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Journal : Respiratory Science

The Association of Acquired Resistance EGFR Exon 20 T790M Mutation and Treatment Response in Lung Adenocarcinoma Patients Receiving EGFR-TKI: Relationship between Acquired Resistance T790M Mutation and RECIST 1.1 Muhammad Harbi Praditya; Noni Novisari Soeroso; Setia Putra Tarigan; Taufik Ashar
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.32

Abstract

Background: Lung adenocarcinoma patients receiving EGFR-TKI may develop acquired resistance within 7-16 months of treatment initiation, which is characterized by the presence of exon 20 T790M mutations in treatment response patients and can be assessed objectively by CECT and then evaluated by RECIST 1.1. The purpose of this study is to look into the association between acquired resistance EGFR Exon 20 T790M mutation and treatment response in lung adenocarcinoma patients receiving EGFR-TKI. Method: This research is an analytic study with a retrospective cohort design carried out at the Oncology Polyclinic at Haji Adam Malik Hospital from October 2020 to January 2021 in all patients with adenocarcinoma lung cancer who were treated with EGFR-TKI for more than 6 months. After that, an evaluation was carried out based on RECIST 1.1 and then examined for EGFR mutations from liquid biopsy specimens in the form of circulating tumor plasma DNA (ct-DNA) with the droplet digital Polymerase Chain Reaction (ddPCR) method to detect EGFR exon 20 T790M mutations as a marker of acquired resistance. Results: It was found that the majority of subjects were female (64.5%), aged 20-69 years (58%), and non-smokers (67.7%). The most common EGFR mutation was exon 19 deletion (58.1%). The incidence of acquired resistance was found in 10 subjects (32.3%). The distribution of RECIST 1.1 results on positive acquired resistance includes progressive diseases of 35.2%; stable disease of 11.1%; partial response of 33.4%; and 100% complete response. Negative acquired resistance includes 64.8% progressive disease, 88.9% stable disease, 66.6% partial response, and 0% complete response (P=0.93). Conclusion: There is no significant association between the incidence of acquired resistance mutations EGFR exon 20 T790M and treatment response in patients with lung adenocarcinoma who received EGFR-TKI therapy.
Co-Authors Adida, Fiony Adri Deslita Situmorang Afiani, Dina Ahmad Fandi Irfandi Alam Bakti Alam Bakti Keloko Alam Bakti Keloko, Alam Bakti Aliandri, Aliandri Amin, Mona N. Andika Pradana Andin Rizqika Aliunputri Andin Anggrainy, Putri Annisa Rizka Lestari Ariantika, Ariantika Arifa Masyitah Panjaitan Arini Agustina Aritonang, Minarni ES. Asfriyati ,MKes Ayu Ulfah Nur Lubis Azmi Ervita Purnama Bambang Wispriyono Berta Kartina Bihar, Syamsul Br. Tobing, Netty Elida Bukit, Dhani Syahputra Chairul Anwar Chrestella, Jessy Chrestella, Jessy Dangana, Amos Darren Wan-Teck Lim Dealita Khairani Daulay Delfi Delfitri Munir Delita Br Panjaitan Delvina Sinaga Dessy Irfi Jayanti Dessy Irfi Jayanti Destanul Aulia, Destanul Destanul Aulia, SKM., MBA., M.Ec., Ph.D Devi Nuraini Santi Dinda Sekar Mentari Dody usman dr. Surya Dharma MPH Eka Lestari Mahyuni Eka Purnamasari Elisna Syahruddin Erman Munir Erna Mutiara ERNA VERONIKA SINAGA Eva Valentine Br. Hotang Evawany Aritonang Evawany Y Aritonang Evi Naria evi naria Evi Naria EVLINA SUZANNA, EVLINA fadhil munthe Fadillah Ismy Faridah Hanum Rajagukguk Fathia Amanda Fatiyah Tul Khoir Nasution Fazidah Aguslina Siregar, Fazidah Aguslina Ferryan Sofyan Fithria Aldy Fransiska, Rosa Berlina Gerry Silaban Gerry Silaban Gerry Silaban Gifani Anastasya Gustina Fajarwati Sihombing Hamidah Fadhilah Hamonangan Nainggolan Hapsari, Sukma Harahap, Pahala Hanafi Harahap, Putri Wulandari Hasbullah Hasbullah Hasbullah Hasbullah Heru Santosa Herwanto, H R Yusa Herwanto, H. R. Yusa Herwanto, R. Yusa Herwanto, Yusa hiswani . Ida Rizkia ika surya agustiani Ikhsan Ibrahim Imerlyn A Silitonga Indirawati, Sri Malem indra cahaya Indra Chahaya Irma Damayanti Irnawati Marsaulina Irnawati Marsaulina Ita Fitriyani Lubis Juita Asnipa Kananda, Vive Kezia Purba Khairiah . kiki agusty lamtiur junita bancin Launeta Maruyun Purba lidia oktavia Lim, Darren Wan-Teck Listyoko, Aditya S. Lita Sri Andayani Lorensia Eninta Lubis, Rodiah Rahmawaty Lubis, Yuliani M Lubis, Yuliani M. lulu marbun Marlina Renta Juyanti Butarbutar Melisah Pitri Siregar Merylanca Manalu Michico Eloista Br. Ginting Minar Indriasih Muhammad Harbi Praditya Muhammad Harbi Praditya Muhammad Syafii Mutiara Nauli Nadhira Marsha Audiva Harahap Nadia Arini Nahrisyah, Putri Nailatun Nadrah Namora Lumongga Lubis Nasution, Erizal Salam Putra Nasution, Nurhalimah Naysya Vitianoza Noni Novisari Soeroso Noni Novisari Soeroso Nurhandini, Astri nurma irama Nurmaini . Nurmaini Nurmaini Nurmaini Nurmaini Nurmaini Nurmaini Nurmaini Nurmaini Nurmaini Nurmaini olivia via Osareniro, Osakue E. Pandia, Pandiaman Pandiaman Pandia Parinduri, Anggi Isnani Parluhutan Siagian Pinem, Agung Haganta Purba, Jenny Marlindawani Putra, Aldi Maulana Putra, Muhammad Yusuf Adira Putra, Wahyu Medsa Yeltas Putri, Syafreni Annisa Ayu R.Kintoko Rochadi Rahayu Lubis Rahayu Lubis Rahmadani Sitepu Rahmi Wardani Rambe, Alvin Rambe, Andriana Yunita Murni Rambe, Andrina Yunita Murni Rasmaliah ,MKes Rasmaliah . reni indra aristi Rio Ferdi Yuandra riris lumban Risanti Febrine Ropita Situmorang Rizka Fiqih Ertika Rizky, Handan Rocky Malindo Sidabutar saddam musthofa Sagala, Irwan Pernandi Samuel Marganda Halomoan Manalu Sari, Masitha Dewi Setiaty Pandia, Setiaty Siagian, Novi Andriani Silvia, S Simanjuntak, Amran Simanjuntak, Saurma O S Simanjutak, Yohana Sinaga, Bintang Yinke Magdalena Sinaga, Bintang YM. Sinulingga, Herison E. Siregar, Annisa Febriana Siregar, Kamal Basri Siregar, Nur Khaidah Siregar, Nurul Rahmah Sitepu, Rahmadani Siti Khadijah siti rahmah Siti Zahara Nasution, Siti Zahara Sitompul, Indah Sari Sormin, Cynthia sri dewi puspita Sri Malem Indirawati Sufia Idya Suriani Gultom Surya Darma Surya Dharma Syahrani, Fajrinur Syarani, Fajrinur Tarigan, Amira P. Tarigan, Amira Permatasari Tarigan, Lina Tarigan, Setia Putra Tatiana, Melza Thomson Siahaan Tony Wibowo Umi Salmah Verarica Silalahi, Verarica Winni R.E Tumanggor Wirsal Hasan Wirsal Hasan Yenni Yulfida Harahap Yudhi Pratama Yuslina FNB Siahaan Yusniar Zahara, Devira Zulfendri Zulfendri Zulfendri Zurhayati, Zurhayati