Article Per Year (5 Year)
p-Index From 2021 - 2026
8.235
P-Index
This Author published in this journals
All Journal Indonesian Journal of Pharmaceutical Science and Technology Unnes Science Education Journal JURNAL GALUNG TROPIKA Jurnal Penelitian Pendidikan IPA (JPPIPA) Al-Kimia Biosfer: Jurnal Pendidikan Biologi Indonesian Journal of Chemistry Journal of Education and Instruction (JOEAI) BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Alignment: Journal of Administration and Educational Management Jurnal Kartika Kimia Bima Abdi: Jurnal Pengabdian Masyarakat Seminar Nasional Pengabdian Kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat Sosiosaintifik Tamaddun Venn: Journal of Sustainable Innovation on Education, Mathematics and Natural Sciences JIPI (Jurnal IPA dan Pembelajaran IPA) Abdi Kimia : Jurnal Pengabdian Masyarakat SMART: Jurnal Pengabdian Kepada Masyarakat Hayyan Journal Mammiri: Jurnal Pengabdian Masyarakat Illea
Irfandi, Rizal
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Negeri Makassar, Makassar, Jalan Daeng Tata Raya Makassar, 90244, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

Published : 62 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 62 Documents
Search

 3   4   5   6   7 
The Use of Various Concentrations of EM4 (Effective Microorganism-4) with Moringa Leaves (Moringa oleifera) as Animal Feed to Reduce Ammonia Levels in Broiler Chicken Manure and Its Implementation in Environmental Pollution Materials Andi Badli Rompegading; Darwis; Rizal Irfandi
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.9962

Abstract

This study was motivated by the pungent odor of broiler manure around the farm. Chicken manure that accumulates in chicken coops and accumulates in large quantities will produce harmful gases such as ammonia. Therefore, an alternative solution is needed to manage chicken manure so that the ammonia content is not high. One process that can be used is to provide EM4 and Moringa leaves as animal feed. The purpose of this study was to determine the concentration of EM4 and Moringa leaves that can stabilize ammonia levels in broiler manure. This research is an experimental study using a group randomized design consisting of 4 treatments and each treatment used 1 kg of animal feed and each was given 2 replicates for 4 weeks. With data analysis techniques using the Anova test and the Honest Real Difference test. The design is as follows: A0: 1 kg of animal feed without EM4 and moringa leaves, A1: 1 kg of animal feed with 15 ml EM4 and 9 gr moringa leaves, A2: 1 kg of animal feed with 25 ml EM4 and 9 gr moringa leaves, A3: 1 kg of animal feed with 35 ml EM4 and 9 g moringa leaves. The results of the research conducted obtained that the concentration of EM4 with moringa leaves as the right animal feed is 25 ml EM4 and 9 gr moringa leaves (A2) where the result is the ammonia level of 10 ppm.
Antihistamine Potential of Red Alga Acanthophora spicifera Through Combination In Vivo, In Vitro, and In Silico Study Wahyuni, Ilmi; Soekamto, Nunuk Hariani; Rasyid, Herlina; Annisa, Nurul; Adriana, Risda; Putri, Alifiah Alfaniah Alfattah; Basir, Djabal Nur; Ahmad, Ahyar; Fauziah, St.; Irfandi, Rizal
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.109199

Abstract

Red alga Acanthophora spicifera is a marine species with potential as a source of natural antihistamines. This study evaluated the bioactivity of its secondary metabolites through in vivo, in vitro, and in silico approaches. Extracts were obtained by successive maceration using n-hexane, ethyl acetate, and methanol. In vivo testing on BALB/c mice showed that extract administration did not cause significant weight loss. However, its effect on allergic symptoms was significant (p < 0.05), with the methanol extract identified as the most effective by the Mann–Whitney test. In vitro assays revealed a significant reduction in histamine levels (p < 0.05) during sensitization, treatment, and post-challenge phases, particularly in the methanol extract group. In silico docking demonstrated that two compounds from the methanol extract exhibited strong binding affinity to the H1 receptor (PDB ID: 3RZE), with binding energies of −6.27 and −5.06 kcal/mol. These findings suggest that A. spicifera, particularly its methanol extract, is a promising source of natural antihistamines with potential applications in the development of safer allergy treatments.
Implementasi Komunikasi Interpersonal Kepala Sekolah dalam Meningkatkan Administrasi Guru SMP Negeri 2 Sajoanging Kec. Sajoanging Kab. Wajo Edi, Baso Bambang Juni; Basir, Sutrisman; Sumarni, Sumarni; Arni, Esti; P, Erna Sulastri; Reski, Baso Muhammad; Arafah, Muhammad; Irfandi, Rizal
JOEAI (Journal of Education and Instruction) Vol. 7 No. 2 (2024): JOEAI (Journal of Education and Instruction)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joeai.v7i2.12546

Abstract

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan implementasi komunikasi interpersonal kepala sekolah dalam meningkatkan administrasi guru di SMP Negeri 2 Sajoanging Kecamatan Sajoanging Kabupaten Wajo. Penelitian ini menggunakan pendekatan kualitatif dengan menggunakan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi. Adapun hasil penelitian ini menunjukkan bahwa secara keseluruhan, kepemimpinan Ibu SD selaku kepala sekolah di SMP Negeri 2 Sajoanging menunjukkan implementasi yang efektif dari indikator-indikator komunikasi interpersonal termasuk 1) Keterbukaan, Ibu Kepala Sekolah menciptakan lingkungan yang nyaman bagi guru untuk berbagi ide, solusi, dan masalah, termasuk masalah administrasi. Ini menunjukkan keterbukaan yang memungkinkan guru berpendapat secara jujur dan terbuka. 2) Empati, Ibu Kepala Sekolah menunjukkan empati tinggi terhadap kebutuhan dan perasaan guru dengan mendengarkan dan peduli terhadap masalah mereka, termasuk administrasi guru. 3) Dukungan, Ibu Kepala Sekolah memberikan dukungan kepada guru, memperhatikan perkembangan dan kelengkapan administrasi mereka. Dukungan ini memotivasi guru dan meningkatkan efektivitas pekerjaan mereka. 4) Rasa Positif, Ibu Kepala Sekolah membangun hubungan baik melalui komunikasi positif, yang meningkatkan kepercayaan, kolaborasi, dan motivasi, sehingga meningkatkan efektivitas administrasi guru dan 5) Kesetaraan, Ibu Kepala Sekolah menunjukkan kesetaraan dengan bersikap adil dan tidak membeda-bedakan guru, yang membuat mereka merasa dihargai dan dapat meningkatkan efektivitas administrasi guru. Adapun kesimpulan dari penelitian ini bahwa secara keseluruhan, kepemimpinan Ibu SD selaku kepala sekolah di SMP Negeri 2 Sajoanging menunjukkan implementasi yang efektif dari indikator-indikator komunikasi interpersonal, termasuk keterbukaan, empati, dukungan, rasa positif, dan kesetaraan dalam meningkatkan administrasi guru di SMP Negeri 2 Sajoanging. Kata kunci: Implementasi, Administrasi Guru, Kepala Sekolah, Komunikasi Interpersonal.
The Effect of Learning Everyone is a Teacher Here in Combined Differentiate Learning on Science Literation Ability and Learning Motivation Muhammad Nur; Reski Aggun Sasmita; Andi Badli Rompeggading; Rizal Irfandi
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3948

Abstract

This study aims to determine the effect of the learning strategy Everyone is A Teacher Here combined with a differentiated learning strategy on scientific literacy skills and learning motivation on environmental pollution material. This research method is a quasi-experimental design with a pretest-posttest control group design. The sampling technique is by means of cluster random sampling. The instruments used in this study were descriptive tests and motivation questionnaires. Results Based on the data analysis of scientific literacy ability, the posttest average in the experimental class was 74.2 while in the control class it was 60.89 with the results of hypothesis testing (t-test) obtained tcount (3.59) > ttable (1.68) indicates that H0 is rejected and H1 is accepted. Furthermore, based on the results of the motivational data analysis, the average percentage in the experimental class was 85.01% while in the control class it was 74.98%, with the results of hypothesis testing (t-test) obtained tcount (9.20) > ttable (1.68) indicates that H0 is rejected and H1 is accepted. The results of this study indicate that there is an influence of the learning strategy Everyone is a Teacher Here combined with a differentiated learning strategy on scientific literacy skills and learning motivation for environmental materials for class X MIPA UPT SMA Negeri 1 Wajo.
Development of Macca Biology Learning Media Based on Android Software Andromo Muhammad Arafah; Arman Arifuddin; Andi Badli Rompegading; Rizal Irfandi; Muhammad Nur; Muhammad Kemal Nasser P; Ahmad Yani; Syamsu Rijal; Ambo Upe
Jurnal Penelitian Pendidikan IPA Vol 9 No 11 (2023): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i11.4638

Abstract

The purpose of this study is to evaluate the applicability, efficacy, and validity of Macca Biology Learning Media, which is based on Andromo Android Software, for environmental pollution content in Class VII SMP Negeri 3 Sengkang. The research methodology employed is research and development, also known as define, design, and development (3D model research and development). This study involved 32 students in class VII and was conducted during the even semester of the 2022–2023 academic year, which began in February–March 2023. The teacher and student practicality questionnaire, student learning outcomes, and validator results provided the research data. A % quantitative descriptive method was used to process the study's results. Macca Biology Learning Media received 90.5% from the media and material validators, 91.6% from the teacher's practical responses and 90.5% from the students' practical responses, and 96.8% of the students received a perfect score from the learning outcomes, according to the study's findings. The study's findings indicate that the Macca Biology Learning Media, which utilizes the Andromo Android platform, is a reliable, useful, and efficient resource for biology education.
Molecular Docking of Quercetin for Inhibition of Enoyl-Acyl Carrier Protein Reductase in Mycobacterium tuberculosis Rizal Irfandi
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4345

Abstract

Tuberculosis remains a global health issue, with treatment hindered by drug resistance. This study aims to identify the potential of Quercetin as an inhibitor of Enoyl-Acyl Carrier Protein Reductase (M. tuberculosis), a key enzyme in the fatty acid biosynthesis of the bacteria. Using molecular docking, Quercetin is evaluated based on its binding affinity and stability with the target protein. The docking results show that Quercetin binds to the active site of Enoyl-Acyl Carrier Protein Reductase through hydrogen bonds, π-alkyl, and π-sigma interactions, with an RMSD value of 1.6466 Å, indicating valid results. Comparison with the control compound, 5-hexyl-2-(2-methylphenoxy)phenol, reveals that Quercetin has a stronger binding affinity, supporting its potential as a more effective enzyme inhibitor. These findings open new opportunities for the development of natural compound-based anti-Tuberculosis therapies that can address the growing problem of drug resistance. Further research is needed for experimental validation in biological models and the development of more efficient Quercetin formulations.
Transition Metal Layered Double Hydroxide Nanosheets for Breast Cancer Drug Delivery Rizal Irfandi
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4375

Abstract

This review synthesizes research on transition metal layered double hydroxide nanosheets in breast cancerdrug encapsulation to address challenges in targeted delivery, drug resistance, and controlled release. Thereview aimed to evaluate synthesis and functionalization strategies, benchmark drug loading and releaseprofiles, elucidate metal doping effects on targeting and uptake, compare therapeutic outcomes, and identifyclinical translation barriers. Literature selection focused on experimental in vitro and in vivo studies publishedup to mid-2024, emphasizing physicochemical characterization, cellular internalization, and therapeuticefficacy. Findings reveal that transition metal doping and surface modifications enable ultrahigh drug loadingcapacities with pH-responsive, tumor-specific release, enhancing intracellular delivery via receptor-mediatedand endocytic pathways. Multifunctional nanosheets demonstrate synergistic anticancer effects throughcombined chemo-, photothermal, and immunotherapies, with favorable biocompatibility and low systemictoxicity in preclinical models. However, variability in synthesis reproducibility, incomplete mechanisticunderstanding of metal ion interactions, and limited long-term safety data impede clinical translation.Integrating these findings underscores the potential of transition metal-doped LDH nanosheets as versatileplatforms for breast cancer nanotherapy while highlighting the need for standardized evaluation andcomprehensive in vivo assessments. These insights inform future research directions toward optimizingnanosheet design and advancing clinical applications in precision oncology.
Visual Detection of Lead Ions (Pb²⁺) Using a Colorimetric Sensor for Fishery Products Ahmad Fudhail; Rizal Irfandi
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4498

Abstract

The presence of lead ions (Pb²⁺) in fishery products poses potential risks to human health. Therefore, simple, rapid, and easily applicable detection methods are highly required. This study aimed to develop a simple colorimetric sensor for the visual detection of Pb²⁺ based on color change as an analytical signal. The sensor was prepared through the interaction of a complexing indicator with the target metal ion, resulting in a distinct and visually observable color response. The novelty of this work lies in the application of a simple colorimetric sensor with a low visual detection limit and high selectivity toward Pb²⁺, as well as its direct applicability to simulated fishery product samples without the need for complex analytical instruments. The results demonstrate that the developed sensor is capable of selectively detecting Pb²⁺ with a clear visual response, indicating its potential use as a low-cost and practical method for preliminary screening of lead contamination.
Metal-Organic Frameworks for Targeted Cancer Drug Delivery: A Systematic Review of Stimuli-Responsive Platforms and Therapeutic Performance Rizal Irfandi
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5289

Abstract

Metal-Organic Frameworks (MOFs) have gained increasing attention as promising nanocarriers for targeted cancer drug delivery due to their high surface area, tunable porosity, adjustable chemical structure, and capacity for controlled drug release. Conventional chemotherapy often faces limitations such as systemic toxicity, poor tumor selectivity, low bioavailability, and damage to healthy tissues. Stimuli-responsive MOFs enable drug release in response to specific tumor microenvironment conditions, including acidic pH, redox imbalance, enzyme overexpression, hypoxia, or external triggers such as light and temperature. This systematic review synthesizes 30 selected studies, focusing on MOF types, therapeutic cargo, stimuli-responsive mechanisms, cancer models, and reported therapeutic outcomes. Findings show that ZIF-8, UiO-66, MIL-series, and related MOF platforms are widely investigated, with doxorubicin and other anticancer drugs frequently used. pH-responsive and redox-responsive systems dominate, while multifunctional MOFs combining chemotherapy with photothermal or photodynamic therapy show strong potential. Clinical translation remains limited due to unresolved concerns regarding long-term biosafety, biodegradation, pharmacokinetics, immune response, reproducibility, and scalability. Stimuli-responsive MOFs represent a promising direction for precision cancer therapy, but further in vivo validation and translational studies are required
Computational Design and Pharmacokinetic Profiling of Novel Fe(II)-Peptide Complex Rizal Irfandi
Hayyan Journal Vol. 3 No. 1 (2026): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i1.5302

Abstract

Metal-peptide complexes represent a promising avenue in medicinal chemistry due to their unique coordination and biological properties. This study aimed to design and evaluate a Fe(II)-proline-arginine-dipeptide complex as a potential therapeutic agent. Computational modeling constructed the ligand and optimized the coordination geometry with Fe(II) and two chloride ligands, forming a stable distorted tetrahedral structure. 1H- and 13C-NMR spectra confirmed preservation of the dipeptide framework. Physicochemical assessment revealed a molecular weight of 396.056 g/mol, low LogP of 0.21947, balanced hydrogen-bond donors and acceptors, and a polar surface area of 139.047 Ų, supporting oral drug-likeness. ADMET analysis predicted moderate intestinal absorption (38.444%), low CNS penetration, minimal CYP enzyme interaction, and moderate clearance (1.11 log mL/min/kg). Toxicity prediction indicated no AMES mutagenicity, hepatotoxicity, or hERG inhibition, with an oral rat LD50 of 2.174 mol/kg. These results demonstrate that the Fe(II)-proline-arginine-dipeptide complex possesses structural stability, favorable pharmacokinetic behavior, and a broad safety profile, highlighting its potential as a therapeutic candidate. The study provides a framework for integrating peptide ligand design with metal coordination and in silico pharmacokinetic evaluation, suggesting avenues for experimental validation and future drug development.
Co-Authors Abd Rahman Abd Rahman Abdul Kadir Ade Sucitra Putri Adriana, Risda Ahmad Fudhail Ahmad Fudhail  Majid Ahmad Fudholi Ahmad Ghazali Samad Ahmad Rinaldy ahmad yani Ahmad Yani Ahmad Yani Ahmad Yani Ahyar Ahmad Ahyar Ahmad Ahyar Ahmad Aisyah Gusfira Ambo Upe Andi Alwa Andi Ameilia Sari Riandika Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompeggading Andi Muh. Fathul Andi Pitung Andi Wilda Resky Angga Andriana Anita Anita Arini Rajab Arisa, Arisa Arman Arifuddin Arman Arifuddin Arni, Esti Asriana Asriana Audya Syahra Ayu Lestari Ayu Muliana Badli Rompegading, Andi Bima Sardina Bunyamin, Andi Bulqiah Nur Cindy Agustina Cindy Agustina Dahlan, Darsal Darsal Dahlan Darwis Desy Kartina Devi Wulandari Ramli Dewi Sartika Dian Ramadhani Dian Ramadhani Diana Eka Pratiwi Dingse Pandiangan Djabal Nur Basir Edi, Baso Bambang Juni Erwing Erwing Faathir Almur Fandi Ahmad Fatimah Febriani Danur, Riny Firdaus Zenta Fudhail Majid, Ahmad Hadarmawandi Hadarmawandi Hadarmawandi, Hadarmawandi Harningsih Karim Harningsih Karim Hasnah Natsir Hasnah Natsir Herlina, Besse ihya, Zahratul Ilyas, Nita Magfirah Indah Raya Indah Raya Indah Raya Jasri Djangi, Muhammad Jayawarsa, A.A. Ketut Lili Suryani Luthfi Siraj, Muhammad Mazaya, Maulida Mirjawanda Mirjawanda Mitha Febriani Muh. Damriansyah Muh. Faqhi S. Muh. Fathir Rahmat Muh. Ilham Muhammad Afdal Muhammad Akbar Muhammad Akbar Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Fadryansah Muhammad Fathir Rahmat Muhammad Kemal Nasser Muhammad Luthfi Siraj Muhammad Nasir Muhammad Nasir Muhammad Nasir Muhammad Nur Muhammad Nur Muhammad Nur Muhammad Nur Muhammad Resky Muhammad Taufiq Muhlis, Nur Fadhillah Muriyati Murniati Safitri Mutmainnah Gani Nasser P, Muh Kemal Negara, Satria Putra Jaya Netti Herawati Nia Febrianti Nirmawati Hamka Nirmayanti Syamsuddin Noer Fauziah Rahman Nunuk Hariani Soekamto Nur Aulia Hazzah Nur Fadhillah Muhlis Nur Fisabilianti, Nur Nur Indah Sari Nur Insani Amir Nur Nur Fisabilianti Nur Rahmi Nurcaya Nurcaya NURUL ANNISA Nurul Hikma Fajar P, Erna Sulastri Paulina Taba Pitung, Andi Putri Dewi Suci Ramadhani Putri, Alifiah Alfaniah Alfattah Rachmat Triandi Tjahjanto Rahma, Besse Nuramalia Rahmawati Rahmawati Ramadani, Ananda Ramadhani, Andi Amaliyah Rani Sengka Rasyid, Herlina Renaldi Reski Aggun Sasmita Reski Hamdiah Reski, Baso Muhammad Riki Rusanda Ririn Eka Riska Febrianti Riska Ramayana Rismawati Rismawati Rizky Arfadilla Rony, Zahara Tussoleha Rosdiana Rosdiana Rugaiyah Arfah Ruslang, Ruslang Sahriah Rahim Santi Santi Sarlan, Sarlan Satria Putra Jaya Negara Sengka, Rani Sir, Panessai Siti Fauziah SITI HALIMAH LAREKENG, SITI HALIMAH Sitti Aminah St. Fauziah Subakir Salnus Subakir Salnus Subakir Salnus Sudarmianti, Sudarmianti Sugiarti Sugiarti Suharni Sudirman Sulistiani Jarre Sumarni Sumarni Sumiati Side Suriati Eka Putri Suriati Eka Putri Suriya Satar Susan Marlein Mambu Susilo Sudarman Desa Syah, Uswah Trywulan Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Tantu, Zakiah Vitrani Vitrani Wahid Wahab Wahyuni, Ilmi Yanti, Reski Yetti Anita Yuliana S Zakiah Tantu Zulfian Armah