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All Journal Jurnal Tumbuhan Obat Indonesia Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Islamic Medicine Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Dunia Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Borneo Journal Of Pharmascientech Bioscientist : Jurnal Ilmiah Biologi Journal Pharmasci (Journal of Pharmacy and Science) Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Indonesian Journal of Cancer Jurnal Ilmiah Multidisiplin Indonesia Jurnal Media Akademik (JMA) Borneo Journal of Pharmacy Jurnal Intelek Dan Cendikiawan Nusantara Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia Gotong Royong Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Jurnal Sains dan Kesehatan Journal Health of Indonesian JES-TM Social and Community Service Abdimas Paspama
Faisal Akhmal Muslikh
Magister Ilmu Farmasi, Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
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ANALISIS KRONOFARMAKOLOGI PENGGUNAAN PARACETAMOL PADA PASIEN COVID-19 DI RSUD DR. SOEDOMO TRENGGALEK Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Oktadiana, Isma; Arifin, Chandra; Rofiq, Abd; Febriana, Laela; Besan, Emma jayanti; Fadel, Muhammad Nurul
Journal of Social Science and Multidisciplinary Analysis Vol. 1 No. 1 (2024): Journal of Social Science and Multidisciplinary Analysis (Jossama), February 20
Publisher : Noble Cendekia Indonesia

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Abstract

The global COVID-19 pandemic has presented complex challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek has actively engaged in managing COVID-19 patients. This study aims to analyze the chronopharmacology of paracetamol usage in COVID-19 patients at the hospital, focusing on the body's biological response to the drug at various time points within the 24-hour cycle. In the treatment of COVID-19, the use of paracetamol has become a primary strategy for addressing symptoms such as fever. However, it is crucial to understand how the timing of paracetamol administration can influence the body's response to the treatment. A chronopharmacological study involving 100 patients analyzed body temperature before and after therapy at three different times: 08:00 AM, 04:00 PM, and 10:00 PM. The results revealed a significant decrease in body temperature after therapy, particularly at 04:00 PM. These findings support the concept of "the right time, the right dose" in clinical practice. Analysis of the body's circadian rhythm emphasizes the need to consider the timing of drug administration to achieve optimal outcomes. Despite the limited sample size, this research provides a foundation for the development of more precise practical guidelines for administering paracetamol to COVID-19 patients.
Eksplorasi Hubungan Tingkat Pengetahuan Terhadap Kepatuhan Terapi Pasien Hipertensi di UPT Puskesmas Tanjung Batu Kabupaten Karimun Maulina, Novia; Luthfi, Fitrati Hasanah; Inayatilah, Fidia Rizkiah; muslikh, Faisal akhmal
Journal of Islamic Medicine Vol 9, No 1 (2025): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2025
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v9i1.25921

Abstract

Background: Hypertension is a condition where blood pressure exceeds normal levels (120/80mmHg), with systolic blood pressure above 140 mmHg and diastolic blood pressure above 90mmHg. Termed as the "silent killer," hypertension often manifests without symptoms and is a leading cause of death in Indonesia. The prevalence of hypertension in the Riau Islands Province reached 25.85% in 2018, with Karimun Regency ranking second. Objectif: This study aims to assess the relationship between knowledge and adherence to antihypertensive medication among hypertensive patients at UPT Puskesmas Tanjung Batu, Karimun, in 2022. Methods: This observational study employs a Cross-sectional design. Data were collected from March to May 2022 from 90 respondents using a questionnaire. The sampling method used was consecutive sampling. Data analysis involved univariate and bivariate analyses with the Spearman rank test (significance level 0.005). Results: The majority of respondents were female (71%), aged 46-55 years (43%), with an educational background of elementary school (62%). On average, they had suffered from hypertension for less than 5 years (56%), and the primary source of information was from doctors (81%). Knowledge level was sufficient (49%), while medication adherence was low (83%). Statistical analysis indicated a significant relationship (p=0.001) and alignment between knowledge and adherence among hypertensive patients at UPT Puskesmas Tanjung Batu, Karimun, with a moderate correlation (r=0.343). Conclusion: There is a significant relationship between knowledge and adherence to antihypertensive medication among hypertensive patients.
Chronopharmacological Study Of Angiotensin-Converting Enzyme Inhibitor Ramipril In Hypertensive Patients In A Hospital: Analysis Of Efficacy And Tolerability Based On Administration Time Variations Fendy Prasetyawan; Faisal Akhmal Muslikh; Yuneka Saristiana; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Dewi Retno Puspitosari
Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID) Vol. 3 No. 02 (2024): Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID), July 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/esaprom.v3i02.4752

Abstract

This research investigates the chronopharmacological effects of Ramipril administration on hypertensive patients, focusing on the timing of drug intake. Studies conducted by Firli Choerun Nisa and Siti Rohmiati in 2022 provide the basis for this analysis. Using observational-analytic methods with cross-sectional designs, data were collected prospectively from 23 patients in each study. Firli Choerun Nisa's study at RSUD Singaparna Medika Citrautama, Tasikmalaya Regency, involved 14 patients in the light zeitgeber group and 9 in the dark zeitgeber group. Results indicated significant reductions in both systolic and diastolic blood pressures, with the dark zeitgeber group experiencing more substantial decreases. The SPSS analysis showed a p-value of 0.062, indicating no statistically significant difference between the groups. Siti Rohmiati's study at RSUD Dr. Soekardjo Tasikmalaya found similar results. The light zeitgeber group showed a systolic decrease of 9.9 mmHg and a diastolic decrease of 5 mmHg, while the dark zeitgeber group had decreases of 16.66 mmHg and 10.56 mmHg, respectively. The SPSS analysis also yielded a p-value of 0.062, supporting the conclusion of no significant difference in Ramipril's efficacy based on administration timing. The comprehensive analyses revealed that Ramipril effectively reduces blood pressure regardless of the administration time. Significant reductions in both the daytime and nighttime groups were noted, with trends suggesting a more pronounced effect during nighttime administration. These findings emphasize the importance of flexibility in medication timing, enhancing patient adherence without compromising therapeutic outcomes. In conclusion, the timing of Ramipril administration, whether in the morning or evening, does not significantly impact its effectiveness in managing hypertension. This flexibility offers practical benefits for clinical practice, supporting better patient adherence and optimized hypertension management. These studies contribute to the broader understanding of chronopharmacology, providing insights for improved treatment strategies in hypertensive care.
Virtual Screening and Comparison of the Binding Effectiveness of Doxorubicin, Paclitaxel, and Ergoloid to ERβ-MDM2 Complex Protein as New Breast Cancer Drug Candidates Salmasfattah, Novyananda; Dhiani, Binar Asrining; Muslikh, Faisal Akhmal; Putra, Galih Satrio
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1325

Abstract

Background: The prevalence of breast cancer continues to increase, it is the second leading cause of death after lung cancer. Estrogen receptor beta (ERβ) has an important role in breast cancer pathology, activation of Akt pathway will trigger E3 ubiquitin ligase murine double minute 2 (MDM2) to ERβ, which will increase the risk of breast cancer. Thus, both proteins have potential as therapeutic agents in breast cancer drug development. This study aims to find breast cancer drug candidates from natural products and compare the effectiveness of these compounds with Doxorubicin and Paclitaxel.Method: ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) proteins were combined using ClusPro 2.0. Doxorubicin and Paclitaxel ligands were obtained from PubChem, there are 842 natural products obtained from the ZINC database, when the energy minimization is reduced to 839 natural products. Virtual screening between proteins and ligands was performed using PyRx 8.0, followed by analysis of amino acid residues resulting from interactions between proteins and ligands using protein interaction calculator (PIC) and protein ligand interaction profiler (PLIP). Results: Ergoloid compounds have the lowest binding affinity compared to doxorubicin and paclitaxel compounds, and are able to interact strongly with the ERβ-MDM2 Protein as determined from the results of interactions between proteins and ligands using PIC and PLIP.Conclusion: Ergoloid compounds can interact well with ERβ-MDM2 Protein. Thus, it can be used as a breast cancer drug candidate in the future. In vitro, in vivo, and biochemical testing needs to be done to confirm this discovery
PREDIKSI DRUGLIKENESS DAN POTENSI AKTIVITAS BIOLOGIS SENYAWA METABOLIT SEKUNDER DAUN ASAM JAWA (Tamarindus indica) Muslikh, Faisal Akhmal; Suryanto; Nahdhia, Nadhifatun; Susilawati, Delis; Sari, Fita; Nugroho, Septiawan; Werdiningsih, Wiwik; Basuki, Dewy
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 6 No 1 (2025): Juni 2025
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v6i1.264

Abstract

Indonesia memiliki biodiversitas tinggi yang mencakup berbagai spesies tumbuhan dengan potensi farmakologi, salah satunya Tamarindus indica (asam jawa). Daun tanaman ini mengandung beragam senyawa metabolit sekunder, seperti Isovitexin, Isovitexin 2’-O-Arabinoside, Orientin, (-)-Epicatechin, dan Hexadecanamide, yang berpotensi memiliki aktivitas biologis. Penelitian ini bertujuan untuk mengevaluasi prediksi drug-likeness dan aktivitas farmakologi senyawa tersebut menggunakan pendekatan in silico. Analisis dilakukan dengan SwissADME untuk menilai kepatuhan terhadap aturan Lipinski dan Way2Drug PASS online untuk memprediksi potensi aktivitas farmakologi. Hasil analisis menunjukkan bahwa dua dari lima senyawa memenuhi aturan Lipinski sepenuhnya, sementara yang lainnya memiliki satu hingga tiga pelanggaran, yang dapat memengaruhi ketersediaan hayati oralnya. Prediksi aktivitas biologis menunjukkan bahwa senyawa-senyawa ini memiliki potensi sebagai agen hepatoprotektif, antioksidan, kardioprotektif, dan kemopreventif, serta berperan dalam regulasi berbagai jalur biologis seperti ekspresi TP53 dan HIF1A. Selain itu, analisis boiled egg diagram menunjukkan bahwa beberapa senyawa memiliki permeabilitas tinggi terhadap sawar darah-otak, yang dapat meningkatkan potensinya dalam terapi berbasis sistem saraf pusat. Studi ini memberikan wawasan awal mengenai potensi farmakologis senyawa dalam daun asam jawa, namun penelitian lebih lanjut melalui uji in vitro dan in vivo diperlukan untuk mengonfirmasi efektivitasnya dalam pengembangan obat herbal.
Prediction Activity Pharmacology and Molecular Docking of Secondary Metabolite Compounds of Tamarind Leaves (Tamarindus indica) as Anticancer Muslikh, Faisal Akhmal; Riwanti, Pramudita; Alrayan, Reza
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57090

Abstract

Introduction: Cancer remains one of the leading causes of morbidity and mortality worldwide, with incidence and death rates increasing annually. One of the most effective therapeutic targets for cancer is the Epidermal Growth Factor Receptor (EGFR). However, the use of synthetic EGFR inhibitors is often associated with significant side effects.  Aims: This study aims to evaluate the potential of compounds derived from Tamarindus indica (tamarind) leaves as anticancer agents through an in silico approach, including pharmacological activity prediction (PASS) and molecular docking against the EGFR receptor.  Methods: Pharmacological activities were predicted using the Way2Drug webtool, while molecular docking analysis was performed using Molegro Virtual Docker (MVD).  Result: The PASS prediction results indicated that the compounds in Tamarindus indica leaves possess a broad spectrum of anticancer activities. Docking analysis revealed that isovitexin exhibited the lowest rerank score among the test compounds and controls (erlotinib and the native ligand), indicating stronger binding affinity to EGFR. Conclusion: These findings support the potential of tamarind leaves, particularly isovitexin, as a promising computationally-predicted anticancer therapeutic candidate.
Optimizing COVID-19 Therapy: Analysis of Prescription Profiles in Non-Comorbid Inpatients to Enhance Treatment Strategies and Clinical Outcomes Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Ilhawa Zahra
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

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Abstract

This study explores the clinical characteristics, treatment patterns, and outcomes of COVID-19 inpatients without comorbidities, aiming to contribute valuable insights to the management of the disease. Through meticulous data collection from medical records of 468 confirmed COVID-19 patients admitted to Gambiran Regional General Hospital between April and June 2020, 36 patients meeting inclusion criteria were identified. The research findings reveal a higher incidence of COVID-19 among males and a prevalent age group of 31-40 years. Notably, elderly individuals and those with underlying health conditions face a greater risk of severe outcomes, underscoring the importance of tailored interventions for vulnerable populations. The study highlights a diverse treatment approach, with a significant proportion of patients receiving supplements to bolster immune function. Antiviral medications like Favipiravir are also utilized to inhibit viral replication, although definitive treatment for COVID-19 remains elusive. Antibiotics play a crucial role in preventing bacterial respiratory infections, while supportive medications help alleviate symptoms commonly associated with the disease. Importantly, the findings emphasize the multifaceted nature of COVID-19 management and the need for targeted interventions to optimize patient outcomes. By elucidating the therapeutic landscape and clinical course of COVID-19 inpatients without comorbidities, this study contributes to the growing body of knowledge surrounding the disease. These insights can inform clinical decision-making, resource allocation, and public health strategies aimed at combating the ongoing pandemic.
Assessment of the Effectiveness of Centella asiatica Ethanol Extract in Alleviating Diarrhea in Castor Oil-Induced White Mice: A Pharmacological Approach Yuneka Sarisitiana; Fendy Prasetyawan; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Ivan Junius Mesak
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

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Abstract

This study investigated the potential anti-diarrheal effects of ethanol extract from Centella asiatica leaves using a castor oil-induced diarrhea model in mice. The extract, obtained from Centella asiatica leaves, was administered orally to mice at various doses. Parameters including the frequency, duration, and onset of diarrhea were measured and compared with control groups. Results indicated a dose-dependent reduction in diarrhea frequency and duration in treated mice. Higher doses of Centella asiatica ethanol leaf extract demonstrated efficacy comparable to loperamide, a standard anti-diarrheal drug. Histopathological analysis further revealed protective effects on intestinal tissue integrity, suggesting a potential mechanism of action for the observed anti-diarrheal activity. These findings underscore the potential of Centella asiatica ethanol leaf extract as a natural alternative for managing diarrhea. The study contributes to the growing body of evidence supporting the traditional use of Centella asiatica in folk medicine for gastrointestinal ailments. However, further research is warranted to elucidate the underlying mechanisms of action responsible for its anti-diarrheal effects and to conduct clinical trials for human validation. In conclusion, this research highlights the significance of exploring natural remedies derived from medicinal plants like Centella asiatica for combating gastrointestinal disorders. The study underscores the potential of Centella asiatica ethanol leaf extract as a therapeutic agent for managing diarrhea and improving public health outcomes.
Unveiling the Mysteries of Pharmacoreincarnation: A Study on the Spiritual and Metaphysical Dimensions of Using Psychoactive Drugs for Accessing Past Life Memories Fendy Prasetyawan; Nanda Ardianto; Yuneka Saristiana; Wahyu Ariawan; Faisal Akhmal Muslikh; Yunita Dian Permatasari
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

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Abstract

The research delves into the multifaceted realm of psychoactive drugs, spirituality, and the exploration of past life memories, known as "pharmacoreincarnation." Psychoactive substances like psilocybin, LSD, and DMT have gained attention for their profound alterations in consciousness and subjective experiences, often described as mystical or spiritual. Belief in reincarnation persists globally, fueled by anecdotal testimonials and cultural traditions. The study aims to explore pharmacoreincarnation through a comprehensive literature review and interdisciplinary perspective. Academic databases such as PubMed, PsycINFO, Scopus, and Google Scholar will be utilized to access relevant articles published in English within the last two decades. Thematic analysis will identify recurring themes and patterns across the literature, synthesizing findings to develop a coherent understanding of pharmacoreincarnation. The methodology involves systematic literature search, screening, and review processes to extract pertinent information aligned with the research objective. The synthesized findings will be organized into logical sections within the literature review, ensuring clarity and rigor. Peer review and revision will validate the quality and accuracy of the review before finalization. The study anticipates contributing significantly to knowledge on pharmacoreincarnation and its implications for consciousness studies, spirituality, and therapeutic practices. By embracing an interdisciplinary approach, it aims to unravel the underlying mechanisms of such experiences and their broader implications for personal identity and reality.
Patterns of Antihypertensive Medication Utilization Among Hypertensive Patients: A Review of Single-Therapy Practices in Outpatient Primary Healthcare Centers Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Chandra Arifin; Abd Rofiq; Elsa Mahardika Putri; Anis Akhwan Dhafin
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.115

Abstract

Hypertension, often referred to as "The Silent Disease," presents a significant global health challenge due to its asymptomatic nature and association with severe cardiovascular complications. Effective management of hypertension primarily relies on the administration of antihypertensive drugs, either as monotherapy or combination therapy. This study investigates the utilization patterns of single antihypertensive drugs among hypertensive patients in the outpatient setting of Puskesmas "X" in Solo City. Utilizing a retrospective approach, data from patient medical records were analyzed to examine drug usage patterns and patient responses to therapy. Results revealed a noteworthy preference for combination therapy, with approximately 64.18% of patients opting for this approach. Combination therapy strategies were favored due to their additive and synergistic effects, potential for reducing side effects, and enhanced blood pressure control. Specifically, amlodipine from the calcium channel blocker (CCB) group emerged as the most commonly prescribed single antihypertensive drug, while the combination of amlodipine with candesartan from the angiotensin receptor blocker (ARB) group was the predominant combination therapy. These findings align with previous research, emphasizing the significance of combination therapies in hypertension management..
Co-Authors Abd Rofiq Adifa, Wildan Hanifatul Aditama, Agnis Agnis Pondineka Ria Aditama Al-Hasyimi, Said Muhammad Alrayan, Reza Aluzia, Aufary Naurah Andhiarto, Yanu Anis Akhwan Dhafin Anis Akhwan Dhafin Anisah Mahardiani Ardianto, Nanda Arief Suryadinata Asri Wido Mukti Asrizal Azis Asti Rahayu Aszari, Efendi H. Azis, Asrizal Azzahra, Azizah Bambang Widjaja Basuki, Dewy Begum Fauziyah Begum Fauziyah Besan, Emma Jayanti Binar Asrining Dhiani Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Candra Arifin, Candra Chandra Arifin Charliandri Saputra Wahab Choiroh, Afifahtul Dafin, Anis Akhwan Della, Desi Mujiastuti Destiya Argo Pamuji Fihuda Dewi Retno Puspitosari Dilla Amalia Dyah Aryantini, Dyah Eka Nur Fatmawati Elsa Mahardika Putri Ema Tri Wulan Emma Jayanti Besan Eryani, Mikhania Christiningtyas Evi Kurniawati, Evi Fadilla, Rahma Nur Farida, Agustini Fatimah Azzahra Febriana, Laela Fendy Prasetyawan Fidia Rizkiah Inayatilah Fihuda, Destiya Argo Pamuji Firdaus, Natasya Octavia Putri Firsta Roisatul Islamiyah Fita Sari, Fita Fricananta, Salma Salsabila Galih Satrio Putra Ginanjar Putri Nastiti Hakim, Adiyansyah Lukman Hasniah Hasniah Hening Laswati Putra Husnul Khotimah Ilhawa Zahra Imanda'ar, Pavitra Meilina Isma Oktadiana Ivan Junius Mesak Izza Nailia Shirvi Kamelin, Badira Khoirunnisa, Zahra Kurniawan Hidayat Perdana Putra Kusumawardani, Arine Giovani Lalong, Paulus Risan F. Latarissa, Nayla Annida Luthfi Achmad Muchlasi Luthfi, Fitrati Hasanah M. Wahyu Ariawan Ma'arif, Burhan Ma’arif, Burhan Mangestuti Agil Marisca Evalina Gondokesumo Marisca Evalina Gondokesumo, Marisca Evalina Maximus M Taek Mayu Rahmayanti Ma’arif, Burhan Mildawati, Ratna Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Muzayanah, Arifatul Nahdhia, Nadhifatun Nanda Ardianto Novia Maulina Nugroho, Septiawan Nurwijayanti Octavian Ashido Nababan Oktadiana, Isma Prameswari, Fadila A. Pramudita Riwanti Prida Ayudianti Priyantri, Risma Virgian Puja Adi Priatna Purbosari, Ira Purwitasari, Neny Putri, Elsa Mahardika Raharjo, Susilo Margining Ratna Mildawati Reyhan Rahma Samudra Reza, Putri Firdaus Shafiera Rina Andayani, Rina Rizki Rahmadi Pratama Rofiq, Abd Rosa Juwita Hesturini Sadli Syarifuddin Salmasfattah, Novyananda Sari, Dewi Perwito Sawjana, Oashiva H. Septianto, Andre Subiyakto, Erlangga Sufi Sukardiman Suko Hardjono Suryanto Suryanto Suryanto Suryanto Suryanto Susilawati, Delis Sya'adah, Puri Zumrotul Taek, Maximus M. Taek, Maximus Markus Tanaya Jati Dharma Dewi Tasya, Pradiva Julias Wahyuni, Ela Weka Sidha Bhagawan Werdiningsih, Wiwik Winayah, Mesri Ananta Wisnu Haryo Widyoko Wiwied Ekasari Wulan, Ema Tri Yuneka Sarisitiana Yuneka Saristiana Yunita Dian Permatasari Zenmas, Syendriva Zeptyan Zulvikar Syambani Ulhaq