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Wendy
Universitas Tanjungpura
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Journal : Narra J

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Association between the CYP24A1 rs2762939 polymorphism and vascular calcification in Indonesian patients with chronic kidney disease on hemodialysis Wendy, Wendy; Muzasti, Riri A.; Tarigan, Radar R.
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2874

Abstract

Vitamin D plays a key role in mineral metabolism, and its dysregulation contributes to vascular calcification, a major complication of chronic kidney disease–mineral and bone disorder (CKD–MBD) in patients undergoing hemodialysis with CKD. The CYP24A1 gene encodes 24-hydroxylase, the enzyme responsible for degrading active vitamin D metabolites and its polymorphisms, particularly rs2762939, have been linked to variability in vitamin D status and coronary artery calcification. The aim of this study was to assess the association between the rs2762939 polymorphism of CYP24A1 and vascular calcification in Indonesian patients with CKD undergoing maintenance hemodialysis. A case–control study was conducted in 92 hemodialysis patients, including 46 with vascular calcification and 46 without. Genotyping of the rs2762939 polymorphism was carried out using PCR–RFLP, and the amplified products were separated by electrophoresis on 4% agarose gel. The frequency of vascular calcification was found to be significantly higher in patients with diabetes mellitus than in the control group (19 (82.6%) vs 4 (17.4%)), whereas in non-diabetic patients the frequency of vascular calcification was lower compared with controls (27 (39.1%) vs 42 (60.9%)). A statistically significant association between CKD etiology and vascular calcification was observed (p=0.001). The prevalence of vascular calcification was lower among carriers of the mutant C allele (45%) compared with the G allele (51.4%), although this difference was not statistically significant (OR=0.77; 95%CI: 0.38–1.56; p=0.592). The rs2762939 polymorphism of the CYP24A1 gene was not significantly associated with vascular calcification in Indonesian patients with CKD undergoing maintenance hemodialysis. Further studies with larger, ethnically diverse cohorts and integration of vitamin D status are needed to clarify the genetic contribution of CYP24A1 and related pathways to vascular calcification.
Co-Authors Achmadi Achmadi Ade Elbani Ade Mirza Afifah Afifah Afrizal - Agustina Listiawati Agustina, Dela Ahmad Shalahuddin Ahmad Shalahuddin, Ahmad Aini Nurul Aktris Nuryanti, Aktris Alhadiansyah Alisa, Alisa Alya Asyura Amanda Dwi Damayanti Amanda, Zhakia Putri Ana Fitriana Andi Ihwan Anggraini Syahputri Anwar Azazi Anwar Azazi Arman Jaya Asep Nursangaji Aswandi - Bintoro Bagus Purmono Bistari Budiman Sutrisno Chaniago, Sheren Rahmawati Clarissa Fransisca Daud, Ilzar Dedi Hariyanto Deri Apriadi Dwi Zulfita Edy Suasono Eka Purwanda Elly Suharlina Elvi Yuli Machmudah Endang Kristiawati Erna Listiana Erni Djun Astuti Eva Dolorosa Fahruna, Yulyanti Fajar Fajar Fifani Anggraini, Cinthia Fitri Imansyah Girang Permata Gusti Giriati Giriati Giriati Giriati Giriati Giriati Giriati Giriati, Giriati Hadary, Ferry Halimah, Putri Hamdani - Harry Setiawan Hasanudin Hasanudin Helma Malini Helma Malini Helma Malini, Helma Heni Safitri Heni Safitri Heriyadi Heriyadi Heriyadi Heriyadi Heriyadi, Heriyadi Herry Sujaini Ilzar Daud Imam Ghozali Irdhayanti, Efa Ismawartati - Jennifer Wirawan Jogiyanto Hartono Juniwati Juniwati Kalis, Maria Christiana Iman Kalista, Apriwina Yulita Khairunnisa Khairunnisa Kurnia, Depi Kurniawan, Johannes Lestari, Ega Dwi Lestari, Eko Budi Liana, Ana LIANTI, LIANTI LISTIANA SRI MULATSIH Lucky P, Muhammad Mandjar, Sherlla Merlinda Laurencia Maria Christiana Iman Kalis Mariana Oktasia Marseliana Marseliana Marwan Asri Mazayatul Mufrihah B11212091 Meilisa Alvita Meiran Panggabean Meisa, Meisa Memet Agustiar Mita Mita, Mita Mochammad Meddy Danial Muanuddin - Muhamad Dafa Ilhani Salim Muhamad Risal Tawil Muhammad Yusuf Muhsin Muhsin Mustaruddin Mustaruddin Mustaruddin Mustarudin Mustarudin Mustarudin Mustarudin Mustika, Uray Ndaru Muzasti, Riri A. Nanda Nanda Nanda Novita, Nanda Ndaru Mustika, Uray Nelly, Apri Yeni Ningsih, Kurnia Ningsih, Welly Putri Nurmainah - Oviska, Astrid Permata Gusti, Girang Phengdrawan, Jonassen Precillia, Cecillia Angelica Priyo Saptomo Purba, Tiurniari Purwaningsih - Rachmawati Rahmidiyani - Ramadania Ramadania Ramadania Ramadania, Ramadania Ratna Herawatiningsih Rayenda Khresna Brahmana Resta Maulita Angreani Riduansyah - Risal Ristati, Ristati Rizani Ramadhan Rizky Fauzan Rommy Patra Rosari, Carviena Alia Samsaga, Fika Angry Sandika Utama Sapitri, Elsi Nanda Setia Budi Sholva, Yus Sianturi, Rosita Naomi Silvia Uslianti Siti Hadijah Siti Halidjah Stepanus Sahala Sitompul Sukhesy Eka Putri Surachman - Sutrisno, Budiman Sy. Hasyim Azizurrahman Syahbandi Syahbandi Syahputri, Anggraini Syaifurrahman Syaifurrahman Syamswisna , Tarigan, Radar R. Theliya, Theliya Theodora, Cindy Tri Wiyono Kurnianto Uray Ndaru Mustika Uray Ndaru Mustika Utami, Eva Yuniarti utari, Della Uti Asikin Vennerico, Nextcell Winoto Vivi Bachtiar Vylexta, Vicella Vyrcellica Wahyuni, Adinda wijaya, dwi nova Winanda Epriyanti Windhu Putra Witarsa - Wowor, Wulan Meiaya Wulansari, Dinda Marsela Yankhi, Yankhi Yasin, Maulana Yen, Siau Yohanes Gatot Sutapa Yuline - Yulis Jamiah Yulyanti Fahruna Zubaidah R