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Journal : Makara Journal of Technology

Production of Lovastatin and Sulochrin by Aspergillus Terreus Using Solid State Fermentation Dewi, Rizna Triana; Artanti, Nina; Mulyani, Hani; Lotulung, Puspa Dewi Narrij; Minarti, Minarti
Makara Journal of Technology Vol. 15, No. 1
Publisher : UI Scholars Hub

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Abstract

Lovastatin is an anti-cholesterol agent that was produced by Aspergillus terreus using solid state fermentation (SSF). During this fermentation process, sulochrin is also produced as an unwanted co-metabolite. However, our previous result showed that sulochrin had potential as antidiabetes because it is an inhibitor agent of α-glucosidase. In this paper, we reported our observation on lovastatin and sulochrin production pattern in relation with inhibitor α-glucosidase activity during eleven days fermentation of A. terreus koji (SSF) ethyl acetate extract. Koji obtained from solid state fermentation with rice as the substrate and incubated at room temperature, sample is taken daily for eleven day (D-1 to D-11). Lovastatin and sulochrin production was measured by Liquid Chromatography- Mass Spectrometer based on their molecular weight m/z 404.5 and 332.3 respectively. The inibitory activity is measured by inhibition model of koji extract against α-glucosidase (EC 3.2.1.20) from Saccharomyces cereviceae. The results show that lovastatin production was started on the day 2 (0.04 mg/g) and achieving the optimal production on day 7 (11.46 mg/g), while sulochrin production was started on day 4 (0.60 mg/g) and keep produced until the end of fermentation period at Day 11 (3.11 mg/g). Koji extract was started to show inhibitory to α-glucosidase activity on Day 5 (IC50= 23.34 μg/mL) and keep showed activity until Day 11 (IC50=3.33 μg/mL). These results suggest that inhibitory activity of koji extract to α- glucosidase activity have relation with sulochrin biosynthesis production.
Co-Authors ., Pestariati A.A. Ketut Agung Cahyawan W Abda Abda Adek Zamrud Adnan Adinata, Ach. Arfan Agus Mukholid Aisya, Sitti Akhmad Darmawan Alfatik, Fatma Amirin Kusmiran Andini Sundowo Anisa Pertiwi Anita Anita Arfiah Ariani, Novita Arif Wijaya Aryadi, Anggi Ayuanda, Leila Nisya Baiq Dewi Harnani R Bayu Argaheni, Niken Chaidir Chaidir Chandra, Tiara Ayu Darmawati, Junay darwis darwis, darwis DEWI CISELIA Dewijanti, Indah Dwiatmi Dina Raidanti Dintya Ivantarina Eka Sarofah Elvi Sunarsih Endarini, Lully Hanni Ernita, Lisa Evy Diah Woelansari Febiayuni, Nabila Fika Minata FIKA MINATA WATHAN Galuh Widiyarti Hani Mulyani, Hani Hartati, Yuli Hendris Hendarsyah Kurniawan, Hendris Hendarsyah Heri Syahrian, Heri Heru Sulistijono Hilmi Yumni Ilham, Rahmaniah Imelda Gernauli Purba, Imelda Gernauli Inoy Trisnaini Insyur, Bergita Irzanita, Irzanita Istanto, Wisnu Jamaluddin Jamaluddin Jamilah Abbas Juliana Christyaningsih Juminten Saimin, Juminten Junuda, Junuda Junuda, Junuda Karnaen, Muh. Kastubi Kastubi, Kastubi Khoiri, M. Khrisna Agung Cendekiawan Kristina Pae Ladyka Viola Aulia Armawan Lanto, Muh Said Lara, Lara Leni Novianti Lia Meilawati Lotulung, Puspa Dewi N Lotulung, Puspa Dewi N. Luthfi Rusyadi Luthfiyah, Sari Mahendika, Devin Maksuk Mamik Mamik Marcello, Steven Aldo Martoni Medi Hendra, Medi Megawati - Minata, Fika Muhammad Altin Massinai Muhammad Fawzy Ismullah Massinai Muhammad Hanafi Museyaroh, Museyaroh Mutiarawati, Diah Titik Namriah, Namriah Nasution, Fitri Faridahtul Aulia Nasution Ngguna, Ani Mura Nikmatul Fadilah Nina Artanti Ningsih, Dewi Andariya Nur Anugrahini, Hepta Nurhayani, Delvi NURUL ANNISA NURUL HIDAYAT Ongko Waluyo, Kiaonarni Padoli Padoli, Padoli Peluw, Zulfikar Prasetyawati Umar, Emi Priadi, Ramadhan Primahana, Gian Puji Budi Setia Asih, Puji Budi Purwanti, Kristin Puspa Dewi Narrij Lotulung Puspa Lotulung, Puspa PUTU LUSITA NATI INDRIANI Rahagia, Rasi Rahma Sari, Indah Rajokiaman Sinaga Ramadona, Mayang Dwi Rembon, Fransiscus S Resman, Resman Riani, Lita Rifanzha, Aqil Naufaldy Ririn Noviyanti Putri Rizki Amalia Rizki Amalia Rizna Dewi Rizna Triana Dewi Ruben, Sethiana Dewi Runtu, Andro Ruben SAHTA GINTING, SAHTA Samrida, Wa Ode Nesya Jeni Sari, Erma Puspita Sartika, Diana Sasongkowati, Retno Satrio Wicaksono Setyorini, Dhiana Suhariyadi Suhariyadi Sukirno Sukirno Suliati Suliati Sumarni Sumarni Supriadi, Edi Supriatin Supriatin, Supriatin Suyono Suyono Syafrudin, Din Syafrudin, Din Syamsiar, Syamsiar Tandiola, Rosdiana Teni Ernawati Ulfa, Dina Amalia Utami, Fatia Arta Veradilla, Veradilla Wahidin, Wahidin Wardana, Ali Warni, Rosma Wiraningsih, Eti Dwi Witono Basuki, Witono Yeninar, Fendi Abraham yuliani, meda Yuliastuti, Rizka Yulizar Yulizar Yuniarti, Nini Iswara