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An in Vitro Approach: Antibacterial Activity of Sansevieria trifasciata Prain. Leaves with Chemometric Analysis Kasmawati, Henny; Sida, Nurramadhani A.; Arfan, Arfan; Indrayanti, Wa Ode Dian; Rusman, Arman
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2087

Abstract

Exploration the antibacterial activity of S.trifasciata Prain. is still limited, therefore this study aims to assess the antibacterial activity of extracts and ethyl acetate fractions of Sansevieria trifasciata Prain. The S.trifasciata leaves was macerated with ethanol 96%, then fractionated using the trituration method with ethyl acetate. The treatment group was divided into positive control group (PC) using ciprofloxacin, negative control (NC) using DMSO, extract, ethyl acetate fraction 5% (ET5%), 10% (ET10%), 20% (ET20%), 40% (ET40 %). Data were analyzed statistically by ANOVA and chemometrically with PCA. The inhibition zone for S.aureus bacteria in each sample is 26.69; 1.40; 23.32;2.82; 6.23; 11.11; 20.15 mm, respectively, E.coli is 26.65;0.63;22.65;3.61;7.11;11.44;21.15 mm respectively, P. aeruginosa is 27.40; 0.00; 23.23; 2.74;7.03;11.69;21.36 mm respectively. Percent inhibition of extract, ET5%, ET10%, ET20%, ET40% on S. aureus bacteria is 82.16; 5.31; 18.12; 36.39; 70.38% respectively, E.coli is 82.67; 11.13; 24.31; 40.56; 76.99% respectively, P. aeruginosa 84.85; 10.01; 25.65; 42.68; 77.98% respectively. Extract and ethyl acetate fraction have significant potential as antibacterial (p<0.05). The results of PCA chemometric analysis showed that the extract and ET40% had similar inhibition zone area to the positive control ciprofloxacin. The extract and the ethyl acetate fraction 40% are promising for development as antibacterials. Keywords:          Sansevieria trifasciata Prain., chemometric, bacterial
Effect of Solvent Polarity on Antioxidant and Antidiabetic Activity of Kesambi Leaf Extract (Schleichera oleosa L.) Nursamsiar, Nursamsiar; Marwati, Marwati; Sami, Fitriyanti J.; Nur, Syamsu; Kasmawati, Henny; Asnawi, Aiyi
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.9439

Abstract

Kesambi (Schleichera Oleosa (L.) is one of the beneficial plants in Indonesia which contains fenolic and flavonoids that exhibit antioxidant properties. The presence of antioxidants in plants could be associated with antidiabetic activity of these plants. This research was conducted to determine the antioxidant and antidiabetic activities of n-hexane, ethyl acetate, acetone and methanol extracts from Kesambi leaves. Extraction was carried out by the ultrasonic assisted extraction (UAE) method. The antioxidant activity was determined quantitatively by DPPH and ABTS method, while the antidiabetic activity was evaluated by using α-glukosidase inhibition method. The IC50 values from the determination of antioxidant and antidiabetic activities were obtained by using Microplate reader at the maximum wavelength. Results of the antioxidant determination DPPH method showed that IC50 values of n-hexane, ethyl acetate, acetone and methanol extracts were 414.1993; 57.7862; 6.33 dan 13.4558 µg/mL, respectively. And for ABTS method showed 162.679; 22.6684; 10.7975; dan 146.869 µg/mL. This indicates the acetone and methanol extracts give the best results in antioxidant activity. Meanwhile, IC50 values of in vitro antidiabetic activity of n-hexane, ethyl acetate, acetone and methanol extracts were 99.3235; 272.8723; 1.6799; dan 24.4653 µg/mL, respectively. Acetone and methanol extracts of kesambi leaf give the best results in antidiabetic activity.
Edukasi Kesehatan tentang Tuberkulosis: Membangun Komitmen Masyarakat untuk Pengendalian TBC Kasmawati, Henny; Hikmah, Nurull; Trinovitasari, Nita; Jannah, Sitti Raodah Nurul; Malina, Rachma; Suryani, Suryani; Nuralifah, Nuralifah; Aswani, Aswani
JIPITI: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 4 (2025): November 2025 - JIPITI: Jurnal Pengabdian kepada Masyarakat
Publisher : PT. Technology Laboratories Indonesia (TechnoLabs)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis (TB) is an infectious disease that is still a global health problem, caused by the bacterium Mycobacterium tuberculosis, which is acid-resistant and mainly attacks the lungs, but can also attack other organs. This disease can affect people of all ages, including babies, children, adults, and the elderly. TB transmission occurs through the air from people who cough or sneeze, with the main factors affecting public health being environmental factors and behaviours, such as uncovered coughing and poor sanitation. TB cases in Southeast Sulawesi Province have shown a significant upward trend in recent years, with the incidence rate continuing to rise every year. The success of TB treatment is influenced by a variety of factors, including medication adherence, which is a major challenge to avoid the emergence of drug resistance, such as TB-MDR. The Government of Indonesia has issued policies and focuses on reducing TB incidence through education and socialisation to encourage active community involvement in TB control to achieve the national target by 2030.
Co-Authors ,, Suryani A Sida, Nurramadhani A.A. Ketut Agung Cahyawan W Abd Rafid Achmad Fuad Hafid Aiyi Asnawi Alfad Fadri Alfian Alfian Anjani, Ratna Anwar, Irvan Arfan Arfan Arfan Arfan Ariani, Eno Retno Armadani, Fery Indradewi Aspadiah, Vica Aswani Aswani Aswani Aswani Aswani Aswani Aswani Aswani Aswani, Aswani Aty Widyawaruyanti Damu, Rusliati Desi Sartina Dian Munasari Solo Eka Pebriana Eka, Bau Mirna Ayu Fery Indradewi Fery Indradewi Armadany Fifi Nirmala Firawati Fitrawan, La Ode Muhammad Fitri Rahmadani Saputri Fitriyanti Jumaetri Sami Fristiohady, Adryan Halik Hasnawati Hasnawati Hasniar, Wa Ode Hikmah, Nurull Indradewa, Rhian Indrayanti, Wa Ode Dian Jamil, Siti Amaliah Jamsir, Asmaidah Jannah, Sitti Raodah Nurul La Ode Aman La Ode Muh. Fitrawan La Ode Muhammad Diman La Ode Muhammad Fitrawan Linggi Allo, Lisa Talita Loly Subhiaty Idrus Loly Subhiyati Idrus Madjid, Waode Istiqamah Malaka, Muhammad Hajrul Malina, Rachma Mallarangeng, Andi Nafisah Tendri Adjeng Mardiani, Siti Marwati Marwati Mesi Leorita, Mesi Muh. Arba Munarsi Munarsi Mutmainna, Mutmainna Nina Salamah Ningsih, Warda Ayu Nur Filzanah Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Kharisma Amin Nur Rayani Nur Syam Hidayah Rahma Ismail Nuralifah Nuralifah, Nuralifah NURFAUSIAH Nurramadhani A. Sida Nursamsiar Nursamsiar Nurull Hikmah Nurull Hikmah Rahmat Muliadi Rahmayani, Nur Rayani, Nur Ridho Fajriyah Jamri Rifa’atul Mahmudah Rimala Sanipurnama Kindkasman Rini Hamsidi Ruben, Sony Ruslin Ruslin Ruslin , Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin, R Ruslin, Ruslin Rusman, Arman Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin, S Sami, Fitriyanti J. Sarmita, Sarmita Septiyana, Wanda Sida, Nurramadhani A. Sida, Nurramdhani A. Siti Ruhima Sitti Raodah Nurul Jannah Soleman, Imelda Sarda Sudiman, Aswan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan, Sunandar Sundar Ihsan Sundar Ihsan Suprianti, Rani Suriani Suriani Suryani Suryani Suryani, S Syamsiar, Syamsiar Syamsu Nur, Syamsu Tri Handayani Trinovitasari, Nita Vica Aspadiah Vica Aspadiah W Wahyuni, W Wa Ode Dian Indrayanti Wanda Hamidah Wardana, Gede Yogi Prana Wiwied Ekasari Yamin Yamin , Yamin Yamin Yamin, Y Zubaydah, Wa Ode Sitti