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All Journal Jurnal Gizi dan Pangan Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Jurnal Media Gizi Indonesia (MGI) MNJ (Malang Neurology Journal) Jurnal Gizi dan Kesehatan Universa Medicina Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Ilmu Gizi Indonesia Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Indonesian Journal of Medicine Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings PROFESI (Profesional Islam): Media Publikasi Penelitian INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Prosiding University Research Colloquium The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Advanced Technology and Multidiscipline (JATM)
Brian Wasita
Fakultas Kedokteran, Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Nexus Biomedika

 1 
Pengaruh Ekstrak Buah Mengkudu (Morinda citrifolia) terhadap Waktu Kematian Cacing Ascaris suum, Goeze In Vitro Deviana, Riza; Utari, Cr. Siti; Wasita, Brian
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Mengkudu (Morinda citrifolia) has a terapeutic effect, such as antibacterial, anthelmintic and imunomodulator. This research was performed to understand the effect of Mengkudu (Morinda citrifolia) fruit extract on death time of  Ascaris suum, Goeze In Vitro. Methods: This research was performed using experimental laboratory method with post-test only controlled group design. Adult Ascaris suum, Goeze (108 worms) were divided into 9 groups. The worms treated with NaCl 0.9 % solution and Piperazine 0.4% g/ml served as negative control and positive control group consecutively. The worms treated with increasing dose of  Mengkudu fruits (Morinda citrifolia) extract (1% g/ml, 2% g/ml, 4% g/ml, 6% g/ml, 8% g/ml, 10% g/ml, and 12% g/ml) served as treatment groups. Observations were performed every half hour until the worms died. LC50 and LT50 were calculated using probit analysis. Statistic analysis was performed using Kruskal-Wallis test continued by Post hoc Test with Bonferroni correction. Results: Probit analysis showed that LC50 and LT50 of Mengkudu fruits extract were 4.94% g/ml and 703.32 minutes. Kruskall-Wallis test showed that significance difference at least in the two groups. Post Hoc Mann-Whitney with Bonferroni correction test showed that treatment had significant difference (p < 0.001) to negative control and 12% g/ml group had significant difference to positive control group. Conclusions: Mengkudu (Morinda citrifolia) fruits extract can induce Ascaris suum death with the death time faster than standard medicine. Keywords: Mengkudu (Morinda citrifolia) extract, Ascaris suum, Piperazin. 
Pengaruh Ekstrak Nanas (Ananas Comosus (L) Merr) SEBAGAI Antihelmintik Terhadap Waktu Kematian Cacing Ascaris suum, Goeze In vitro Dewi, Cindikya Saftiari; SitiUtari, Cr.; Wasita, Brian
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background:Pineapple (Ananas comosus (L) Merr) was reported to have a bromelain enzyme that belonged to a group of proteolytic enzymes. This enzyme has been known as anti-edematous, anti-inflammatory, anti-thrombotic and fibrinolytic activities. The proteolytic effect of bromelain enzyme can change protein to be simple amino acid. This research was performed to understand the effect of pineapple (Ananas comosus (L) Merr) extract as anthelmintic on death time of Ascaris suum, Goeze In Vitro. Methods:This research was performed using experimental laboratory method with the post test only controlled group design. Eighty four adult Ascaris suum, Goeze were used. The worms divided into seven groups consisted of six treatment groups (pineapple (Ananas comosus (L) Merr) extract with the dose of 0 % g/ml, 3 % g/ml, 6 % g/ml, 12 % g/ml, 24 % g/ml and 48 % g/ml) and positive control group (Pirantel pamoat with the dose of 0.236% g/ml). Each group consisted of four worms. Ascaris suum, Goeze were incubated in incubator at 37ºC. Observation was performed every fifteen minute to determine the death time of the worms. Experimental data was analyzed using One Way ANOVA test continued with Post hoc Tukey test (α = 0.05). LC50 and LT50 were calculated using probit analysis.   Results:One Way ANOVA test showed significance difference (p < 0.05). Pineapple (Ananas comosus (L) Merr) extract had a significant effect on the worm death time and showed dose dependent manner. Probit analysis showed that LC50 and LT50 of pineapple (Ananas comosus (L) Merr) extract were 21.059% g/ml and 396.929 minutes. At the concentration of 4% g/ml pineapple extract had a better effect than positive control. Conclusions:Pineapple (Ananas comosus (L) Merr) extract had an effect on the death time of Ascaris suum, Goeze which was showed by significance difference on the death time between treatment and negative control group, and this effect was comparable with positive control group. Keywords:Pineapple (Ananas comosus (L) Merr) extract, bromelain enzyme, Ascaris suum, Goeze, pirantel pamoat
Co-Authors Adi Magna, Adi Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Amarduan, Tince Bety Amilia Yuni Damayanti Ana Rima Ari Probandari Asrial, An A. Bambang Purwanto Binti Maulina Budiningsih, Fatichati Budiyanti Wiboworini Cindikya Saftiari Dewi Cr. Siti Utari Cr. SitiUtari Darmayani, Aritantri David Perdana Dentiko Wasis Aulia Dewi Okta Anggraini Didik Prasetyo Diffah Hanim Dono Indarto Eka Puspita Sari Ellistasari, Endra Yustin ernawati, ammik Eti Poncorini Pamungkasari Fadila, F Gardjito, Fajar Baskoro Gunawan, Timotheus A. Hari Wujoso Harsono Salimo Hermansyah, Muhamad Lukman Herviana, Herviana Ida Nurwati Idulhaq, Mujaddid Irma Suryani Jati, Agus Kariosentono, ⁠⁠Harijono Kusumaningrum, Sulistyani Laqif, Abdurrahman LAWEI, THARINA Marintan, Elita Muchamad Syamsulhadi, Muchamad Muhammad Riza Mulianto, ⁠Nurrachmat Muthmainah Muthmainah Muthmainah Nanang Wiyono Nofia, Yasinta Novan Adi Setyawan Nur Shani Meida Nursulistyo, Fajar Paramasari Dirgahayu Paulus Kusnanto Pesik, Riza N. Poncorini, Eti Primisawitri, Pratiwi Prasetya Pudjiastuti, Anggit puguh santoso, puguh Rachmi Fauziah Rahayu Rahayu, Rachmi F. Rahmah Rahmah Ratih Puspita Febrinasari Reviono Reviono Risya Cilmiaty, Risya Riza Deviana Riza Novierta Pesik Rizma, Amalina Sabariyah, Lely Santi, Nur Saputra, Rhyan Darma Senyum Indrakila Setianto, Budi Y. Soestrisno, Soestrisno Soetrisno Soetrisno Soetrisno Suyatmi Suyatmi Tamaulina Br Sembiring Taufiqurrahman, Surya Tedjo Danudjo Tonang Dwi Ardyanto Tri Harsono Tri Nugraha Susilawati Triyanta Yuli Pramana Umi Mahmudah Vitri Widyaningsih Wardhani, Lusi O. Wayanshakty, Janur Widhiati, Suci Wulandari, Eka T. Wulansari, Indry Yarsa, Kristanto Y. Yudhani, Ratih D. Yudhistira, Muhammad Yurizar Yundari, Yundari yusari Yusup Subagio Yusup Subagio Sutanto Zahidah, Fairuz Zaidah, Lailatuz