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All Journal Jurnal Gizi dan Pangan Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Jurnal Media Gizi Indonesia (MGI) MNJ (Malang Neurology Journal) Jurnal Gizi dan Kesehatan Universa Medicina Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Ilmu Gizi Indonesia Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Indonesian Journal of Medicine Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings PROFESI (Profesional Islam): Media Publikasi Penelitian INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Prosiding University Research Colloquium The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Advanced Technology and Multidiscipline (JATM)
Brian Wasita
Fakultas Kedokteran, Universitas Sebelas Maret
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Journal : Nexus Kedokteran Translasional

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Pengaruh Pemberian Topikal Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) Terhadap Jumlah Sel Fibroblas Pada Penyembuhan Luka Sayat Pada Kulit Tikus Putih (Rattus norvegicus) strain wistar Aulia, Dentiko Wasis; Wasita, Brian; Pesik, Riza Novierta
Nexus Kedokteran Translasional Vol 2, No 1 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Binahong (Anredera cordifolia (Ten.) Steenis) is a common plant in Indonesia and contain many secondary metabolites such as flavonoids, tannins, saponins, terpenoids, and alkaloids. These secondary metabolite substances were expected to increase the number of fibroblast cells in the wound healing process. This study aims to demonstrate that topical administration of binahong leaf extract jelly on Wistar rats (Rattus norvegicus) skin cut will increase the number of fibroblasts in these wound healing process.   Methods: This is a laboratoric experimental study with randomize post test only control group design. The samples were 25 male Wistar rats aged 3 months and given a dorsal incision of 2 cm long and 0.5 cm deep. The rats were divided randomly into 5 groups (positive control, negative control, and 3 treatment group) consisting of 5 rats each. Positive control group were topically treated with patent medicine Bioplacenton®. Negative control group was not given any treatment. Treatment groups were topically treated with a binahong leaf extract jelly 2.5%, 5%, and 10% respectively. Bioplacenton® and binahong leaf extract jelly is given 2 times a day on its wound for 5 days. On the fifth day, all rat’s wound were scored using Bates-Jensen Wound Assassment Tool and then sacrificed to make histophatology slides on the part of the injured skin. The slides were stained with Van Giesson staining and the fibroblast in the granulation tissue was calculated. The data obtained was analyzed with Oneway ANOVA (p <0.05).   Result: The macroscopic wound scoring and average number of fibroblast cells in each group showed no significant difference (p>0.05). However, in the 2nd treatment groups (binahong leaf extract jelly 5%) showed the highest number of fibroblasts (153.72 (±SD 23.39)) than the other groups. Conclusion: Topical administration of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) did not affect the macroscopic wound scoring but it increase the number of fibroblast cells in healing skin cuts on Wistar rats (Rattus norvegicus) even thought it did not reach the significant level. Keywords: wound healing, fibroblast, binahong (Anredera cordifolia (Ten.) Steenis)
Co-Authors Adi Magna, Adi Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Amarduan, Tince Bety Amilia Yuni Damayanti Ana Rima Ari Probandari Asrial, An A. Bambang Purwanto Binti Maulina Budiningsih, Fatichati Budiyanti Wiboworini Cindikya Saftiari Dewi Cr. Siti Utari Cr. SitiUtari Darmayani, Aritantri David Perdana Dentiko Wasis Aulia Dewi Okta Anggraini Didik Prasetyo Diffah Hanim Dono Indarto Eka Puspita Sari Ellistasari, Endra Yustin ernawati, ammik Eti Poncorini Pamungkasari Fadila, F Gardjito, Fajar Baskoro Gunawan, Timotheus A. Hari Wujoso Harsono Salimo Hermansyah, Muhamad Lukman Herviana, Herviana Ida Nurwati Idulhaq, Mujaddid Irma Suryani Jati, Agus Kariosentono, ⁠⁠Harijono Kusumaningrum, Sulistyani Laqif, Abdurrahman LAWEI, THARINA Marintan, Elita Muchamad Syamsulhadi, Muchamad Muhammad Riza Mulianto, ⁠Nurrachmat Muthmainah Muthmainah Muthmainah Nanang Wiyono Nofia, Yasinta Novan Adi Setyawan Nur Shani Meida Nursulistyo, Fajar Paramasari Dirgahayu Paulus Kusnanto Pesik, Riza N. Poncorini, Eti Primisawitri, Pratiwi Prasetya Pudjiastuti, Anggit puguh santoso, puguh Rachmi Fauziah Rahayu Rahayu, Rachmi F. Rahmah Rahmah Ratih Puspita Febrinasari Reviono Reviono Risya Cilmiaty, Risya Riza Deviana Riza Novierta Pesik Rizma, Amalina Sabariyah, Lely Santi, Nur Saputra, Rhyan Darma Senyum Indrakila Setianto, Budi Y. Soestrisno, Soestrisno Soetrisno Soetrisno Soetrisno Suyatmi Suyatmi Tamaulina Br Sembiring Taufiqurrahman, Surya Tedjo Danudjo Tonang Dwi Ardyanto Tri Harsono Tri Nugraha Susilawati Triyanta Yuli Pramana Umi Mahmudah Vitri Widyaningsih Wardhani, Lusi O. Wayanshakty, Janur Widhiati, Suci Wulandari, Eka T. Wulansari, Indry Yarsa, Kristanto Y. Yudhani, Ratih D. Yudhistira, Muhammad Yurizar Yundari, Yundari yusari Yusup Subagio Yusup Subagio Sutanto Zahidah, Fairuz Zaidah, Lailatuz