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Syariful Mubarok
Departemen Budidaya, Fakultas Pertanian, Universitas Padjadjaran
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Pharmacology and Pharmacoeconomics of Kombucha as a Functional Immunomodulatory Food for Children with Special Needs at Elementary School Level: Literature Review Jubaedah, Siti; Surahman, Yugga Tri; Rezaldi, Firman; Huda, Fahmi Alamil; Suminar, Erni; Mubarok, Syariful
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11652

Abstract

Kombucha is a fermented tea-based beverage containing various bioactive compounds such as polyphenols, flavonoids, organic acids (acetic, gluconic, and glucuronic acids), and probiotic microorganisms produced by the Symbiotic Culture of Bacteria and Yeast (SCOBY). These compounds exhibit antioxidant, anti-inflammatory, and immunomodulatory activities that may support immune function. This study aimed to analyze the pharmacological and pharmacoeconomic aspects of kombucha as a functional immunomodulatory food for elementary-level children with special needs through a systematic literature review approach. Data were collected from Scopus-indexed journals and other reputable scientific databases published between 2016 and 2025. The findings indicate that kombucha exerts pharmacological effects by modulating pro-inflammatory and anti-inflammatory cytokines, enhancing antioxidant activity, and improving gut microbiota balance, thereby contributing to immune homeostasis. From a pharmacoeconomic perspective, kombucha shows potential as a cost-effective preventive functional food intervention with relatively low production costs and potential long-term healthcare cost efficiency. However, direct clinical evidence in children with special needs remains limited, highlighting the need for further experimental and clinical studies to establish safety, efficacy, and comprehensive cost-benefit evaluation.
Respons Fisiologis Tanaman Secang (Caesalpinia sappan L.) terhadap Variasi Jarak Tanam dan Aplikasi Metil Jasmonat serta Asam Salisilat Rachman, Annisa Lugina; Rosniawaty, Santi; Mubarok, Syariful; Ariyanti, Mira
Agrikultura Vol 37, No 1 (2026): April, 2026
Publisher : Fakultas Pertanian Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/agrikultura.v37i1.67820

Abstract

Secang adalah tanaman berguna dalam bidang farmakologis, namun budidayanya belum banyak dilakukan. Teknik budidaya yang dapat dilakukan yaitu dengan pengaturan jarak tanam dan aplikasi fitohormon berupa asam salisilat (SA) dan metil jasmonat (MeJA). Tujuan penelitian ini yaitu untuk mengetahui interaksi antara jarak tanam dengan fitohormon SA dan MeJA terhadap respons fisiologis tanaman secang. Penelitian dilaksanakan di Kebun Percobaan dan Laboratorium Pangan dan Perkebunan, Fakultas Pertanian, Universitas Padjadjaran pada bulan Juli hingga Desember 2024. Percobaan menggunakan Rancangan Petak Terbagi, dengan jarak tanam (J) sebagai petak utama dan aplikasi hormon eksogen (H) sebagai anak petak. Penelitian ini dilakukan dengan 3 ulangan. Petak terdiri dari tiga taraf, yaitu jarak tanam: j1 = 1 m x 1 m, j2 = 2 m x 2 m, dan j3 = 3 m x 3 m. Adapun anak petak, yaitu aplikasi hormon eksogen (H) yang terdiri dari 3 taraf, yaitu: h0 = tanpa aplikasi hormon eksogen, h1 = SA 200 ppm, dan h2 = MeJA 100 ppm. Pengamatan fisiologis yang dilakukan meliputi indeks klorofil daun, nilai konduktansi stomata, dan kerapatan stomata. Hasil penelitian menunjukkan bahwa indeks klorofil daun dipengaruhi secara mandiri oleh h1, dengan interaksi terbaik pada j2 × h2. Konduktansi stomata tertinggi diperoleh pada jarak tanam lebar (j3), baik secara mandiri maupun dalam interaksi dengan AS. Sementara itu, kerapatan stomata dipengaruhi secara mandiri oleh jarak tanam sempit (j1) serta MeJA yang tidak berbeda nyata dengan kontrol, dan interaksi terbaik ditunjukkan oleh j1 × h2. Secara keseluruhan, pengaturan jarak tanam dan aplikasi fitohormon SA serta MeJA berpotensi dioptimalkan sebagai strategi budidaya untuk meningkatkan respons fisiologis tanaman secang secara lebih efektif.
Optimization of Physalis angulata L. callus induction and salinity-induced antioxidant production Sistyananda, Firstian Naufal; Suminar, Erni; Nuraini, Anne; Kadapi, Muhamad; Murgayanti, Murgayanti; Mubarok, Syariful; Budiarto, Rahmat; Renaldi, Eddy; Kusumiyati, Kusumiyati
Kultivasi Vol 25, No 1 (2026)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/kultivasi.v25i1.69556

Abstract

Groundcherry (Physalis angulata L.) is a plant with many medicinal potentials due to its rich secondary metabolites such as phenolic and flavonoid. However, conventional agriculture practices are still limited, especially in Indonesia. This study was divided into two stages. The first stage was conducted to determine optimal 6-BAP and 2,4-D combination for callus induction, while the second stage was conducted to determine callus phenolic, flavonoid, and antioxidant response to salinity stress. The first stage was arranged in factorial completely randomized design with two factors: 6-BAP (0, 2, and 4 mg/L) and 2,4-D (0, 0.5, 1, and 1.5 mg/L). The second stage was arranged in simple completely randomized design with different NaCl concentration (0, 25, 50, 75, 100 mM) as treatments. The results showed significant interaction (p < 0.05) between 6-BAP and 2,4-D on callus induction. Combination of 2 mg/L 6-BAP and 1 mg/L 2,4-D showed the highest callus formation percentage (46% increase), callus size (60.12% increase), and fresh weight (179.69% increase), and greener compact callus. Application of NaCl as salinity stress at second stage experiment served as an elicitor to enhance callus antioxidant capacity. Salinity level at 100 mM NaCl showed the most accumulation of phenolic content (17.8% increase), flavonoid content (25.17% increase), and antioxidant activities (6.84% IC50 decrease). This study demonstrates plant growth regulator optimization with salinity stress elicitation integration as an effective strategy to enhance antioxidant production in P. angulata callus, providing a practical approach for controlled secondary metabolite production. 
Co-Authors A Salimah A.A. Ketut Agung Cahyawan W Abdullakasim, Supatida Abraham Suriadikusumah Ade Ismail Ade Ismail Ade Risti Oktavia Ade Setiawan Ade Sumiardi Adinda Cikal Amalia Agung Karuniawan Agung Rahmadi Agung Rahmadi Agus Wahyudin Aida Fadlilah Rahmani Ainun Fadilah Al Aufa, Elfa Muhammad Ihsan Al- Adawiah, Alin Robial Alin Robiah Al Adawiyah Alin Robial Al- Adawiah Amalia, Inneke Anas Anas Anas Anas, Anas Andianingsih, Nindi Anne Nuraini Anni Yuniarti Ardika Albi Fauzi Arif Affan Wicaksono Arin Rosmala Ariyanto, Nur Budi Arrin Rosmala Asyifa Mardatillah Ayu Ratna Ningrum Azizah, Annisa Nanda Nur Bachtiar, Nedya Putri Bambang Nurhadi Bayu Pradana Nur Rahmat Boy Macklin Pareira Prawiranegara Ceppy Nasahi Christine Angel Cinthiya Muizz Abita Sari Citra Bakti, Citra Danar Dono Darmawan, Ricco Basarestu Debby Ustari Dedeh Jubaedah Denny Sobardini Denny Sobardini Denny Sobardini Sobarna Denny Sobardini Sobarna Desi Maulida Dewi, Tessa Prima Dikdik Kurnia Diky Indrawibawa dilla febria, dilla Dinnur Afiifah Dinnur Afiifah, Dinnur Drikarsa, Drikarsa Eddy Renaldi Ega Raisya Ega Raisya Elfira Rosalita Elma, Tiara Elok Zubaidah Endah Yulia Erika Wahyuni Saragih Erizon, Meisyela Salsabila Ernah Ernah Erni Erni Erni Suminar Eva Aprilia Ezura, Hiroshi Fadilah, M. Fariz Fahmie Firmansyah Farida Farida Damayanti Farida Farida Farida Farida Farida Farida Fauzi, Ardika Albi Fauzi, Ardika Albi Fiky Yulianto Wicaksono Fitri Widya Fitriatin Fitri Widya Lestari Fitrianti Widya Lestari Giyarto, Gunes Gungun Wiguna Gungun Wiguna Gustiono Tegar Prasetyo Hamiranti, Rahmadyah Hari Hariadi Herjayanto, Muh. Hiroshi Ezura Hiroshi Ezura Hiroshi Ezura Huda, Fahmi Alamil Ine Elisa Putri Ine Elisa Putri Ine Elisa Putri Inneke Amalia Jajang Sauman Hamdani Kartina Kartina Kusumadewi, Vira Kusumiyati Kusumiyati Lamro Purba Lestari, Rahma Wati Lilis Sugiarti Lisa Erfa Luciana Djaya, Luciana M. Fariz Fadillah Maharani Maharani Maolana, Adrian Maritha, Vevi Masako Akutsu Maulana, Yusuf Eka Maura Zhafira Putri Mega Fatimah Rosana Meisyela Erizon Mia Munggarani Mira Ariyanti Mita Indriani Mochamad Arief Soleh Mochammad Arief Soleh Mochammad Imron Awalludin Mu’jijah Muhamad Joddy Ramadhan Muhamad Kadapi Muhammad Abdillah Hasan Qonit Muhammad Andry Muhammad Faizal Fathurrohim Muhammad Rizki Muhardiono, Iman Munir, Misbakhur Murgayanti Murgayanti Mustika Arsri Mutiara, Pipit Nedya Deninta Neni Rostini Nindi Andianingsih Nisa, Kahirun Nita Suswati Endah Rini Noladhi Wicaksana Noor Istifadah Nur Azizah Romadhoni Nur Budi Ariyanto Nurlilasari, Puspita Nursuhud Nursuhud Pamungkas, Barolym Tri Pujawati Suryatmana Putri, Adinda Rosmaya Putri, Azizah Tiara Putri, Dina Qonit, Muhammad Abdilah Hasan Rachmad Akbar Rachman, Annisa Lugina Rahma, Siti Auliya Rahmat Budiarto Rahmat, Bayu Pradana Nur Raisa Fadila Raisya, Ega Rani Andriani Budi Kusumo Ratu Amalia Hayani Reviana Aulia Rija Sudirja Rika Bhernike Sitepu Rika Meliansyah Rina Hermawati, Rina Risa Nurul Falah Rohmatulloh, Rizal Roni Gumilar Rosniawati, Santi Rufaidah, Fathi Ruminta Ruminta Rusmana Rusmana Saadah, Imas Rita Saifullah, Ipul Salsabila Dwi Ananda Santi Rosniawaty Santika Sari Sari, Cinthiya Muizz Abita Sari, Dwi Novanda Saskia Pratiwi SIska Rasiska, SIska Sistyananda, Firstian Naufal Siti Julaeha, Siti Siti Rakhmah Tenrisui Pakki Siti Rakhmah Tenrisui Pakki Sitompul, Kiki Nuratni Sudarjat Sudarjat Sudarjat Sudarjat Sudarjat Sugiono Sugiono Sulistyaningsih Sulistyaningsih Sulistyaningsih Sulistyaningsih SUMADI SUMADI Sumadi Sumadi Sumadi Sumadi Sumadi Sumadi Surahman, Yugga Tri Suryaman, Teguh Firman Susiyanti Susiyanti Susiyanti Susiyanti Susiyanti, Susiyanti Taisa, Rianida Tiara Elma Toto Sunarto Usman Setiawan Varinto, Irvan Venny Revia Viola Vevi Maritha Vevi Maritha Vijaya Isnaniawardhani Wahyu Ferdiyansyah Wahyu Prajaka, Nanang Waluyo, Nurmalita Wawan Sutari Wibawa, Rangga Widayani, Neneng Sri Wieny Marma Jaya Wieny Rizky Y Rochayat Y Setiati Yanyan Mochamad Yani Yayat Rochayat Suradinata Yenny, Ratna Fitry Yuda Hadiwijaya Yuda Hadiwijaya Yudhistari Sihombing Yuliana Kolo Yulianto, Fiky Yusup Hidayat Zulfatunnisa, Zulfatunnisa