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All Journal Jurnal Tumbuhan Obat Indonesia Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Islamic Medicine Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Dunia Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Riset Kefarmasian Indonesia Borneo Journal Of Pharmascientech Bioscientist : Jurnal Ilmiah Biologi Journal Pharmasci (Journal of Pharmacy and Science) Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Indonesian Journal of Cancer Jurnal Ilmiah Multidisiplin Indonesia Jurnal Media Akademik (JMA) Borneo Journal of Pharmacy Jurnal Intelek Dan Cendikiawan Nusantara Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia Gotong Royong Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Jurnal Sains dan Kesehatan Journal Health of Indonesian JES-TM Social and Community Service
Faisal Akhmal Muslikh
Magister Ilmu Farmasi, Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
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Optimasi Kombinasi Ramuan Etnomedisin Penumbuh Rambut Nusa Tenggara Timur Menggunakan Orthogonal Stimulus Response Method Pada Kepadatan Rambut Mencit (Mus musculus) Taek, Maximus M.; Megawati, Dewi Sinta; Subiyakto, Erlangga Sufi; Khoirunnisa, Zahra; Maulina, Novia; Muslikh, Faisal Akhmal; Ma’arif, Burhan
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 4 (2025): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i4.18301

Abstract

This study aimed to optimize a traditional ethnomedicinal formulation from East Nusa Tenggara (RENTT) as a natural hair-growth candidate and to evaluate its antioxidant activity and biological effectiveness using an alopecia model. A true experimental design was applied using the Taguchi–Orthogonal Stimulus Response Method (OSRM) to determine the optimal combination of five plant extracts, namely Aleurites moluccanus, Hibiscus rosa-sinensis, Ficus benjamina, Polyscias scutellaria, and Hibiscus tiliaceus. In vitro optimization was conducted using the DPPH radical scavenging assay with a Taguchi L27 orthogonal array design. The optimal formulation was subsequently evaluated in vivo using male mice (Mus musculus) with croton oil–induced alopecia. Hair growth effectiveness was assessed based on hair density percentage through histomorphometric analysis with hematoxylin–eosin staining. The results demonstrated that the optimal RENTT formulation exhibited very strong antioxidant activity with an IC₅₀ value of 27.46 ppm. Taguchi analysis identified F. benjamina as the most influential factor in determining formulation performance. In vivo evaluation showed that the RENTT-treated group achieved the highest hair density (49.45 ± 4.70), which was significantly higher than that of the positive control, negative control, and normal control groups. In conclusion, the optimized RENTT formulation demonstrates strong antioxidant properties and a significant stimulatory effect on hair growth, indicating its promising potential as a natural cosmeceutical product based on the local wisdom of East Nusa Tenggara.
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN MASKER WAJAH GEL PEEL-OFF EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) Aditama, Agnis Pondineka Ria; Kusumaningtyas, Rili; Karimah, Widya Nuratika; Paramita, Denok Risky Ayu; Rashati, Dewi; Muslikh, Faisal Akhmal
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.467

Abstract

            Red dragon fruit (Hylocereus polyrhizus) has many benefits. The fruit peel is rich in antioxidants which have the potential to improve the health and beauty of facial skin. Traditional use requires a long preparation time and formulation is needed to make preparations with more effective, practical and long-lasting storage. The facial mask formulation is a peel-off gel preparation that can moisturize the skin and increase the effect of the active ingredients. Quality assurance, namely safety, quality and benefits, is very necessary, which can be done by testing the physical stability of the preparation. The aim of this research is to obtain a formula made from the active ingredient Hylocereus polyrhizus fruit peel extract in the form of a peel-off gel facial mask and the best physical stability. HPMC was used as a carrier base by varying the concentration, namely 2%; 3% and 5%. Evaluation of the physical stability of the preparation was carried out, namely homogeneity, organoleptic, spreadability, viscosity, pH and dry time tests of 14 and 28 days. Storage is carried out at warm (30-40°C), room (15-30°C), and cold (2-8°C) temperatures. The best formula is 3% HPMC concentration with the best physical stability. Variations in storage temperature have an effect on physical organoleptics (color), viscosity and dispersion, but have no effect on physical homogeneity, drying time and pH. Cold temperatures (2-8°C) show the best stability because they can maintain physical stability.
Co-Authors Abd Rofiq Adifa, Wildan Hanifatul Aditama, Agnis Agnis Pondineka Ria Aditama Al-Hasyimi, Said Muhammad Alrayan, Reza Andhiarto, Yanu Anis Akhwan Dhafin Anis Akhwan Dhafin Anisah Mahardiani Ardianto, Nanda Arief Suryadinata Asri Wido Mukti Asti Rahayu Aszari, Efendi H. Azis, Asrizal Azzahra, Azizah Bambang Widjaja Basuki, Dewy Begum Fauziyah Begum Fauziyah Besan, Emma Jayanti Binar Asrining Dhiani Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Candra Arifin, Candra Chandra Arifin Charliandri Saputra Wahab Choiroh, Afifahtul Dafin, Anis Akhwan Della, Desi Mujiastuti Denok Risky Ayu Paramita Destiya Argo Pamuji Fihuda Dewi Retno Puspitosari Dilla Amalia Dyah Aryantini, Dyah Eka Nur Fatmawati Elsa Mahardika Putri Emma Jayanti Besan Eryani, Mikhania Christiningtyas Evi Kurniawati, Evi Fadilla, Rahma Nur Farida, Agustini Febriana, Laela Fendy Prasetyawan Fidia Rizkiah Inayatilah Fihuda, Destiya Argo Pamuji Firdaus, Natasya Octavia Putri Firsta Roisatul Islamiyah Fita Sari, Fita Fricananta, Salma Salsabila Galih Satrio Putra Ginanjar Putri Nastiti Hakim, Adiyansyah Lukman Hasniah Hasniah Hening Laswati Putra Husnul Khotimah Ilhawa Zahra Imanda'ar, Pavitra Meilina Isma Oktadiana Ivan Junius Mesak Izza Nailia Shirvi Kamelin, Badira Karimah, Widya Nuratika Khoirunnisa, Zahra Kurniawan Hidayat Perdana Putra Kusumaningtyas, Rili Kusumawardani, Arine Giovani Lalong, Paulus Risan F. Latarissa, Nayla Annida Luthfi Achmad Muchlasi Luthfi, Fitrati Hasanah M. Wahyu Ariawan Ma'arif, Burhan Ma’arif, Burhan Mangestuti Agil Marisca Evalina Gondokesumo Marisca Evalina Gondokesumo, Marisca Evalina Maximus M Taek Ma’arif, Burhan Mildawati, Ratna Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Muzayanah, Arifatul Nahdhia, Nadhifatun Nanda Ardianto Novia Maulina Nugroho, Septiawan Nurwijayanti Octavian Ashido Nababan Oktadiana, Isma Prameswari, Fadila A. Pramudita Riwanti Priyantri, Risma Virgian Puja Adi Priatna Purbosari, Ira Purwitasari, Neny Putri, Elsa Mahardika Raharjo, Susilo Margining Rashati, Dewi Ratna Mildawati Reyhan Rahma Samudra Reza, Putri Firdaus Shafiera Rina Andayani, Rina Rizki Rahmadi Pratama Rofiq, Abd Rosa Juwita Hesturini Sadli Syarifuddin Salmasfattah, Novyananda Sari, Dewi Perwito Sawjana, Oashiva H. Septianto, Andre Subiyakto, Erlangga Sufi Sukardiman Suko Hardjono Suryanto Suryanto Suryanto Suryanto Suryanto Susilawati, Delis Sya'adah, Puri Zumrotul Taek, Maximus M. Taek, Maximus Markus Tanaya Jati Dharma Dewi Tasya, Pradiva Julias Wahyuni, Ela Weka Sidha Bhagawan Werdiningsih, Wiwik Winayah, Mesri Ananta Wisnu Haryo Widyoko Wiwied Ekasari Wulan, Ema Tri Yuneka Sarisitiana Yuneka Saristiana Yunita Dian Permatasari Zenmas, Syendriva Zeptyan Zulvikar Syambani Ulhaq