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Journal : MEDICINUS

Nanobubbles for Precision Oncology Zumratul Rabbani, Khadijah; Dwi Laksono, Pudjo Dwi Laksono; Anurogo, Dito
MEDICINUS Vol. 39 No. 1 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/gsz6t860

Abstract

Nanobubbles (NBs) represent a unique class of sub-200 nm carriers that integrate deep tissue penetration with ultrasound (US)-responsive functionality, offering opportunities for simultaneous imaging, oxygenation, and therapeutic delivery in solid tumors. This review synthesizes the physicochemical principles governing NB stability with translational designconsiderations, including interfacial charge, free-lipid content, bubble spacing, and zeta (ζ)-potential as determinants of uptake and cytotoxicity. Particular emphasis is placed on gas-based payloads: oxygen nanobubbles for alleviating tumor hypoxia and carbon monoxide-releasing molecules (CO-RMs), nitric oxide (NO), and hydrogen sulfide (H₂S) for redoximmunometabolicmodulation within hormetic dose windows. Preclinical data demonstrate that oxygen nanobubbles enhance radiotherapy and chemotherapy responses by reversing hypoxia-induced resistance, while CO, NO, and H₂Sdonors—delivered in biphasic, dose-sensitive ranges—enable immunomodulation and reprogramming of the tumor microenvironment. We further distill case-level evidence (e.g., IR780–docetaxel nanobubbles in pancreatic cancer) intopractical design rules and discuss engineering levers such as shell composition, crosslinking chemistry, and acoustic parameterization. Finally, this review outlines translational roadmaps covering scalable manufacturing, imaging-guideddosimetry, and early-phase clinical strategies. Collectively, nanobubble-based, gas-augmented, ultrasound (US)-triggered systems represent an emerging precision platform with the potential to transition from experimental prototypes towardcontrolled clinical evaluation in oncology.
Co-Authors Abdul Rahim Abdul Rahman Rahim Adhy Firdaus Agus Gunawan Ainun Jariyah Albertus Ata Maran Albina Bare Telan, Albina Bare Amansyah, Farid Ami Febriza Andari, Soetji Andarmoyo, Sulistyo Anis Fauzi, Anis Arda, Darmi Ardi, Abdullah Aripa, Lusyana Arli Aditya Parikesit Asbath Said Auliah, Rezki Awaliah, Nur Rahmah Bahjah, Dzata Bambang Winardi Bansaleng, Yessikah Feiby Borut, Mohamad Budhy Munawar Rachman Buka, Sisilia Prima Yanuaria Dadang Muhammad Hasyim Dewantara, Muhammad Iqbal Dwi Laksono, Pudjo Dwi Laksono Ekawati, Nur Eko Prastyo Eni Kurniati, Eni Erlinawati, Noor Diah Ernita Sari Fachry Abda El Rahman Farooq Mujahid, Muhammad Umer Farzani, Dwi Andina Fatany, Alief Ihram Fitria, Anni Fitriani, Fenny Gangga Anuraga Gonzales, Samantha Guilin, Xie Habibi Habibi Hani Brilianti Rochmanto Hardin La Ramba Harfika, Meiana Harmanto Harmanto Harris, Oliver Hasibuan, Evis Ritawani Haulussy, Rais Rahman Heni Widyaningsih, Heni Herlambang Prehananto, Herlambang Hermansyah Hermansyah Hidayati, Nanda Hijrah Hijrah Hiola, Siti Fatmah Ibad, M. Nashoihul Ibrahim, Juliani Idris Idris Ikrar, aruna Ikrar, Taruna Ilmi, Ahmad Alfarobi Jauharul Indra, Indra Intes, Amina Iwan Harsono Jia Yi Wang (王 家儀) , Jia Yi Wang Joko Sangaji Judijanto, Loso Junaedi, J Juwariyah, Siti K, Fitriani. Kao, Tzu-Jen Karimah, Annisa Ayu Kasmiati Kasmiati Kerwanto Khairunnisa Khairunnisa Krit, Pong Kurniawati Kurniawati Latif, Sarifudin Andi Lek, Siri Leli, Leli lidia fitri, lidia Mahendika, Devin Mappanyompa, Fatimah Mardikawati, Budi MAURITZ PANDAPOTAN MARPAUNG Mohamad Firdaus Mudrika Mudrika Muhammad Azhar Irwansyah Muhammad Hanif Muhtadi, Muhamad Ammar Mulyadi, Amelia Astrid Muntasir, Muntasir Musiana, Musiana Muslimin Muslimin Nabila Diyana Putri Nelly Nelly ningrum, dedah - Nunung Suryana Jamin Nur Faidah, Nur Nur Hasanah Nuralfin Anripa Nurkhalika, Rachmi Nurmila, Nurmila Nursiah, Andi Nursinah, A. Pannyiwi, Rahmat Parikesit, Arli A Puspita, Kori R. Rusli Rachman , Budhy Munawar Rahagia, Rasi Rahmat, Rezqiqah Aulia Reyes, Maria Clara Rieuwpassa, Sarmalina Rina Inda Sari Rini Nuraini, Rini Rini Susanti Rosdiana Rosdiana Saad, Rahmiyani Sahabuddin, Rosdiana Sakriawati, Sakriawati Salsabila, Anindya Samsani, Samsani Santos, Luis Saprudin, Udin Sardi Anto Sasmita, Niken Sasadhara Sembiring, Rinawati Sipahutar, Pongki Siti Aisyah Smith, James Sobihah, Hani Solehudin, Solehudin Sompa, Andi Weri Srifitayani, Nur Rahma Suarni, Agusdiwana Suat, Hatty Suat, Rahmawati Sulaeman Sulaeman SULASMI ANGGO Sulfiani, Sulfiani Sumarauw, Jeane L.I. Sumerli A, Chevi Herli Syahrir, Andi Karlina Syarif, Abdillah Syarif, Ubed Abdilah Tyas Putri Utami Ulfah Mahardika Pramono Putri Utami, Dia Rejeki Verawati Verawati Wahidin Wahidin Wilanda, Alifah Ximenis, Virgolie Diknas Yakobus, I Ketut Yamtana Yamtana, Yamtana Yanik, Carri Noer Fida Yermi, Yermi Yusraa, Yusraa Zani, Benny Novico Zohriah, Anis Zulham, Zulham Zulhan Widya Baskara Zumratul Rabbani, Khadijah