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The effect of salung leaf extract (Psychotria viridiflora) on blood glucose levels in mice Dara, Niki Dwi Dia; Ruyani, Aceng; Wardana, Rendy Wikrama; Mayub, Afrizal; Karyadi, Bhakti
Jurnal Penelitian Saintek Vol 30, No 2 (2025)
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v30i2.87757

Abstract

This research is crucial in the context of the rising global prevalence of diabetes, a metabolic disorder that significantly affects public health. This study aims to determine the effect of salung leaf extract (Psychotria viridiflora) on blood glucose levels in hyperglycemic mice (Mus musculus). The study used 25 mice (Mus musculus) weighing 20-40 grams, divided into 5 treatment groups (P). Each group consisted of 5 mice, including a negative control, positive control, and three experimental groups with the administration of P. viridiflora extract at various doses (0.0112; 0.0225; and 0.0337 g/kgBW). Blood glucose measurements were conducted four times, on days 0, 6, 12, and 18, which included an initial glucose measurement, post-alloxan induction, and subsequent measurements after treatment. Among the three tested doses, the highest dose (0.0337 g/kg BW) proved to be the most effective in reducing blood sugar levels in alloxan-induced M. musculus, with effectiveness comparable to the standard drug Glibenclamide. Thus, the extract of P. viridiflora leaves shows strong potential as an alternative herbal antidiabetic therapy for M. musculus.
POTENTIALS OF BENGKULU’S LOCAL BIOMASS FOR BIOETHANOL PRODUCTION: A SYSTEMATIC LITERATURE REVIEW Heryensi, Elza; Ruyani, Aceng; April Yanti, Fitri; Wikrama Wardana, Rendy; Lutfi Firdaus, M
Physics and Science Education Journal (PSEJ) Physics and Science Education Journal (PSEJ), Volume 5 Number 3, December 2025
Publisher : Physics Education Departement, Islamic State University Sulthan Thaha Saifuddin Jambi - Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30631/t2b9ec11

Abstract

The development of bioethanol based on local biomass is an important strategy to support national energy diversification. Still, the potential of Bengkulu biomass and its technical feasibility have not been systematically studied. This study aims to analyze the potential of cassava waste, coconut coir, oil palm empty fruit bunches (OPEFB), and water hyacinth as raw materials for second-generation bioethanol production, and to identify the multidimensional challenges associated with their conversion processes. The method employed is a Systematic Literature Review (SLR) with a qualitative thematic synthesis, based on the PRISMA 2020 guidelines. The search was conducted across five major databases (Scopus, Web of Science, ERIC, IEEE Xplore, and ScienceDirect) with a publication range of 2018-2025, resulting in 414 articles. Twelve articles met the criteria after a quality assessment using MMAT. The results indicate that the utilization of local biomass in Bengkulu remains fragmented. However, there is significant technical potential, including an ethanol yield of 75-180 L/ton of cassava waste, coconut coir through pretreatment with DES/NADES, OPEFB ±10% (v/v) with adaptive yeast, and water hyacinth at 7-8 g/L through SSF. The study offers a multi-feedstock conceptual framework and recommends pilot plants, LCA analyses, and economic studies to support sustainable regional implementation.
Pengaruh Pemberian Ekstrak Daun Salung (Psychotria viridiflora) terhadap Glukosa Darah Mencit (Mus musculus) Niki Dwi Dia Dara; Aceng Ruyani; Rendy Wikrama Wardana; Afrizal Mayub; Bhakti Karyadi
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 8 No. 5 (2025): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/zj7jqp95

Abstract

This study aimed to determine the effect of salung (Psychotria viridiflora) leaf extract on blood glucose levels in hyperglycemic mice (Mus musculus). A total of 25 mice weighing 20–40 grams were divided into five treatment groups: P1 (negative control: feed and distilled water), P2 (alloxan 10 mg/kg BW + glibenclamide 0.1 mg/kg BW), P3 (alloxan 10 mg/kg BW + P. viridiflora leaf extract 0.0112 g/kg BW), P4 (alloxan 10 mg/kg BW + P. viridiflora leaf extract 0.0225 g/kg BW), and P5 (alloxan 10 mg/kg BW + P. viridiflora leaf extract 0.0337 g/kg BW). Blood glucose levels were measured four times—on days 0, 6, 12, and 18—covering baseline measurement, post-alloxan induction, and after treatment administration. The results showed that the highest dose (0.0337 g/kg BW) was the most effective in reducing blood glucose levels in alloxan-induced mice, with an effect comparable to the standard drug glibenclamide. In conclusion, P. viridiflora leaf extract has potential as an alternative herbal antidiabetic therapy in M. musculus.  Keywords: Antidiabetic, Blood Glucose, Extract Leaf, Hyperglycemia, Mus musculus, Psychotria viridiflora
Pemberian Jus Buah (Etlingera hemisphaerica) terhadap Pemulihan Eritrosit dan Leukosit Akibat Perlakuan Merkuri Klorida (HgCl2) pada Mencit (Mus musculus) Fatimah Azzahrah; Aceng Ruyani; Deni Parlindungan; Arsela Eko Listiono; Afrizal Mayub
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 8 No. 5 (2025): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/7ef7hb33

Abstract

This study aims to determine the effect of Etlingera hemisphaerica (honje) fruit juice on the recovery of erythrocyte and leukocyte counts in mice (Mus musculus) exposed to mercuric chloride (HgCl₂). The method used was an experimental design using male mice as test animals, divided into three groups: K1 (control), K2 (honje juice 0.3 mL/20 g BW for 3 days), and K3 (HgCl₂ 5 mg/kg BW + honje juice 0.3 mL/20 g BW for 3 days). The observed parameters were the number of erythrocytes and leukocytes before and after treatment. The results showed that honje juice administration increased the erythrocyte count in group K2, while in group K3, erythrocyte recovery was affected by mercury exposure, making the honje juice less effective, although the values remained within the normal range compared to the control group. In leukocyte count, group K2 showed a stabilizing effect, whereas group K3 experienced an increase due to HgCl₂ exposure. In conclusion, Etlingera hemisphaerica fruit juice has potential as a phytotherapy agent to repair hematological damage caused by heavy metal toxicity, although its effectiveness is influenced by the metabolic condition of the mice and the high concentration of mercury. Keywords: Etlingera hemisphaerica, Erythrocytes, Leukocytes, Mice, Mercuric Chloride
Praktik Pembuatan Ekoenzim dalam Upaya Menstimulus Pengetahuan dan Peduli Lingkungan pada Siswa SMP: Practice of Making Ecosenzymes In an Effort to Stimulate Environmental Knowledge and Care for Students of SMP Karyadi, Bhakti; Ruyani, Aceng; Mayub, Afrizal; Parlindungan, Deni; Prayogo, Bambang
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 11 No. Suppl-1 (2026): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v11iSuppl-1.9259

Abstract

This community service aims to equip students and teachers of SMP IT Khoiru Ummah Rejang Lebong with knowledge about managing school gardens using household waste through ecoenzymes, natural boosters, and POC. This school has a large area of underutilized land, especially for organic waste management. Household waste is not managed correctly, and most of it is disposed of in landfills, even though it can be processed into valuable products. Converting organic waste into eco-enzymes is expected to reduce waste and create a greener, more environmentally friendly school ecosystem. This training was carried out from April to December 2024, by using the Participatory Action Research (PAR) method, divided into three stages: exploration, provision of materials and practice, and evaluation. The evaluation's student response data show that around 61% of students demonstrated excellent knowledge, 30% good, and 9% sufficient. The level of concern for the environment was very high. The success of this activity was measured by the level of participation and enthusiasm among participants, which reflected the objectives of community service: increasing awareness and skills in waste management. Further evaluation is needed to assess the long-term impacts and to determine how this activity can be implemented outside of school, thereby providing benefits to the surrounding community.
Guardians of the Forest Floor: Learning Conservation from the Asian Forest Tortoise (Manouria emys) Pratama, Ariyoga; Ruyani, Aceng
BIODIVERS - BIOTROP Science Magazine Vol. 5 No. 1 (2026): BIODIVERS Volume 5 No. 1 (2026)
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56060/bdv.2026.5.1.2856

Abstract

Deep within the tropical forests of Southeast Asia, the Asian forest tortoise (Manouria emys) moves with the quiet memory of millions of years. Yet today, its path is threatened by deforestation, illegal trade, and a warming climate. In Bengkulu, Indonesia, the University of Bengkulu’s ex-situ program has successfully increased the survival and breeding success of rescued tortoises, providing controlled habitats where health, behavior, and reproduction can be monitored. Supported by collaboration with the University of North Carolina Greensboro, the program rehabilitates confiscated individuals and prepares them for long-term population recovery. Beyond protecting a species, this initiative transforms conservation into education, where the tortoise becomes a living teacher of patience, empathy, and coexistence.
Life cycle assessment dan keberlanjutan ekonomi-lingkungan produksi bioetanol dari kulit pisang kepok kuning: Systematic review Putri Ramadan Lazuardi; Aceng Ruyani; M. Lutfi Firdaus
Papanda Journal of Mathematics and Science Research Vol. 5 No. 1 (2026): Volume 5 Nomor 1 Maret 2026
Publisher : Papanda Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56916/pjmsr.v5i1.3092

Abstract

This study synthesizes recent findings on the environmental and economic sustainability of banana peel-based bioethanol production using a Life Cycle Assessment (LCA) approach. The utilization of yellow kepok banana peel waste offers significant opportunities to support clean energy transition and sustainable waste management in Indonesia. This research employs a Systematic Literature Review (SLR) method, analyzing 15 peer-reviewed articles indexed in Scopus and SINTA published between 2020 and 2025. The review follows the PRISMA 2020 framework with inclusion criteria focusing on quantitative LCA studies and economic-environmental sustainability aspects. Literature was retrieved from Scopus, ScienceDirect, MDPI, SpringerLink, and SINTA databases using the keywords “banana peel”, “bioethanol”, “LCA”, and “sustainability”. The results indicate that pretreatment and distillation stages are the main contributors to energy consumption and greenhouse gas emissions, accounting for approximately 55–65% of total Global Warming Potential (GWP). However, the implementation of coproduct systems, such as converting residues into biogas or organic fertilizer, can reduce GWP by up to 30–40%. From an economic perspective, banana peel-based bioethanol production is financially viable at a medium scale when supported by renewable energy integration and centralized waste management systems. This study highlights the critical role of LCA as an evaluation tool for waste-based energy development and underscores the need for national standards for LCA methodologies in the bioenergy sector. To the best of our knowledge, this is the first comprehensive SLR integrating LCA and economic-environmental sustainability analysis for yellow kepok banana peel bioethanol, providing relevant insights for renewable energy policy and circular waste management in Indonesia.
EKSTRAK PISANG BARLIN (Musa acuminata AA.) SEBAGAI ANTI HIPERKOLESTROLEMIA PADA MENCIT (Mus musculus) Simamora, Johannes Anju Gabriel; Ruyani, Aceng; Karyadi, Bhakti; Winarni, Endang Widi; Johan, Henny
EDUPROXIMA : Jurnal Ilmiah Pendidikan IPA Vol 7, No 4 (2025)
Publisher : Universitas Bhinneka PGRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29100/.v7i4.8678

Abstract

Kolesterol dibutuhkan tubuh dalam jumlah tertentu, namun jika berlebihan dapat menyebabkan hiperkolesterolemia yang berisiko memicu penyakit jantung, stroke, dan gangguan kesehatan lainnya. Penelitian ini bertujuan untuk mengevaluasi efek anti-hiperkolesterolemia dari ekstrak pisang Barlin (Musa acuminata AA) pada mencit jantan (Mus musculus). Sebanyak 25 ekor mencit dibagi dalam lima kelompok perlakuan selama 28 hari, termasuk kelompok K (-) kontrol negatif, pakan standar, K (+) kontrol positif pakan standar, Pakan Tinggi Lemak (PTL) dengan Simvastatin 20 mg/kg BB, P(1) diberi pakan standar, PTL, ekstrak kulit M acumniata AA 0,4 mL/kg BB, P(2) diberi pakan standar, PTL, ekstrak buah M acumniata AA 0,4 mL/kg BB, dan P(3) diberi pakan standar, PTL, ekstrak kulit dengan buah M acumniata AA 0,4 mL/kg BB. Parameter yang diamati meliputi berat badan serta kadar kolesterol total (CT), trigliserida (TG), HDL, dan LDL menggunakan alat Autocheck Cholesterol Strips/ Lipid Pro. Hasil menunjukkan bahwa pemberian ekstrak buah M. acuminata AA secara signifikan menurunkan CT, TG, dan LDL, serta meningkatkan HDL, dengan efek setara Simvastatin. Ekstrak kulit dan kombinasi buah dengan kulit menunjukkan efektivitas lebih rendah. Kesimpulannya ekstrak buah M. acuminata AA berpotensi sebagai agen anti-hiperkolesterolemia, diduga karena kandungan pati resisten, flavonoid, magnesium, dan saponin yang tidak ditemukan pada ekstrak kulit.
Strategi Konservasi Integratif Kura-Kura Raksasa (Orlitia borneensis) sebagai Upaya Mitigasi Kepunahan di Provinsi Bengkulu Reza Wahyuni; Aceng Ruyani
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 13 No 1 (2026): APRIL 2026
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v13i1.28498

Abstract

Keanekaragaman hayati sangat penting bagi kelangsungan hidup setiap makhluk hidup. Sekitar 356 kura-kura ditemukan hidup di daratan benua kecuali di Antartika, serta di air laut dan air tawar dengan 14 famili. Salah satu jenis kura-kura yang terdapat di Provinsi Bengkulu adalah jenis Orlitia borneensis (Kura Bajuku/Byuku/Gading/Raksasa) terancam punah. Penulisan ini bertujuan memberikan literasi atau referensi dengan metode kepustakaan (library reseairch) mengenai krusialitas dan eksotisme jenis yang terancam punah dengan tiga hal cakupan penting, yakni perlindungan dengan badan krusial seperti CITES, IUCN dan Peraturan landasan hukum eksploitasi dan non hukum seperti perlindungan jenis dari infeksi dan wabah penyakit, pelestarian dengan konservasi in situ dan ex situ seperti TLC UNIB Bengkulu dan pemanfaatan sesuai dengan fungsi alaminya di alam dalam keseimbangan ekosistem, rantai dan jarring-jaring makanan yang dilakukan dengan pembentukan atau pembangunan penangkaran budidaya kura-kura untuk keperluan ekonomi tanpa harus melakukan tangkap dari alam yang menyebabkan kepunahan jenis tersebut.
BIBLIOMETRIK RISET TEKNOLOGIKAL PEDAGOGI, PEMECAHAN MASALAH, DAN LABORATORIUM VIRTUAL DALAM PENDIDIKAN SAINS Desy Hanisa Putri Johan; Nurul Astuty Yensi; Aceng Ruyani; Fitri April Yanti
Jurnal Kumparan Fisika Vol. 9 No. 1: April 2026
Publisher : Unib Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/jkf.9.1.1-8

Abstract

ABSTRAK   Penelitian ini bertujuan untuk memetakan perkembangan, keterkaitan konseptual, dan arah penelitian dalam tiga domain utama, yaitu teknologikal pedagogi, pemecahan masalah, dan laboratorium virtual dalam pendidikan sains. Penelitian ini menggunakan pendekatan bibliometrik dengan menganalisis 143 artikel yang diperoleh dari basis data internasional dan telah dibersihkan menggunakan OpenRefine. Analisis dilakukan menggunakan perangkat lunak VOSviewer untuk menghasilkan peta visual yang menggambarkan hubungan antarkata kunci, kluster penelitian, serta struktur tema dominan. Hasil analisis menemukan empat kluster utama, yaitu kluster laboratorium virtual, kluster Pemecahan masalah (problem solving), kluster technological pedagogy (TPACK), dan kluster keterlibatan peserta didik dalamm proses pembelajaran (learning process student engagement). Kluster laboratorium virtual muncul sebagai kluster terbesar, menunjukkan bahwa penggunaan simulasi dan eksperimen digital telah menjadi fokus utama dalam inovasi pembelajaran sains. Kluster Pemecahan masalah memiliki keterkaitan kuat dengan laboratorium virtual, menunjukkan bahwa teknologi eksperimen digital mampu mendukung pengembangan keterampilan berpikir tingkat tinggi. Sementara itu, kluster technological pedagogy (TPACK) menegaskan pentingnya kompetensi guru dalam mengintegrasikan teknologi, meskipun keterkaitannya dengan laboratorium virtual masih menunjukkan ruang penelitian yang belum tergarap optimal. Selain itu, kluster keterlibatan peserta didik (student engagement) mengungkapkan bahwa keberhasilan teknologi pembelajaran sangat bergantung pada tingkat keterlibatan peserta didik. Secara keseluruhan, penelitian ini memberikan gambaran komprehensif mengenai arah penelitian global serta mengidentifikasi peluang penelitian baru yang mengintegrasikan TPACK, laboratorium virtual, dan Pemecahan masalah (problem solving) sebagai pendekatan pembelajaran sains yang berorientasi pada kompetensi abad ke-21.   Kata  kunci : Laboratorium Virtual, Pemecahan Masalah, TPACK   ABSTRACT   This study aims to map the development, conceptual relationships, and research directions within three major domains: technological pedagogy, problem solving, and virtual laboratory in science education. A bibliometric approach was employed by analyzing 143 articles retrieved from international databases and refined using OpenRefine. VOSviewer software was used to generate visual network maps representing keyword relationships, research clusters, and dominant thematic structures. The results identified four main clusters: the virtual laboratory cluster, the problem solving–critical thinking cluster, the technological pedagogy (TPACK) cluster, and the learning process–student engagement cluster. The virtual laboratory cluster emerged as the largest, indicating that digital simulations and virtual experiments have become a major focus of innovation in science learning. The strong linkage between problem solving and virtual laboratory suggests that digital experimentation supports the development of higher-order thinking skills. The technological pedagogy cluster highlights the importance of teachers’ technological integration competence, although its linkage to virtual laboratory use remains limited, revealing a potential research gap. Meanwhile, the student engagement cluster indicates that the effectiveness of digital learning technologies is strongly influenced by learners’ cognitive and emotional involvement. Overall, this study provides a comprehensive overview of global research trends and identifies future research opportunities that integrate TPACK, virtual laboratory environments, and problemsolving approaches to support 21st century science learning.   Keywords: problem solving,  technological pedagogy, problem solving, virtual laboratory
Co-Authors Abas Abas, Abas Abdul Rahman Abdul Rahman Singkam Afrizal Mayub Ananda, Resti Annisa Puji Astuti April Yanti, Fitri Ariefa Primair Yani Ariefa Primair Yani Arsela Eko Listiono ASTUTI, ANNISA PUJI Athika Ulfah Putri Bambang Prayogo, Bambang Bella, Anisa Bhakti Karyadi Bhakti Karyadi BHAKTI KARYADI BHAKTI KARYADI Budi Maryani Budiyanto Budiyanto Budiyanto Budiyanto Cally Piramida, Cally CHOIRUL MUSLIM Choirul Muslim CHOIRUL MUSLIM Cut Kandy Safiera Dara, Niki Dwi Dia Defianti, Aprina Deka Agustina Delviastri Widyana Deni Parlindungan Deni Parlindungan Desy Hanisa Putri Johan Dewi , Deshinta Arrova Dewi, Novi Ratna Diah Suprihatin Dwi Mentari Dwita, Uci Rahma Elsi Adelia Fitri Elsi Adelia Fitri Elvida Sari Yunilarosi Endang Widi Winarni Endang Widi Winarni Enny Nugraheni Eria Irmawati Erik Perdana Putra Erna Yunita Sari Fahmizal, Fahmizal Fannyda, Raidatul Fatimah Azzahrah Febrian, Intan Fema Anggriani Fitri April Yanti Fitri April Yanti, Fitri April Ginting, Nesty Apulina Br Hardiansyah, Akbari Harlita Hartuti, Endah Dwi Haryono, M. Henny Johan Henny Johan Heriwati Heriwati Herlina Herlina HERNANI - HERRY HARYANTO Hery Haryanto Hery Suhartoyo Hery Suhartoyo Hery Suhartoyo Heryensi, Elza Hilda Taurina Husein, Ahmad Saddam ICE PURNAMAWATI Iman Rusmana Indah Maryani Irwan Koto, Irwan Irwandi Ansori Irwandi Ansori Iskandar, Aiza Sabina Putri Isytigfarini, Anisah Putri Jabidi Jabidi Julianti, Apri Julita Pasaribu Jumiarni, Dewi Kartika Sari Kasrina Kasrina Khairunnisa Kurniani, Riska Lazfihma, Lazfihma Leditiya Lestari Lia Anggraini Lien A. Sutasurya Lily Ismaini Lingga, Rahmad Liya Agustin Umar Lutfi Firdaus, M M. Lutfi Firdaus M. Lutfi Firdaus, M. Lutfi Marisadonna Asteria Marliansa, Meiredo Maryani, Budi Mayshah Purnamasari Mayub, Afrizal MUSNI MARNIS NADYA NADYA Naintyn Novitasari, Naintyn Niki Dwi Dia Dara Nurcahyani Nurhamidah Nurleli Nurleli Nurma Yunita Indriyanti Nursa'adah, Euis Nursaadah, Euis Nursa’adah, Euis Nurul Astuty Yensi Nur’azizah Prihatiningsih Palindungan, Deni Parlindungan, Deni Pratama, Ariyoga Primair Yani, Ariefa Purnama, Intan Putri Ramadan Lazuardi Putri, Zakyya Septiana R. R. Sri Astuti Rahyuni Rahyuni Rani, Silvia Reka Susanti Rendy Wikrama Wardana Rendy Wirakrama Reza Wahyuni Rica Yuniar Tanjung Rika Partika Sari Roni Sastiawan Safniyeti Safniyeti Santi Nurul Kamilah Saputra, Fajar Eko Sari, Anjeli Rama Sari, Fenty Fitrian Sari, Gina Aprella Sari, Intan Indah Sari, Nurma Yunita Selpiya, Mega Shabrina, Annida Nurul Sherlo Maulana Simamora, Johannes Anju Gabriel Sipriyadi Siti Habiburrahmah Ash Shadar Sitorus, Lizken Sonia, Gina Sri Sudarwati Sukarso, A. A. Sukarso, A.A. Sumiyati - Sumpono Sumpono Sutarno Sutarno Sutarno Sutarno Sutarno, M. Sylvia Rianissa Putri Tendri Ayu Putri Tomi Hidayat, Tomi Trisna, Dwi Martha Uliyandari, Mellyta Untung Priadi Urip Santoso Wahyuni, Reza Wardana, Rendy Wikrama Wibowo, Risky Hadi Widia Gusti Wikrama Wardana, Rendy Wiryono Wiryono Wiryono, Wiryono Wulandari, Cessi Yennita Yulinda Fitriani Yunita Arianti Zamzaili Zamzaili Zamzaili Zamzaili