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All Journal Hemera Zoa Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan World Nutrition Journal Respiratory Science The Indonesian Journal of Community and Occupational Medicine The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Ari Fahrial Syam
Division Of Gastroenterology, Department Of Internal Medicine, University Of Indonesia/Cipto Mangunkusumo Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Public Health

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Perbedaan pH Lambung pada Pasien Dispepsia dengan atau Tanpa Diabetes Melitus Tipe 2 Anam, Ilum; Syam, Ari Fahrial; Saksono, Dante; Abdullah, Murdani
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Pendahuluan. Sindroma dispepsia sering dialami oleh penderita DM. Asam lambung salah satu faktor agresif terjadinya sindroma dispepsia dan tukak lambung. Penelitian ini bertujuan untuk mencari perbedaan pH lambung pada pasien dispepsia DM dengan yang bukan DM dan untuk mengetahui apakah ada korelasi antara pH lambung dengan proteinuria dan HbA1c. Metode. Pasien terdiri dari 30 kelompok DM dan 30 kelompok bukan DM. Masing-masing kelompok dihitung pH lambung basal. pH lambung basal diukur dgn memasukkan elektroda kateter kedalam lambung selama 30 menit kemudian di rekam dgn alat pH Metri merek Digitrapper pH-Z. Beratnya komplikasi DM diukur dengan mikroalbuminuria, sedangkan kendali gula darah diukur dgn HbA1c. Dilakukan uji chi square utk mencari perbedaan pH lambung kelompok DM dgn yg bukan DM, dengan terlebih dahulu menentukan titik potong dgn analisa ROC (Receiver Operating Caracteristic). Dilakukan uji korelasi antara pH lambung basal dengan mikroalbuminuria dan HbA1c pada kelompok pasien DM Hasil. pH lambung basal pada dispepsia DM vs non DM (2.30±0.83 vs 2.19±0.52). Dgn uji chi square terdapat perbedaan bermakna antara kelompok DM dengan yang bukan DM. Pada uji korelasi antara pH lambung dengan mikroalbuminuria dijumpai r = 0.47 dan p < 0.05, sedangkan HbA1c dijumpai r=0,59 dan p > 0.05. Simpulan. Ada perbedaan bermakna pH lambung basal antara pasien dispepsia DM dengan pasien dispepsia bukan DM. Ada korelasi antara pH lambung basal dengan mikroalbuminuria, sedangkan dengan HbA1c tidak ada korelasi. pH lambung basal pada pasien DM adalah 2.03±0.83 sedangkan pada yang bukan DM adalah 2.19±0.52.
Diagnosis dan Tata Laksana Enteropati akibat Obat Anti Inflamasi Non Steroid (OAINS) Mardhiyah, Radhiyatam; Fauzi, Achmad; Syam, Ari Fahrial
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Obat anti inflamasi non steroid (OAINS) merupakan salah satu golongan obat yang paling banyak dan paling sering diresepkan di Indonesia. Meskipun mampu mengurangi gejala inflamasi, penggunaan OAINS juga menimbulkan gangguan dalam mekanisme pertahanan mukosa saluran pencernaan. Kerusakan mukosa saluran pencernaan akibat OAINS tidak hanya dialami lambung, namun juga dialami oleh usus halus yang disebut enteropati. Namun demikian, enteropati akibat OAINS masih belum mendapat perhatian yang besar.
ANALISIS GAMBARAN GASTROSKOPI DAN HISTOPATOLOGI GASTRITIS PADA PENDERITA SINDROMA DISPEPSIA DI RS YARSI JAKARTA Syafruddin A. R. Lelosutan; Nunung Ainur Rahmah; Ari Fahrial Syam
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.237

Abstract

ABSTRAK Prevalensi Helicobacter pylori (HP) di Indonesia bervariasi sesuai lokasi daerah dan etnis. Di RS YARSI Jakarta kasus Sindroma Dispepsia (SD) cukup banyak mendapat prosedur tindakan Esofagogastroduodenoskopi (EGD) dan biopsi mukosa lambung (BML) dengan hasil histopatologi berupa sejumlah gambaran positif adanya HP. Mendapatkan angka prevalensi infeksi HP serta hasil analisis hubungan infeksi bakteri HP dengan gambaran diagnosis makroskopis EGD dan histopatologi hasil BML di RS YARSI, Jakarta. Studi retrospektif kasus SD yang mengalami prosedur tindakan EGD dan sekaligus pengambilan spesimen BML selama 1 tahun (2023‒2024) Data dipilih sesuai kriteria inklusi dan eksklusi. Pengolahan statistik memakai SPSS versi 26 dan uji analisis data menggunakan uji Chi-Square dalam batas kemaknaan 0,05 dan interval kepercayaan 95%. Sebanyak 72 subyek memenuhi kriteria. Prevalensi bakteri HP di RS YARSI Jakarta sebesar 18.0%. Ada hubungan antara infeksi bakteri HP dengan gambaran makroskopis (EGD) jaringan mukosa lambung (Gastritis hiperemikum-eritematousa, Gastritis erosif, dan Gastritis ulseratif) dan dengan kerusakan histologis mukosa lambung (Gastritis kronik aktif/GKA dan Gastritis kronik inaktif/GKI) yang signifikan masing-masing dengan p = 0,003 (p < 0,05) dan p = 0,004 (p < 0,05). Frekuensi kerusakan jaringan mukosa lambung akibat infeksi bakteri HP berupa GKA (Gastritis kronik aktif) dan GKI (Gastritis kronik inaktif) masing-masing sebesar 8,3% dan 9,7% dari keseluruhan Subyek. Ada hubungan infeksi bakteri HP dengan gambaran diagnosis makroskopis EGD dan histopatologi hasil BML di RS YARSI, Jakarta.
The Evolution of Double Pylorus Associated With NSAIDs-Induced Gastric Ulcer Sihombing, Rasco Sandy; Agustinus, Taolin; Syam, Ari Fahrial
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202593-97

Abstract

Double pylorus is an uncommon condition where two communicating channels between the gastric antrum and duodenal bulb exist and found incidentally by esophagogastroduodenoscopy. This case report presented a 77-year old Timorese man with long-term frequent use of nonsteroidal anti-inflammatory drugs (NSAIDs) who came to hospital because of hematemesis and melena. The initial endoscopy showed gastric ulcer and the double pylorus. Nine months later, the double pylorus structure fused into one large opening. This elderly patient with a history of NSAIDs abuse was diagnosed with acquired double pylorus due to a gastric ulcer complication. The fusion of the two channels occurred as a result of septum destruction, likely caused by fistulous tract ulceration or mechanical damage from food bolus. This structure predisposes the patient to bile regurgitation and ulcer recurrence, emphasizing the need for continued monitoring and avoidance of ulcerogenic factors. Keywords : double pylorus, gastroduodenal fistula, NSAIDs, gastric ulcer, follow-up
COVID-19 with Acute Cholecystitis: A Case Report Syam, Ari Fahrial; Achmadsyah, Armand; Mazni, Yarman; Sari, Cut Yulia Indah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1108.189 KB) | DOI: 10.24871/231202282-86

Abstract

Novel Coronavirus 2019 (COVID-19) also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, non-segmented positive-sense RNA virus that belonging to the beta-coronaviridae family. Patients were said to had various symptoms of fever, cough, anosmia, and chest stuffiness in addition to other non-specific clinical manifestations, including diarrhea, vomiting, anorexia, abdominal pain, and so on. Although this gastrointestinal symptoms were present in COVID-19 case, there was not enough evidence about the involvement of gallbladder and biliary tract in literature to date. We report a rare case of Acute Cholecystitis on a COVID-19 patient in Jakarta, Indonesia. A case of 54-year-old female with COVID-19 confirmed by RT-PCR Test who had constant pain in the right upper quadrant of her abdomen during her arrival at the hospital that was finally diagnosed as Acute Cholecystitis. The Laboratory Findings revealed normal level of White Blood Cells(6.73 K/aeL). The Multidisciplinary team decided to treat COVID-19 infection with antiviral (Favipiravir, according to Indonesian COVID-19 Guideline) for 2 weeks until her RT-PCR was found to be negative then perform a laparoscopic cholecystectomy as the first treatment. During the administration of Favipiravir, there was a reduction of pain in the right upper quadrant abdomen and an overall clinical improvement.The precise mechanism of Acute Cholecystitis in COVID-19 Patients was still unclear. However, Acute Cholecystitis could be a possible complication of COVID-19 although there was not enough evidence whether the gallbladder might be vulnerable to COVID-19. In this case, the normal level of white blood cells could be a hint that Acute Cholecystitis was not caused by bacterial colonization and could be potentially triggered by COVID-19. Laparoscopic Cholecystectomy was chosen as the first management after RT-PCR COVID-19 was negative with 2-weeks of antiviral treatment. Although the lack of evidence and guidelines for Acute Cholecystitis management during The COVID-19 Pandemic, Laparoscopic Cholecystectomy remains the chosen treatment for Acute Cholecystitis Management on COVID-19 Patients. More research is needed to understand the possible relationship between Acute Cholecystitis and COVID-19.
Co-Authors -, Arles - -, Suhendro - -, Suhendro - A.A. Ketut Agung Cahyawan W Aan Santi Aan Santi Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Achmad Fauzi ACHMAD FAUZI Achmad Fauzi Achmadsyah, Armand Adiwinata, Sheila Adjeg Tarius Afifah Is Agasjtya Wisjnu Wardhana Agnes Kurniawan Agustinus, Taolin Ahani, Ardhi Rahman Ahimsa, Titos Ahimsa, Titos Ahmad Aulia Ahmad Fauzi Ali Imron Yusuf Alkindi Bahar Amanda Pitarini Utari Andi Kristanto Andreas Pekey Andreas Pekey, Andreas Andree Kurniawan Andri Sanityoso Andri Sanityoso Andri Sanityoso Anggie Indari Anggilia Stephanie Anggilia Stephanie, Anggilia Anis Karuniawati Ari, Franciscus Arles - - Armen Muchtar Armen Muchtar Arya Govinda Aryanto Basuki Awang, Iqbal I Aziz Rani Bambang Pontjo Priosoeryanto Bambang Setyohadi Beatrice Belinda Phang Bhanu S Kumar Birry Karim Bona Adhista Bradley Jimmy Waleleng Bradley Jimmy Waleleng Budi Tan Oto C Martin Rumende C Rinaldi A Lesmana Caputra, Hadyanto Catarina Budyono Catarina Budyono, Catarina Ceva W. Pitoyo Christy Efiyanti Chudahman Manan Chudahman Manan Chudahman Manan Chyntia Olivia MJ Cindy Rahardja Cleopas Martin Rumende Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Daniel Gunawan Dante Saksono Harbuwono Deddy Gunawanjati Dedy Gunawanjati Sudrajat Dharmika Djojoningrat Diah Rini Handjari Diah Rini Handjari Diany N Taher Didi Kurniadhi Didi Kurniadhi Djulzasri Albar Dwi Suseno E Mudjaddid E Mudjaddid, E E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eka Ginanjar Ekowati Rahajeng Ekowati Rahajeng Elizabeth Merry Wintery Ellen Susanti Elli Arsita Elli Arsita Elza Febria Sari Elza Febria Sari Endang Susalit Endang Susalit Ening Krisnuhoni Esthika Dewiasty, Esthika Euphemia Seto, Euphemia Evita H Effendi Evy Yunihastuti Fajar Raditya Fauzi Ahmad Muda Feriadi Suwarna FJW Ten Kate Florentina Caroline Puspita Franciscus Ari Futihati Ruhama Zulfa Gerie Amarendra Ginova Nainggolan Ginova Nainggolan GNJ Tytgat Grace Nami Sianturi Gunawanjati Sudrajat Hadyanto Caputra Hamzah Shatri Hamzah Shatri Hantoro, Ibnu Fajariyadi Haris Widita Haris Widita Haryanto Rahardjo Hasan Maulahela Hasan Maulahela Hasan Maulahela, Hasan Hayatun Nufus Hayatun Nufus Helsi Helsi Heru Sundaru Hery Djagat Purnomo Hery Djagat Purnomo Hotmen Sijabat I Gusti Bagus Wiksuana Ikhwan Rinaldi Ilham Ahmadi Ilum Anam Ilum Anam, Ilum Ina Susianti Timan Indra Marki Indra Marki Indra Marki Indra, Suwito Iqbal I Awang Ira Laurentika Irsan Hasan Ivo Novita Sah Bandar Iwan Ariawan Jacobus Albertus Jeffri Gunawan Joseph JY Sung Josephin Rasidi Julwan Pribadi Jumhana Atmakusuma Kaka Renaldi Karmel Tambunan Katharina Setyawati Khaira Utia Yusrie Kharia Utia Khie Chen L A Lesmana Laksmi, Purwita W. Laurentika, Ira Laurentius A Pramono Laurentius A Pramono, Laurentius A Laurentius Aswin Pramono Laurentius Aswin Pramono Laurentius Lesmana Laurentius Lesmana Leonard Nainggolan Leonard Nainggolan Leonita Ariesti Putri Listya, Luh Putu Luciana Budiati Sutanto Luciana Budiati Sutanto Luh Putu Listya Lusy Erawati Lusy Erawati Lydia D Simatupang M Purnomo Isnaeni Marcellus S Kolopaking Marcellus S. Kolopaking Marcellus Simadibrata Marcellus Simadibrata Marcellus Simadibrata Marcellus Simadibrata Marcellus Simadibrata K Marcellus Simadibrata Kolopaking Marthino Robinson Mazni, Yarman Menaldi Rasmin Moch Ikhsan Mokoagow Murdani Abdulah Murdani Abdullah Murdani Abdullah Murdani Abdullah Murdani Abdullah Murdani Abdullah Nata Pratama Nikko Darnindro Nikko Darnindro Nikko Darnindro Novie Rahmawati Zirta Nugroho, Prionggodigdo Nunung Ainur Rahmah Nur Rasyid Nur Rasyid Nurul Akbar Nurul Akbar Oktaramdani, Tessa Paulus Kusnanto Phang, Beatrice Belinda Pringgodigdo Nugroho, Pringgodigdo Prionggodigdo Nugroho Purwita W Laksmi, Purwita W Puspita, Florentina Caroline Putri, Leonita Ariesti Rabbinu Rangga Pribadi Radhiyatam Mardhiyah Radhiyatam Mardhiyah, Radhiyatam Rahardja, Cindy Ralph Girson Ralph Girson Gunarsa Randy Adiwinata Randy Adiwinata, Randy Ranty, Stefanus Satrio Rasco Sandy Sihombing, Rasco Sandy Rasidi, Josephine Resti Mulya Sari Riadi Wirawan Riadi Wirawan Riahdo Saragih Rino A Gani Rino A Gani Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani Rio Zakaria Rio Zakaria Rio Zakaria Rolan Sitompul Rudi Putranto Ryan Herardi Ryan Ranitya Sari, Cut Yulia Indah Sayid Ridho Sedijono Sedijono Seri Mei Maya Ulina Sheila Adiwinata Simon Salim Siti Setiati Siti Setiati Stefanus Satrio Ranty Stella Evangeline Bela Stephanie Dewi, Stephanie Steven Sumantri Suhendro - - Suhendro Suhendro Suhendro Suhendro Suhendro Suwarto, Suhendro Sumaryono Sumaryono Sumaryono Sumaryono Suryantini Suryantini Suryantini Suryantini Suwito Indra Suzana Ndraha Syafruddin A. R. Lelosutan Taufiq Taufiq Taufiq Taufiq Teguh Hardjono Tena Djuartina, Tena Tessa Oktaramdani Timoteus Richard Timoteus Richard, Timoteus Tito Ardi Titos Ahimsa Tjahjadi Robert Tedjasaputra Toman L Toruan Tommy P Sibuea Tri Isyani Tungga Dewi Vera D Yoewono Vera Yoewono Vera Yuwono Wardhana, Agasjtya Wisjnu Willy Brodus Uwan Willy Brodus Uwan, Willy Brodus Wina Sinaga Wirasmi Marwoto Wirasmi Marwoto Wulyo Rajabto