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All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences Journal of Marine Research Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Pharmacoscript Nusantara Science and Technology Proceedings Jurnal Insan Farmasi Indonesia Current Research on Biosciences and Biotechnology Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Farmasi Sains dan Praktis Pharmaceutical Reports Molekul: Jurnal Ilmiah Kimia Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Jurnal Vokasi Indonesia Borneo Journal of Pharmacy Jurnal Sains dan Teknologi Pangan Biodiversitas Journal of Biological Diversity
Agung Wibawa Mahatva Yodha
Politeknik Bina Husada Kendari
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Education on the Dangers of Environmental Chemical Exposure and Urine Protein Examination as Risk Factors for Impaired Renal Function Among Students at SDN 6 Kendari Firda Yanti; Ani Umar; Jeoun Jung; Kraichat Tantrakarnapa; Sri Aprilianti Idris; Susanti Susanti; Muhammad Azdar Setiawan; Muhammad Sultanul Aulya; Kemal Idris Balaka; Ramadhan Tosepu; Tuti Dharmawati; Angriani Fusvita; Agung Wibawa Mahatva Yodha
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 12, No 1 (2026): Maret
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.103358

Abstract

This community service activity aimed to improve primary school students’ knowledge regarding environmental chemical exposure and kidney health while introducing a simple renal screening approach as an educational awareness tool. The program was conducted in 2023 at Sekolah Dasar Negeri 6 Kendari and involved 30 grade 5 and grade 6 students selected using accidental sampling. The activities consisted of interactive, age-appropriate education sessions and preliminary screening using urine protein dipstick testing, together with serum urea and creatinine measurements. Knowledge scores increased from a mean of 3.13 (SD 1.93) before the education sessions to 8.83 (SD 1.02) after the sessions (p < 0.001), indicating substantial short-term improvement in understanding. Most participants had negative urine protein findings, with a small proportion showing low-level positivity, whereas biochemical values were generally within expected ranges. The screening results are presented descriptively to support awareness and should not be interpreted as a clinical diagnosis or as evidence of impaired renal function. Overall, the activity demonstrates the feasibility of integrating school-based health education with simple screening to promote awareness and engagement, providing a practical model for community health promotion while avoiding overstatement of clinical implications.
Exploring the Anti-Inflammatory Potential of Ethyl Acetate Extract of Lobophytum sp. from Southeast Sulawesi Sea Adryan Fristiohady; Diasty Nuraisya; Lidya Agriningsih Haruna; Parawansah Parawansah; Agung W.M. Yodha; La Ode Muhammad Julian Purnama; Sahidin Sahidin; Rathapon Asasutjarit; Muhammad Hajrul Malaka
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 4 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.4.533-543

Abstract

Compounds derived from marine organisms have gained significant interest for their potential therapeutic effects on inflammatory diseases. Lobophytum sp., a soft coral species, has demonstrated anti-inflammatory properties by inhibiting the production of TNF-α and IL-1β, two crucial cytokines involved in the inflammatory process. This study assessed the anti-inflammatory potential of the ethyl acetate extract of Lobophytum sp. (LEA) using in vivo models. The extract was obtained through maceration using ethyl acetate.  Phytochemical screening identified various bioactive compounds, including flavonoids, alkaloids, and terpenoids, known for their ability to modulate various biological pathways. To evaluate the anti-inflammatory effects, LEA was tested in a mouse model of xylene-induced ear edema, a common assay for inflammation. Diclofenac sodium, a well-known anti-inflammatory drug, was used as a positive control. LEA was administered at a dose of 0.05, 0.1, and 0.2 mg.mL-1. The results revealed that LEA significantly reduced the swelling of the ear and suppressed the release of key pro-inflammatory cytokines, such as TNF-α and IL-1β. The expression levels of IL-1β and TNF-α were measured using the ELISA reader method. These findings suggest that the anti-inflammatory effects of LEA are likely mediated by the modulation of inflammatory signalling pathways, potentially involving the inhibition of cytokine production. The most effective dose in this study was 0.1 mg.mL-1. Overall, the results highlight the promising therapeutic potential of LEA as a natural anti-inflammatory agent. Further investigation is needed to explore the underlying mechanisms of action and evaluate its clinical applications for treating inflammatory diseases.
Chemotaxonomy in the Etlingera Genus from Sulawesi, Indonesia: Design and molecular docking of antioxidant marker RINI HAMSIDI; KARMILAH KARMILAH; NUR SAADAH DAUD; MUHAMMAD HAJRUL MALAKA; AGUNG WIBAWA MAHATVA YODHA; MUSDALIPAH MUSDALIPAH; ARFAN ARFAN; SAHIDIN SAHIDIN
Biodiversitas Journal of Biological Diversity Vol. 25 No. 2 (2024)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d250202

Abstract

Abstract. Hamsidi R, Karmilah, Daud NS, Malaka MH, Yodha AWM, Musdalipah, Arfan, Sahidin. 2024. Chemotaxonomy in the Etlingera Genus from Sulawesi, Indonesia: Design and molecular docking of antioxidant marker. Biodiversitas 25: 449-457. Etlingera is one of the important genera in the Zingiberaceae family because of its potential uses. Several studies have been conducted on the Genus Etlingera as nutraceuticals and drugs. Recently new species have been found in the Sulawesi Region, Indonesia, namely E. canaria A.D.Poulsen and E. echinulate A.D.Poulsen. Based on literature review through sciencedirect and springer link, both species unknown for their chemical and pharmacological content, so it is necessary to continue to reveal the deeper potential. The fruits of E. calophrys (K.Schum.) A.D.Poulsen, E. canaria and E. echinulate were extracted with methanol by maceration method. The chemical content of each extract was analyzed using a Liquid Chromatography Mass Spectrometer (LCMS). Antioxidant activity was tested based on the 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) method. The ability as an antioxidant is proven by the molecular interactions of marker compounds in inhibiting xanthine oxidase. The secondary metabolites contained in the fruit extracts of E. calophrys, E. canaria and E. echinulate are E-p-Coumatic acid, 1,5-Dimethyl citrate, Trimethyl citrate, Crocetin, Tanshinone IIA, Ethinyl Estradiol, Yakuchinone B, Anisalacetone, Yakuchinone A, Nobilin, ?-Estradiol, Momor-cerebroside I, Spinasterone, 12-Hydroxy-methyl abietate, Spinasterol, 2,3-Dihydroxypropyl oleate, 11-Octadecenoate acid methyl ester, Stigmastan-3,6-dione, b-Sitosterol- 3-O-b-D-glucopyranoside, Trilaurin, 28-O-Hexahydrophthalate and Fasciculol C. Yakuchinone A and Yakuchinone B are chemotaxonomic marker compounds identified in all species. The antioxidant properties of each extract of 42.27±0.53, 46.59±0.81 and 35.66±0.73 mg/L have been proven by the molecular interactions of the marker compounds in their ability to act as xanthine oxidase inhibitors. The compounds Yakuchinone A and Yakuchinone B are thought to be responsible for the pharmacological activity of the species E. calophrys, E. canaria and E. echinulate. Yakuchinone A and Yakuchinone B are marker compounds because they are distributed in all samples.
Characterization of essential oils and biological activities of Etlingera spp. from different agroecology in Southeast Sulawesi, Indonesia SELFYANA AUSTIN TEE; SYAMSU ALAM; YURIKA SASTYARINA; AGUNG WIBAWA MAHATVA YODHA; REYMON REYMON; MUH. AZDAR SETIAWAN; MUSDALIPAH MUSDALIPAH
Biodiversitas Journal of Biological Diversity Vol. 26 No. 4 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260416

Abstract

Abstract. Tee SA, Alam S, Sastyarina Y, Yodha AWM, Reymon, Setiawan MA, Musdalipah. 2025. Characterization of essential oils and biological activities of Etlingera spp. from different agroecology in Southeast Sulawesi, Indonesia. Biodiversitas 26: 1653-1665. Genus Etlingera, a part of Zingiberaceae, shows potential due to secondary metabolites influenced by agroecological factors, enhancing its therapeutic uses. The study aimed to characterize essential oils and biological activities of Etlingera elatior, Etlingera rubroloba, and Etlingera calophrys rhizomes collected from South Konawe, Wakatobi, and Muna District. Gas Chromatography-Mass Spectrometry (GC-MS) profiled the essential oils, while phenolic (TPC) and flavonoid (TFC) concentrations were determined using Folin-Ciocalteu and aluminum chloride methods. Antioxidant activity was assessed using DPPH and ABTS assays, and toxicity testing was performed on shrimp larvae. The research found that multiple species grow in areas with annual rainfall ranging from 1,800-2,100 mm/year, temperatures of 23-30°C, humidity levels of 78-84%, topography of 9-72 masl, and pH of 4.9-6.5. The essential oil content includes fatty acids (20.1-42.48%), phenolic (6.28-29.52%), and terpenoid (1.24-2.39). The IC50 of antioxidant activity (ABTS) for E. elatior, E. rubroloba, and E. calophrys were 1.3 mg/mL, 1.5 mg/mL, and 1.1 mg/mL, compared to vitamin C at 2.23 mg/mL. The DPPH assay IC50 values were 2.09 mg/mL, 2.17 mg/mL, and 2.42 mg/mL, compared to vitamin C at 2.78 mg/mL, respectively. TPC values were 113.63 mgGAE/g, 26.56 mgGAE/g and 143.00 mgGAE/g, respectively. TFC values were 62.03 mgQE/g, 21.07 mgQE/g, and 34.51 mgQE/g, respectively. Toxic LC50 values for extracts were 6.98 mg/L, 18.72 mg/L, and 120.86 mg/L compared to the positive control at 3.24 mg/L. The Structural Equation Models (SEM) approach demonstrates the direct and indirect influence of climatic and soil factors on secondary metabolites and biological activity of the genus Etlingera. In conclusion, the genus Etlingera is a promising source of antioxidants and anticancer agents. It is recommended for cultivation in suitable locations in Southeast Sulawesi, instilling hope and optimism about the future of this research.
Pogostemon cablin from North Konawe Targets MCF-7 Cells and Inflammatory Responses Through Protein Denaturation and Membrane Stabilization Adryan Fristiohady; Jafriati Jafriati; Irvan Anwar; Rathapon Asasutjarit; La Ode Muhammad Julian Purnama; Lidya Agriningsih Haruna; Agung Wibawa Mahatva Yodha; Hariana Hariana; Mentarry Bafadal
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.10168

Abstract

Pogostemon cablin (Patchouli), a medicinal plant traditionally used in Indonesia, is gaining scientific attention for its potential pharmacological activities. This study aimed to investigate the anti-inflammatory and anticancer effects of P. cablin ethanolic leaf extract specifically sourced from North Konawe, Southeast Sulawesi. To evaluate its anti-inflammatory activity, two in vitro models were used: the protein denaturation inhibition assay, simulating inflammatory protein response, and the human red blood cell (HRBC) membrane stabilization assay, which mimics lysosomal membrane stability in inflamed tissues. The extract showed significant, dose-dependent inhibition of protein denaturation, with an IC50 value of 62.98 µg/mL. In the HRBC assay, the extract demonstrated membrane stabilization activity with a maximum inhibition of 64.24% at the highest tested concentration (100 µg/mL). The cytotoxic potential was assessed using the MTT assay on MCF-7 hormone-responsive breast cancer cells. The extract exhibited potent anti-proliferative activity, with an IC50 value of 91.56 ± 1.31 µg/mL, indicating its effectiveness in inhibiting breast cancer cell growth. These findings highlight P. cablin from North Konawe as a promising natural source of anti-inflammatory and anticancer agents, with the potential to contribute to the development of plant-based therapeutics. However, this study is limited to in vitro analyses; further investigations are needed to isolate active compounds and confirm efficacy through in vivo and mechanistic studies.
Antioxidant and Anti-Breast Cancer Potentials of the Hydrophilic Fraction from Soft Coral Nepthea sp.: In Vitro and In Silico Assessment Sahidin Sahidin; Baru Sadarun; Marianti A Manggau; Adryan Fristiohady; Dzaky Aulia Rahman; Agung Wibawa Mahatva Yodha; Arfan Arfan; Andini Sundowo; Sofa Fajriah
Molekul Vol 21 No 2 (2026)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2026.21.2.19418

Abstract

ABSTRACT. Soft corals of the genus Nepthea are recognized as rich sources of marine bioactive compounds, yet their hydrophilic metabolites remain poorly explored. This study characterized the hydrophilic fraction of Nepthea sp. and assessed its antioxidant and anti–breast cancer activities through in vitro and in silico approaches. Ethyl acetate extract (EAE) of Nepthea sp. was fractionated into six subfractions (F1–F6), with F5–F6 representing hydrophilic fractions. Phytochemical screening, TPC, TFC, and LC–MS/MS analyses were conducted alongside antioxidant (DPPH, ABTS), cytotoxicity (MTT, MCF-7), and molecular docking assays against xanthine oxidase (XO) and estrogen receptor alpha (ERα). Phytochemical profiling revealed alkaloids, phenolics, flavonoids, saponins, and terpenoids, with F5 exhibiting the highest TPC (73.11 mg GAE/g) and TFC (2.20 mg QE/g). LC–MS/MS identified rengyolester and piperolactam-C9:1(8E) in F5 and isosalsoline and 3-tert-butyl-4-methoxyphenol in F6. F5 demonstrated stronger antioxidant (DPPH IC₅₀ = 67.39 mg/L; ABTS IC₅₀ = 54.12 mg/L) and cytotoxic (MTT IC₅₀ = 42.68 mg/L) activities than F6. Docking analysis supported these results: rengyolester and piperolactam-C9:1(8E) showed strong affinities toward XO (−8.4, −8.7 kcal/mol) and ERα (−7.6, −7.4 kcal/mol), forming interactions with key residues (Phe914, Phe1009, Glu353, Leu525) similar to reference ligands. The hydrophilic fraction particularly F5 contains multifunctional metabolites exhibiting both antioxidant and anticancer properties. The synergistic role of phenolic and terpenoid constituents highlights Nepthea sp. as a promising marine source of bioactive therapeutic leads. Keywords: Antioxidant, breast cancer, hydrophilic fraction, molecular docking, Nepthea sp.
Co-Authors Abdulkadir Kamaluddin Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agustini Ajeng Diantini, Ajeng Anas Subarnas Andini Sundowo Andini Sundowo Andini Sundowo Andini Sundowo Andini Sundowo Andini Sundowo Angriani Fusvita Angriani Fusvita Ani Umar Anwar, Irvan Arba, Muhammad Arfan Arfan ARFAN ARFAN Arfan Arfan Arfan Arfan Ari Sartinah Ari Sartinah ARMAN FASLIH, ARMAN Asasutjarit, Rathapon Asnani Asnani Astrid Indalifiany Austin Tee, Selfyana Badia, Esti Bafadal, Mentarry Baharum, Syarul Nataqain Baru Sadarun Baru Sadarun Baru Sadarun Baru Sadarun Budipramana, Krisyanti Daud, Nur Saadah Dhea, Alisha Dian Munasari Diasty Nuraisya Dzaky Aulia Rahman Elfahmi Elfahmi, Elfahmi Eny Nurhikma Euis Julaeha Fadhliyah Malik Fajri Fitra Amalia Fauzia Azzahra, Fauzia Fauziah, Yulianti Firasmi Sangadji Firda Yanti Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitria Nurcahyani Frangky Sangande Fristiohady, Adryan Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Hariana Hariana Hariana Hariana Hariana Hariana Hariana Hariana, Hariana Harnita, Wa Ode Haruna, Lidya A. Haruna, Lidya Agriningsih Hasidu, La Ode Abdul Fajar Haslianti Haslianti, Haslianti I Sahidin I W. Sutapa I. Sahidin I. Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin, Sahidin Idris, Sri Aprilianti Ikhsan, Ainussalbi Al Ilyas Y, Muhammad Imran Indra Ardiansyah Iren Meylani Irnawati Irnawati Irnawati Irvan Anwar Jafriati Jeoun Jung Jumadil Jumriani Jumriani Jumriani, Jumriani Junli Hong Karmilah KARMILAH KARMILAH Karmilah, Karmilah Kasnia Kaatu Kemal Idris Balaka Kraichat Tantrakarnapa La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Lidya Agriningsih Haruna Lidya Agriningsih Haruna Lisa Wulansari Siregar Loly Subhiaty Idrus Loly Subhiaty Idrus M. Hajrul Malaka Maharani Maharani Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Marianti A Manggau Marianti A. Manggau Masrika, Nur Upik En Maulidyah Maulidyah Maulidyah Maulidyah Mega Fatimah Rosana Melati Octapian Simanjuntak Mentarry Bafadal Mohammad Ghozali Muamar Abdillah Muh. Arnas MUH. AZDAR SETIAWAN Muhammad Azdar Setiawan Muhammad Azhar MUHAMMAD HAJRUL MALAKA Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Israwan Azis Muhammad Sultanul Aulya Muktiarni, Muktiarni Munasari, Dian Murtafia Murtafia Musdalipah MUSDALIPAH MUSDALIPAH MUSDALIPAH MUSDALIPAH N. Nohong NASRUDIN Nirwati Rusli Nohong Nur Af’idah Anas Nur Illiyyin Akib Nur Indri Rahayu NUR SAADAH DAUD Nur Syifa Rahmatika Nur Syifa Rahmatika Nur Syifa Rahmatika Nuralifah Nuralifah Nurcahyani, Fitria Nurpajriani, Nurpajriani Nurramadhani A. Sida Nursaadah Daud Parawansah Parawansah Pascayantri, Asniar Pryangan, Wulandari Purnama, La O. M. J. Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian Raden Maya Febrianti RAHMAT MULIADI, RAHMAT Rahmatika, Nur S. Ramadhan Tosepu Randa Wulaisfan Raodatul Jannah Rathapon Asasutjarit Rathapon Asasutjarit REYMON REYMON Reymon, Reymon Riezki Amalia Rina Andryani Rina Maryanti RINI HAMSIDI Rini Hamsidi Rissyelly Rissyelly Sahidin Sahidin Sahidin . SAHIDIN SAHIDIN Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Santi Oktaviani, Santi Saripuddin SELFYANA AUSTIN TEE Selfyana Austin Tee Sernita Seren Setiawan, Muh. Azdar Sitti Raodah Nurul Jannah Sofa Fajriah Sofa Fajriah Sofa Fajriah Solo, Dian Munasari Sri Aprilianti Idris Sukrasno Sukrasno SURYANI Suryani Suryani Suryani Suryani Susanti Susanti Susanti Susanti Syaikhul Aziz SYAMSU ALAM Syamsu Alam Syarul Nataqain Baharum Tee, Selfyana Austin Thamrin Azis Tien Tien Tuti Dharmawati W. Wahyuni Wa Ode Mutiara WAHYUNI wahyuni wahyuni Wahyuni Wahyuni Wahyuni Wahyuni Wenty, Darmayanita Yuni Elsa Hadisaputri YURIKA SASTYARINA Zeptiano, Zeptiano