengue Patients: A Key Indicator of Disease Severity Silma Farraha; Husni; Deswita Sari; Rikarni; Zelly Dia; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1278

Abstract

Background: Dengue infection remains a significant health concern in Indonesia, with a high mortality rate. Early identification and prediction of severe dengue are crucial for effective management and mortality reduction. The platelet-to-lymphocyte ratio (PLR) has emerged as a potential biomarker for assessing dengue severity due to its association with inflammatory responses. Methods: This descriptive study included 48 pediatric patients diagnosed with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) at Dr. M. Djamil General Hospital Padang between March and August 2024. Patients were included if they were aged 0-18 years, had a confirmed diagnosis of DHF or DSS, and underwent complete blood count and serological testing for dengue. Patients with chronic diseases or other comorbidities were excluded. Complete blood counts were performed using flow cytometry, and PLR was calculated by dividing the platelet count by the absolute lymphocyte count. Clinical data were obtained from medical records. Results: The majority of patients were aged 6-18 years (68.8%), with 20 (41.7%) presenting with DHF and 28 (58.3%) with DSS. The median platelet count was lower in DSS patients (26,000/mm3) compared to DHF patients (35,500/mm3). The median PLR was also significantly lower in DSS patients (8.95) compared to DHF patients (15.61). A PLR value <20 was more frequently observed in DSS patients (89.3%) than in DHF patients (75%). Conclusion: A lower PLR value was associated with more severe clinical manifestations of dengue infection, particularly DSS. PLR can serve as a valuable biomarker for assessing dengue severity, utilizing readily available and cost-effective complete blood count results.
The Triglyceride-Glucose Index: A Potential Simple Screening Tool for Insulin Resistance in Young Adults Kenny; Efrida; Elfira Yusri; Rismawati Yaswir; Husni; Syofiati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1281

Abstract

Background: Insulin resistance is a key factor in the development of metabolic diseases, which are increasingly prevalent in young adults. Early detection is crucial for timely intervention. The triglyceride-glucose (TyG) index, calculated from fasting triglyceride and glucose levels, has emerged as a potential alternative to the more complex homeostasis model assessment of insulin resistance (HOMA-IR). This study aimed to evaluate the agreement between the TyG index and HOMA-IR in detecting insulin resistance in young adults. Methods: A cross-sectional study was conducted on 102 non-diabetic young adults (aged 18-22 years). Fasting blood samples were collected to measure triglyceride, glucose, and insulin levels. The agreement between the TyG index and HOMA-IR was assessed using the Kappa coefficient. Results: The median age of the participants was 20 years, with 65.7% being female. The prevalence of insulin resistance was 79.4% based on the TyG index (cut-off value of 4.25) and 43.1% based on HOMA-IR (cut-off value of 2.2). The agreement between the two indices was slight (Kappa = 0.155, p = 0.001). Conclusion: The TyG index showed a higher prevalence of insulin resistance compared to HOMA-IR in this population. However, the agreement between the two indices was low. Further research is needed to validate the TyG index as a screening tool for insulin resistance in young adults.
Impact of Donation Frequency on Iron Stores and Hemoglobin Levels in Regular Blood Donors Lili Novri Yanti; Rofinda, Zelly Dia; Syofiati; Rikarni; Husni; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1282

Abstract

Background: Regular blood donation, while crucial for healthcare systems, can lead to iron deficiency and anemia in donors. This study investigated the impact of donation frequency on iron stores and hemoglobin levels in regular blood donors. Methods: A cross-sectional study was conducted on 82 regular blood donors at the blood transfusion unit of Dr. M. Djamil General Hospital from February to April 2024. Participants underwent pre-transfusion screening, including a questionnaire on donation frequency and iron supplement use. Blood samples were collected during donation, and serum ferritin, hemoglobin, and erythrocyte indices (MCV, MCH, MCHC) were measured if the C-reactive protein (CRP) test was negative. Data were analyzed using the Kruskal-Wallis test. Results: The mean age of the donors was 31 years, with the majority being female (56.1%). The most common donation frequency was 6-10 times (34.15%). None of the donors reported using iron supplements. Serum ferritin levels showed significant differences among female donors based on donation frequency (p=0.004) but not among male donors (p=0.114). Hemoglobin levels also differed significantly among female donors (p=0.002), but not among male donors (p=0.213). Significant differences were observed in MCV and MCH values in both male and female donors (p<0.001 and p=0.001, respectively), but not in MCHC values (p=0.135). Conclusion: Donation frequency significantly impacts iron stores and hemoglobin levels in female blood donors but not in male donors. Regular monitoring of iron stores, particularly in female donors, is crucial to prevent iron deficiency and anemia.
Co-Authors A. R. Jatnika Abdul Azis Abdul Majid, Basrul Abdulrauf , Rukayya Adebisi Ade Yeni Afiqah Jumatul Saadah Ahmaniyah Akhyar Ali, Masri ALI, NURDIN Arianto Syahruddin Arif, Zainal Asmawati Azwar Anwar Badriah Bastiar Bukhari Buston, Erni Dandi Bahtiar Desiekawati Deswita Sari Desywar Dwi Yulia Efrida Elfira Yusri Fatahillah Fatma Azzahra Fatma Azzahra Firman syah, Firman Fitriana, Maya Hartini Hendri Heriyanto Henri Heriyanto Hudaya, Chairul I. Munandar Ida Rahmah Burhan Ihsan, Rafiq Indrawati Noor Kamila IRMA DEWI ISKANDAR Jarnawi Jarnawi Jepisa, Tomi Johari Kenny Khairil Fata Khaulah Karimah L. Abdullah Lia Safrina Lili Novri Yanti Linda Wati M. Nizar Machmud Maghfira Ramadhania Mardiani Masri Ibrahim Mayviza, Liza Monarisa Muammar Muhammad Amin Muhammad Fadillah Ghifari Muhammad Hatta Muhammad Nur MUHAMMAD RIZAL Muhammad Saleh Muhibbuddin Muhibuddin Mukhtasar Munawar Rizki Jailani Munawir Mustafa Nasrah Nasution, Elvy Sahnur Nengsih, Reska Multia Nisa, Khoerunisa Novita Laily Shalatiah Nurarafah Nurjannah Pardosi, Sariman Putra, T. Edisah R. Priyanto Rahma Anisa Ramalinggam Rajamanickam Reza , Mohamad Reza, T. Surya Rikarni Ririn Rismawati Yaswir Romi Asmara Roswati Ruliati, Ruliati S. Nealma Sabri Sahade Sahran Satria Utomo Septiyanti Silma Farraha Siregar, Askari Guna Siregar, Fadhilaturrizqie Siti Safaria Sofia Ratna Awaliyah Fitri Sofyan Jafar Subaidi, Joelman Sulaiman Thalib Sumiadi Syahrizal Syarli, Setiadi Syarwani Syofiati Tating Rohaeti Teuku Yudi Afrizal tomi jepisa Tomi Jepisa Ujang Endang Ujuh Ilham Simak Ummi Kalsum Vania Ilmi Basri Wahid , Irza Widia Lestari Yoshie Anto Chicamy Yulia, Dwi Yulianti Yunengsih, Yuyun Yusuf Zahara, Annisa Zainal Abidin Zelly Dia Zelly Dia Rofinda Zul Akli Zulfadhli Zulfan Zulfiani