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Eksplorasi Antioksidan dan Anti-Inflamasi Madu Hutan Pulau Buton Secara in-Vitro dan Efek Inhibisi Edema Telinga Secara in-Vivo Hariana; Wahyuni; Idrus, Loly Subhiaty; Malik, Fadhliyah; Purnama, La Ode Muhammad Julian; Fristiohady, Adryan
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.1633

Abstract

Forest honey is a natural product derived from the nectar of wild plants and is known to contain various bioactive compounds, such as flavonoids and phenolics, which contribute to its antioxidant and anti-inflammatory potential. Buton Regency in Southeast Sulawesi is recognized as a producer of forest honey; however, scientific studies on its biological activities remain limited. This study aimed to evaluate the free radical scavenging activity and anti-inflammatory effects of Buton forest honey through both in vitro and in vivo approaches. Antioxidant activity was assessed using DPPH and ABTS assays, while anti-inflammatory evaluation involved inhibition of BSA protein denaturation and a mouse ear edema model induced by xylene. The honey exhibited IC₅₀ values of 71.69 ± 2.73 mg/L (DPPH) and 49.23 ± 4.24 mg/L (ABTS). Its protein denaturation inhibition showed an IC₅₀ of 14.17 ± 3.18 mg/L. In vivo testing demonstrated that high-dose honey significantly reduced ear thickness in mice, with a percentage of inhibition comparable to diclofenac sodium. Statistical analysis revealed significant differences (p < 0.05) across most parameters. These findings indicate that Buton forest honey holds promise as a natural antioxidant and anti-inflammatory agent.
Co-Authors ,, Suryani Aan Zurniwatih P Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Afriana, Dian Agustina Amaliah, Nur Syafitri Andriyani, Elfi Andryani Ningsih Angriani Fusvita Annisa Fatinah Gani Annisaa, Nur Apriyanto Apriyanto Apriyanto, Apriyanto Arba, Muhammad Arfan Arfan Armadany, Fery Indradewi Asasutjarit, Rathapon Asniar Pascayantri Asniar Pascayantri Asniar Pascayantri Aspadiah, Vica Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Astrid Indalifiany Azis, Muhammad Israwan Badia, Esti Bafadal, Mentarry Bambang Bambang Bangkit Saputra Baru Sadarun Baru Sadarun Carla Wulandari Sabandar Chatarina Umbul Wahyuni Chichi Fauziyah Dian Afriana Dian Munasari Dian Munasari Dian Munasari Solo Dian Munasari Solo Dwi Arini Jufri Elma Winarti Fahria Nadiryati Sadimantara Fahria Nadiryati Sadimantara Fahriah Nadiryati Sadimantara Fahriah Nadiryati Sadimantara Faisal Faisal Fatima, Nur Fea, Waode Aisyah Fery Indradewi Armadany Firasmi Sangadji Firdayanti Firdayanti Fitrah Fajriani Haming Fitrawan, La Ode Muhammad Fredy Talebong Fristiohady, Adryan Gusti Ray Sadimantara Gusti Ray Sadimantara Gusti Ray Sadimantara Halik Halik Halik Halik, Halik Handoyo, Muhammad Hariana Hartawaty, Siska Septy Haruna, Lidya Agriningsih Hasanah, Nur Uswatun Hendra Febriansyah Herda Dwi Saktiani Herdianawati Ringgu Hilman, Seprian Holidin, Wiwin I Sahidin I Sahidin I Sahidin I Sahidin I Sahidin Idrus, Loly Subhiaty Ilyas Y, Muhammad Ilyas Y., Muhammad - Indalifiany, Astrid Indri Wulandari Indri Wulandari, Indri Irma Irnawati Irnawati Irnawati Irnawati Jabbar, Asriullah Jannah, Sitti Raodah Nurul Jufri, Dwi Arini Jumriani Jumriani Junli Hong Kardin, Laode Karmilah Kirana, Rezky Marwah La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Loly Subhiaty Idrus Lubis, Adryan Fristiohady Mahmudah, Rifa’atul Malaka, Muhammad Hajrul Meilany, Elvianti Mesi Leorita Mesi Leorita, Mesi Mini Bekti Ningsih Mini Bekti Ningsih Mochammad Imron Awalludin Mubarak Mubarak Mubarak Mubarak Mubarak Mubarak Mubarak Muh. Ilyas Yusuf Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y. Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Israwan Azis Muhammad Israwan Aziz Mulviana, Astrawanda Munasari, Dian Mursanti, Wa Ode Indah Arum NASRUDIN Nasrudin Nasrudin Nasrudin Nasrudin Nasrudin Newulasindo, Sri Madani Ningsi, Andryani Ningsih, Aprilia Surya Nining Yulianti Nirwati Rusli Nita Trinovitasari Nohong Nohong, Nohong Nur Annisaa Nur Hikmah Nur Hikmah Nur Illiyyin Akib Nur Illiyyin Akib Nuralifah Nuralifah, Nuralifah Nurfadillah Siddiqah Nurfenti Nurfenti Nurfenti, Nurfenti Nurhikma Nurhikma Nurhikma, Nurhikma Nurjeddah Fariane Nurramadhani A. Sida Okwani, Yustian Parawansah Parawansah Pascayantri, Asniar Purnama, La Ode Muhammad Julian Putri, Olivia Dicha Rahayu, Faulia Fajar Rahmat Muliadi Rahmat Muliadi Rahmat Muliadi RAHMAT MULIADI, RAHMAT Rasak, Adriatman Rezky Marwah Kirana RH. Fitri Faradilla Rina Andriani Ringgu, Herdianawati Rini Hamsid Rini Hamsidi Rosmaria, Rosmaria Rusli, Nirwati Ruslin Ruslin, Ruslin SADIMANTARA, I GUSTI RAY Sahidin Sahidin . Sahidin F. Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Saktiani, Dwi Nur Salem, Sri Rahayu Saputri, Nita Saranani, Muhammad Aqsal Azriel Fajar Saripuddin Saripuddin Sarry, Elita Puspita Seprian Hilman Septrilia, Shara Sida, Nurramadhani A. Siti Helmyati Sitti Masyithah Amaluddin Solo, Dian Munasari Sri Madani Newulasindo Sulsiah, Sulsiah Sunandar Ihsan, Sunandar Suryani Suryani Susanty, Sry Tanzil, Dwi Lestari Khaulani Tias, Ayuning Timung, Yusni Oktaviani Ulfa Ulfa Ulfa Ulfa Vica Aspadiah W Wahyuni, W W. Wahyuni Wa Ode Nurfinti Wa Ode Salma Wa Ode Sitti Musnina Wa Ode Sitti Zubaydah WAHYUNI wahyuni wahyuni Wahyuni Wahyuni Wiwin Holidin Y, Muhammad Ilyas Yani, Rica Dwi Yodha, Agung Wibawa Mahatva Yuliansyah Yuliansyah Yustian Okwani Yuyun Asna Sari Zakhrafia, Ainun Zulkifli Halid