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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Pharmacon Majalah Obat Tradisional Public Health of Indonesia Biomedical Journal of Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Pharmasipha JFL : Jurnal Farmasi Lampung Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia PROFESSIONAL HEALTH JOURNAL Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Klinik dan Sains Sciences of Pharmacy Jurnal Kesehatan Reproduksi Jurnal Kesehatan Bakti Tunas Husada Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia
Lalu Muhammad Irham
Faculty Of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Formulation and Stability Evaluation of Red Dragon Fruit (Hylocereus polyrhizus) Extract Gel Febrianti, Novi; Widyastuti, Lina; Saputri, Septiana; Irham, Lalu Muhammad
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404379

Abstract

Red dragon fruit (Hylocereus polyrhizus) is known for its strong antioxidant properties and potential anti-aging effects. To enhance its benefits and improve usability, this fruit extract was formulated into a gel preparation. This study aimed to determine the optimal proportions of Carbopol 940 and triethanolamine (TEA) to obtain a gel with desirable physical characteristics. The flesh of red dragon fruit was juiced and concentrated to produce an 8% extract. Three formulations were prepared with varying ratios of Carbopol 940 to TEA: 0.5%:0.3% (F1), 1.2%:0.7% (F2), and 2%:1.2% (F3). The gels were evaluated for physical properties, antioxidant activity, and antibacterial activity. The most promising formula was subjected to stability testing for three cycles under different temperature conditions: cold (3 °C), room temperature (27 °C), and climatic chamber (40 °C, 75% RH). Results showed that formula F2 exhibited a characteristic red color, clear appearance, distinctive oleum rosae aroma, moderately thick and homogeneous consistency, viscosity of 3112.47 ± 177.90 cps, spreading diameter of 5.20 ± 0.20 cm, adhesion time of 18.45 ± 0.89 s, and pH of 5.33 ± 0.02. No significant changes were observed after the stability testing (p > 0.05), indicating that the formulation remained stable under all temperature conditions. F2 also showed higher antioxidant activity than F1 and better antibacterial properties than F3. Its stability and bioactivity support its potential as a promising natural cosmeceutical formulation.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Nutritional Status and Quality of Life of Hemodialysis Patients in a Hospital in Yogyakarta Siswandi, Siswandi; Suhendra, Gugun; Wulandari, D; Simanjuntak, LB; Dania, Haafizah; Irham, Lalu Muhammad; Faridah, Imaniar; Adnan, Adnan; Perwitasari, Dyah Aryani
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23313

Abstract

Kidney failure is a disease with a moderate prevalence in Indonesia but causes the second highest cost burden in Indonesia. One of the treatments for chronic kidney failure is hemodialysis. The problem with hemodialysis patients is a high incidence of malnutrition, which can affect the patient's quality of life. Therefore, this study will examine the relationship between nutritional status and quality of life in chronic kidney failure patients undergoing hemodialysis. This research is a cross-sectional study by collecting medical record data and filling out questionnaires. Selection of research subjects with inclusion criteria aged ≥18 years, routinely undergoing hemodialysis, willing to participate in the study and complete medical record data. The patient's nutritional status was seen from the Body Mass Index (BMI), and the patient's quality of life was assessed by the Indonesian version of the Kidney Disease Quality of Life Short-Form (KDQoL-SFTM) questionnaire. The average age of the hemodialysis patients in this study was 53.70 years, the average body weight was 57.24 kg and the average height was 10.82 cm. Patients with lean BMI were 20.5%, normal 56.4%, overweight 23.1%, and obesity 2.6%. The domain of employment status is related to nutritional status (p-value 0.005). Nutritional status is related to the quality of life of hemodialysis patients in the occupational status domain.
THE TREND OF STUDIES RELATED TO MYASTHENIA GRAVIS AND GENETICS IN VARIOUS POPULATIONS AROUND THE WORLD Fitri, Dwiki; Irham, Lalu Muhammad; Sulistyani, Nanik; Adikusuma, Wirawan; Sianu, Rahman S; Ma’ruf, Muhammad
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1944

Abstract

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction, mainly influenced by antibodies to acetylcholine receptors. In addition, antibodies to Muscle-Specific Kinase (MUSK), Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4). It is essential to determine publication trends regarding Myasthenia gravis because, currently, there are no studies that describe Myasthenia gravis publication trends related to genes in this field of study. Bibliometric analysis is used to see research trends, including frequently used keywords, most published journals, most cited publishers, author agencies, and collaboration between authors depicted in visualization using the VOSViewer application. Bibliometric analysis shows that the research trend is increasing from 1969 to 2023. The most frequently used keywords are myasthenia gravis, human, autoimmune disease, genetics, and article. The leading information related to the data is that the average annual publication is 5.89%, and the average citation for documents is 13.9%. Indonesia, as one of the countries experiencing Myasthenia gravis, has excellent potential to increase the number of research articles, which can be a means of exchanging knowledge, ideas, and technology and also has the potential for collaboration with other countries
UNCOVERING PATHOGENIC MISSENSE VARIANTS IN ENDOMETRIOSIS USING A GENOME-WIDE ASSOCIATION STUDY Nurullita Santri, Ichtiarini; Adikusuma, Wirawan; Theda Philothra, Petrina; Fadhliati Maulida, Nurul; Chong, Rockie; Ates, Ilker; Vincent Abero Phiri, Yohane; Muhammad Irham, Lalu
JURNAL KESEHATAN REPRODUKSI Vol 16 No 2 (2025): JURNAL KESEHATAN REPRODUKSI VOLUME 16 NOMOR 2 TAHUN 2025
Publisher : IAKMI South Tangerang Branch

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58185/jkr.v16i2.407

Abstract

Background: Endometriosis is a complex gynecological disorder with a strong genetic component. Although genome-wide association studies (GWAS) have identified numerous risk loci, the functional interpretation of protein-altering missense variants remains limited. Objective: This study identified pathogenic missense variants linked to endometriosis risk using publicly available GWAS data and explored implications for genetic risk detection, particularly in underrepresented populations such as Indonesia. Methods: Endometriosis-associated missense single nucleotide polymorphisms (SNPs) were identified from GWAS data, and a total of eight missense SNPs were analyzed. Functional effects were evaluated in silico using PolyPhen-2 and SIFT. Allele frequency distributions were assessed across global populations, and pathway enrichment analysis was conducted using the Reactome database. Results: Several missense variants were significantly associated with increased endometriosis risk (e.g., rs75801644, OR = 3.88; rs144824657, OR = 3.52), while rs2341097 showed a potential protective effect. Functional prediction prioritized variants in genes such as KCNG2 and BSG as potentially damaging. Population analyses revealed marked allele frequency differences, and enriched pathways were related to potassium channel activity, metabolism, extracellular matrix organization, and signal transduction. Conclusion: This study identifies missense variants contributing to endometriosis susceptibility and provides insight into biological pathways. Further experimental validation and clinical studies are warranted.
Trend Studi Berkaitan dengan Ulcerative Colitis dan Genomik dari Tahun 2000-2023 Rahman Sianu; Lalu Muhammad Irham
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 1 (2024): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i1.17728

Abstract

Ulcerative Colitis (UC) merupakan suatu inflamasi kronis yang terjadi pada saluran cerna terutama pada rectum dan kolon. Gangguan genetik seperti aktivitas dari Nuclear Factor - Kappa Beta (NF-kB) menjadi salah satu penyebab UC. Analisa bibliometrik merupakan suatu metode yang dapat digunakan untuk mengidentifikasi frekuensi dan banyaknya kutipan dari suatu jurnal. Analisa ini dapat memberikan informasi terkait kredibilitas, kualitas dan dampak dari suatu karya ilmiah. Analisis bibliometrik dilakukan menggunakan VOSViewer version 1.6.16 dan perangkat Biblioshiny R. VOSViewer dan Biblioshiny merupakan dua program software digunakan untuk membuat dan menampilkan peta bibliometrik. Hasil yang diperoleh berupa jenis dokumen jurnal dengan bahasa inggris, kata kunci yang banyak digunakan berupa Ulcerative Colitis, peningkatan publikasi terkait Genomik pada UC, Amerika Serikat menjadi Negara yang paling banyak disitasi, Frontier menjadi sumber jurnal yang paling produktif, penulis dari negara-negara maju menjadi Negara yang paling tinggi dalam kolaborasi antar Negara baik Single Country Publications (SCP) dan Multiple Country Publications (MCP) terkait studi Genomik pada Ulcerative Colitis. Trend publikasi artikel terkait Studi Genomik pada UC dari tahun 2000 sampai 2023 yang semakin meningkat menggambarkan bahwa tersebut semakin diminati dan menarik untuk diteliti.
The Effect of CYP3A4, CYP3A5 and ABCB1 Polymorphisms on Tacrolimus Dose Requirements in Adult Kidney Transplant Patients Khusnul Khotimah; Lolita; Lalu Muhammad Irham
PROFESSIONAL HEALTH JOURNAL Vol. 8 No. 1 (2026)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v8i1.1371

Abstract

Introduction: Polymorphisms in the CYP3A4, CYP3A5, and ABCB1 genes play a significant role in the response to tacrolimus therapy in kidney transplant patients. Tacrolimus, a commonly used immunosuppressant, has a narrow therapeutic index and is highly influenced by individual genetic variation. These genetic polymorphisms significantly affect the response to tacrolimus therapy in patients undergoing kidney transplantation. Inaccurate dosing can lead to serious consequences: a tacrolimus dose that is too low increases the risk of acute rejection, while a dose that is too high can cause nephrotoxicity and other serious side effects. Therefore, accurate initial dosing of tacrolimus is critical in the clinical practice of kidney transplantation.. Methods: The article search was conducted using the CrossRef database, which provided access to various scientific journals. The focus was on research published in the last five years, ensuring that only studies exploring polymorphisms related to the CYP3A4, CYP3A5, and ABCB1 genes in the context of tacrolimus were used. Results: Previous analysis revealed that CYP3A5 polymorphisms were the most consistent genetic factors influencing tacrolimus metabolism; expressors with the *1/*1 and *1/*3 genotypes required higher doses to reach target levels, while non-expressors with the *3/*3 genotypes experienced a greater risk of toxicity with elevated trough levels, although contributions from CYP3A4 and ABCB1 varied based on ethnicity and transplantation stage. Conclusions: From the results of this review, it can be concluded that CYP3A5 gene polymorphisms are the primary predictors of tacrolimus dose requirements. Recommendations for implementing CYP3A5 genotyping before transplantation may enhance the efficacy of immunosuppression and reduce the risk of toxicity. Further research is necessary to develop more adaptive, pharmacogenetic-based dosing models and to evaluate the clinical factors influencing tacrolimus pharmacokinetics.
Bibliometric Analysis of Parents' Health Belief Model Study of Vaccine Administration of Covid-19 Eka Wuri Handayani; Dyah Aryani Perwitasari; Fredrick Dermawan Purba; Lalu Muhammad Irham
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.4209

Abstract

A bibliometric analysis was conducted to assess the interest and significance of research on the Health Belief Model. The bibliographical information provides insights into the Health Belief Model concerning parents of children receiving the COVID-19 vaccine. As of January 25, 2023, data for the study were obtained from the Scopus database. Our analysis identified 876 articles with the keywords: Health Belief Model, Parents, and COVID-19 Vaccine. Articles were exclusively selected in English, and the analysis was performed using the R Studio 4.2.2 application for Bibliometric Analysis. China hosts the top five most productive authors, with Peking University contributing the highest number of articles (66 in total). The Vaccines Journal emerges as the primary publisher, while the majority of collaborative research on COVID-19 involves authors from the United States. Frequently used keywords include Human, Female, Male, Adult, COVID-19, and Article. The increasing trend in Health Belief Model articles related to the COVID-19 vaccine from 2020 to 2023 underscores the widespread interest in and appeal of this subject for discussion. Given the study's limitation, including only publications released before January 25, 2023, it is plausible that some more recent publications were unintentionally overlooked.
The Role of SLC22A1 Polymorphisms in Metformin Therapeutic Response: A Bioinformatics Based Literature Review Danang Prasetyaning Amukti; Lalu Muhammad Irham; Daru Estiningsih; Nurul Kusumawardani; Barkah Djaka Purwanto; Ria Indah Pratami; Mauritz Pandapotan Marpaung
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 9 No. 01 (2026): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v9i01.23991

Abstract

Metformin is the most common first-line therapy used in the management of type 2 diabetes mellitus (T2DM). However, therapeutic response to metformin varies between individuals, which is largely influenced by genetic factors, especially polymorphisms in the SLC22A1 gene. This gene encodes the organic cation transporter 1 (OCT1), which plays a role in the transport of metformin into hepatocytes. This literature review used a bioinformatics approach to explore the impact of SLC22A1 polymorphisms on the efficacy of metformin. Genetic and pharmacogenomic data were collected from two major databases, namely PharmGKB and GTEx Portal. Relevant polymorphic variants were identified based on data that were associated with drug response. Tissue expression analysis of SLC22A1 in GTEx was used to evaluate the biological relevance of gene expression in metformin target organs. The results showed that SLC22A1 gene expression was significantly highest in liver tissue, which plays a key role in the efficacy of metformin in T2DM patients. SLC22A1 functions as a major transporter in transporting metformin into hepatocytes, where its pharmacological action occurs. Genetic variations such as rs622342, rs594709, and rs628031 can significantly affect the expression and function of these transporters, which ultimately have a direct impact on the efficacy of metformin therapy. This study emphasizes the importance of pharmacogenomic approaches in personalized medicine for T2DM patients.
Co-Authors Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Adi Wira Septama Adnan Adnan Afief, Arief Rahman Ageng Brahmadhi Ana Hidayati Anisa Devi Kharisma Wibowo Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anita Silas La’ah Any Guntarti Arief Rahman Afief Arief Rahman Afief Arief Rahman Afief Ates, Ilker Auren Nathania Ayu Lifia Nur Kartikasari Azzahra, Fara Barkah Djaka Purwanto Barkah Djaka Purwanto Barkah Djaka Purwanto Bramadi Arya Cheung, Rocky Chita Widia Chong, Rockie Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Danang Prasetyaning Amukti Darmawi . Darmawi Darmawi Daru Estiningsih Daud, Intan Delfi Iskardyani Denys Chichi Kusumastuti Didik Setiawan Donel S Dwiki Fitri Dyah Aryani Perwitasari Eka Wuri Handayani Eko Mugiyanto Fadhliati Maulida, Nurul Faridah, Imaniar Febriana Astuti Firdayani Firdayani Firdayani Firdayani, Firdayani Firman Firman Fredrick Dermawan Purba Galuh, Tiwi Gina Noor Djalilah Gustinanda, Rizky Haafizah Dania Haafizah Dania Haafizah Dania Hanisari, Putri Henry Budiawan Prasetya Herjanti Ratnawiningsih Herlina, Tetie Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ilham alifiar Ilham Alifiar Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Iwan Santoso, Iwan Kartikasari, Ayu Lifia Nur Khair, Riat Khairi, Sabiah Khairurrizki, Amanda Khusnul Khotimah Kusumawardani, Nurul La Malihi Laela Hayu Nurani La’ah, Anita Silas Leina Putri Zahra Lisza Niarisessa Lolita Made Ary Sarasmita Maliza, Rita MARIA BINTANG Maulida Mazaya Ma’ruf, Muhammad Medi Sushanti, Nining Melodia Rezadhini Melodia Rezadhini Menit Ardhiani Menit Ardhiani Muh. Deni Kurniawan Muhammad Fathurrahman Muhammad Ma'ruf Mutmainnah Siradjuddin Nanik Sulistyani Nathania, Auren Ni Made Ary Sarasmita Nining Medi Sushanti Nining Medi Sushanti Nining Sugihartini Novi Febrianti Nugraha, Media Fitri Isma Isma Nur Ismiyati Nur Rahayuningsih Nurullita Santri, Ichtiarini Pendicho Eko Yuliyanto Pradika, Jaka Pranata, Satria Pratama, Kharisma Puriyanto, Riky Dwi Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Rafiastiana Capritasari Rahman Sianu Rahmat Dani Satria Razali, Renardy Reza Renardy Reza Razali Rezadhini, Melodia Ria Indah Pratami Ria Indah Pratami Riat El Khair Riat Khair Rizka Novia Atmadani Rockie Chong Rocky Cheung Rocky Cheung Rocky Cheung Rudi, Nyoman S, Donel S, Yuni Salamah, Siti Hajar Sany Sapto Yuliani Saputri, Septiana Satria, Rahmat Dani Sianu, Rahman S Simanjuntak, LB Siswahyudianto Siswandi Siswandi, Siswandi Siswanto, Lalu Muhammad Harmain Siti Rofida Siti Urbayatun Solikhah Solikhah, EfA Wakhidatus Sugiyanto - Suhandri, Wiwin Suhendra, Gugun Sulistiyani, Nanik Susan Fitria Candradewi Theda Philothra, Petrina Triantoro Safaria Triantoro Safaria Uswatun Chasanah Vincent Abero Phiri, Yohane Wahyu Rahmatulloh Wahyu Widyaningsih Wahyu Widyaningsih Wibowo, Anisa Devi Karisma Widyastuti, Lina Wigka Pawestri, Novianti Winarto Winarto Winarto Winarto Wirawan Adikusuma Wiwin Suhandri Wiwit Ade Fidiawati Wiwit Ade Fidiawati Woro Supadmi Woro Supadmi Wulandari, D Yudha Rizky Nuari Zahra, Leina Putri Zainul Amiruddin Zakaria Zakaria, Zainul Amiruddin Zukhruf Saputri, Ginanjar