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All Journal International Journal of Public Health Science (IJPHS) Jurnal Keperawatan Jurnal Kedokteran Brawijaya JURNAL ILMIAH KESEHATAN KEPERAWATAN Research Journal of Life Science Journal of Mathematical and Fundamental Sciences MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kesehatan FKUB Jurnal Kesehatan Mesencephalon NurseLine Journal Jurnal Kesehatan Mesencephalon Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Chemistry Journal Of Holistic Nursing Science Indonesian Journal of Cardiology Journals of Ners Community Jurnal Keperawatan Malang (JKM) The Indonesian Journal of Health Science Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Ilmiah Kesehatan Rustida Heart Science Journal JSMARTech : Journal of Smart Bioprospecting and Technology Babali Nursing Research Jurnal Health Sains Indian Journal of Forensic Medicine & Toxicology Caring : Jurnal Pengabdian Masyarakat Journal of Applied Nursing and Health International Journal of Science and Society (IJSOC) Nursing Information Journal Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Journal of Nursing Science Update DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Jurnal Ilmiah Kesehatan Keperawatan Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery)
Titin Andri Wihastuti
Brawijaya University
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Heart Science Journal

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Interleukin-6 (IL-6) as a Marker of Endothelial Dysfunction Confirmed Using Flow Mediated Dilatation in Active Smoker Wicaksono, Arif; Kurnianingsih, Novi; Tjahjono, Cholid Tri; Widito, Sasmojo; Swastikaputri, Valerina Yogibuana; Wihastuti, Titin Andri
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.4

Abstract

Background: The pro-inflammatory cytokine interleukin-6 (IL-6) is thought to be the catalyst for endothelial dysfunction caused by smoking. Flow-mediated dilatation (FMD) is a non-invasive method to identify the development of blood vessel endothelial dysfunction at an early stage. However, several studies have not sufficiently explained how smoking and IL-6 interact.Objective: This study focuses on the role of Interleukin-6 (IL-6) in the process of endothelial dysfunction confirmed using non-invasive modalities such as Flow Mediated Dilatation (FMD) in smokers related to the risk of cardiovascular disease in the future with the hope of providing insight in education to smokers to quit smoking.Material and Methods: In this study, we gathered 116 male participants, of which 56 were nonsmokers, and 60 were smokers, and we used IL-6 and FMD testing. SPSS for Windows version 23 will be used to analyze the data.Result: According to the analysis of laboratory tests, the average IL-6 level in light smokers was 67.7±3.2 and in moderate smokers it was 95.1±11.0; with a p-value of 0.009, indicating a significant difference among the groups. The average FMD in the smoking group was 5.4±0.4% (p-value 0.000), whereas the average FMD in the non-smoker samples was 10.9±0.9%. We also looked at the average FMD among light and moderate smokers based on Brinkman Index, which was 5.5±0.4% and 5.0±0.4%, with a p-value of 0.780, indicating no significant difference between the groupsConclusion: Compared to non-smokers, this study demonstrates a correlation between IL-6 and smoking activity. However, there was no statistically significant difference between the prevalence of endothelial dysfunction and the degree of smoking dependence in this investigation.
Correlation Study of Cotinine and Monocyte Chemoattractant Protein-1 (MCP-1) with Carotid Intima-Media Thickness (cIMT) in Male Active Tobacco Smoke Satwikajati, Sawitri; Kurnianingsih, Novi; Tjahjono, Cholid Tri; Wihastuti, Titin Andri; Sargowo, Djanggan; Rizal, Ardian
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.6

Abstract

Background : Tobacco smoke exposure induces intima-media thickness by reducing nitric oxide and increasing adhesive molecule activity, with circulating cotinine serving as a marker; we hypothesize a correlation between monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (cIMT) in active male smokers. Method : We conducted an observational cross-sectional analytic study involving 125 male participants, with 62 being active tobacco smokers and 63 non-smokers. Data were presented as mean ± SD, and the correlation between variables was analyzed using Pearson correlation. Result : Cotinine and MCP-1 levels were significantly higher in the smoker population (p 0.000) compared to non-smokers. The incidence of positive cIMT findings was higher in the smoker group (5%) than in the non-smoker group (2%). In the active smoker population, cotinine (r 0.21; p 0.11) showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 showed a negative correlation (r -0.19, p 0.14) with positive cIMT findings. Smoking duration (r 0.162; p 0.223) and the amount of tobacco smoke (r 0.003; p 0.982) demonstrated a positive correlation with cotinine. MCP-1 exhibited a non-significant positive correlation with smoking duration (r 0.122; p 0.345) and a non-significant negative correlation with the amount of tobacco smoke (r -0.002; p 0.989). Conclusion : Among active tobacco smokers, cotinine showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 exhibited a non-significant negative correlation with positive cIMT findings. 
Co-Authors A.A Istri Dalem Hana Yundari A.A. Ketut Agung Cahyawan W Abdul Patawari Abdul Patawari Adi Suyitno Adi Suyitno, Adi Agus Putra Murdani Agustina, Mulya Akbar Farid Hasibuan Aldita Husna Violita Amanda, Efina Amanda, Febrina Antonius Christianto Anwar Santoso Ardhia, Jessica Fio Ardiansyah, Wahyu Arif Wicaksono Arifah, Medisa Roro Putri Nur Ariska, Hanisa Iis Ariyani, Anita Dwi Asti Melani Astari Asy’ary, Qomaruddin Awaliyah Muslimah Suwetty Ayut Merdikawati Ayut Merdikawati, Ayut Balqis, Rani Diana Basyar Adnani Berty Febrianti Rahayu Caressa, Dea Amanda Cathrine Theodora Sukotjo Cece Indriani Cholid Tri Tjahjono Christianingsih, Siska Christianto, Antonius Cipto Susilo Damayanti, Fransiska Erna Debby Hatmalyakin Dewi Kartikawati Ningsih Dewi Kartikawatiningsih Dewi, Heriberta Tabita Marta Dhelya Widasmara Dhiar Widianingtyas, Dhiar Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dudella Desnani Firman Yasin, Dudella Desnani Firman Dwi Agustian Faruk Ibrahim Efris Kartika Sari, Efris Kartika Elvira Sari Dewi Emi Wuri Wuryaningsih Endrian Kurniawan, Dicky Erik Irham Lutfi Evie, Sova Fahmi, Muhamad Fajar Ari Nugroho fatchiyah . Fatchiyah Fatchiyah Firman Prastiwi FitriaNugraha Aini Hasibuan, Akbar Farid Hayati, Yati Sri Heri Kristanto Heri Kristianto Hermanto, Andrik Hidayat Sujuti Husnul Khotimah I Wayan Edi Sanjana Ida Ayu Putu Sri Widnyani Indah Nur Chomsy Indhiarti, Tantri Refa Indriyani, Damayanti Inggita Kusumastuty Intan Yusuf Habibie Ismail, Dina Dewi Sartika Lestari Jannah, Riska Raudhatul Jatim Sugiyanto Juwitasari Juwitasari Kartika, Annisa Wuri Karyono Mintaroem Katsuhiro Miyajima Kawitantri, Orchidara Herning Kumboyono Kumboyono Kurnianingsih, Nia Kurnianingsih, Novi Kusuma, Ayu Widia Kusumawati, Diana Laily Yuliatun Lidwina Faraline Triprisila Lidwina Faraline Triprisila Liemena Harold Adrian Lilik Supriati Lilik Supriati Lilik Supriati Lilik Supriati, Lilik Lola Ayu Istifiani M Saifur Rohman Machfud, Savinka Salsabiela Iriana Maria Fatimah Fouk Maulidah Maulidah Merry P Mesa, Nofita Dewi Kok Mochamad Ali Sodikin Muhammad Ridwan Mukhamad Fathoni Mukhamad Fathoni Muladefi Choiriyah Munif, Badrul Nana Septiana Widayati Nanang Bagus Sasmito Nanik Setijowati Narwasthu, Sekararum Nawang Wulandari Nawang Wulandari, Nawang Nur 'Aini Nurdiana Nurdiana Nurdiana Nurdiana Nurul Evi Nurul Muslihah Olivia Handayani Pamungkas, Akhmad Yanuar Fahmi Patawari, Abdul Prasanti Mahesa Anjani Prasetyawan, Riyan Dwi Putra Agina Widyaswara Suwaryo Rahmawan, Fajri Andi Renny Nova Renny Nova, Renny Retno Lestari Retno Lestari Ridhoyanti Hidayah, Ridhoyanti Rina Anggraini Rislan Faiz Muhammad Rismawan Adi Yunanto Rista Nikmatu Rohmah Rista Nikmatu Rohmah, Rista Nikmatu Rizal, Ardian Roesardhyati, Ratna Roshanti, Dian Rosikhah Al-Maris Rosuli, Ahmad Rudiyanto Rudiyanto, Rudiyanto Safira Dita Arviana Sanjana, I Wayan Edi Saputri, Diana Nanda Sartika Lestari Ismail, Dina Dewi Sasnita Salam Sassanti, Suci Wulandari Satrianto, Anang Satwikajati, Sawitri Septi Dewi Rachmawati Servasius To’o Jala Mulu Setyoadi Setyoadi Setyoadi Setyoadi Shahdevi Nandar Kurniawan, Shahdevi Nandar Siska Christianingsih Siska Puji Lestari Siska Puji Lestari Siska Puji Lestari Suis Galischa Wati Supriyadi, Muchamad Supriyanto Supriyanto Suryanto Suryanto Susilowati Susilowati Susilowati Susilowati Suwaryo, Putra Agina Widyaswara Swastikaputri, Valerina Yogibuana Teuku Heriansyah Tina Handayani Nasution Tita Hariyanti Toga, Erik Tony Suharsono Tony Suharsono Tony Suharsono, Tony Widiani, Luh Widito, Sasmojo Wisnasari, Shila Yati Sri Hayati Yoga Tribakti Rachmad Yulian Wiji Utami Yulian Wiji Utami Yulian Wiji Utami Yuliatun . Yuliatun ., Yuliatun Yuyun Yueniwati