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All Journal International Journal of Evaluation and Research in Education (IJERE) Perkebunan dan Lahan Tropika Jurnal Konseling dan Pendidikan Techno.Com: Jurnal Teknologi Informasi Indonesian Journal of Cancer Chemoprevention Journal of Educational Science and Technology Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry VOLT : Jurnal Ilmiah Pendidikan Teknik Elektro Jurnal Panorama Hukum Journal of Psychological Science and Profession Medicinus : Jurnal Kedokteran INTECOMS: Journal of Information Technology and Computer Science RISTEKDIK : Jurnal Bimbingan dan Konseling Journal of Educational Research and Evaluation Journal of Dynamics Global Conference Index INTERNATIONAL JOURNAL OF NURSING AND MIDWIFERY SCIENCE (IJNMS) Care : Jurnal Ilmiah Ilmu Kesehatan EDUKATIF : JURNAL ILMU PENDIDIKAN Jurnal Ilmiah Edunomika (JIE) JATI (Jurnal Mahasiswa Teknik Informatika) Jurnal Inovasi dan Pelayanan Publik Makassar JURNAL KESEHATAN BHAKTI HUSADA Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Epistema Jurnal PTI (Jurnal Pendidikan Teknologi Informasi) Jurnal Pengabdian Masyarakat (ABDIRA) Algoritme Jurnal Mahasiswa Teknik Informatika Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Jurnal Pendidikan dan Pembelajaran Jurnal Komtekinfo Hang Tuah Medical Journal Jurnal Manajemen dan Bisnis SENTRI: Jurnal Riset Ilmiah YASIN: Jurnal Pendidikan dan Sosial Budaya Populer: Jurnal Penelitian Mahasiswa Tarbiyah bil Qalam : Jurnal Pendidikan Agama dan Sains International Journal of Educational Research Excellence (IJERE) PIJAR: Jurnal Pendidikan dan Pengajaran RISTEC : Research in Information Systems and Technology Journal of Research and Investigation in Education Indo-Fintech Intellectuals: Journal of Economics and Business Jurnal Pengabdian Harapan Ibu (JPHI) Jurnal Kajian Dan Penalaran Ilmu Manajemen JURNAL KARYA ILMIAH MULTIDISIPLIN (JUMPER) Media Akuntansi Perpajakan Jurnal Pelita Ilmu Pendidikan (JPIP) Journal Of Psychology, Counseling And Education Physical Sciences, Life Science and Engineering El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam Inovasi Sosial : Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Pendidikan Indonesia Journal of Citizenship Journal of Exploratory Dynamic Problems Blockchain Frontier Technology (BFRONT) JER Journal of Informatics and Information Security Jurnal Ilmiah Multidisiplin Keilmuan Mandira Cendikia (JIMK-MC) Interdisciplinary Journal of Advanced Research and Innovation Journal of Ekonomics, Finance, and Management Studies Jurnal PETISI (Pendidikan Teknologi Informasi)
Wijaya, Indra
Universitas Putra Indonesia YPTK Padang
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Journal : Indonesian Journal of Cancer Chemoprevention

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Correlation between Plasma Soluble CD36 Levels with Body Mass Index of Breast Cancer Patients in the Indonesian Population Rachman, Andhika; Irawan, Cosphiadi; R.R., Aditia; Koesnoe, Sukamto; Wijaya, Indra
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp12-21

Abstract

The cluster of differentiation 36 (CD36) is a multiligand receptor protein that plays a role in lipid metabolism. Its biological functions involve lipid uptake, immune recognition, inflammation, molecular adhesion, and tumor metastasis. Soluble CD36 (sCD36) is the circulating form of CD36 in plasma. Research on the role of sCD36 in breast cancer is limited. This study aimed to investigate sCD36 concentration and evaluate the correlation between sCD36 concentration and BMI in breast cancer patients. This is a multi-center cross-sectional study done from June 2018 to February 2019 in Indonesia. Consecutive sampling was done for women with invasive breast cancer aged 18-70. Patients with locoregional recurrences, multiple comorbidities, diabetes, stroke, or liver impairment were excluded. Patients were grouped based on their BMI into normo-weight and overweight/obese. Plasma sCD36 was analyzed using Bioassay Laboratory™ ELISA. The correlation between plasma sCD36 and the patient's characteristics (metastasis status and molecular subtype) were then analyzed. A total of 76 patients were enrolled, 36 of whom were categorized into the overweight/obese group and 40 of them in the normo-weight. Plasma levels of sCD36 in breast cancer patients were higher than controls at 0.24±0.163 ng/mL and 0.46±0.175 ng/mL, respectively (p=0.006). However, no difference in plasma sCD36 levels was found between the overweight/obese group and the normo-weight breast cancer subjects (p>0.05). Plasma sCD36 increased significantly in breast cancer patients, but no significant difference was found based on body mass index. Further research is needed to determine the role of sCD36 in determining clinical outcomes and prognosis in breast cancer patients.Keywords: Soluble CD36, body mass index, breast cancer, indonesia.
Distribution and Viability of Peripheral Blood Mononuclear Cells from Imatinib-resistant Chronic Myeloid Leukemia Patients: an In Vitro Study Ramadhanti, Julia; Utami, Kharima Dwi; Bashari, Muhammad Hasan; Wijaya, Indra
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp22-32

Abstract

The incidence of Chronic Myeloid Leukemia (CML) in the world is approximately 1.5 cases per 100,000 individuals. The level of resistance to CML treatment, imatinib in Indonesia is relatively high compared to Europe. Culturing CML cells can be used as a model for the determination of pathogenesis of CML, drug efficacy testing, and drug resistance testing. Studies using CML patients’ cells to be cultured in vitro and the methods used are rarely varied. This study aims to examine the distribution and viability of peripheral blood mononuclear cells from imatinib-resistant CML patients, expected to be a reference for mononuclear cell cultures from CML patients. This study was conducted in June-August 2019 using quantitative descriptive methods. The sample was mononuclear cells isolated from peripheral blood of three imatinib-resistant CML patients at the Hemato-Oncology Polyclinic of Hasan Sadikin Hospital, each of which was cultured in vitro using RPMI 1640 for 28 days. Distribution were seen using Giemsa staining, while viability was calculated using trypan blue. Data is processed using Microsoft Excel 2013 and Graphpad. Cell viability decreased during culture. Cell distribution had a different development pattern. Blast cells, eosinophils and basophils had presentation of between 0-5%. The percentage of lymphocyte changed between 11-31%. The percentage of neutrophil changed between 16-41%. The percentage of immature cells decreased, whereas the percentage of monocyte increased. In conclusion, cell viability decreases during the culture. Distribution of cells similar to the initial condition lasted until the 7th day and in the final phase it was only dominated by monocytes.Keywords: myeloid leukemia, chronic, cell culture, in vitro, peripheral blood mononuclear cell, cell viability.
Co-Authors Abdul Alim Abdul Hafis Lubis Adif, Anjjani Mardhika Afdilatun Nisa Afrilia Syafitri Ahmad Sarif Rambe Ainil Mardiah Alvin Faiz Nuthgi Padli Amalia Amelia, Rizana Andhika Rachman Andree Kurniawan Andres Christian Aritonang Anggraini, Septaria Arief Ichwan, Solachuddin Jauhari Arsyah, Rahmatul Husna Asih Minarningtyas Astri Indah Juwita Avia, Imelda Ayu Ningsih Saputri Azmi Asra Bantam, Dian Juliarti Bashari, Muhammad Hasan Bening Rabbani Nengsyh Chandra Lukita Chindy Prata Sari Cosphiadi Irawan Cut Miftahul Jannah Cut Zahwa Putri Naswadiah Dade Nurdiniah Daniel Marcello Debi Setiawan Della Andriani Deni Hardiansyah Harahap Deya Husnul Khatimah Dharmeizar Dharmeizar Dicky Firmansyah Dio Agung Herubawa Dito Adi Saputra Doni Pernanda Dwiantoro, Luky Eamon Fletcher Ediward, Deni Sartika Em Yunir, Em Endang Sjamsudin Euphemia Seto, Euphemia Evelyn Agustin Fadli, Mahril Fadli, Radinal Farisi, Ahmad Fazira Nasywa Febianingsih, Ani Ferisanti Ferisanti, Ferisanti Frysilia Tri Oktiasari Gebriuna Apriyani Guntur Darmawan Handika Gita Prasojo Harahap, Desrinah Harry Pratama Figna Herio Rizki Dewinda Ifadhila, Ifadhila Ihsanul Kamil Ika Prasetya Wijaya Ilwandri Indria Larasati Iren Meita Iren Meita, Iren Irna Sufiawati Irsan Hasan Irwan, Reyhan Anugrah Jafnihirda, Lika Jean Josh Hung Joheri Fransiski Jusirwan, Stifanni Juwita, Astri Indah Kahar Gani Kheriah Kheriah Laniyati Hamijoyo, Laniyati Latifah Annisa Leni Triani Libriyanty, Rina Lika Jafnihirda Linda Fitria Linda Fitria Linda Fitria Linda Fitria LISTIANA SRI MULATSIH Lukito, Laksono Edhi M.Ali Hanafiah Margaret Merlyn Tjiang, Margaret Merlyn Masyeni, Sri Mega Heldiana Meidiana Dwidiyanti Menrisal Menrisal Menrisal Menrisal Menrisal Menrisal Menrisal Menrisal Menrisal Menrisal Menrisal Minarningtyas, Asih Muhamad Dafin Al Dzky Muharika Dewi Musliadi Sitompul Musran Munizu Mustika Amri Mustofa, Khairul Naila Anastasya Nata Pratama Hardjo Lugito Nora Mutiara Nazara Novianti, Nunuk Novysuryantiindrayani Nur Fadillah Nurdiniah, Dade Nurmaliati Nurmaliati Nurmaliati, Nurmaliati Oktafadilla, Reyhan Oktavia, Anggi Windi Parlindungan Siregar Patriani Patriani, Patriani Pemy Christian Pinory, Clara Mayvinestania Sabrina Pipit Lestari Pipit Lestari Popi Radyuli Popi Radyuli Popi Radyuli Pratama, Rachendra Pratama, Riki Denata Pratiwi Sitorus Prayetno Prayetno Purnamasari, Pricylia Oka Diah Ayu Purnawansyah Putra Putra, Rangga Nugraha R.R., Aditia RADYULI, POPI Rahayu, Dinar Rahmat Dani Ramadhani, Lecya Bela Ramadhani, Lecya Bella Ramadhanti, Julia Ramsen Cahyatri Fatmasari Rina Sepriana Rini Susana Risma Vriyanti Romi Ferdian Ronaldo, Patrisius Jones Rumintar J. H. Marpaung Sandy Setiawan SANJAYA LIE, MIRACLE NYOMAN Sardiyanti, Opi Sari Nasution Sari, Afifah Velda Sefriani, Rini Sela Seli Septian Hadi Prakoso Setiadinata, Resa Siti Aisyah Siti Setiati Slamet Triadi Smita Catur Sudyantara Soesanto, Edi Solih Setiawan, Asep Widi Muharom Stevent Sumantri, Stevent Suherman, Ujang Sukamto Koesnoe Sunirah Sunirah Sunirah, Sunirah Suriya, Melti Syarifah Fatimah, Syarifah Tasman Yuza, Abel Tata Arya Cahyaaty Tatik Mariyanti, Tatik Teza Julita THEO AUDI YANTO, THEO AUDI Tomi Apra Santosa Toni Megris Trinugroho Heri Fadjari, Trinugroho Heri Ulfina, Ita Umamah, Ai Usman, Ardi Utami, Eva Yuniarti Utami, Kharima Dwi Utomo, Sulistyo Budi Wahyu Illahi Wahyudin Wahyudin Wijaya, Anis Boedi Winfrey Pangestu, Winfrey Yama Hendra, R. Oktav Yuliawati Yunus Yuliawati Yunus Yunie Armiyati Zulhaila, Mila Zuriati