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All Journal Medical Journal of Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Rheumatology Journal of Stem Cell Research and Tissue Engineering The New Ropanasuri Journal of Surgery JOURNAL LA MEDIHEALTICO eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Journal Medical Informatics Technology
Murdani Abdullah
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Indonesia/Dr. Cipto Mangunkusumo General National Hospital
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Medical Journal of Indonesia

 1 
A comparison of 5 or 7 days of rabeprazole triple therapy for eradication of Helicobacter pylori Syam, Ari F.; Abdullah, Murdani; Rani, Abdul A.; Nurdjanah, Siti; Adi, Pangestu; Djumhana, Ali; Tarigan, Pangarapen; Wibawa, I. D.N.
Medical Journal of Indonesia Vol 19, No 2 (2010): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (28.389 KB) | DOI: 10.13181/mji.v19i2.390

Abstract

Aim A combination of PPI and 1000 mg amoxicillin/500 mg clarithromycin twice daily for 2 weeks has been proven effective in the eradication of H. pylori. Most studies suggested that treatment for 7 and 10 days may be equally effective. Few data are available on the efficacy of 5-day triple therapy. Aim of this study was to compare 5-day and 7-day rabeprazole triple therapy for eradication of H. pylori infection.Methods We prospectively studied 60 consecutive H. pylori-infected patients who came to hospitals in six centres in Indonesia and who underwent upper endoscopy and biopsy. H. pylori infection was confirmed if two rapid urease tests (Pronto Dry) and histology or urea breath test were positive. Patients were assigned to either an open-labelled 5-day or 7-day course of oral amoxicillin 1000 mg b.i.d., clarithromycin 500 mg b.i.d., and rabeprazole 10 mg b.i.d. (RAC). Four weeks after therapy, all patients had a repeated UBT for evaluation of the presence of H. pylori.Results Of the 60 patients (42 males and 18 females) with mean age (± SD) 47.63 ± 13.93 years, range 21–74 years, 25 patients (41.7%) had 5-day treatment and 35 patients (58.3%) had 7-day treatment. With 5-day treatment, 18 patients (72%) and with 7-day treatment 32 patients (91.4%) became negative for H. pylori infection. The eradication failure was found on 7 patients (28.0%) in 5-day treatment and 3 patients (8.6%) in 7-day treatment.Conclusions The study showed that the eradication of H. pylori infection by triple rabeprazole-based treatment in 7-day is still better than in 5-day. (Med J Indones 2010; 19:113-7)Keywords: H. pylori, rabeprazole, triple therapy
The gastro-esophageal reflux disease questionnaire using Indonesian language: A language validation survey Simadibrata, Marcellus; Rani, Aziz; Adi, Pangestu; Djumhana, Ali; Abdullah, Murdani
Medical Journal of Indonesia Vol 20, No 2 (2011): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (38.269 KB) | DOI: 10.13181/mji.v20i2.442

Abstract

Background: The aims of this study were to test the usefulness of the Gastro-esophageal Reflux Disease Questionnaire (GERDQ) in the diagnosis of GERD, to validate the GERDQ written in Indonesian language, and to evaluate the reliability of the GERDQ for use in Indonesian-speaking GERD patients (Virginia study).Methods: This was a prospective survey of 40 patients diagnosed with GERD, based on an endoscopic examination, in 3 cities in Indonesia (Jakarta, Bandung, and Surabaya) from 15 January to 15 May 2009. Patients were asked to complete the GERDQ, and the validity and reliability of the questionnaire were assessed.Results: The percentages of respondents who reported symptoms lasting 4–7 days were as follows: 68% had a burning sensation behind the breastbone (heartburn); 65% had stomach content (fluid) move upwards to the throat or mouth (regurgitation); 70% had a pain in the centre of the upper abdomen; 58% had nausea; 63% had difficulty sleeping because of the heartburn and/or regurgitation; and 63% took additional medication for heartburn and/or regurgitation. Cronbach’s alpha was 0.83, indicating that all of the questions in the Indonesian-language GERDQ are valid and reliable for Indonesian GERD patients.Conclusions: This study achieved the primary objectives and showed that the GERDQ is valid and reliable for use with Indonesian-speaking GERD patients. The results were consistent with those of the DIAMOND study, which showed that the GERDQ can be used to diagnose GERD on the basis of the reported symptoms. (Med J Indones 2011; 20:125-30)Keyword: GERD, GERDQ, Reliability test, Validity test, Virginia study
Effect of enhanced external counterpulsation therapy on myeloperoxidase in lowering cardiovascular events of patients with chronic heart failure Rampengan, Starry H.; Setianto, Budhi; Posangi, Jimmy; Immanuel, Suzanna; Prihartono, Judo; Siagian, Minarma; Kalim, Harmani; Inneke, Sirowanto; Abdullah, Murdani; Waspadji, Sarwono
Medical Journal of Indonesia Vol 22, No 3 (2013): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (911.558 KB) | DOI: 10.13181/mji.v22i3.584

Abstract

Background: Chronic heart failure (CHF) is a slowly progressive disease with high morbidity and mortality; therefore, the management using pharmacological treatments frequently fails to improve outcome. Enhanced external counterpulsation (EECP), a non-invasive treatment, may serve as alternative treatment for heart failure. This study was aimed to evaluate the influence of EECP on myeloperoxidase (MPO) as inflammatory marker as well as cardiac events outcome.Methods: This was an open randomized controlled clinical trial on 66 CHF patients visiting several cardiovascular clinics in Manado between January-December 2012. The subjects were randomly divided into two groups, i.e. the group who receive EECP therapy and those who did not receive EECP therapy with 33 patients in each group. Myeloperoxidase (MPO) as inflammatory marker was examined at baseline and after 6 months of observation. Cardiovascular events were observed as well after 6 months of observation. Unpaired t-test was use to analyze the difference of MPO between the two groups, and chi-square followed by calculation of relative risk were used for estimation of cardiovascular event outcomes.Results: MPO measurement at baseline and after 6 months in EECP group were 643.16 ± 239.40 pM and 422.31 ± 156.26 pM, respectively (p < 0.001). Whereas in non EECP group, the MPO values were 584.69 ± 281.40 pM and 517.64 ± 189.68 pM, repectively (p = 0.792). MPO reduction was observed in all patients of EECP group and in 13 patients (48%) of non-EECP group (p < 0.001). Cardiovascular events were observed in 7 (21.21%) and 15 (45.45%) of patients in EECP and non-EECP groups, respectively (p = 0.037).Conclusion: EECP therapy significantly decreased the level of MPO as inflammatory marker and this decrease was correlated with the reduction of cardiovascular events in CHF patients. (Med J Indones. 2013;22:152-60. doi: 10.13181/mji.v22i3.584)Keywords: CHF, cardiovascular events, EECP, myeloperoxidase
Total serum IgE levels among adults patients with intermittent and persistent allergic asthmas Rengganis, Iris; Rambe, Dirga S.; Rumende, Cleopas M.; Abdullah, Murdani
Medical Journal of Indonesia Vol 27, No 4 (2018): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.536 KB) | DOI: 10.13181/mji.v27i4.2910

Abstract

Background: Obesity with knee osteoarthritis (OA) is related to chronic pain causing physical inactivity that leads to decreased cardiorespiratory endurance and quality of life. Aquatic and land-based exercises are effective in improving physical activity. The aim of this study is to compare between aquatic and land-based exercise to improve cardiorespiratory endurance and quality of life in obese patients with knee osteoarthritis.Methods: A single-blind, randomized, controlled trial was conducted on thirty-three obese patients with knee OA who visited Obesity Clinic of Medical Rehabilitation Cipto Mangunkusumo Hospital, from October 2016 to January 2017, subjects were divided into aquatic or land-based exercise group. Aerobic and knee-strengthening exercises were given. Cardiorespiratory endurance was assessed using the Borg Scale, whereas both the BORG CR-10 and SF-36 questionnaires were used to assess quality of life.Results: After intervention, there were significant improvements in the land-based exercise group in the rating of perceived exertion (p=0.02), role limitations due to physical health (p=0.024), role limitations due to emotional problems (p=0.041), energy/fatigue (p=0.016), and the decline in pain (p=0.049) parameters. While in the aquatic exercise, there were significant improvements in leg fatigue (p=0.016), energy/fatigue (p=0.025), emotional well-being (p<0.001), and general health (p=0.045) parameters. Despite this, there were no significant differences between two groups regarding cardiorespiratory endurance and quality of life.Conclusion: This study found that patients could start aquatic exercise to reduce leg fatigue and enhance general health and energy. After that, exercise could be continued in land-based settings to improve cardiorespiratory endurance and quality of life.
Antiproliferative activity and caspase enhancement properties of Annona muricata leaves extract against colorectal cancer cells Indrawati, Lili; Ascobat, Purwantyastuti; Bela, Budiman; Abdullah, Murdani; Surono, Ingrid S.; Pramono, Suwijiyo
Medical Journal of Indonesia Vol 25, No 3 (2016): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (498.684 KB) | DOI: 10.13181/mji.v25i3.1449

Abstract

Background: The prevalence of colorectal cancer is rising in Asia including Indonesia. Annona muricata tea leaves, that is traditionally used for maintaining health, and lately being used by cancer patients. The objectives of this study is to investigate its effects in human colorectal cancer cell in vitro and ex vivo.Methods: Thirty patients with colorectal cancer (CRC) were enrolled in a randomized double-blind placebo-controlled trial. They were equally divided into two groups: those treated with 300 mg A. muricata leaf extract and placebo daily for 8 weeks. Serum from supplemented CRC patients of both groups was compared for caspase 9 and caspase 8 enhancement activity. Antiproliferative effect of water extract of A. muricata leaves and its fractions were evaluated against colorectal cancer cell line (DLD-1 and COLO 205) compared with 5-fluorouracil and placebo, the dose range was 62.5-2,000 µg/mL. Method used was 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Data were analyzed by Mann-Whitney U test. The p value was set at 0.05.Results: Ethanol-soluble fraction of A. muricata leaves extract water extract (ESFAM) leaves extract had cytotoxicity effects on DLD-1 as well as COLO 205 cell line, as shown by the lower IC50 compared to 5-fluorouracil and placebo, 20.59 μg/mL and 654.9μg/mL, respectively. Serum of subjects supplemented with extract significantly induced caspase 9 (p=0.001) activity of DLD-1 colorectal cancer cell line, but not for caspase 8 activity (p=0.372).Conclusion: The study's results suggest the cytotoxicity potential of  A. muricata  leaves extract  in in vitro and ex vivo studies.
Co-Authors A.A. Ketut Agung Cahyawan W Aan Santi Abdul A. Rani Abdul Aziz Rani Abdullah, Arman Adel Achmad Fauzi Achmad, Ibrahim Adang Bachtiar Adeputri Tanesha Idhayu Adiningsih Srilestari Aditya Rachman, Aditya Adityo Susilo, Adityo Adli, Mizanul Afifah Is Afistianto, Muhammad Fikri Ahmad Soefyani Ahmar Abyadh Aida Lydia, Aida Akmal Taher Alexander, Reinaldo Ali Djumhana Ali Imron Yusuf Amanda P Utari, Amanda P Amanda Pitarini Utari Anastasia Yoveline Andri Sanityoso Ari F Syam Ari F. Syam Ari Fahrial Syam Ari Wijayanti Ariadi Humardani Arleni Bustami Arman A Abdullah Arnelis Arnelis Artati Murwaningrum, Artati Ascobat, Purwantyastuti Asysyifa, Nisrina Aziz Rani Azzaki Abubakar, Azzaki Birry Karim Bisuk, Batara Bona Adhista Budhi Setianto Budi Tan Oto Budiman Bela Budiman Budiman Budimutiar, Felix C Martin Rumende Ceva W. Pitoyo Chairul R Nasution Chatarina Umbul Wahyuni Chudahman Manan Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Chyntia Olivia MJ Cleopas Martin Rumende Cosphiadi Irawan Czeresna Heriawan Soejono Dadang Makmun Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Dante Saksono Harbuwono Dasril Nizam Deddy Gunawanjati Dewantoro, Okto Dharmeizar Dharmeizar Dharmika Djojoningrat Diah Rini Handjari Diani Kartini Diany N Taher Diding Heri Prasetyo Djumhana A Dolly Dolven Kansera Dono Antono Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edy Rizal Wahyudi Ekowati Rahajeng Ellen Susanti Elli Arsita Em Yunir, Em Ening Krisnuhoni Eric Daniel Tenda Evy Yunihastuti Fauzi Ahmad Muda Fiastuti Witjaksono Fransiska Hardi Fumiaki Kitahara Gaol, Donnie Lumban Giri Aji, Giri Guntur Darmawan Haloho, Raja Mangatur Harini Oktadiana, Harini Harmani Kalim Harry Isbagio Haryana, Sofia M Haryanto Surya Hasan Maulahela, Hasan Hasan Mihardja Hayatun Nufus Hazim, Ahmad Herdiman T Pohan Herdiman T. Pohan Heri Wibowo Hiroyuki Otsuka Hotmen Sijabat I. D.N. Wibawa Ibrahim Basir Ibrahim Basyir Idrus Alwi Ifransyah Fuadi, Ifransyah Ika Prasetya Wijaya Ikhwan Rinaldi Ilum Anam, Ilum Indra Marki Inge Sutanto Ingrid S. Surono Irfan Maulani Iris Rengganis Irsan Hasan Irwin Tedja Iskandar, Rizka Puteri Ivo Novita Sah Bandar Jacobus Albertus Jamhari Jamhari Jane Estherina Jeffri Gunawan Jeffry Beta Tenggara Jimmy Posangi Jonlean, Reganedgary Joseph JY Sung Judo Prihartono Julwan Pribadi Jumhana Atmakusuma Jusman, Sri W Kahar Kusumawidjaja, Kahar Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Khie Chen Khomimah Khomimah, Khomimah Kuntjoro Harimurti Laras Budiyani, Laras Liem, Isabella Kurna Liem, Isabella Kurnia Lies Luthariana Lili Indrawati Lusiani Rusdi, Lusiani M Purnomo Isnaeni M Usman SM Maharani, Shabrina Mansur, M. Tasrif Marcellus Simadibrata Marcellus Simadibrata K Marthino Robinson Maruhum B.H. Marbun Masayuki A Fujino Masayuki A. Fujino Masdalina Pane Maulana Suryamin, Maulana Meriza, Tanggo Minarma Siagian Moch Ikhsan Mokoagow Mochamad Iqbal Hassarief Putra, Mochamad Iqbal Hassarief Mohammad Adi Firmansyah Mondrowinduro, Prionggo Muhadi Muhadi, Muhadi Muhammad Artisto Adi Yussac MUHAMMAD SYAFIQ Muhammad Yamin Muhammad Yamin Lubis, Muhammad Yamin Mulia Mulia Mustikarani, Dewi Mutiara, Rizka Muzellina, Virly Nanda Nababan, Saut Horas H. Nana Supriana Nanda N. Muhammad, Nanda N. Nata Pratama Novie Rahmawati Zirta Nully Juariah M Nur Rasyid Nur Riviati, Nur Nury Dyah, Nury Oktarina, Caroline Pambudi, Joko Rilo Pamela Abineno Pamela Abineno Damaledo Pangarapen Tarigan Pangestu Adi Parhusip, Santi Sumihar Rumondang Pattiiha, Arief Paulus Kusnanto Paulus Simadibrata Pawitan , Jeanne Adiwinata Pradipta, Saraswati Primariadewi Rustamadji Purwantyastuti Purwantyastuti Purwita W Laksmi, Purwita W Purwoko, Reza Yuridian Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi, Rahmad Ralph Girson Rambe, Dirga S. Ratu Ratih Kusumayanti Raymond R. Tjandrawinata Riahdo Saragih Rianto Setiabudy Rino A Gani Rino Alvani Gani Rio Zakaria Risa Ismadewi, Risa Rizki Yaruntradhani Rozaliyan, Anna Rudi Putranto Rumagesan, Djahalia Rumende, Cleopas M. Ryan Ranitya Sabarudin, Adang Saleha Sungkar Salius Silih Sally Aman Nasution, Sally Aman Sari, Nina Kemala Sarwono Waspadji Sedijono Sedijono Seri Mei Maya Ulina Simadibrata, Daniel Martin Simanjuntak, Tiroy Sari Bumi Sirowanto Inneke Siti Setiati Soleha, Winna Sonar S. Panigoro Sri Wahdini Starry H. Rampengan Steven Sumantri Sudirman Katu, Sudirman Sugita, Peter Suhardjono Suhardjono Suharko Soebardi Suhendro Suhendro Suhendro Suwarto, Suhendro Sukamto Koesnoe Sumariyono Sumariyono Surono, Ingrid S Suryantini Suryantini Susanto, Liana W SUWIJIYO PRAMONO Suzana Ndraha Suzanna Immanuel Syari, Lucky Novita Tadashi Sato Tandan, Manu Tandarto, Kevin Telly Kamelia Tito Ardi Tjahjadi Robert Tedjasaputra Toman L Toruan Tonny Loho TR Fitriyani, TR Tri Juli Edi T Ummi Ulfah Madina, Ummi Ulfah Ummu Habibah, Ummu Velma Herwanto Vera Yuwono Wijaya, Anthony Eka Wirasmi Marwoto Wismandari Wisnu Wulandari, Yohannessa Wulyo Rajabto Yoga, Vesri Yohana Sitompul, Yohana Yonathan, I Wayan Murna Yuichiro Kojima Yundari, Yundari Yustar Mulyadi Zubairi Djoerban