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All Journal Jurnal Diskursus Islam Indonesian EFL Journal al-Afkar, Journal For Islamic Studies YUSTISI Jurnal Pengabdian Magister Pendidikan IPA JURNAL FARMASIMED (JFM) Manutech : Jurnal Teknologi Manufaktur Jurnal Restorative Justice Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Pendidikan Kewarganegaraan Ethical Lingua: Journal of Language Teaching and Literature Mutawasith: Jurnal Hukum Islam Yustisi: Jurnal Hukum dan Hukum Islam JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Jurnal Mesin Nusantara Jurnal Ilmiah Administrasita' Judikatif: Jurnal Desain Komunikasi Kreatif KASBANA : Jurnal Hukum Ekonomi Syariah Majalah Ilmiah Tabuah: Ta`limat, Budaya, Agama dan Humaniora International Journal Of Computer, Network Security and Information System (IJCONSIST) Al-Muamalat : Jurnal Ekonomi Syariah International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET) Al-Mizan: Jurnal Hukum Islam dan Ekonomi Syariah Journal Of Sustainable Research In Management Of Agroindustry (SURIMI) Veteran Society : Jurnal Pengabdian Masyarakat Jurnal Riset Hukum Keluarga islam Dulang: Jurnal Pengabdian Kepada Masyarakat Bandung Conference Series : Islamic Family Law Sejahtera: Jurnal Inspirasi Mengabdi Untuk Negeri Jurnal Penelitian Ekonomi Manajemen dan Bisnis Journal of Education and Culture Journal AK-99 Prosiding Seminar Nasional Inovasi Teknologi Terapan Jurnal Pengabdian Masyarakat Al-Zayn: Jurnal Ilmu Sosial & Hukum Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Pengabdian Rekayasa Sistem Jurnal Budi Pekerti Agama Islam Quantum Wellness : Jurnal Ilmu Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan International Journal of English Language and Pedagogy Jurnal Sains Farmasi dan Kesehatan SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA Jurnal Kemitraan Masyarakat AGHNINA: Jurnal Penelitian Hukum Ekonomi Syariah Jurnal Pustaka Cendekia Hukum dan Ilmu Sosial IPSSJ AL ITQAN: Jurnal Studi Al-Qur'an Tourism Economics, Hospitality, and Business Management Journal Ambacang: Jurnal Inovasi Pengabdian Masyarakat Galen: Jurnal Ilmu Farmasi dan Kesehatan Sinergi : Jurnal Ilmiah Multidisiplin Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Cendekia : Jurnal Pendidikan dan Pengajaran Jurnal Kapita Sosial Politik
Muhammad Yunus
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Journal : JURNAL FARMASIMED (JFM)

 1 
Efficacy of Keji Beling Leaf Extract Gel (Sericocly Crispi Folium) as an Anti-Ulcer Agent in Alloxan-Induced Diabetic Rat Models: A Histological and Inflammatory Mediator Study Grace Angel Natalia br tarigan; Muhammad Yunus; Nerly Juli pranita simanjuntak
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jttdap47

Abstract

Background: Diabetes mellitus is a chronic disease that can cause complications in the form of diabetic ulcers, which are wounds that are difficult to heal due to high blood glucose levels and prolonged inflammation. One herbal plant with potential wound-healing properties is keji beling leaf (Sericocly Crispi Folium), as it contains flavonoids, alkaloids, saponins, and antibacterial compounds. Objective: This study aimed to determine the effect of keji beling leaf extract gel on burn wound healing in alloxan-induced diabetic rats. Methods: This was an experimental study using 30 white rats divided into six groups: normal control, negative control (gel base), positive control (bioplasenton gel), and treatment groups receiving keji beling leaf extract gel at concentrations of 5%, 10%, and 15%. Results : Diabetes was induced using alloxan at a dose of 120 mg/kg body weight. Burn wounds were created on the dorsal area of the rats, followed by treatment for 14 days. Wound healing was evaluated by measuring wound diameter and through histopathological examination of skin tissue. Results and Conclusion: The results showed that keji beling leaf extract gel accelerated wound healing in diabetic rats compared to the negative control. The 15% concentration produced the best outcomes, indicated by the greatest reduction in wound diameter and improved histopathological features, including better re-epithelialization, increased collagen deposition, and reduced inflammation.
Co-Authors A Adjie ABDUL MUIS Abdul Rosyid Minhaj Adelia Pratiwi Adinda Putri Sari Rahayu Afifah Mardiah Agus Pribadi Akhmad Ramli Alfan Zuhairi Almahfuz Alya Fadila Amahar Riadi amalia, roviatul Andi Nurul Ulum Anggi Maulana Nasution Anggun Pratiwi Anita Mauliyanti Anwar Anwar Ardi Antariksa Ardiansyah Putra ARIFUDDIN Arum Setia Ningsih Arvianti Pramudita Tjandra Arya Adjie Asif, Muhammad Asriadi Astriani Natalia Br Ginting Asyrun Alkhairi Lubis Bachrul Ulum Bambang Wijanarko Bentar Putra Setiyanto Bravo Chandra Arista Cholid Shihabul Hikam Cristin Natali Rouli Daimah Wirdatus Sanaun Harahap Dandan Ramdani Daniel Happy Putra Debrina Putri Buana Desri Nurul Aeni Devin Rio Alvaro Dewa Gede Eka Setiawan Didit Panji Saputra Dimas Aji Guntoro Dinatul Adawiyah Dinda Dwi Puspita Dinda Nila Sabrina Diyanto, Rahman Djafar, Suriani Ega Yos Sanda Elsa Encep Abdul Rojak Eny Rachmawati Erdian Suntosa Erida Novriani Eril Kapri Ervinda Hardina Dwi Pratiwi Erwansyah, Erwansyah Erwanto Erwanto Esa Claudia Putri Eva Fauziah Faren Kesita Gelioni Fathurachman Samba Fauziah Finna Piska Firdaus, Riska Firkian Rinanda George Adios Niko Glory Stevi Natasia Saragih Grace Angel Natalia br tarigan Hariyadi Dharmawan Syahputra Harsano Jayadi Hartono, Rudi Hasaruddin Hindri Syahputri HS, Fatimah Husnul Puad I Ketut Astawa I Mahyudi Idiar Idiar Idiar Ika Vitriasari Ilham Mujahid Ira Gustina Irwan Putra Irwansyah Irwansyah Ismail Jecika Stefany Br Tumanggor Juanda Khairil Anam Khojir Kintan Puspita Wardani M. Mahbubi Mahmood Kooria Maimun MARIA BINTANG Maria Canny Astuti Gea Masbiyanti Meidji, Icha Untari Mgarifina N Ngarifin Mikha Marcellius Saragih Mita Widyastuti Mochamad Farizal Moh. Irmawan Jauhari Mohammad Wijaya.M Muhamad Osamah Fahrul Roji Muhamad Ridwan Fauzi Muhammad Akbar Muhammad al-Fain Arrafi MUHAMMAD ANWAR Muhammad Arief Nasutions Muhammad Bahit Muhammad Firdaus Muhammad Galuh Elga Romadhon Muhammad H Amrullah Muhammad Hamdan Firmanta Muhammad Ibnu Huda Muhammad Jusman Rivay Rumra Muhammad Rizki Pratama Pratama Muhammad Rusdi Muhammad Sariyulis Muhammad Waspul Hasyim Muhammad Wiharto Muhammad Zulfan Mukhamad Agung Maulana Mulia Wiwin Muliawiwin Nanda Pranandita Nehru Millat Ahmad Nerly Juli Pranita Simanjuntak Nia Novranda Pertiwi Nor Cholis Nur Mu’min Nur Vina Yulfana Pratiwi, Lulu Puput Anggraeni Putri Diah Ayu Lestari Putri Virda Rahayu Rafiatul Latifah Rahmawati Rahwan, Rahwan Razoki Razoki Razoki Resky Amalia Hamka Ria Rismayati Ricky Damara Paulus Ricky Martino Ridwan, Ahmad Hasan Rina Riyanti Risma Millatul Ummah Robert Napitupulu Robiatul Adawiyah Rangkuti Rohani Lubis Rollastin, Boy Romiano Romual Yonathan Simangunsong Rosliana, Rosliana Roy Indrianto Bangar Rullyansyah Rustiani S Salwa Firdaus Syah Sari, Syilvi Rinda Sintia Roseta Dela Siswahyudianto Siti Albadriyah Siti Hasbiah Siti Rahmah Diana Sosa Ester Kristiani Lase Sri Maya Indira Nst Stefvany Suaningrat Suarti Djafar subarjo, Subarjo Sudadi Suko Susilo Syamsul Arifin Syukri Tedy Wiraseptya Tiara Ayu Lestari Tice Lestari Ndruru Titin Suprihatin Ubaidillah Ubaidillah Ubaidillah Universitas Muhadi Setiabudi Vony Puspitasari Wiryanto Yadi Janwari Yuandani Yusnaini Zainal Ruma Zaldy Kurniawan Zidni Ilman Nafi'an Zulkarnain Umar, Zulkarnain