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Socialization of the Level of Public Awareness and Knowledge about the Benefits of Kombucha Tea in Overcoming Sleep Paralysis During the COVID-19 Pandemic Yuneka Saristiana; Fendy Prasetyawan; Chadra Arifin; Widhi Astutik; Wahyu Ariawan; Achmad Wahdi
Abdimas Paspama Vol. 2 No. 1 (2023): Abdimas Paspama, December 2023
Publisher : Abdimas Paspama

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The COVID-19 pandemic has profoundly impacted global public health, prompting a heightened focus on both physical and mental well-being worldwide. In this uncertain landscape, sleep paralysis has emerged as a notable health concern, characterized by the inability to move or speak upon waking or falling asleep, often accompanied by distressing hallucinations. With stress levels on the rise during the pandemic, cases of sleep paralysis have shown an upward trend. Conversely, probiotic beverages like kombucha tea have garnered attention for their potential health benefits, including digestive improvement, enhanced energy levels, and better sleep quality. Despite these benefits, public awareness regarding kombucha tea's efficacy in addressing sleep paralysis remains limited.To address this knowledge gap, a community service program has been developed to educate the public about kombucha tea's potential in managing sleep paralysis amidst the COVID-19 pandemic. The program involves collaboration with local communities, health institutions, and experts in mental health and nutrition. Scheduled for January 2021, the program will be executed across various locations, engaging community members and fostering dialogue on sleep health and nutrition. Preliminary results indicate a significant improvement in public understanding of sleep paralysis and kombucha tea benefits post-program. Participants exhibited heightened awareness of symptoms, causes, and treatment options for sleep paralysis, as well as a better grasp of kombucha tea's health advantages. Practical workshops on kombucha tea preparation garnered considerable interest, signaling a potential shift towards healthier lifestyle choices among participants.

Optimalisasi Peran Pengajar Farmasi melalui Edukasi Implementasi Pelayanan Kefarmasian dalam Rangka Persiapan Kompetensi Fendy Prasetyawan; Yuneka Saristiana; M Wahyu Ariawan; Ratna Mildawati
Jurnal Pengabdian Inovatif Multidisipliner Vol. 1 No. 02 (2026): ISSUE APRIL
Publisher : Jurnal Pengabdian Inovatif Multidisipliner

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Pelayanan kefarmasian merupakan bagian penting dalam sistem pelayanan kesehatan yang menuntut tenaga kefarmasian memiliki kompetensi profesional yang memadai. Tenaga pengajar farmasi memiliki peran strategis dalam membentuk kompetensi mahasiswa sehingga perlu memiliki pemahaman yang baik mengenai implementasi pelayanan kefarmasian. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kompetensi tenaga pengajar farmasi melalui kegiatan edukasi mengenai implementasi pelayanan kefarmasian. Kegiatan dilaksanakan pada tanggal 28 Februari 2026 di Gedung Adipadma II Institut Ilmu Kesehatan Bhakti Wiyata Kediri dalam rangka acara briefing komponen pelaksanaan Ujian Kompetensi Apoteker Indonesia (UKAI) Apoteker dengan jumlah peserta sebanyak 12 tenaga pengajar farmasi dari Universitas Kadiri dan Institut Ilmu Kesehatan Bhakti Wiyata Kediri. Metode kegiatan menggunakan pendekatan edukatif partisipatif melalui penyampaian materi, diskusi interaktif, serta evaluasi menggunakan pre-test dan post-test. Hasil kegiatan menunjukkan adanya peningkatan nilai rata-rata peserta dari 62,50 pada pre-test menjadi 85,42 pada post-test dengan nilai N-Gain sebesar 0,61 yang termasuk dalam kategori efektivitas sedang hingga tinggi. Hasil ini menunjukkan bahwa kegiatan edukasi yang dilaksanakan mampu meningkatkan pemahaman tenaga pengajar farmasi secara signifikan mengenai konsep dan implementasi pelayanan kefarmasian. Kegiatan ini diharapkan dapat meningkatkan kompetensi tenaga pengajar farmasi sehingga mampu mengintegrasikan konsep pelayanan kefarmasian dalam proses pembelajaran dan mendukung terbentuknya tenaga kefarmasian yang profesional.

Edukasi Menjaga Pola Hidup Sehat Tentang Penyakit Diabetes Melitus dan Hipertensi Pada Era COVID-19 Di Car Free Day Kota Kediri Fendy Prasetyawan; Devangga Darma Karingga Karingga; Yuneka Saristiana; Ratna Mildawati; Widhi Astutik
Interaksi : Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 1 (2024): Interaksi - Juni
Publisher : PT. Faaslib Serambi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66341/interaksi.v1i1.26

Implementasi edukasi pola hidup sehat terkait diabetes melitus dan hipertensi selama pandemi COVID-19 melibatkan persiapan, pelaksanaan, dukungan, dan kolaborasi. Materi edukasi komprehensif disampaikan melalui sesi tatap muka dan virtual serta media sosial. Evaluasi menunjukkan peningkatan signifikan dalam pengetahuan, sikap, dan perilaku kesehatan peserta. Program ini mendorong adopsi pola makan seimbang, aktivitas fisik rutin, dan manajemen stres efektif. Kolaborasi dengan organisasi kesehatan dan komunitas lokal memperluas jangkauan program. Meskipun dihadapi tantangan seperti pembatasan sosial dan akses terbatas, solusi adaptif telah diterapkan untuk memastikan kelangsungan program. Evaluasi kontinu dan adaptasi strategi mendukung upaya program dalam mencapai perubahan positif dalam kesehatan masyarakat.

The Role of the NF-kB Pathway and Oxidative Stress Markers in the Protective Effects of Peperomia pellucida in a Gastroenteritis Model Lisa Savitri; Fendy Prasetyawan; Yuneka Saristiana; Elfred Rinaldo Kasimo; Rochmad Krissanjaya; Cornelia Amanda; Konradus Klala Mebung
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.803-808

Gastroenteritis is a common gastrointestinal disorder characterized by intestinal inflammation, epithelial damage, and oxidative stress. Activation of the nuclear factor kappa B (NF-kB) signaling pathway and excessive production of reactive oxygen species play key roles in its pathogenesis. Peperomia pellucida is a medicinal plant traditionally used for inflammatory and gastrointestinal conditions; however, its molecular mechanisms of action remain poorly understood. This study aimed to investigate the protective effects of P. pellucida extract in an experimental gastroenteritis model, with a particular focus on NF-kB pathway modulation and oxidative stress markers. Gastroenteritis was induced in experimental animals, followed by oral administration of P. pellucida extract at different doses. NF-kB p65 expression was assessed using molecular analysis, while oxidative stress was evaluated through malondialdehyde levels and antioxidant enzyme activities, including superoxide dismutase and catalase. Histopathological examination of intestinal tissue was also performed. The results demonstrated that P. pellucida treatment significantly suppressed NF-kB p65 activation, reduced lipid peroxidation, restored antioxidant enzyme activities, and improved intestinal histopathological features compared to the untreated gastroenteritis group. These findings indicate that P. pellucida confers intestinal protection by attenuating inflammation and oxidative stress, supporting its potential as a natural therapeutic agent for gastroenteritis.

IN SILICO EVALUATION OF FLAVONOIDS FROM ACALYPHA INDICA L. AS Α-GLUCOSIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS Lisa Savitri; Kharisul Ihsan; Fendy Prasetyawan; Yuneka Saristiana; Imam Agus Faizal; Meri Meri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

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Type 2 diabetes mellitus continues to pose a significant global health burden, highlighting the urgent need for safer and more effective therapeutic agents with minimal adverse effects. One promising strategy involves targeting α-glucosidase, a key enzyme in postprandial glucose regulation, using bioactive compounds derived from medicinal plants. Acalypha indica, a tropical species widely used in traditional medicine, contains diverse flavonoids with potential antidiabetic activity; however, their molecular mechanisms remain insufficiently explored. This study employed an in silico approach to systematically evaluate the α-glucosidase inhibitory potential of five flavonoids from A. indica—mauritanin, repandusinic acid, hesperetin, glucogalin, and acaindinin. Molecular docking analysis using AutoDock revealed that all compounds exhibited favorable binding affinities toward the α-glucosidase enzyme (PDB ID: 5NN8), indicating spontaneous interactions at the active site. Among them, mauritanin demonstrated the highest binding affinity (–10.3 kcal/mol), forming multiple stabilizing hydrogen bonds with critical catalytic residues, including ASP69, HIS279, and GLU411. Notably, both mauritanin and repandusinic acid showed stronger binding interactions compared to the standard inhibitor acarbose, suggesting superior inhibitory potential. Further interaction analysis using LigPlot+ and Discovery Studio Visualizer confirmed stable ligand–enzyme complex formation, while ADMET predictions using SwissADME indicated favorable pharmacokinetic properties, including good oral bioavailability, low toxicity risk, and absence of major cytochrome P450 inhibition. Overall, these findings identify mauritanin and repandusinic acid as promising lead compounds for α-glucosidase inhibition and support the therapeutic potential of A. indica as a natural source for antidiabetic drug development. This study provides a strong computational foundation for future experimental validation and drug design efforts.

IN SILICO MOLECULAR TARGETING AND ADMET PROFILING OF BETA-SITOSTEROL AS A MULTI-TARGET THERAPEUTIC CANDIDATE Fendy Prasetyawan; Yuneka Saristiana; Lisa Savitri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

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Beta-sitosterol is a naturally occurring phytosterol with potential biological activities, including anticancer effects. This study aimed to evaluate the pharmacokinetic characteristics and molecular targets of beta-sitosterol using in silico approaches involving ADMET analysis and target prediction. The ADMET results indicated that beta-sitosterol exhibited favorable membrane permeability and high absorption potential; however, it demonstrated poor aqueous solubility and high plasma protein binding, which may affect its bioavailability. Additionally, metabolic prediction suggested potential involvement of cytochrome P450 enzymes in beta-sitosterol biotransformation. Target prediction analysis revealed that beta-sitosterol may interact with multiple proteins involved in lipid metabolism and hormonal regulation. The highest predicted affinity was observed toward NPC1L1, a protein involved in cholesterol absorption, as well as nuclear receptors including LXR-α, ROR-γ, and androgen receptor, which regulate lipid metabolism and hormone signaling. Furthermore, beta-sitosterol was predicted to interact with HMG-CoA reductase and several cytochrome P450 isoforms involved in cholesterol biosynthesis and steroidogenesis. The findings suggest that beta-sitosterol possesses a multi-target profile associated with lipid metabolism and hormonal regulation pathways.

IN SILICO PREDICTION OF BIOACTIVE TARGET CLASSES AND ADMET PROFILE OF CAPSAICIN WITH RELEVANCE TO DAYAK CHILI (Capsicum frutescens L.) Yuneka Saristiana; Fendy Prasetyawan; Lisa Savitri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

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Capsaicin is a well-known bioactive compound present in various Capsicum species, including Dayak chili (Capsicum frutescens L.). This study aimed to predict the bioactive target classes and ADMET profile of capsaicin using an in silico approach. The chemical structure of capsaicin was retrieved from the PubChem database and analyzed using SwissTargetPrediction, SwissADME, and pkCSM platforms. The prediction results indicated that capsaicin interacts with multiple protein classes, including oxidoreductases, cytochrome P450 enzymes, voltage-gated ion channels, G-protein-coupled receptors, hydrolases, phosphatases, kinases, and membrane receptors. High-probability predicted targets included PTGS1, CYP1A2, TRPV1, CNR1, and FAAH, suggesting potential anti-inflammatory, analgesic, neuromodulatory, and metabolic regulatory effects. ADMET analysis demonstrated favorable absorption and distribution characteristics, with predicted hepatotoxicity and hERG II inhibition requiring further investigation. These findings represent computational predictions and should be interpreted cautiously, as in silico results require further experimental validation. Capsaicin demonstrates multi-target potential that may support future pharmacological development and experimental studies.

IN SILICO EVALUATION OF FLAVONOIDS FROM ACALYPHA INDICA L. AS Α-GLUCOSIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS Lisa Savitri; Kharisul Ihsan; Fendy Prasetyawan; Yuneka Saristiana; Imam Agus Faizal; Meri Meri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Type 2 diabetes mellitus continues to pose a significant global health burden, highlighting the urgent need for safer and more effective therapeutic agents with minimal adverse effects. One promising strategy involves targeting α-glucosidase, a key enzyme in postprandial glucose regulation, using bioactive compounds derived from medicinal plants. Acalypha indica, a tropical species widely used in traditional medicine, contains diverse flavonoids with potential antidiabetic activity; however, their molecular mechanisms remain insufficiently explored. This study employed an in silico approach to systematically evaluate the α-glucosidase inhibitory potential of five flavonoids from A. indica—mauritanin, repandusinic acid, hesperetin, glucogalin, and acaindinin. Molecular docking analysis using AutoDock revealed that all compounds exhibited favorable binding affinities toward the α-glucosidase enzyme (PDB ID: 5NN8), indicating spontaneous interactions at the active site. Among them, mauritanin demonstrated the highest binding affinity (–10.3 kcal/mol), forming multiple stabilizing hydrogen bonds with critical catalytic residues, including ASP69, HIS279, and GLU411. Notably, both mauritanin and repandusinic acid showed stronger binding interactions compared to the standard inhibitor acarbose, suggesting superior inhibitory potential. Further interaction analysis using LigPlot+ and Discovery Studio Visualizer confirmed stable ligand–enzyme complex formation, while ADMET predictions using SwissADME indicated favorable pharmacokinetic properties, including good oral bioavailability, low toxicity risk, and absence of major cytochrome P450 inhibition. Overall, these findings identify mauritanin and repandusinic acid as promising lead compounds for α-glucosidase inhibition and support the therapeutic potential of A. indica as a natural source for antidiabetic drug development. This study provides a strong computational foundation for future experimental validation and drug design efforts.

IN SILICO MOLECULAR TARGETING AND ADMET PROFILING OF BETA-SITOSTEROL AS A MULTI-TARGET THERAPEUTIC CANDIDATE Fendy Prasetyawan; Yuneka Saristiana; Lisa Savitri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Beta-sitosterol is a naturally occurring phytosterol with potential biological activities, including anticancer effects. This study aimed to evaluate the pharmacokinetic characteristics and molecular targets of beta-sitosterol using in silico approaches involving ADMET analysis and target prediction. The ADMET results indicated that beta-sitosterol exhibited favorable membrane permeability and high absorption potential; however, it demonstrated poor aqueous solubility and high plasma protein binding, which may affect its bioavailability. Additionally, metabolic prediction suggested potential involvement of cytochrome P450 enzymes in beta-sitosterol biotransformation. Target prediction analysis revealed that beta-sitosterol may interact with multiple proteins involved in lipid metabolism and hormonal regulation. The highest predicted affinity was observed toward NPC1L1, a protein involved in cholesterol absorption, as well as nuclear receptors including LXR-α, ROR-γ, and androgen receptor, which regulate lipid metabolism and hormone signaling. Furthermore, beta-sitosterol was predicted to interact with HMG-CoA reductase and several cytochrome P450 isoforms involved in cholesterol biosynthesis and steroidogenesis. The findings suggest that beta-sitosterol possesses a multi-target profile associated with lipid metabolism and hormonal regulation pathways.

IN SILICO PREDICTION OF BIOACTIVE TARGET CLASSES AND ADMET PROFILE OF CAPSAICIN WITH RELEVANCE TO DAYAK CHILI (Capsicum frutescens L.) Yuneka Saristiana; Fendy Prasetyawan; Lisa Savitri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Capsaicin is a well-known bioactive compound present in various Capsicum species, including Dayak chili (Capsicum frutescens L.). This study aimed to predict the bioactive target classes and ADMET profile of capsaicin using an in silico approach. The chemical structure of capsaicin was retrieved from the PubChem database and analyzed using SwissTargetPrediction, SwissADME, and pkCSM platforms. The prediction results indicated that capsaicin interacts with multiple protein classes, including oxidoreductases, cytochrome P450 enzymes, voltage-gated ion channels, G-protein-coupled receptors, hydrolases, phosphatases, kinases, and membrane receptors. High-probability predicted targets included PTGS1, CYP1A2, TRPV1, CNR1, and FAAH, suggesting potential anti-inflammatory, analgesic, neuromodulatory, and metabolic regulatory effects. ADMET analysis demonstrated favorable absorption and distribution characteristics, with predicted hepatotoxicity and hERG II inhibition requiring further investigation. These findings represent computational predictions and should be interpreted cautiously, as in silico results require further experimental validation. Capsaicin demonstrates multi-target potential that may support future pharmacological development and experimental studies.

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