Article Per Year (5 Year)
p-Index From 2021 - 2026
7.528
P-Index
This Author published in this journals
All Journal Indonesian Journal of Pharmaceutical Science and Technology Unnes Science Education Journal JURNAL GALUNG TROPIKA Jurnal Penelitian Pendidikan IPA (JPPIPA) Al-Kimia Biosfer: Jurnal Pendidikan Biologi Indonesian Journal of Chemistry Journal of Education and Instruction (JOEAI) BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Alignment: Journal of Administration and Educational Management Jurnal Kartika Kimia Seminar Nasional Pengabdian Kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat Sosiosaintifik Tamaddun Venn: Journal of Sustainable Innovation on Education, Mathematics and Natural Sciences JIPI (Jurnal IPA dan Pembelajaran IPA) Abdi Kimia : Jurnal Pengabdian Masyarakat SMART: Jurnal Pengabdian Kepada Masyarakat Hayyan Journal Mammiri: Jurnal Pengabdian Masyarakat Illea
Irfandi, Rizal
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Negeri Makassar, Makassar, Jalan Daeng Tata Raya Makassar, 90244, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

Published : 58 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 58 Documents
Search

 2   3   4   5   6 
Pelatihan Penerapan Artificial Intelligence dan Simulasi Molecular Docking untuk Peningkatan Kompetensi Riset Mahasiswa Program Studi Kimia Fakultas MIPA Universitas Negeri Makassar Putri, Suriati Eka; Pratiwi, Diana Eka; Irfandi, Rizal; Bunyamin, Andi Bulqiah Nur; Side, Sumiati
SMART: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 2 (2025): Oktober
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/smart.v5i2.77714

Abstract

Lamanya masa studi mahasiswa Program Studi Kimia FMIPA Universitas Negeri Makassar disebabkan oleh ketergantungan pada penelitian laboratorium yang memerlukan waktu lama dan sering mengalami trial and error. Untuk mengatasi hal tersebut, dilakukan kegiatan pengabdian kepada masyarakat berupa pelatihan penerapan Artificial Intelligence (AI) dan simulasi molecular docking guna meningkatkan kompetensi riset mahasiswa. Metode pelaksanaan meliputi sosialisasi, pelatihan, penerapan teknologi, pendampingan, dan evaluasi. Mahasiswa dilatih menggunakan perangkat lunak komputasi seperti Yasara, ChemDraw, ChemSketch, PLANTS dan Discovery Studio Visualizer, serta platform AI seperti SuperPRED, SwissTargetPrediction, dan pKCSM untuk memprediksi sifat farmakokinetik dan aktivitas biologis senyawa kimia. Hasil kegiatan menunjukkan peningkatan signifikan dalam pemahaman dan keterampilan mahasiswa terhadap riset kimia berbasis teknologi digital. Pelatihan ini berhasil menumbuhkan literasi digital, efisiensi riset, serta kesiapan mahasiswa menghadapi tantangan penelitian kimia di era kecerdasan buatan. 
Pelatihan Koding dan Kecerdasan Artifisial untuk Meningkatkan Berpikir Komputasional Guru Sekolah Dasar Kabupaten Bone Irfandi, Rizal; Akbar, Muhammad; Luthfi Siraj, Muhammad; Fudhail Majid, Ahmad; Ahmad, Fandi
MAMMIRI: JURNAL PENGABDIAN MASYARAKAT Vol. 2 No. 3 (2025): Oktober 2025
Publisher : Education and Talent Development Center Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kapasitas dan Studi ini menginvestigasi efektivitas program pelatihan koding dan kecerdasan artifisial (KA) untuk guru sekolah dasar di Kabupaten Bone, Indonesia, yang berfokus pada peningkatan berpikir komputasional. Pelatihan ini bertujuan untuk meningkatkan literasi digital dan membekali guru dengan keterampilan yang diperlukan untuk mengajarkan konsep koding dan KA di kelas. Dengan menggunakan metode pengajaran plugged (digital) dan unplugged (non-digital), program ini menargetkan pengembangan pemecahan masalah dan berpikir kreatif. Metodologi yang digunakan melibatkan pelatihan langsung, pembelajaran berbasis tugas, dan implementasi lapangan di kelas. Hasil penelitian menunjukkan bahwa 95% guru menunjukkan pemahaman yang solid tentang berpikir komputasional, dengan 80% siswa melaporkan peningkatan keterlibatan dalam pelajaran yang berkaitan dengan koding. Metode unplugged terbukti sangat efektif dalam mengajarkan konsep dasar algoritma dan pengenalan pola, sementara metode plugged meningkatkan pemahaman siswa melalui aplikasi perangkat lunak seperti Scratch dan Blockly. 70% guru berhasil mengintegrasikan berpikir komputasional dalam kurikulum mereka, menunjukkan dampak positif dari program ini. Temuan ini menyoroti pentingnya inisiatif pengajaran berbasis teknologi di daerah terpencil dan menyarankan agar pekerjaan selanjutnya difokuskan pada perluasan skala pendekatan ini ke daerah lain di seluruh Indonesia, memastikan akses yang lebih luas ke pendidikan digital.
Potensi Kurkumin sebagai Inhibitor Estrogen Receptor-α (ER-α) dalam Terapi Kanker Payudara Estrogen-Dependent: Studi Molecular Docking Irfandi, Rizal
Illea : Journal of Health Sciences, Public Health and Medicine Vol.1, No.3 (2025): Oktober 2025
Publisher : Education and Talent Development Center Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kanker payudara merupakan penyebab utama kematian di kalangan wanita di seluruh dunia, dengan sebagian besar kasus bergantung pada estrogen. Estrogen Receptor-α (ER-α) berperan penting dalam proliferasi sel kanker payudara. Kurkumin, senyawa alami dari tanaman kunyit, diketahui memiliki potensi antikanker, namun mekanisme interaksinya dengan ER-α belum banyak diteliti. Penelitian ini bertujuan untuk mengeksplorasi potensi kurkumin sebagai inhibitor ER-α menggunakan pendekatan molecular docking. Protein ER-α dan kurkumin dipersiapkan, dan hasil docking dianalisis untuk mengidentifikasi interaksi yang terlibat. Hasil docking menunjukkan bahwa kurkumin memiliki afinitas tinggi terhadap ER-α, dengan ikatan hidrogen, interaksi hidrofobik, dan π-alkil yang berkontribusi pada stabilitas pengikatan. Selain itu, kurkumin berpotensi menghambat aktivitas ER-α secara kompetitif terhadap estrogen, mengurangi proliferasi sel kanker payudara yang bergantung pada estrogen. Namun, optimasi struktur kurkumin diperlukan untuk meningkatkan afinitasnya terhadap ER-α. Temuan ini memberikan dasar bagi pengembangan terapi kanker payudara berbasis kurkumin yang lebih efektif. Penelitian lebih lanjut diharapkan dapat meningkatkan efisiensi kurkumin dalam terapi kanker payudara.
Molecular Docking of Quercetin for Inhibition of Enoyl-Acyl Carrier Protein Reductase in Mycobacterium tuberculosis Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4345

Abstract

Tuberculosis remains a global health issue, with treatment hindered by drug resistance. This study aims to identify the potential of Quercetin as an inhibitor of Enoyl-Acyl Carrier Protein Reductase (M. tuberculosis), a key enzyme in the fatty acid biosynthesis of the bacteria. Using molecular docking, Quercetin is evaluated based on its binding affinity and stability with the target protein. The docking results show that Quercetin binds to the active site of Enoyl-Acyl Carrier Protein Reductase through hydrogen bonds, π-alkyl, and π-sigma interactions, with an RMSD value of 1.6466 Å, indicating valid results. Comparison with the control compound, 5-hexyl-2-(2-methylphenoxy)phenol, reveals that Quercetin has a stronger binding affinity, supporting its potential as a more effective enzyme inhibitor. These findings open new opportunities for the development of natural compound-based anti-Tuberculosis therapies that can address the growing problem of drug resistance. Further research is needed for experimental validation in biological models and the development of more efficient Quercetin formulations.
Transition Metal Layered Double Hydroxide Nanosheets for Breast Cancer Drug Delivery Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4375

Abstract

This review synthesizes research on transition metal layered double hydroxide nanosheets in breast cancerdrug encapsulation to address challenges in targeted delivery, drug resistance, and controlled release. Thereview aimed to evaluate synthesis and functionalization strategies, benchmark drug loading and releaseprofiles, elucidate metal doping effects on targeting and uptake, compare therapeutic outcomes, and identifyclinical translation barriers. Literature selection focused on experimental in vitro and in vivo studies publishedup to mid-2024, emphasizing physicochemical characterization, cellular internalization, and therapeuticefficacy. Findings reveal that transition metal doping and surface modifications enable ultrahigh drug loadingcapacities with pH-responsive, tumor-specific release, enhancing intracellular delivery via receptor-mediatedand endocytic pathways. Multifunctional nanosheets demonstrate synergistic anticancer effects throughcombined chemo-, photothermal, and immunotherapies, with favorable biocompatibility and low systemictoxicity in preclinical models. However, variability in synthesis reproducibility, incomplete mechanisticunderstanding of metal ion interactions, and limited long-term safety data impede clinical translation.Integrating these findings underscores the potential of transition metal-doped LDH nanosheets as versatileplatforms for breast cancer nanotherapy while highlighting the need for standardized evaluation andcomprehensive in vivo assessments. These insights inform future research directions toward optimizingnanosheet design and advancing clinical applications in precision oncology.
Visual Detection of Lead Ions (Pb²⁺) Using a Colorimetric Sensor for Fishery Products Fudhail, Ahmad; Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4498

Abstract

The presence of lead ions (Pb²⁺) in fishery products poses potential risks to human health. Therefore, simple, rapid, and easily applicable detection methods are highly required. This study aimed to develop a simple colorimetric sensor for the visual detection of Pb²⁺ based on color change as an analytical signal. The sensor was prepared through the interaction of a complexing indicator with the target metal ion, resulting in a distinct and visually observable color response. The novelty of this work lies in the application of a simple colorimetric sensor with a low visual detection limit and high selectivity toward Pb²⁺, as well as its direct applicability to simulated fishery product samples without the need for complex analytical instruments. The results demonstrate that the developed sensor is capable of selectively detecting Pb²⁺ with a clear visual response, indicating its potential use as a low-cost and practical method for preliminary screening of lead contamination.
The Use of Various Concentrations of EM4 (Effective Microorganism-4) with Moringa Leaves (Moringa oleifera) as Animal Feed to Reduce Ammonia Levels in Broiler Chicken Manure and Its Implementation in Environmental Pollution Materials Andi Badli Rompegading; Darwis; Rizal Irfandi
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.9962

Abstract

This study was motivated by the pungent odor of broiler manure around the farm. Chicken manure that accumulates in chicken coops and accumulates in large quantities will produce harmful gases such as ammonia. Therefore, an alternative solution is needed to manage chicken manure so that the ammonia content is not high. One process that can be used is to provide EM4 and Moringa leaves as animal feed. The purpose of this study was to determine the concentration of EM4 and Moringa leaves that can stabilize ammonia levels in broiler manure. This research is an experimental study using a group randomized design consisting of 4 treatments and each treatment used 1 kg of animal feed and each was given 2 replicates for 4 weeks. With data analysis techniques using the Anova test and the Honest Real Difference test. The design is as follows: A0: 1 kg of animal feed without EM4 and moringa leaves, A1: 1 kg of animal feed with 15 ml EM4 and 9 gr moringa leaves, A2: 1 kg of animal feed with 25 ml EM4 and 9 gr moringa leaves, A3: 1 kg of animal feed with 35 ml EM4 and 9 g moringa leaves. The results of the research conducted obtained that the concentration of EM4 with moringa leaves as the right animal feed is 25 ml EM4 and 9 gr moringa leaves (A2) where the result is the ammonia level of 10 ppm.
Antihistamine Potential of Red Alga Acanthophora spicifera Through Combination In Vivo, In Vitro, and In Silico Study Wahyuni, Ilmi; Soekamto, Nunuk Hariani; Rasyid, Herlina; Annisa, Nurul; Adriana, Risda; Putri, Alifiah Alfaniah Alfattah; Basir, Djabal Nur; Ahmad, Ahyar; Fauziah, St.; Irfandi, Rizal
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.109199

Abstract

Red alga Acanthophora spicifera is a marine species with potential as a source of natural antihistamines. This study evaluated the bioactivity of its secondary metabolites through in vivo, in vitro, and in silico approaches. Extracts were obtained by successive maceration using n-hexane, ethyl acetate, and methanol. In vivo testing on BALB/c mice showed that extract administration did not cause significant weight loss. However, its effect on allergic symptoms was significant (p < 0.05), with the methanol extract identified as the most effective by the Mann–Whitney test. In vitro assays revealed a significant reduction in histamine levels (p < 0.05) during sensitization, treatment, and post-challenge phases, particularly in the methanol extract group. In silico docking demonstrated that two compounds from the methanol extract exhibited strong binding affinity to the H1 receptor (PDB ID: 3RZE), with binding energies of −6.27 and −5.06 kcal/mol. These findings suggest that A. spicifera, particularly its methanol extract, is a promising source of natural antihistamines with potential applications in the development of safer allergy treatments.
Co-Authors Abd Rahman Abd Rahman Abdul Kadir Ade Sucitra Putri Adriana, Risda Ahmad Fudholi Ahmad Ghazali Samad Ahmad Rinaldy ahmad yani Ahmad Yani Ahmad Yani Ahmad Yani Ahyar Ahmad Ahyar Ahmad Ahyar Ahmad Aisyah Gusfira Ambo Upe Ambo Upe Andi Alwa Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Muh. Fathul Andi Pitung Andi Wilda Resky Angga Andriana Anita Anita Arifuddin, Arman Arini Rajab Arisa, Arisa Arman Arifuddin Asriana Asriana Audya Syahra Ayu Lestari Ayu Muliana Badli Rompegading, Andi Baso Bambang Juni Edi Baso Muhammad Reski Bima Sardina Bunyamin, Andi Bulqiah Nur Cindy Agustina Cindy Agustina Dahlan, Darsal Darsal Dahlan Darwis Desy Kartina Devi Wulandari Ramli Dewi Sartika Dian Ramadhani Dian Ramadhani Diana Eka Pratiwi Dingse Pandiangan Djabal Nur Basir Erna Sulastri P Erwing Erwing Esti Arni Fandi Ahmad Fatimah Fatimah Febriani Danur, Riny Firdaus Zenta Fudhail Majid, Ahmad Fudhail, Ahmad Hadarmawandi Hadarmawandi Hadarmawandi, Hadarmawandi Harningsih Karim Harningsih Karim Hasnah Natsir Hasnah Natsir Herlina, Besse ihya, Zahratul Ilyas, Nita Magfirah Indah Raya Indah Raya Indah Raya Jasri Djangi, Muhammad Jayawarsa, A.A. Ketut Lili Suryani Luthfi Siraj, Muhammad Mazaya, Maulida Mirjawanda Mirjawanda Mitha Febriani Muh. Damriansyah Muh. Faqhi S. Muh. Fathir Rahmat Muh. Ilham Muhammad Afdal Muhammad Akbar Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Fadryansah Muhammad Fathir Rahmat Muhammad Nasir Muhammad Nasir Muhammad Nasir Muhammad Nur Muhammad Nur Muhammad Nur Muhammad Resky Muhammad Taufiq Muhlis, Nur Fadhillah Muriyati Murniati Safitri Mutmainnah Gani Nasser P, Muh Kemal Nasser P, Muhammad Kemal Negara, Satria Putra Jaya Netti Herawati Nia Febrianti Nirmawati Hamka Nirmayanti Syamsuddin Nunuk Hariani Soekamto Nur Aulia Hazzah Nur Fadhillah Muhlis Nur Fisabilianti, Nur Nur Indah Sari Nur Insani Amir Nur Nur Fisabilianti Nur Rahmi Nurcaya Nurcaya Nurcaya Nurcaya NURUL ANNISA Nurul Hikma Fajar Paulina Taba Pitung, Andi Putri Dewi Suci Ramadhani Putri, Alifiah Alfaniah Alfattah Rachmat Triandi Tjahjanto Rahma, Besse Nuramalia Rahmawati Rahmawati Ramadani, Ananda Ramadhani, Andi Amaliyah Rani Sengka Rasyid, Herlina Renaldi Reski Hamdiah Riki Rusanda Ririn Eka Riska Febrianti Riska Ramayana Rismawati Rismawati Rizky Arfadilla Rompeggading, Andi Badli Rony, Zahara Tussoleha Rosdiana Rosdiana Rugaiyah Arfah Ruslang, Ruslang Sahriah Rahim Santi Santi Sarlan, Sarlan Sasmita, Reski Aggun Sengka, Rani Sir, Panessai Siti Fauziah SITI HALIMAH LAREKENG, SITI HALIMAH Sitti Aminah St. Fauziah Subakir Salnus Subakir Salnus Sudarmianti, Sudarmianti Sugiarti Sugiarti Suharni Sudirman Sulistiani Jarre Sumarni Sumarni Sumiati Side Suriati Eka Putri Suriati Eka Putri Suriya Satar Susan Marlein Mambu Susilo Sudarman Desa Syah, Uswah Trywulan Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Tantu, Zakiah Vitrani Vitrani Wahid Wahab Wahyuni, Ilmi Yanti, Reski Yetti Anita Yuliana S Zakiah Tantu Zulfian Armah