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Effect of Garlic Powder Supplementation on Total Cholesterol and Low Density Lipoprotein Level in Patient with Hypercholesterolemia: A Meta-Analysis Zulkarnain, Zuraida; Dewi, Yulia Lanti Retno; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.128 KB) | DOI: 10.26911/theijmed.2022.7.1.522

Abstract

Background: Hypercholesterolemia is a risk factor for cardiovascular disease that can cause death and disability, so it must be managed properly. Garlic flour (GP) is one of the dosage forms of garlic that has the potential to reduce cholesterol. This study is a systematic review and meta-analysis that aims to determine the effectiveness of GP in reducing total cholesterol (TC) and low density lipoprotein (LDL).Subjects and Method: Search articles through the Pubmed database, Google scholar, Proquest, Springer link, and Science direct with the appropriate keywords. Population= patients with hyper­cholesterolemia. Intervention= GP. Comparison= placebo. Outcome= TC and LDL. Inclusion crite­ria included complete articles in English or Indonesian published from 2010-2022, Randomized Con­trolled Trial (RCT) design, subjects >18 years old with hypercholesterolemia, the study had a complete fat profile outcome, duration of intervention 2 weeks-12 months. The flow of article selection is based on the PRISMA flow diagram. Meta-analysis using RevMan 5.3 with effect size standardized mean difference (SMD) and Random Effect Model (REM) analysis model.Results: A total of 10 articles were eligible for a meta-analysis. The GP group had TC levels 1.49 units lower than the placebo group (SMD = -1.49; 95% CI = -1.95 to -0.55; p = 0.005) and LDL levels 0.68 units lower than the placebo group (SMD= -0.68; CI95). %= -1.08 to -0.27; p=0.001). Subgroup analysis based on the length of the intervention showed that administration of GP <12 weeks only significantly reduced TC while administration > 12 weeks significantly reduced TC and LDL.Conclusion: GP is effective in lowering TC and LDL especially at 12 weeks or more.Keywords: garlic powder, hypercholesterolemia, RCTCorrespondence: Zuraida Zulkarnain. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java 57126. Mobile: 081393933862. Email: zuraida.zu@gmail.com.Indonesian Journal of Medicine (2022), 07(01): 102-114https://doi.org/10.26911/theijmed.2022.07.01.11
Path Analysis of the Relationship between Nutritional Status, Maternal Knowledge, Dietary Compliance and Health-Related Quality of Life in Children with Acute Lymphoblastic Leukemia Arini Tri Lestari; Dewi, Yulia Lanti Retno; Salimo, Harsono; Hikmayani, Nur Hafidha
Journal of Maternal and Child Health Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2025.10.03.04

Abstract

Background: Acute Lymphoblastic Leukemia (ALL) is the most common type of blood cancer in children. Treatment for ALL may affect the patient's quality of life. Factors such as nutritional status, maternal knowledge of nutrition, and dietary compliance play a role in determining the quality of life of children with ALL. This study aims to analyze the relationship between nutritional status, maternal knowledge, and dietary compliance with health-related quality of life (HRQoL) in children with ALL. Subjects and Method: This study used a cross-sectional design with a sample of 52 children with ALL at the Pediatric Hematology Clinic of Dr. Moewardi Surakarta Hospital in October-November 2024. The independent variables were nutritional status, maternal knowledge, and dietary compliance, while the dependent variable was HRQoL. Data were collected using anthropometric instruments and questionnaires, then analyzed with single logistic regression and path analysis. Results: Single logistic regression analysis showed that nutritional status (OR= 4.60; 95% CI= 1.311 to 16.139; p = 0.017) and dietary compliance (OR= 4.82; 95% CI= 1.39 to 16.78; p= 0.013) were significantly associated with HRQoL. Maternal knowledge had no significant effect (OR= 1.88; 95% CI = 0.35 to 10.18; p = 0.467). Path analysis showed that nutritional status, dietary compliance, and body mass index had a direct positive association with the child's quality of life. The path analysis model showed a good fit with the data (goodness of fit p = 0.594). Conclusion: Nutritional status and dietary compliance are major factors in improving the quality of life of children with ALL. Although maternal knowledge does not have a direct effect, the mother's role remains important through improving the child's dietary compliance. Multidisciplinary interventions that integrate nutrition education and family support are needed to enhance HRQoL in pediatric patients with ALL.
Faktor determinan risiko kardiometabolik pada remaja usia 15-18 tahun Wiboworini, Budiyanti; Shabrina, Amalina; Dewi, Yulia Lanti Retno; Sari, Amelya Augusthina Ayu; Handayani, Sutartinah Sri; Damayanti, Kusmadewi Eka; Azzahrah, Aisyah; Tjung, Vivienne
Jurnal Gizi Klinik Indonesia Vol 21, No 1 (2024): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.90010

Abstract

Determinant factors of cardiometabolic risk in adolescents aged 15-18 yearsBackground: Cardiometabolic diseases are increasing worldwide, and the risk of developing them starts as early as adolescence. In the long term, they may lead to comorbidities. Evidence suggests the risk factors of cardiometabolic diseases among adolescents are obesity, excessive food intake, socioeconomic status, breakfast habits, and physical activity, among others. Objective: This study aimed to determine the determinants of cardiometabolic risk in adolescents aged 15-18. Methods: This was a cross-sectional study in Al-Abidin High School Surakarta with 146 study subjects. Cardiometabolic risks were classified using Cardiometabolic Disease Staging (CMDS), waist circumference was measured with Medline, physical activity was measured using a Physical Activity Questionnaire for Adolescents (PAQA), and blood pressure was measured with a sphygmomanometer. Socioeconomic, transportation, and breakfast habits were obtained from the general questionnaire. Chi-square, ANOVA, and logistic regression were then performed using SPSS 23. Results: Gender was significantly associated with cardiometabolic risk (p=0.001). A total of 41.3% of boys were at risk of cardiometabolic (OR=3.964). Socioeconomic, breakfast habits, transportation, and physical activity were not associated with cardiometabolic risk (p>0.05).Conclusion: Boys 15 – 18 years were at a higher risk of cardiometabolic, by 3.694 times greater than girls. Socioeconomic status, breakfast habits, transportation, and physical activity were not correlated with cardiometabolic risk among adolescents.
The Effect Of Blood Transfusion On The Risk Of Hepatitis B Infection In Hemodialysis Patients : Meta Analysis Astuti, Yuli; Dewi, Yulia Lanti Retno; Murti, Bhisma
Jurnal Riset Kesehatan Vol 14 No 1 (2025): MEI 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v14i1.9342

Abstract

Background Hepatitis B is caused by infection with the Hepatitis B virus, this disease affects 240-280 million people in the world. Hepatitis B virus causes chronic disease that develops in liver damage, cirrhosis and liver cancer, more than 600,000 people die every year. Giving repeated blood transfusions increases a person's risk of developing hepatitis infection. Hemodialysis patients who receive blood transfusion therapy are more at risk of developing hepatitis infection. Objective of this study was to study and estimate the influence of blood transfusion history on the risk of hepatitis B infection in hemodialysis patients based on the results of previous similar studies by meta-analysis. Method is a meta-analysis conducted by searching for articles from the databased Google Scholar, PubMed, Springer Link, and Research Gate. The keywords used were "blood transfusion" OR "risk factor" AND "HBV" OR "hepatitis B infection" OR "TTI" AND "patient hemodyalysis" OR "Patient renal failure". The inclusion criteria in this study were full text articles, from 2000-2020, with a cross sectional study design. Article analysis using RevMan 5.3. Results of data analysis studies 6 articles in the forest plot, giving blood transfusions was able to increase the incidence of hepatitis B infection in hemodialysis patients 1.30 times more at risk than those who did not transfuse, statistically significant (aOR 1.30; 95% CI = 1.02-1.66; p = 0.03) and based on the funnel plot, there was no publication bias. Conclusion blood transfusion affects hepatitis B infection in hemodialysis patients.
Low Birth Weight as Predictor of Underweight and Stunting Among Female Students Aged 6-9 Years: an Observational Study in Surakarta Shabrina, Amalina; Ayusari, Amelya Augusthina; Dewi, Yulia Lanti Retno; Wiboworini, Budiyanti; Sudarsono, Joko; Handayani, Sutartinah Sri; Rahayu, Dwi
Smart Medical Journal Vol 7, No 1 (2024): April
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v7i1.79718

Abstract

Introduction: Undernutrition remains a leading cause of premature mortality among children in developing countries. Previous studies discussed that the risk of undernutrition elevated with child’s age, stressing the need to address undernutrition in older children. Maternal factors also caused undernutrition through intergenerational transmission. However, data related to nutritional status of female children age >5 years in Indonesia are lacking. This study aimed to elucidate determinants associated with nutritional status among primary school girls in Surakarta.Methods: This was an observational, cross-sectional study. A total of 61 female students aged 6-9 years from Nur Hidayah Primary School Surakarta participated in this study. Data were collected through online questionnaire filled by parents who were directed to follow the procedures of anthropometric measurement at home. Z-score was calculated using WHO AnthroPlus software. Nutritional status of children was measured in weight-for-age and height-for-age. Statistical analyses were performed using Spearman’s correlation and backward linear regression. Variables with p<0.05 from the final model were considered as the determinants.Results: Among study participants, 4.9% were underweight and 9.9% were stunted. Our study found one common determinant of nutritional status by weight-for-age and height-for-age, namely birth weight (p=0.027 and p=0.011 respectively). Maternal height was, in particular, associated with nutritional status by height-for-age (p=0.001).Conclusion: Birth weight was significantly associated with nutritional status by weight-for-age and height-for-age, while maternal height was significantly correlated with only nutritional status by height-for-age. Nutrition programs for female students such as school lunch and multivitamin supplementation could be implemented to prevent the intergenerational effects of stunting and underweight.
Co-Authors ?Arub, Lathifah Abd. Rasyid Syamsuri Adriyani, Rita Benya Agusningtyas, Nisia Hari Alvianti, Neily Widya Ambarwati, Dyah Anggraeni, Anastasia Dwi Anik Lestari Anindya, Ivanda Glanny Annarahayu, Lutfi Annisaa, Salwa Apriyanti, Ruth Ardianti, Febrina Arini Tri Lestari Ayusari, Amelya Augusthina Aziza, Triana Ulfa Nur Azizah, Alfi Makrifatul Azzahrah, Aisyah ‘Arub, Lathifah Babys, Isna Yuswella Bhisma Murti Budiyanti Wiboworini Damalita, Annisa Fitriana Dania, Samara Rahma Dewi, Ayu Rosita Dewi, Ayu Rosita Dhewi Nurahmawati Dianika, Bani Didik Gunawan Tamtomo Didik Tamtomo, Didik Dono Indarto Dwi Rahayu Dwi Wijayanti Endang Sutisna Sulaeman Eti Kuswandari Eti Poncorini Pamungkasari Fatmawati, Zeny Fauziyyah, Rona Luthfi Firdausia, Shalsabilla Tiara Firstiafina Tiffany Fitriyaningsih, Ayu Hadianti, Ayunita Dwi Handayani, Anggun Fitri Handayani, Sutartinah Sri Harsono Salimo Harsono, Rizki Dwi Agustin Hastuti, Uki Retno Budi Huwaida, Dhea Zahra Ika Yuli Ayuningrum Indarwati, Ika Indria, Gita Ayu Indriyani, Eny Khairunnisa, Lia Krisnawati, Hesthi Kudu, Stevani Rambu Kunaryanti, Kunaryanti Kusmadewi Eka Damayanti kusnandar kusnandar Latifah, Mirzawati Lestari, Esti Lolita Lolita Mariyana, Anna MDF, Renidya Asyura Mega Fatimah Rosana Muhammad Rifqi Azhary Murdikawati, Dayang Fitri Muslimah, Putri Andini MY. Cendy Nindra Brilliana Nirwana, Astika Candra Nur Hafidha Hikmayani Nurjanah, Ahmitta Laila Nurlaili, Riftiani Nikmatul Nurmayanti, Rika Nurvitasari, Rahsunji Intan Nuswantari, Atika Pangestu, Utami Pangestuti, Restu Pardosi, Firman Prasetya, Hanung Priscilla Jessica Pihahey Purnasari, Ratih Hermas Purwaningsih, Yustina Purwiyanti, Risye Endri Putra, Sinar Perdana Qadrijati, Isna Rachmawati, Nur Cahya Rahardjo, Setyo Sri Rakhmahayu, Atika Ramadhaningtiyas, Ahshaina Ratna, Tantri Yunita RB. Soemanto Reviana, Prita Alvina Riski Anisa, Riski Rita Adriani Benya Adriani Romiza Arika Rosyidah, Milatur Safriana, Latifah Sajalia, Husniyati Sani, Mario Febrianus Helan Sapja Anantanyu, Sapja Sari, Amelya Augusthina Ayu Septianawati, Linda Wahyu Setyo Sri Raharjo Shabrina, Amalina Simatupang, Abdul Malik Sinawangwulan, Indah Permatasari Sitorukmi, Galuh Slamet Riyadi Sudarsono, Joko Sugihardjo Sugihardjo Sukoco, Amin Tjung, Vivienne Tri Rejeki Andayani Uki Retno Budihastuti Vitri Widyaningsih Wayanshakty, Janur Putri Wekadigunawan, CSP Wekadigunawan, CSP. widardo, Widardo Widhiyanti, Fitria Wijayanti, Poppy Wulandari Wulandari Yopiana, Elma Yuli Astuti Yuniarti, Windy Yunita, Astri Zummatul Atika Zuraida Zulkarnain, Zuraida